Reviewed, UniProtKB/Swiss-Prot Q61527 (ERBB4_MOUSE)

Names and origin

Protein names

Recommended name:
    Receptor tyrosine-protein kinase erbB-4
    EC=2.7.10.1

Gene names

Name:	Erbb4
Synonyms:	Mer4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Specifically binds and is activated by neuregulins, NRG-2, NRG-3, heparin-binding EGF-like growth factor, betacellulin and NTAK. Interaction with these factors induces cell differentiation. Not activated by EGF, TGF-A, and amphiregulin By similarity.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subunit structure	Homodimer or heterodimer with each of the other ERBB receptors. Interacts with PDZ domains of DLG2, DLG3, DLG4 and the syntrophin SNTB2. Interacts with WWOX and MUC1 By similarity. Interacts with CBFA2T3.
Subcellular location	Membrane; Single-pass type I membrane protein.
Post-translational modification	Ligand-binding increases phosphorylation on tyrosine residues.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Disulfide bond Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell fate commitment Inferred from direct assay. Source: MGI heart development Inferred from mutant phenotype. Source: MGI nervous system development Inferred from mutant phenotype. Source: MGI protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: The 2 isoforms differ functionally in their response to phorbol ester: isoform JM-A is processed but not isoform JM-B. So, they respectively represent cleavable and non-cleavable forms of the receptor. Both isoforms are expressed in cerebellum, cerebral cortex, spinal cord, medulla oblongata and eye, but the kidney expresses solely isoform JM-A and the heart solely isoform JM-B.

Isoform JM-A (identifier: Q61527-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform JM-B (identifier: Q61527-2)

The sequence of this isoform differs from the canonical sequence as follows:
     626-648: NGPTSHDCIYYPWTGHSTLPQHA → IGSSIEDCIGLTD

Isoform 3 (identifier: Q61527-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1045-1045: R → RSEIGHSPPPAYTPMWG

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 1292	1267	Receptor tyrosine-protein kinase erbB-4		PRO_0000270146
Regions
	Topological domain	26 – 652	627	Extracellular Potential
	Transmembrane	653 – 673	21	Potential
	Topological domain	674 – 1292	619	Cytoplasmic Potential
	Domain	718 – 985	268	Protein kinase
	Nucleotide binding	724 – 732	9	ATP By similarity
	Motif	1032 – 1035	4	WW-binding 1 By similarity
	Motif	1282 – 1285	4	WW-binding 2 By similarity
	Motif	1290 – 1292	3	PDZ-binding By similarity
	Compositional bias	186 – 262	77	Cys-rich
	Compositional bias	496 – 593	98	Cys-rich
	Compositional bias	1281 – 1284	4	Poly-Pro
Sites
	Active site	843	1	Proton acceptor By similarity
	Binding site	751	1	ATP By similarity
Amino acid modifications
	Modified residue	733	1	Phosphotyrosine By similarity
	Modified residue	1146	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	1172	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	1242	1	Phosphotyrosine; by autocatalysis By similarity
	Modified residue	1268	1	Phosphotyrosine; by autocatalysis By similarity
	Glycosylation	138	1	N-linked (GlcNAc...) Potential
	Glycosylation	174	1	N-linked (GlcNAc...) Potential
	Glycosylation	181	1	N-linked (GlcNAc...) Potential
	Glycosylation	253	1	N-linked (GlcNAc...) Potential
	Glycosylation	410	1	N-linked (GlcNAc...) Potential
	Glycosylation	473	1	N-linked (GlcNAc...) Potential
	Glycosylation	495	1	N-linked (GlcNAc...) Potential
	Glycosylation	548	1	N-linked (GlcNAc...) Potential
	Glycosylation	576	1	N-linked (GlcNAc...) Potential
	Glycosylation	620	1	N-linked (GlcNAc...) Potential
	Disulfide bond	29 ↔ 56		By similarity
	Disulfide bond	156 ↔ 186		By similarity
	Disulfide bond	189 ↔ 197		By similarity
	Disulfide bond	193 ↔ 205		By similarity
	Disulfide bond	213 ↔ 221		By similarity
	Disulfide bond	217 ↔ 229		By similarity
	Disulfide bond	230 ↔ 238		By similarity
	Disulfide bond	234 ↔ 246		By similarity
	Disulfide bond	249 ↔ 258		By similarity
	Disulfide bond	262 ↔ 289		By similarity
	Disulfide bond	293 ↔ 304		By similarity
	Disulfide bond	308 ↔ 323		By similarity
	Disulfide bond	326 ↔ 330		By similarity
	Disulfide bond	503 ↔ 512		By similarity
	Disulfide bond	507 ↔ 520		By similarity
	Disulfide bond	523 ↔ 532		By similarity
	Disulfide bond	536 ↔ 552		By similarity
	Disulfide bond	555 ↔ 569		By similarity
	Disulfide bond	559 ↔ 577		By similarity
	Disulfide bond	580 ↔ 589		By similarity
	Disulfide bond	593 ↔ 614		By similarity
	Disulfide bond	617 ↔ 625		By similarity
	Disulfide bond	621 ↔ 633		By similarity
Natural variations
	Alternative sequence	626 – 648	23	NGPTS…LPQHA → IGSSIEDCIGLTD in isoform JM-B.		VSP_002896
	Alternative sequence	1045	1	R → RSEIGHSPPPAYTPMWG in isoform 3.		VSP_022149
Experimental info
	Sequence conflict	1019	1	A → V in AAC28334. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform JM-A [UniParc]. Last modified January 9, 2007. Version 3. Checksum: 46FBDC6AE4CB2908	FASTA	1,292	145,213
	10 20 30 40 50 60 MKLATGLWVW GSLLMAAGTV QPSASQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 70 80 90 100 110 120 GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 130 140 150 160 170 180 LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNMTLVST 190 200 210 220 230 240 NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 250 260 270 280 290 300 PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 310 320 330 340 350 360 SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 370 380 390 400 410 420 KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 430 440 450 460 470 480 VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 490 500 510 520 530 540 INQRIVIRDN RRAENCTAEG MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD 550 560 570 580 590 600 GEFREFENGS ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 610 620 630 640 650 660 NSFIFKYADQ DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 670 680 690 700 710 720 LFILVIMALT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 730 740 750 760 770 780 VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 790 800 810 820 830 840 VRLLGVCLSP TIQLVTQLMP HGCLLDYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 850 860 870 880 890 900 HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 910 920 930 940 950 960 SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 970 980 990 1000 1010 1020 ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 1030 1040 1050 1060 1070 1080 EYLVPQAFNI PPPIYTSRTR IDSNRNQFVY QDGGFATQQG MPMPYRATTS TIPEAPVAQG 1090 1100 1110 1120 1130 1140 ATAEMFDDSC CNGTLRKPVA PHVQEDSSTQ RYSADPTVFA PERNPRGELD EEGYMTPMHD 1150 1160 1170 1180 1190 1200 KPKQEYLNPV EENPFVSRRK NGDLQALDNP EYHSASSGPP KAEDEYVNEP LYLNTFANAL 1210 1220 1230 1240 1250 1260 GSAEYMKNSV LSVPEKAKKA FDNPDYWNHS LPPRSTLQHP DYLQEYSTKY FYKQNGRIRP 1270 1280 1290 IVAENPEYLS EFSLKPGTVL PPPPYRHRNT VV
	Isoform JM-B. Checksum: B1795C174A9CE1D5	FASTA	1,282	143,953
	10 20 30 40 50 60 MKLATGLWVW GSLLMAAGTV QPSASQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 70 80 90 100 110 120 GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 130 140 150 160 170 180 LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNMTLVST 190 200 210 220 230 240 NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 250 260 270 280 290 300 PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 310 320 330 340 350 360 SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 370 380 390 400 410 420 KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 430 440 450 460 470 480 VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 490 500 510 520 530 540 INQRIVIRDN RRAENCTAEG MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD 550 560 570 580 590 600 GEFREFENGS ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 610 620 630 640 650 660 NSFIFKYADQ DRECHPCHPN CTQGCIGSSI EDCIGLTDRT PLIAAGVIGG LFILVIMALT 670 680 690 700 710 720 FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR VKVLGSGAFG 730 740 750 760 770 780 TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL VRLLGVCLSP 790 800 810 820 830 840 TIQLVTQLMP HGCLLDYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV HRDLAARNVL 850 860 870 880 890 900 VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ SDVWSYGVTI 910 920 930 940 950 960 WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID ADSRPKFKEL 970 980 990 1000 1010 1020 AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE EYLVPQAFNI 1030 1040 1050 1060 1070 1080 PPPIYTSRTR IDSNRNQFVY QDGGFATQQG MPMPYRATTS TIPEAPVAQG ATAEMFDDSC 1090 1100 1110 1120 1130 1140 CNGTLRKPVA PHVQEDSSTQ RYSADPTVFA PERNPRGELD EEGYMTPMHD KPKQEYLNPV 1150 1160 1170 1180 1190 1200 EENPFVSRRK NGDLQALDNP EYHSASSGPP KAEDEYVNEP LYLNTFANAL GSAEYMKNSV 1210 1220 1230 1240 1250 1260 LSVPEKAKKA FDNPDYWNHS LPPRSTLQHP DYLQEYSTKY FYKQNGRIRP IVAENPEYLS 1270 1280 EFSLKPGTVL PPPPYRHRNT VV
	Isoform 3. Checksum: 64803278A53A45F6	FASTA	1,308	146,922
	10 20 30 40 50 60 MKLATGLWVW GSLLMAAGTV QPSASQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 70 80 90 100 110 120 GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 130 140 150 160 170 180 LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNMTLVST 190 200 210 220 230 240 NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 250 260 270 280 290 300 PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 310 320 330 340 350 360 SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 370 380 390 400 410 420 KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 430 440 450 460 470 480 VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 490 500 510 520 530 540 INQRIVIRDN RRAENCTAEG MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD 550 560 570 580 590 600 GEFREFENGS ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 610 620 630 640 650 660 NSFIFKYADQ DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 670 680 690 700 710 720 LFILVIMALT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 730 740 750 760 770 780 VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 790 800 810 820 830 840 VRLLGVCLSP TIQLVTQLMP HGCLLDYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 850 860 870 880 890 900 HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 910 920 930 940 950 960 SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 970 980 990 1000 1010 1020 ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 1030 1040 1050 1060 1070 1080 EYLVPQAFNI PPPIYTSRTR IDSNRSEIGH SPPPAYTPMW GNQFVYQDGG FATQQGMPMP 1090 1100 1110 1120 1130 1140 YRATTSTIPE APVAQGATAE MFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERN 1150 1160 1170 1180 1190 1200 PRGELDEEGY MTPMHDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHS ASSGPPKAED 1210 1220 1230 1240 1250 1260 EYVNEPLYLN TFANALGSAE YMKNSVLSVP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 1270 1280 1290 1300 EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1247. Strain: C57BL/6J. Tissue: Kidney.
[3]	"A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester." Elenius K., Corfas G., Paul S., Choi C.J., Rio C., Plowman G.D., Klagsbrun M. J. Biol. Chem. 272:26761-26768(1997) [PubMed: 9334263] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 624-650 (ISOFORMS JM-A AND JM-B). Tissue: Heart and Kidney.
[4]	"Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle." Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R. Dev. Biol. 172:158-169(1995) [PubMed: 7589796] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1019-1086. Strain: C57BL/6. Tissue: Brain.
[5]	"Potential signaling network by EGF-like growth factors in the mouse uterus during early pregnancy." Lim H., Das S.K., Dey S.K. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1019-1077 (ISOFORM 3). Strain: CD-1. Tissue: Uterus.
[6]	"ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression." Linggi B., Carpenter G. J. Biol. Chem. 281:25373-25380(2006) [PubMed: 16815842] [Abstract] Cited for: INTERACTION WITH CBFA2T3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC099604 Genomic DNA. No translation available. AC107673 Genomic DNA. No translation available. AC138110 Genomic DNA. No translation available. AC138285 Genomic DNA. No translation available. AC139369 Genomic DNA. No translation available. CAAA01019932 Genomic DNA. No translation available. CAAA01109085 Genomic DNA. No translation available. AK144050 mRNA. Translation: BAE25671.1. L47241 mRNA. Translation: AAA93534.1. AF059177 mRNA. Translation: AAC28334.1.
IPI	IPI00122341. IPI00357770. IPI00896073.
RefSeq	NP_034284.1.
UniGene	Mm.442420
3D structure databases
SMR	Q61527. Positions 26-641.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61527.
Proteomic databases
PRIDE	Q61527.
Genome annotation databases
Ensembl	ENSMUST00000082184; ENSMUSP00000080821; ENSMUSG00000062209; Mus musculus. [Genome view] ENSMUST00000097703; ENSMUSP00000095310; ENSMUSG00000062209; Mus musculus. [Genome view] ENSMUST00000119142; ENSMUSP00000112713; ENSMUSG00000062209; Mus musculus. [Genome view] ENSMUST00000121473; ENSMUSP00000114123; ENSMUSG00000062209; Mus musculus. [Genome view]
GeneID	13869.
KEGG	mmu:13869.
UCSC	uc007bjb.1. mouse.
Organism-specific databases
CTD	13869.
MGI	MGI:104771. Erbb4.
Phylogenomic databases
HOVERGEN	Q61527.
Enzyme and pathway databases
BRENDA	2.7.10.1. 244.
Gene expression databases
ArrayExpress	Q61527.
Bgee	Q61527.
Genevestigator	Q61527.
GermOnline	ENSMUSG00000062209. Mus musculus.
Family and domain databases
InterPro	IPR000494. EGF_rcpt_L. IPR006211. Furin-like. IPR006212. Furin_repeat. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR016245. Tyr_kinase_rcpt_EGF/ERB/XmrK. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR004019. YLP_motif. [Graphical view]
Pfam	PF00757. Furin-like. 1 hit. PF07714. Pkinase_Tyr. 1 hit. PF01030. Recep_L_domain. 2 hits. PF02757. YLP. 2 hits. [Graphical view]
PIRSF	PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00261. FU. 5 hits. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	284772.
SOURCE	Search...

Entry information

Entry name

ERBB4_MOUSE

Accession

Primary (citable) accession number: Q61527
Secondary accession number(s): O88460, Q3UNS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 9, 2007
Last modified:	October 13, 2009
This is version 87 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)