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Q61500

- ITM2A_MOUSE

UniProt

Q61500 - ITM2A_MOUSE

Protein

Integral membrane protein 2A

Gene

Itm2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Integral membrane protein 2A
    Alternative name(s):
    Protein E25
    Gene namesi
    Name:Itm2a
    Synonyms:E25, Itm2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:107706. Itm2a.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Integral membrane protein 2APRO_0000154819Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi160 ↔ 219By similarity
    Glycosylationi166 – 1661N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61500.

    PTM databases

    PhosphoSiteiQ61500.

    Expressioni

    Tissue specificityi

    Expressed in mandibular condyles, in bone and in hair follicles. Strong expression in osteogenic tissues, such as neonatal calvaria, paws, tail and skin.

    Gene expression databases

    BgeeiQ61500.
    CleanExiMM_ITM2A.
    GenevestigatoriQ61500.

    Interactioni

    Protein-protein interaction databases

    IntActiQ61500. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61500.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei54 – 7421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 22795BRICHOSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ITM2 family.Curated
    Contains 1 BRICHOS domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283703.
    GeneTreeiENSGT00390000005162.
    HOGENOMiHOG000231259.
    HOVERGENiHBG059373.
    InParanoidiQ61500.
    KOiK18241.
    OMAiPYFLPVT.
    OrthoDBiEOG70KGQD.
    PhylomeDBiQ61500.
    TreeFamiTF317770.

    Family and domain databases

    InterProiIPR007084. BRICHOS_dom.
    [Graphical view]
    PfamiPF04089. BRICHOS. 1 hit.
    [Graphical view]
    SMARTiSM01039. BRICHOS. 1 hit.
    [Graphical view]
    PROSITEiPS50869. BRICHOS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61500-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKIAFNTPT AVQKEEARQD VEALVSRTVR AQILTGKELR VVPQEKDGSS    50
    GRCMLTLLGL SFILAGLIVG GACIYKYFMP KSTIYHGEMC FFDSEDPVNS 100
    IPGGEPYFLP VTEEADIRED DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT 150
    AYLDLLLGNC YLMPLNTSIV MTPKNLVELF GKLASGKYLP HTYVVREDLV 200
    AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA IDKCWKIRHF 250
    PNEFIVETKI CQE 263
    Length:263
    Mass (Da):29,691
    Last modified:December 21, 2004 - v2
    Checksum:i3F809DB8DA2BCC37
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211V → I in AAC37700. (PubMed:8702637)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38971 mRNA. Translation: AAC37700.1.
    AF074020 Genomic DNA. Translation: AAD14549.2.
    AK014024 mRNA. Translation: BAB29119.1.
    AK051956 mRNA. Translation: BAC34819.1.
    AK167351 mRNA. Translation: BAE39450.1.
    BC031420 mRNA. Translation: AAH31420.1.
    CCDSiCCDS30349.1.
    RefSeqiNP_032435.2. NM_008409.2.
    UniGeneiMm.193.

    Genome annotation databases

    EnsembliENSMUST00000033591; ENSMUSP00000033591; ENSMUSG00000031239.
    GeneIDi16431.
    KEGGimmu:16431.
    UCSCiuc009ucg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L38971 mRNA. Translation: AAC37700.1 .
    AF074020 Genomic DNA. Translation: AAD14549.2 .
    AK014024 mRNA. Translation: BAB29119.1 .
    AK051956 mRNA. Translation: BAC34819.1 .
    AK167351 mRNA. Translation: BAE39450.1 .
    BC031420 mRNA. Translation: AAH31420.1 .
    CCDSi CCDS30349.1.
    RefSeqi NP_032435.2. NM_008409.2.
    UniGenei Mm.193.

    3D structure databases

    ProteinModelPortali Q61500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61500. 1 interaction.

    PTM databases

    PhosphoSitei Q61500.

    Proteomic databases

    PRIDEi Q61500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033591 ; ENSMUSP00000033591 ; ENSMUSG00000031239 .
    GeneIDi 16431.
    KEGGi mmu:16431.
    UCSCi uc009ucg.1. mouse.

    Organism-specific databases

    CTDi 9452.
    MGIi MGI:107706. Itm2a.

    Phylogenomic databases

    eggNOGi NOG283703.
    GeneTreei ENSGT00390000005162.
    HOGENOMi HOG000231259.
    HOVERGENi HBG059373.
    InParanoidi Q61500.
    KOi K18241.
    OMAi PYFLPVT.
    OrthoDBi EOG70KGQD.
    PhylomeDBi Q61500.
    TreeFami TF317770.

    Miscellaneous databases

    ChiTaRSi ITM2A. mouse.
    NextBioi 289665.
    PROi Q61500.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61500.
    CleanExi MM_ITM2A.
    Genevestigatori Q61500.

    Family and domain databases

    InterProi IPR007084. BRICHOS_dom.
    [Graphical view ]
    Pfami PF04089. BRICHOS. 1 hit.
    [Graphical view ]
    SMARTi SM01039. BRICHOS. 1 hit.
    [Graphical view ]
    PROSITEi PS50869. BRICHOS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins."
      Deleersnijder W., Hong G., Cortvrindt R., Poirier C., Tylzanowski P., Pittois K., Vanmarck E., Merregaert J.
      J. Biol. Chem. 271:19475-19482(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Mandible.
    2. "Genomic organization and chromosomal localization of the Itm2a gene."
      Pittois K., Wauters J., Bossuyt P., Deleersnijder W., Merregaert J.
      Mamm. Genome 10:54-56(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. Van den Plas D., Merregaert J.
      Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 21.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Amnion, Embryonic eye and Embryonic head.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiITM2A_MOUSE
    AccessioniPrimary (citable) accession number: Q61500
    Secondary accession number(s): Q3TJP5, Q8K0H4, Q9CRW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3