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Q61526

- ERBB3_MOUSE

UniProt

Q61526 - ERBB3_MOUSE

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Protein

Receptor tyrosine-protein kinase erbB-3

Gene
Erbb3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5 By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei740 – 7401ATP By similarity
Active sitei832 – 8321Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi713 – 7219ATP By similarity
Nucleotide bindingi786 – 7883ATP By similarity
Nucleotide bindingi832 – 8376ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: UniProtKB
  3. protein tyrosine kinase activator activity Source: Ensembl
  4. receptor signaling protein tyrosine kinase activity Source: InterPro
  5. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. cranial nerve development Source: MGI
  2. endocardial cushion development Source: MGI
  3. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  4. negative regulation of cell adhesion Source: Ensembl
  5. negative regulation of neuron apoptotic process Source: MGI
  6. negative regulation of secretion Source: Ensembl
  7. negative regulation of signal transduction Source: Ensembl
  8. neuron apoptotic process Source: Ensembl
  9. peripheral nervous system development Source: MGI
  10. phosphatidylinositol 3-kinase signaling Source: Ensembl
  11. regulation of cell proliferation Source: Ensembl
  12. Schwann cell differentiation Source: MGI
  13. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_188191. Signaling by ERBB2.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)
Alternative name(s):
Glial growth factor receptor
Proto-oncogene-like protein c-ErbB-3
Gene namesi
Name:Erbb3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:95411. Erbb3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 641622Extracellular Reviewed predictionAdd
BLAST
Transmembranei642 – 66221Helical; Reviewed predictionAdd
BLAST
Topological domaini663 – 1339677Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. basolateral plasma membrane Source: Ensembl
  3. extracellular space Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. lateral plasma membrane Source: MGI
  6. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed predictionAdd
BLAST
Chaini20 – 13391320Receptor tyrosine-protein kinase erbB-3PRO_0000042231Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi186 ↔ 194 By similarity
Disulfide bondi190 ↔ 202 By similarity
Disulfide bondi210 ↔ 218 By similarity
Disulfide bondi214 ↔ 226 By similarity
Disulfide bondi227 ↔ 235 By similarity
Disulfide bondi231 ↔ 243 By similarity
Disulfide bondi246 ↔ 255 By similarity
Glycosylationi250 – 2501N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi259 ↔ 286 By similarity
Disulfide bondi290 ↔ 301 By similarity
Disulfide bondi305 ↔ 320 By similarity
Disulfide bondi323 ↔ 327 By similarity
Glycosylationi353 – 3531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi408 – 4081N-linked (GlcNAc...) Reviewed prediction
Glycosylationi414 – 4141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi437 – 4371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi469 – 4691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi500 ↔ 509 By similarity
Disulfide bondi504 ↔ 517 By similarity
Disulfide bondi520 ↔ 529 By similarity
Glycosylationi522 – 5221N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi533 ↔ 549 By similarity
Disulfide bondi552 ↔ 565 By similarity
Disulfide bondi556 ↔ 573 By similarity
Glycosylationi566 – 5661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi576 ↔ 585 By similarity
Disulfide bondi589 ↔ 610 By similarity
Disulfide bondi613 ↔ 621 By similarity
Glycosylationi616 – 6161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi617 ↔ 629 By similarity

Post-translational modificationi

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61526.
PaxDbiQ61526.
PRIDEiQ61526.

PTM databases

PhosphoSiteiQ61526.

Expressioni

Tissue specificityi

In the muscle, expression localizes to the synaptic sites of muscle fibers.

Gene expression databases

BgeeiQ61526.
GenevestigatoriQ61526.

Interactioni

Subunit structurei

Monomer and homodimer. Heterodimer with each of the other ERBB receptors Reviewed prediction. Interacts with CSPG5, PA2G4, GRB7 and MUC1 By similarity. Interacts with MYOC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Erbb2P704242EBI-931878,EBI-2945468

Protein-protein interaction databases

IntActiQ61526. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61526.
SMRiQ61526. Positions 27-630, 672-990.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini707 – 964258Protein kinaseAdd
BLAST

Domaini

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00600000084253.
HOGENOMiHOG000230982.
HOVERGENiHBG000490.
InParanoidiQ61526.
KOiK05084.
OMAiCYHHSLN.
OrthoDBiEOG7V49XM.
PhylomeDBiQ61526.
TreeFamiTF106002.

Family and domain databases

Gene3Di3.80.20.20. 2 hits.
InterProiIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamiPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61526-1 [UniParc]FASTAAdd to Basket

« Hide

MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY     50
KLYEKCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP 100
NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRFTQLT EILLGGVYIE 150
KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG GNCPPCHEVC KGRCWGPGPE 200
DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN 250
DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 300
CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG 350
FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ 400
SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS 450
AGRVYISANQ QLCYHHSLNW TRLLRGPAEE RLDIKYNRPL GECVAEGKVC 500
DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP REFVHEAHCF 550
SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL 650
TVIFLILGGS FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR 700
IFKETELRKL KVLGSGVFGT VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS 750
FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS LQLVTQYLPL GSLLDHVRQH 800
RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML KSPSQVQVAD 850
FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE 950
NIRPTFKELA NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD 1000
AELEPDLDLD LDVEVEEEGL ATTLGSALSL PTGTLTRPRG SQSLLSPSSG 1050
YMPMNQSNLG EACLDSAVLG GREQFSRPIS LHPIPRGRQT SESSEGHVTG 1100
SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV TPLSPPGLEE 1150
EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200
RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG 1250
TTPDEDYEYM NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP 1300
HVRYARLKTL RSLEATDSAF DNPDYWHSRL FPKANAQRI 1339
Length:1,339
Mass (Da):147,613
Last modified:October 11, 2005 - v2
Checksum:i59D56FD9C9536FBE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1067 – 10671A → V in AAA93533. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY686636 mRNA. Translation: AAT95433.1.
BC029028 mRNA. Translation: AAH29028.1.
BC049279 mRNA. Translation: AAH49279.1.
BC106091 mRNA. Translation: AAI06092.1.
L47240 mRNA. Translation: AAA93533.1.
CCDSiCCDS24283.1.
RefSeqiNP_034283.1. NM_010153.1.
UniGeneiMm.373043.

Genome annotation databases

EnsembliENSMUST00000082059; ENSMUSP00000080716; ENSMUSG00000018166.
GeneIDi13867.
KEGGimmu:13867.
UCSCiuc007hnm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY686636 mRNA. Translation: AAT95433.1 .
BC029028 mRNA. Translation: AAH29028.1 .
BC049279 mRNA. Translation: AAH49279.1 .
BC106091 mRNA. Translation: AAI06092.1 .
L47240 mRNA. Translation: AAA93533.1 .
CCDSi CCDS24283.1.
RefSeqi NP_034283.1. NM_010153.1.
UniGenei Mm.373043.

3D structure databases

ProteinModelPortali Q61526.
SMRi Q61526. Positions 27-630, 672-990.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61526. 2 interactions.

PTM databases

PhosphoSitei Q61526.

Proteomic databases

MaxQBi Q61526.
PaxDbi Q61526.
PRIDEi Q61526.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082059 ; ENSMUSP00000080716 ; ENSMUSG00000018166 .
GeneIDi 13867.
KEGGi mmu:13867.
UCSCi uc007hnm.1. mouse.

Organism-specific databases

CTDi 2065.
MGIi MGI:95411. Erbb3.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00600000084253.
HOGENOMi HOG000230982.
HOVERGENi HBG000490.
InParanoidi Q61526.
KOi K05084.
OMAi CYHHSLN.
OrthoDBi EOG7V49XM.
PhylomeDBi Q61526.
TreeFami TF106002.

Enzyme and pathway databases

Reactomei REACT_188191. Signaling by ERBB2.
REACT_188574. SHC1 events in ERBB2 signaling.
REACT_188579. Signaling by ERBB4.
REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
REACT_199058. GRB7 events in ERBB2 signaling.
REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
REACT_215348. PI3K events in ERBB2 signaling.
REACT_226341. PIP3 activates AKT signaling.

Miscellaneous databases

ChiTaRSi ERBB3. mouse.
NextBioi 284768.
PROi Q61526.
SOURCEi Search...

Gene expression databases

Bgeei Q61526.
Genevestigatori Q61526.

Family and domain databases

Gene3Di 3.80.20.20. 2 hits.
InterProi IPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view ]
Pfami PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view ]
PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSi PR00109. TYRKINASE.
SMARTi SM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Involvement of the ErbB3 signaling pathway in Schwann cell migration."
    Yamauchi J., Shooter E.M.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor and Thyroid.
  3. "Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle."
    Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R.
    Dev. Biol. 172:158-169(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1061-1154.
    Tissue: Muscle fibroblast.
  4. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
    Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
    J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYOC.

Entry informationi

Entry nameiERBB3_MOUSE
AccessioniPrimary (citable) accession number: Q61526
Secondary accession number(s): Q3KQR1
, Q68J64, Q810U8, Q8K317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 11, 2005
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi