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Q61495

- DSG1A_MOUSE

UniProt

Q61495 - DSG1A_MOUSE

Protein

Desmoglein-1-alpha

Gene

Dsg1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: MGI

    GO - Biological processi

    1. homophilic cell adhesion Source: InterPro

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_212869. Apoptotic cleavage of cell adhesion proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Desmoglein-1-alpha
    Short name:
    Desmoglein-1
    Short name:
    Dsg1-alpha
    Alternative name(s):
    DG1
    DGI
    Desmosomal glycoprotein I
    Gene namesi
    Name:Dsg1a
    Synonyms:Dsg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:94930. Dsg1a.

    Subcellular locationi

    GO - Cellular componenti

    1. desmosome Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Propeptidei24 – 4926Sequence AnalysisPRO_0000003839Add
    BLAST
    Chaini50 – 10571008Desmoglein-1-alphaPRO_0000003840Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein

    Proteomic databases

    PaxDbiQ61495.
    PRIDEiQ61495.

    PTM databases

    PhosphoSiteiQ61495.

    Expressioni

    Tissue specificityi

    Expressed in testis.1 Publication

    Developmental stagei

    Expressed in embryo at 17 dpc.1 Publication

    Gene expression databases

    BgeeiQ61495.
    CleanExiMM_DSG1A.
    GenevestigatoriQ61495.

    Interactioni

    Subunit structurei

    Binds to JUP/plakoglobin.By similarity

    Protein-protein interaction databases

    BioGridi199323. 6 interactions.
    IntActiQ61495. 4 interactions.
    STRINGi10090.ENSMUSP00000076393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61495.
    SMRiQ61495. Positions 47-483.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini50 – 564515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini586 – 1057472CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei565 – 58521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 157108Cadherin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini158 – 269112Cadherin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini270 – 389120Cadherin 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 493108Cadherin 4PROSITE-ProRule annotationAdd
    BLAST
    Repeati832 – 85827Desmoglein repeat 1Add
    BLAST
    Repeati859 – 88830Desmoglein repeat 2Add
    BLAST
    Repeati889 – 91830Desmoglein repeat 3Add
    BLAST
    Repeati919 – 94628Desmoglein repeat 4Add
    BLAST
    Repeati947 – 97529Desmoglein repeat 5Add
    BLAST

    Domaini

    Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

    Sequence similaritiesi

    Contains 4 cadherin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283402.
    GeneTreeiENSGT00740000114904.
    HOGENOMiHOG000236266.
    HOVERGENiHBG005532.
    InParanoidiA8WFQ4.
    KOiK07596.
    OMAiDSDPSWP.
    OrthoDBiEOG7VTDM9.
    PhylomeDBiQ61495.
    TreeFamiTF331809.

    Family and domain databases

    Gene3Di2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProiIPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view]
    PANTHERiPTHR24025. PTHR24025. 1 hit.
    PfamiPF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTiSM00112. CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF49313. SSF49313. 4 hits.
    PROSITEiPS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61495-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDWHSFRIAA LLLTSLVVLE VNSEFQIQVR DHNAKNGTIK WHSIRRQKRE     50
    WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QPVTYRISGV GIDQPPYGIF 100
    IINQKTGEIN ITSIVDREVT PFFIIYCRAL NAQGQDLENP LELRVRVMDI 150
    NDNPPVFSMT TFLGQIEENS NANTLVMKLN ATDADEPNNL NSMIAFKIIR 200
    QEPSDSPMFI INRKTGEIRT MNNFLDREQY SQYSLVVRGS DRDGGADGMS 250
    AESECSITIL DVNDNIPYLE QSSYDITIEE NALHSQLVQI RVIDLDEEFS 300
    DNWKAIIFFI SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMKNLQLSIG 350
    VRNVAEFHQS IISQYRLTAT MVTVTVLNVI EGSVFRPGSK TFVVDSRMEA 400
    NHRVGEFVAT DLDTGRASTN VRYEMGNNPE NLLVVDSRTG IITLRNRVTM 450
    EQYQRLNGEY KGTVLSIDDS LQRTCTGTIV IELSGTGWVT GSESGGSSSG 500
    SGDDRDRVTN GYQGTSSTEN PQRVTGSWGG SGIDGTRPNT NPFQGDPDET 550
    LETPLYGDNV HFGPAGIGLL IMGFLVLGLV PFLLICCDCG GAPGGGAGFE 600
    PVPECSDGAI HTWAVEGPQP EPHEGITTIC VPQMPPGNAN VIEYIDNSGV 650
    YTNEYCGREM QDLGGGERTT GFELMDGVKT SAAPEICQEY SGTLRRNSMR 700
    ECRDGGLNMN FMESYFCQKA YAYADEDEGR PSNDCLLIYD IEGVGSPAGS 750
    VGCCSFIGED LDESFLDTLG PKFKKLADIS LGKEIDSYPD SDPSWPPQST 800
    EPMCPQHTEP LGSGHPPISP HFGTTTVISE NAYHSGPGVQ HPVPIPDPLG 850
    YGNVTVRESY TTSGTLKPSV HFHDNQQASN VVVTERVVGP ISGADLHGML 900
    EIPDLRGGAN VIVTERVIAP GSSLPTSLTI PNPQETSNVV VTERVIQPTS 950
    GMIGNLSMTP ELSSAHNVIV TERVVSGAGM SEIAGTAGLG GVGGIGSSGL 1000
    VSTTMGASGT GLNMGGTATI GHMRSSSDHH FSQTVGSASP SMARSRITKY 1050
    NTVQYSK 1057
    Length:1,057
    Mass (Da):114,597
    Last modified:March 1, 2005 - v2
    Checksum:iEEF6AF26E57051A0
    GO

    Sequence cautioni

    The sequence BAC26378.1 differs from that shown. Reason: Frameshift at position 748.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti749 – 7502GS → EG in CAA52382. (PubMed:7959727)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC154410 mRNA. Translation: AAI54411.1.
    AK029294 mRNA. Translation: BAC26378.1. Frameshift.
    X74335 mRNA. Translation: CAA52382.1.
    CCDSiCCDS50231.1.
    PIRiB54742.
    RefSeqiNP_034209.2. NM_010079.2.
    UniGeneiMm.37953.

    Genome annotation databases

    EnsembliENSMUST00000077146; ENSMUSP00000076393; ENSMUSG00000069441.
    GeneIDi13510.
    KEGGimmu:13510.
    UCSCiuc008eel.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC154410 mRNA. Translation: AAI54411.1 .
    AK029294 mRNA. Translation: BAC26378.1 . Frameshift.
    X74335 mRNA. Translation: CAA52382.1 .
    CCDSi CCDS50231.1.
    PIRi B54742.
    RefSeqi NP_034209.2. NM_010079.2.
    UniGenei Mm.37953.

    3D structure databases

    ProteinModelPortali Q61495.
    SMRi Q61495. Positions 47-483.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199323. 6 interactions.
    IntActi Q61495. 4 interactions.
    STRINGi 10090.ENSMUSP00000076393.

    PTM databases

    PhosphoSitei Q61495.

    Proteomic databases

    PaxDbi Q61495.
    PRIDEi Q61495.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077146 ; ENSMUSP00000076393 ; ENSMUSG00000069441 .
    GeneIDi 13510.
    KEGGi mmu:13510.
    UCSCi uc008eel.2. mouse.

    Organism-specific databases

    CTDi 13510.
    MGIi MGI:94930. Dsg1a.

    Phylogenomic databases

    eggNOGi NOG283402.
    GeneTreei ENSGT00740000114904.
    HOGENOMi HOG000236266.
    HOVERGENi HBG005532.
    InParanoidi A8WFQ4.
    KOi K07596.
    OMAi DSDPSWP.
    OrthoDBi EOG7VTDM9.
    PhylomeDBi Q61495.
    TreeFami TF331809.

    Enzyme and pathway databases

    Reactomei REACT_212869. Apoptotic cleavage of cell adhesion proteins.

    Miscellaneous databases

    NextBioi 284060.
    PROi Q61495.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61495.
    CleanExi MM_DSG1A.
    Genevestigatori Q61495.

    Family and domain databases

    Gene3Di 2.60.40.60. 4 hits.
    4.10.900.10. 1 hit.
    InterProi IPR002126. Cadherin.
    IPR015919. Cadherin-like.
    IPR020894. Cadherin_CS.
    IPR000233. Cadherin_cytoplasmic-dom.
    IPR027397. Catenin_binding_dom.
    IPR009123. Desmoglein.
    IPR009122. Desmosomal_cadherin.
    [Graphical view ]
    PANTHERi PTHR24025. PTHR24025. 1 hit.
    Pfami PF00028. Cadherin. 3 hits.
    PF01049. Cadherin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00205. CADHERIN.
    PR01818. DESMOCADHERN.
    PR01819. DESMOGLEIN.
    SMARTi SM00112. CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF49313. SSF49313. 4 hits.
    PROSITEi PS00232. CADHERIN_1. 2 hits.
    PS50268. CADHERIN_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interspecies conservation and differential expression of mouse desmoglein gene family."
      Mahoney M.G., Simpson A., Aho S., Uitto J., Pulkkinen L.
      Exp. Dermatol. 11:115-125(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Keratinocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 734-1057.
      Strain: C57BL/6J.
      Tissue: Head.
    4. "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18."
      Buxton R.S., Wheeler G.N., Pidsley S.C., Marsden M.D., Adams M.J., Jenkins N.A., Gilbert D.J., Copeland N.G.
      Genomics 21:510-516(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 748-974.
    5. "Novel member of the mouse desmoglein gene family: Dsg1-beta."
      Pulkkinen L., Choi Y.W., Kljuic A., Uitto J., Mahoney M.G.
      Exp. Dermatol. 12:11-19(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiDSG1A_MOUSE
    AccessioniPrimary (citable) accession number: Q61495
    Secondary accession number(s): A8WFQ4, Q8CE03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3