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Q61500

- ITM2A_MOUSE

UniProt

Q61500 - ITM2A_MOUSE

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Protein

Integral membrane protein 2A

Gene

Itm2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein 2A
Alternative name(s):
Protein E25
Gene namesi
Name:Itm2a
Synonyms:E25, Itm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:107706. Itm2a.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Integral membrane protein 2APRO_0000154819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi160 ↔ 219By similarity
Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61500.

PTM databases

PhosphoSiteiQ61500.

Expressioni

Tissue specificityi

Expressed in mandibular condyles, in bone and in hair follicles. Strong expression in osteogenic tissues, such as neonatal calvaria, paws, tail and skin.

Gene expression databases

BgeeiQ61500.
CleanExiMM_ITM2A.
GenevestigatoriQ61500.

Interactioni

Protein-protein interaction databases

IntActiQ61500. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ61500.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei54 – 7421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 22795BRICHOSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ITM2 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283703.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiQ61500.
KOiK18241.
OMAiPYFLPVT.
OrthoDBiEOG70KGQD.
PhylomeDBiQ61500.
TreeFamiTF317770.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61500-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVKIAFNTPT AVQKEEARQD VEALVSRTVR AQILTGKELR VVPQEKDGSS
60 70 80 90 100
GRCMLTLLGL SFILAGLIVG GACIYKYFMP KSTIYHGEMC FFDSEDPVNS
110 120 130 140 150
IPGGEPYFLP VTEEADIRED DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT
160 170 180 190 200
AYLDLLLGNC YLMPLNTSIV MTPKNLVELF GKLASGKYLP HTYVVREDLV
210 220 230 240 250
AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA IDKCWKIRHF
260
PNEFIVETKI CQE
Length:263
Mass (Da):29,691
Last modified:December 21, 2004 - v2
Checksum:i3F809DB8DA2BCC37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211V → I in AAC37700. (PubMed:8702637)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38971 mRNA. Translation: AAC37700.1.
AF074020 Genomic DNA. Translation: AAD14549.2.
AK014024 mRNA. Translation: BAB29119.1.
AK051956 mRNA. Translation: BAC34819.1.
AK167351 mRNA. Translation: BAE39450.1.
BC031420 mRNA. Translation: AAH31420.1.
CCDSiCCDS30349.1.
RefSeqiNP_032435.2. NM_008409.2.
UniGeneiMm.193.

Genome annotation databases

EnsembliENSMUST00000033591; ENSMUSP00000033591; ENSMUSG00000031239.
GeneIDi16431.
KEGGimmu:16431.
UCSCiuc009ucg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L38971 mRNA. Translation: AAC37700.1 .
AF074020 Genomic DNA. Translation: AAD14549.2 .
AK014024 mRNA. Translation: BAB29119.1 .
AK051956 mRNA. Translation: BAC34819.1 .
AK167351 mRNA. Translation: BAE39450.1 .
BC031420 mRNA. Translation: AAH31420.1 .
CCDSi CCDS30349.1.
RefSeqi NP_032435.2. NM_008409.2.
UniGenei Mm.193.

3D structure databases

ProteinModelPortali Q61500.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61500. 1 interaction.

PTM databases

PhosphoSitei Q61500.

Proteomic databases

PRIDEi Q61500.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000033591 ; ENSMUSP00000033591 ; ENSMUSG00000031239 .
GeneIDi 16431.
KEGGi mmu:16431.
UCSCi uc009ucg.1. mouse.

Organism-specific databases

CTDi 9452.
MGIi MGI:107706. Itm2a.

Phylogenomic databases

eggNOGi NOG283703.
GeneTreei ENSGT00390000005162.
HOGENOMi HOG000231259.
HOVERGENi HBG059373.
InParanoidi Q61500.
KOi K18241.
OMAi PYFLPVT.
OrthoDBi EOG70KGQD.
PhylomeDBi Q61500.
TreeFami TF317770.

Miscellaneous databases

ChiTaRSi ITM2A. mouse.
NextBioi 289665.
PROi Q61500.
SOURCEi Search...

Gene expression databases

Bgeei Q61500.
CleanExi MM_ITM2A.
Genevestigatori Q61500.

Family and domain databases

InterProi IPR007084. BRICHOS_dom.
[Graphical view ]
Pfami PF04089. BRICHOS. 1 hit.
[Graphical view ]
SMARTi SM01039. BRICHOS. 1 hit.
[Graphical view ]
PROSITEi PS50869. BRICHOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins."
    Deleersnijder W., Hong G., Cortvrindt R., Poirier C., Tylzanowski P., Pittois K., Vanmarck E., Merregaert J.
    J. Biol. Chem. 271:19475-19482(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Mandible.
  2. "Genomic organization and chromosomal localization of the Itm2a gene."
    Pittois K., Wauters J., Bossuyt P., Deleersnijder W., Merregaert J.
    Mamm. Genome 10:54-56(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. Van den Plas D., Merregaert J.
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 21.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Embryonic eye and Embryonic head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiITM2A_MOUSE
AccessioniPrimary (citable) accession number: Q61500
Secondary accession number(s): Q3TJP5, Q8K0H4, Q9CRW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 21, 2004
Last modified: October 1, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3