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Q61500 (ITM2A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Integral membrane protein 2A
Alternative name(s):
Protein E25
Gene names
Name:Itm2a
Synonyms:E25, Itm2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Expressed in mandibular condyles, in bone and in hair follicles. Strong expression in osteogenic tissues, such as neonatal calvaria, paws, tail and skin.

Sequence similarities

Belongs to the ITM2 family.

Contains 1 BRICHOS domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 263263Integral membrane protein 2A
PRO_0000154819

Regions

Transmembrane54 – 7421Helical; Signal-anchor for type II membrane protein; Potential
Domain133 – 22795BRICHOS

Amino acid modifications

Glycosylation1661N-linked (GlcNAc...) Potential
Disulfide bond160 ↔ 219 By similarity

Experimental info

Sequence conflict211V → I in AAC37700. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61500 [UniParc].

Last modified December 21, 2004. Version 2.
Checksum: 3F809DB8DA2BCC37

FASTA26329,691
        10         20         30         40         50         60 
MVKIAFNTPT AVQKEEARQD VEALVSRTVR AQILTGKELR VVPQEKDGSS GRCMLTLLGL 

        70         80         90        100        110        120 
SFILAGLIVG GACIYKYFMP KSTIYHGEMC FFDSEDPVNS IPGGEPYFLP VTEEADIRED 

       130        140        150        160        170        180 
DNIAIIDVPV PSFSDSDPAA IIHDFEKGMT AYLDLLLGNC YLMPLNTSIV MTPKNLVELF 

       190        200        210        220        230        240 
GKLASGKYLP HTYVVREDLV AVEEIRDVSN LGIFIYQLCN NRKSFRLRRR DLLLGFNKRA 

       250        260 
IDKCWKIRHF PNEFIVETKI CQE 

« Hide

References

« Hide 'large scale' references
[1]"Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins."
Deleersnijder W., Hong G., Cortvrindt R., Poirier C., Tylzanowski P., Pittois K., Vanmarck E., Merregaert J.
J. Biol. Chem. 271:19475-19482(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Mandible.
[2]"Genomic organization and chromosomal localization of the Itm2a gene."
Pittois K., Wauters J., Bossuyt P., Deleersnijder W., Merregaert J.
Mamm. Genome 10:54-56(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BALB/c.
[3]Van den Plas D., Merregaert J.
Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 21.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Amnion, Embryonic eye and Embryonic head.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L38971 mRNA. Translation: AAC37700.1.
AF074020 Genomic DNA. Translation: AAD14549.2.
AK014024 mRNA. Translation: BAB29119.1.
AK051956 mRNA. Translation: BAC34819.1.
AK167351 mRNA. Translation: BAE39450.1.
BC031420 mRNA. Translation: AAH31420.1.
CCDSCCDS30349.1.
RefSeqNP_032435.2. NM_008409.2.
UniGeneMm.193.

3D structure databases

ProteinModelPortalQ61500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61500. 1 interaction.

PTM databases

PhosphoSiteQ61500.

Proteomic databases

PRIDEQ61500.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000033591; ENSMUSP00000033591; ENSMUSG00000031239.
GeneID16431.
KEGGmmu:16431.
UCSCuc009ucg.1. mouse.

Organism-specific databases

CTD9452.
MGIMGI:107706. Itm2a.

Phylogenomic databases

eggNOGNOG283703.
GeneTreeENSGT00390000005162.
HOGENOMHOG000231259.
HOVERGENHBG059373.
InParanoidQ61500.
KOK18241.
OMAPYFLPVT.
OrthoDBEOG70KGQD.
PhylomeDBQ61500.
TreeFamTF317770.

Gene expression databases

BgeeQ61500.
CleanExMM_ITM2A.
GenevestigatorQ61500.

Family and domain databases

InterProIPR007084. BRICHOS_dom.
[Graphical view]
PfamPF04089. BRICHOS. 1 hit.
[Graphical view]
SMARTSM01039. BRICHOS. 1 hit.
[Graphical view]
PROSITEPS50869. BRICHOS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSITM2A. mouse.
NextBio289665.
PROQ61500.
SOURCESearch...

Entry information

Entry nameITM2A_MOUSE
AccessionPrimary (citable) accession number: Q61500
Secondary accession number(s): Q3TJP5, Q8K0H4, Q9CRW4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: December 21, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot