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Protein

Integral membrane protein 2A

Gene

Itm2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • immunoglobulin production Source: MGI
  • negative regulation of amyloid precursor protein biosynthetic process Source: GO_Central
  • nervous system development Source: GO_Central
  • plasma cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Integral membrane protein 2A
Alternative name(s):
Protein E25
Gene namesi
Name:Itm2a
Synonyms:E25, Itm2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:107706. Itm2a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 74Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001548191 – 263Integral membrane protein 2AAdd BLAST263

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi160 ↔ 219By similarity
Glycosylationi166N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61500.
PeptideAtlasiQ61500.
PRIDEiQ61500.

PTM databases

iPTMnetiQ61500.
PhosphoSitePlusiQ61500.

Expressioni

Tissue specificityi

Expressed in mandibular condyles, in bone and in hair follicles. Strong expression in osteogenic tissues, such as neonatal calvaria, paws, tail and skin.

Gene expression databases

BgeeiENSMUSG00000031239.
CleanExiMM_ITM2A.
GenevisibleiQ61500. MM.

Interactioni

Protein-protein interaction databases

IntActiQ61500. 1 interactor.
STRINGi10090.ENSMUSP00000033591.

Structurei

3D structure databases

ProteinModelPortaliQ61500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 227BRICHOSPROSITE-ProRule annotationAdd BLAST95

Sequence similaritiesi

Belongs to the ITM2 family.Curated
Contains 1 BRICHOS domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiQ61500.
KOiK18241.
OMAiPYFLPVT.
OrthoDBiEOG091G0E78.
PhylomeDBiQ61500.
TreeFamiTF317770.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61500-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKIAFNTPT AVQKEEARQD VEALVSRTVR AQILTGKELR VVPQEKDGSS
60 70 80 90 100
GRCMLTLLGL SFILAGLIVG GACIYKYFMP KSTIYHGEMC FFDSEDPVNS
110 120 130 140 150
IPGGEPYFLP VTEEADIRED DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT
160 170 180 190 200
AYLDLLLGNC YLMPLNTSIV MTPKNLVELF GKLASGKYLP HTYVVREDLV
210 220 230 240 250
AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA IDKCWKIRHF
260
PNEFIVETKI CQE
Length:263
Mass (Da):29,691
Last modified:December 21, 2004 - v2
Checksum:i3F809DB8DA2BCC37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21V → I in AAC37700 (PubMed:8702637).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38971 mRNA. Translation: AAC37700.1.
AF074020 Genomic DNA. Translation: AAD14549.2.
AK014024 mRNA. Translation: BAB29119.1.
AK051956 mRNA. Translation: BAC34819.1.
AK167351 mRNA. Translation: BAE39450.1.
BC031420 mRNA. Translation: AAH31420.1.
CCDSiCCDS30349.1.
RefSeqiNP_032435.2. NM_008409.2.
UniGeneiMm.193.

Genome annotation databases

EnsembliENSMUST00000033591; ENSMUSP00000033591; ENSMUSG00000031239.
GeneIDi16431.
KEGGimmu:16431.
UCSCiuc009ucg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38971 mRNA. Translation: AAC37700.1.
AF074020 Genomic DNA. Translation: AAD14549.2.
AK014024 mRNA. Translation: BAB29119.1.
AK051956 mRNA. Translation: BAC34819.1.
AK167351 mRNA. Translation: BAE39450.1.
BC031420 mRNA. Translation: AAH31420.1.
CCDSiCCDS30349.1.
RefSeqiNP_032435.2. NM_008409.2.
UniGeneiMm.193.

3D structure databases

ProteinModelPortaliQ61500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61500. 1 interactor.
STRINGi10090.ENSMUSP00000033591.

PTM databases

iPTMnetiQ61500.
PhosphoSitePlusiQ61500.

Proteomic databases

PaxDbiQ61500.
PeptideAtlasiQ61500.
PRIDEiQ61500.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033591; ENSMUSP00000033591; ENSMUSG00000031239.
GeneIDi16431.
KEGGimmu:16431.
UCSCiuc009ucg.1. mouse.

Organism-specific databases

CTDi9452.
MGIiMGI:107706. Itm2a.

Phylogenomic databases

eggNOGiKOG4681. Eukaryota.
ENOG410XRNN. LUCA.
GeneTreeiENSGT00390000005162.
HOGENOMiHOG000231259.
HOVERGENiHBG059373.
InParanoidiQ61500.
KOiK18241.
OMAiPYFLPVT.
OrthoDBiEOG091G0E78.
PhylomeDBiQ61500.
TreeFamiTF317770.

Miscellaneous databases

ChiTaRSiItm2a. mouse.
PROiQ61500.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031239.
CleanExiMM_ITM2A.
GenevisibleiQ61500. MM.

Family and domain databases

InterProiIPR007084. BRICHOS_dom.
[Graphical view]
PfamiPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTiSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEiPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITM2A_MOUSE
AccessioniPrimary (citable) accession number: Q61500
Secondary accession number(s): Q3TJP5, Q8K0H4, Q9CRW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 21, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.