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Q61526 (ERBB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor tyrosine-protein kinase erbB-3

EC=2.7.10.1
Alternative name(s):
Glial growth factor receptor
Proto-oncogene-like protein c-ErbB-3
Gene names
Name:Erbb3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1339 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5 By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Monomer and homodimer. Heterodimer with each of the other ERBB receptors Potential. Interacts with CSPG5, PA2G4, GRB7 and MUC1 By similarity. Interacts with MYOC. Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

In the muscle, expression localizes to the synaptic sites of muscle fibers.

Domain

The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

Post-translational modification

Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Transferase
Tyrosine-protein kinase
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processSchwann cell differentiation

Inferred from mutant phenotype PubMed 9338783. Source: MGI

cranial nerve development

Inferred from mutant phenotype PubMed 9338783. Source: MGI

endocardial cushion development

Inferred from mutant phenotype PubMed 9362461. Source: MGI

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell adhesion

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 9338783. Source: MGI

negative regulation of secretion

Inferred from electronic annotation. Source: Ensembl

negative regulation of signal transduction

Inferred from electronic annotation. Source: Ensembl

neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

peripheral nervous system development

Inferred from mutant phenotype PubMed 9362461. Source: MGI

phosphatidylinositol 3-kinase signaling

Inferred from electronic annotation. Source: Ensembl

regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

transmembrane receptor protein tyrosine kinase signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentapical plasma membrane

Inferred from direct assay PubMed 15306553. Source: MGI

basolateral plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

lateral plasma membrane

Inferred from direct assay PubMed 15306553. Source: MGI

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein tyrosine kinase activator activity

Inferred from electronic annotation. Source: Ensembl

receptor signaling protein tyrosine kinase activity

Inferred from electronic annotation. Source: InterPro

transmembrane receptor protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Erbb2P704242EBI-931878,EBI-2945468

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 13391320Receptor tyrosine-protein kinase erbB-3
PRO_0000042231

Regions

Topological domain20 – 641622Extracellular Potential
Transmembrane642 – 66221Helical; Potential
Topological domain663 – 1339677Cytoplasmic Potential
Domain707 – 964258Protein kinase
Nucleotide binding713 – 7219ATP By similarity
Nucleotide binding786 – 7883ATP By similarity
Nucleotide binding832 – 8376ATP By similarity

Sites

Active site8321Proton acceptor By similarity
Binding site7401ATP By similarity

Amino acid modifications

Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation2501N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation4081N-linked (GlcNAc...) Potential
Glycosylation4141N-linked (GlcNAc...) Potential
Glycosylation4371N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential
Glycosylation5221N-linked (GlcNAc...) Potential
Glycosylation5661N-linked (GlcNAc...) Potential
Glycosylation6161N-linked (GlcNAc...) Potential
Disulfide bond186 ↔ 194 By similarity
Disulfide bond190 ↔ 202 By similarity
Disulfide bond210 ↔ 218 By similarity
Disulfide bond214 ↔ 226 By similarity
Disulfide bond227 ↔ 235 By similarity
Disulfide bond231 ↔ 243 By similarity
Disulfide bond246 ↔ 255 By similarity
Disulfide bond259 ↔ 286 By similarity
Disulfide bond290 ↔ 301 By similarity
Disulfide bond305 ↔ 320 By similarity
Disulfide bond323 ↔ 327 By similarity
Disulfide bond500 ↔ 509 By similarity
Disulfide bond504 ↔ 517 By similarity
Disulfide bond520 ↔ 529 By similarity
Disulfide bond533 ↔ 549 By similarity
Disulfide bond552 ↔ 565 By similarity
Disulfide bond556 ↔ 573 By similarity
Disulfide bond576 ↔ 585 By similarity
Disulfide bond589 ↔ 610 By similarity
Disulfide bond613 ↔ 621 By similarity
Disulfide bond617 ↔ 629 By similarity

Experimental info

Sequence conflict10671A → V in AAA93533. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61526 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: 59D56FD9C9536FBE

FASTA1,339147,613
        10         20         30         40         50         60 
MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 

        70         80         90        100        110        120 
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 

       130        140        150        160        170        180 
LNYNTNSSHA LRQLRFTQLT EILLGGVYIE KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG 

       190        200        210        220        230        240 
GNCPPCHEVC KGRCWGPGPE DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 

       250        260        270        280        290        300 
TDCFACRHFN DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 

       310        320        330        340        350        360 
CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 

       370        380        390        400        410        420 
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 

       430        440        450        460        470        480 
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPAEE 

       490        500        510        520        530        540 
RLDIKYNRPL GECVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP 

       550        560        570        580        590        600 
REFVHEAHCF SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 

       610        620        630        640        650        660 
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL TVIFLILGGS 

       670        680        690        700        710        720 
FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 

       730        740        750        760        770        780 
VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 

       790        800        810        820        830        840 
LQLVTQYLPL GSLLDHVRQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 

       850        860        870        880        890        900 
KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 

       910        920        930        940        950        960 
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 

       970        980        990       1000       1010       1020 
NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD AELEPDLDLD LDVEVEEEGL 

      1030       1040       1050       1060       1070       1080 
ATTLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSNLG EACLDSAVLG GREQFSRPIS 

      1090       1100       1110       1120       1130       1140 
LHPIPRGRQT SESSEGHVTG SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 

      1150       1160       1170       1180       1190       1200 
TPLSPPGLEE EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 

      1210       1220       1230       1240       1250       1260 
RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 

      1270       1280       1290       1300       1310       1320 
NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP HVRYARLKTL RSLEATDSAF 

      1330 
DNPDYWHSRL FPKANAQRI 

« Hide

References

« Hide 'large scale' references
[1]"Involvement of the ErbB3 signaling pathway in Schwann cell migration."
Yamauchi J., Shooter E.M.
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor and Thyroid.
[3]"Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle."
Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R.
Dev. Biol. 172:158-169(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1061-1154.
Tissue: Muscle fibroblast.
[4]"Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYOC.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY686636 mRNA. Translation: AAT95433.1.
BC029028 mRNA. Translation: AAH29028.1.
BC049279 mRNA. Translation: AAH49279.1.
BC106091 mRNA. Translation: AAI06092.1.
L47240 mRNA. Translation: AAA93533.1.
RefSeqNP_034283.1. NM_010153.1.
UniGeneMm.373043.

3D structure databases

ProteinModelPortalQ61526.
SMRQ61526. Positions 27-630, 672-990.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61526. 2 interactions.

PTM databases

PhosphoSiteQ61526.

Proteomic databases

PaxDbQ61526.
PRIDEQ61526.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000082059; ENSMUSP00000080716; ENSMUSG00000018166.
GeneID13867.
KEGGmmu:13867.
UCSCuc007hnm.1. mouse.

Organism-specific databases

CTD2065.
MGIMGI:95411. Erbb3.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00600000084253.
HOGENOMHOG000230982.
HOVERGENHBG000490.
InParanoidQ61526.
KOK05084.
OMACYHHSLN.
OrthoDBEOG7V49XM.
PhylomeDBQ61526.
TreeFamTF106002.

Gene expression databases

BgeeQ61526.
GenevestigatorQ61526.

Family and domain databases

Gene3D3.80.20.20. 2 hits.
InterProIPR000494. EGF_rcpt_L.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
[Graphical view]
PfamPF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000619. TyrPK_EGF-R. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00261. FU. 5 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSERBB3. mouse.
NextBio284768.
PROQ61526.
SOURCESearch...

Entry information

Entry nameERBB3_MOUSE
AccessionPrimary (citable) accession number: Q61526
Secondary accession number(s): Q3KQR1 expand/collapse secondary AC list , Q68J64, Q810U8, Q8K317
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 11, 2005
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot