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Q61526

- ERBB3_MOUSE

UniProt

Q61526 - ERBB3_MOUSE

Protein

Receptor tyrosine-protein kinase erbB-3

Gene

Erbb3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (11 Oct 2005)
      Previous versions | rss
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    Functioni

    Binds and is activated by neuregulins and NTAK. May also be activated by CSPG5 By similarity.By similarity

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei740 – 7401ATPPROSITE-ProRule annotation
    Active sitei832 – 8321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi713 – 7219ATPPROSITE-ProRule annotation
    Nucleotide bindingi786 – 7883ATPPROSITE-ProRule annotation
    Nucleotide bindingi832 – 8376ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: UniProtKB
    3. protein tyrosine kinase activator activity Source: Ensembl
    4. receptor signaling protein tyrosine kinase activity Source: InterPro
    5. transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cranial nerve development Source: MGI
    2. endocardial cushion development Source: MGI
    3. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    4. negative regulation of cell adhesion Source: Ensembl
    5. negative regulation of neuron apoptotic process Source: MGI
    6. negative regulation of secretion Source: Ensembl
    7. negative regulation of signal transduction Source: Ensembl
    8. neuron apoptotic process Source: Ensembl
    9. peripheral nervous system development Source: MGI
    10. phosphatidylinositol 3-kinase signaling Source: Ensembl
    11. regulation of cell proliferation Source: Ensembl
    12. Schwann cell differentiation Source: MGI
    13. transmembrane receptor protein tyrosine kinase signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Kinase, Receptor, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_188191. Signaling by ERBB2.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor tyrosine-protein kinase erbB-3 (EC:2.7.10.1)
    Alternative name(s):
    Glial growth factor receptor
    Proto-oncogene-like protein c-ErbB-3
    Gene namesi
    Name:Erbb3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:95411. Erbb3.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. basolateral plasma membrane Source: Ensembl
    3. extracellular space Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. lateral plasma membrane Source: MGI
    6. receptor complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 13391320Receptor tyrosine-protein kinase erbB-3PRO_0000042231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi186 ↔ 194By similarity
    Disulfide bondi190 ↔ 202By similarity
    Disulfide bondi210 ↔ 218By similarity
    Disulfide bondi214 ↔ 226By similarity
    Disulfide bondi227 ↔ 235By similarity
    Disulfide bondi231 ↔ 243By similarity
    Disulfide bondi246 ↔ 255By similarity
    Glycosylationi250 – 2501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi259 ↔ 286By similarity
    Disulfide bondi290 ↔ 301By similarity
    Disulfide bondi305 ↔ 320By similarity
    Disulfide bondi323 ↔ 327By similarity
    Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi408 – 4081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi414 – 4141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi437 – 4371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi500 ↔ 509By similarity
    Disulfide bondi504 ↔ 517By similarity
    Disulfide bondi520 ↔ 529By similarity
    Glycosylationi522 – 5221N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi533 ↔ 549By similarity
    Disulfide bondi552 ↔ 565By similarity
    Disulfide bondi556 ↔ 573By similarity
    Glycosylationi566 – 5661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi576 ↔ 585By similarity
    Disulfide bondi589 ↔ 610By similarity
    Disulfide bondi613 ↔ 621By similarity
    Glycosylationi616 – 6161N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi617 ↔ 629By similarity

    Post-translational modificationi

    Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ61526.
    PaxDbiQ61526.
    PRIDEiQ61526.

    PTM databases

    PhosphoSiteiQ61526.

    Expressioni

    Tissue specificityi

    In the muscle, expression localizes to the synaptic sites of muscle fibers.

    Gene expression databases

    BgeeiQ61526.
    GenevestigatoriQ61526.

    Interactioni

    Subunit structurei

    Monomer and homodimer. Heterodimer with each of the other ERBB receptors Potential. Interacts with CSPG5, PA2G4, GRB7 and MUC1 By similarity. Interacts with MYOC.By similarity1 PublicationCurated

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Erbb2P704242EBI-931878,EBI-2945468

    Protein-protein interaction databases

    IntActiQ61526. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61526.
    SMRiQ61526. Positions 27-630, 672-990.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 641622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini663 – 1339677CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei642 – 66221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini707 – 964258Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00600000084253.
    HOGENOMiHOG000230982.
    HOVERGENiHBG000490.
    InParanoidiQ61526.
    KOiK05084.
    OMAiCYHHSLN.
    OrthoDBiEOG7V49XM.
    PhylomeDBiQ61526.
    TreeFamiTF106002.

    Family and domain databases

    Gene3Di3.80.20.20. 2 hits.
    InterProiIPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view]
    PfamiPF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61526-1 [UniParc]FASTAAdd to Basket

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    MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY     50
    KLYEKCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP 100
    NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRFTQLT EILLGGVYIE 150
    KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG GNCPPCHEVC KGRCWGPGPE 200
    DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD TDCFACRHFN 250
    DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 300
    CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG 350
    FVNCTKILGN LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ 400
    SWPPHMHNFS VFSNLTTIGG RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS 450
    AGRVYISANQ QLCYHHSLNW TRLLRGPAEE RLDIKYNRPL GECVAEGKVC 500
    DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP REFVHEAHCF 550
    SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 600
    YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL 650
    TVIFLILGGS FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR 700
    IFKETELRKL KVLGSGVFGT VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS 750
    FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS LQLVTQYLPL GSLLDHVRQH 800
    RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML KSPSQVQVAD 850
    FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 900
    ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE 950
    NIRPTFKELA NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD 1000
    AELEPDLDLD LDVEVEEEGL ATTLGSALSL PTGTLTRPRG SQSLLSPSSG 1050
    YMPMNQSNLG EACLDSAVLG GREQFSRPIS LHPIPRGRQT SESSEGHVTG 1100
    SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV TPLSPPGLEE 1150
    EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 1200
    RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG 1250
    TTPDEDYEYM NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP 1300
    HVRYARLKTL RSLEATDSAF DNPDYWHSRL FPKANAQRI 1339
    Length:1,339
    Mass (Da):147,613
    Last modified:October 11, 2005 - v2
    Checksum:i59D56FD9C9536FBE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1067 – 10671A → V in AAA93533. (PubMed:7589796)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686636 mRNA. Translation: AAT95433.1.
    BC029028 mRNA. Translation: AAH29028.1.
    BC049279 mRNA. Translation: AAH49279.1.
    BC106091 mRNA. Translation: AAI06092.1.
    L47240 mRNA. Translation: AAA93533.1.
    CCDSiCCDS24283.1.
    RefSeqiNP_034283.1. NM_010153.1.
    UniGeneiMm.373043.

    Genome annotation databases

    EnsembliENSMUST00000082059; ENSMUSP00000080716; ENSMUSG00000018166.
    GeneIDi13867.
    KEGGimmu:13867.
    UCSCiuc007hnm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY686636 mRNA. Translation: AAT95433.1 .
    BC029028 mRNA. Translation: AAH29028.1 .
    BC049279 mRNA. Translation: AAH49279.1 .
    BC106091 mRNA. Translation: AAI06092.1 .
    L47240 mRNA. Translation: AAA93533.1 .
    CCDSi CCDS24283.1.
    RefSeqi NP_034283.1. NM_010153.1.
    UniGenei Mm.373043.

    3D structure databases

    ProteinModelPortali Q61526.
    SMRi Q61526. Positions 27-630, 672-990.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61526. 2 interactions.

    PTM databases

    PhosphoSitei Q61526.

    Proteomic databases

    MaxQBi Q61526.
    PaxDbi Q61526.
    PRIDEi Q61526.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000082059 ; ENSMUSP00000080716 ; ENSMUSG00000018166 .
    GeneIDi 13867.
    KEGGi mmu:13867.
    UCSCi uc007hnm.1. mouse.

    Organism-specific databases

    CTDi 2065.
    MGIi MGI:95411. Erbb3.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00600000084253.
    HOGENOMi HOG000230982.
    HOVERGENi HBG000490.
    InParanoidi Q61526.
    KOi K05084.
    OMAi CYHHSLN.
    OrthoDBi EOG7V49XM.
    PhylomeDBi Q61526.
    TreeFami TF106002.

    Enzyme and pathway databases

    Reactomei REACT_188191. Signaling by ERBB2.
    REACT_188574. SHC1 events in ERBB2 signaling.
    REACT_188579. Signaling by ERBB4.
    REACT_196588. Constitutive PI3K/AKT Signaling in Cancer.
    REACT_199058. GRB7 events in ERBB2 signaling.
    REACT_199061. Downregulation of ERBB2:ERBB3 signaling.
    REACT_215348. PI3K events in ERBB2 signaling.
    REACT_226341. PIP3 activates AKT signaling.

    Miscellaneous databases

    ChiTaRSi ERBB3. mouse.
    NextBioi 284768.
    PROi Q61526.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61526.
    Genevestigatori Q61526.

    Family and domain databases

    Gene3Di 3.80.20.20. 2 hits.
    InterProi IPR000494. EGF_rcpt_L.
    IPR006211. Furin-like_Cys-rich_dom.
    IPR006212. Furin_repeat.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR016245. Tyr_kinase_EGF/ERB/XmrK_rcpt.
    [Graphical view ]
    Pfami PF00757. Furin-like. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF01030. Recep_L_domain. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000619. TyrPK_EGF-R. 1 hit.
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00261. FU. 5 hits.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF57184. SSF57184. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Involvement of the ErbB3 signaling pathway in Schwann cell migration."
      Yamauchi J., Shooter E.M.
      Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor and Thyroid.
    3. "Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle."
      Moscoso L.M., Chu G.C., Gautam M., Noakes P.G., Merlie J.P., Sanes J.R.
      Dev. Biol. 172:158-169(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1061-1154.
      Tissue: Muscle fibroblast.
    4. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
      Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
      J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYOC.

    Entry informationi

    Entry nameiERBB3_MOUSE
    AccessioniPrimary (citable) accession number: Q61526
    Secondary accession number(s): Q3KQR1
    , Q68J64, Q810U8, Q8K317
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 11, 2005
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3