Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q61495 (DSG1A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Desmoglein-1-alpha

Short name=Desmoglein-1
Short name=Dsg1-alpha
Alternative name(s):
DG1
DGI
Desmosomal glycoprotein I
Gene names
Name:Dsg1a
Synonyms:Dsg1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1057 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

Subunit structure

Binds to JUP/plakoglobin By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Cell junctiondesmosome.

Tissue specificity

Expressed in testis. Ref.5

Developmental stage

Expressed in embryo at 17 dpc. Ref.5

Domain

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similarities

Contains 4 cadherin domains.

Sequence caution

The sequence BAC26378.1 differs from that shown. Reason: Frameshift at position 748.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Propeptide24 – 4926 Potential
PRO_0000003839
Chain50 – 10571008Desmoglein-1-alpha
PRO_0000003840

Regions

Topological domain50 – 564515Extracellular Potential
Transmembrane565 – 58521Helical; Potential
Topological domain586 – 1057472Cytoplasmic Potential
Domain50 – 157108Cadherin 1
Domain158 – 269112Cadherin 2
Domain270 – 389120Cadherin 3
Domain386 – 493108Cadherin 4
Repeat832 – 85827Desmoglein repeat 1
Repeat859 – 88830Desmoglein repeat 2
Repeat889 – 91830Desmoglein repeat 3
Repeat919 – 94628Desmoglein repeat 4
Repeat947 – 97529Desmoglein repeat 5

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict749 – 7502GS → EG in CAA52382. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q61495 [UniParc].

Last modified March 1, 2005. Version 2.
Checksum: EEF6AF26E57051A0

FASTA1,057114,597
        10         20         30         40         50         60 
MDWHSFRIAA LLLTSLVVLE VNSEFQIQVR DHNAKNGTIK WHSIRRQKRE WIKFAAACRE 

        70         80         90        100        110        120 
GEDNSKRNPI AKIHSDCAAN QPVTYRISGV GIDQPPYGIF IINQKTGEIN ITSIVDREVT 

       130        140        150        160        170        180 
PFFIIYCRAL NAQGQDLENP LELRVRVMDI NDNPPVFSMT TFLGQIEENS NANTLVMKLN 

       190        200        210        220        230        240 
ATDADEPNNL NSMIAFKIIR QEPSDSPMFI INRKTGEIRT MNNFLDREQY SQYSLVVRGS 

       250        260        270        280        290        300 
DRDGGADGMS AESECSITIL DVNDNIPYLE QSSYDITIEE NALHSQLVQI RVIDLDEEFS 

       310        320        330        340        350        360 
DNWKAIIFFI SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMKNLQLSIG VRNVAEFHQS 

       370        380        390        400        410        420 
IISQYRLTAT MVTVTVLNVI EGSVFRPGSK TFVVDSRMEA NHRVGEFVAT DLDTGRASTN 

       430        440        450        460        470        480 
VRYEMGNNPE NLLVVDSRTG IITLRNRVTM EQYQRLNGEY KGTVLSIDDS LQRTCTGTIV 

       490        500        510        520        530        540 
IELSGTGWVT GSESGGSSSG SGDDRDRVTN GYQGTSSTEN PQRVTGSWGG SGIDGTRPNT 

       550        560        570        580        590        600 
NPFQGDPDET LETPLYGDNV HFGPAGIGLL IMGFLVLGLV PFLLICCDCG GAPGGGAGFE 

       610        620        630        640        650        660 
PVPECSDGAI HTWAVEGPQP EPHEGITTIC VPQMPPGNAN VIEYIDNSGV YTNEYCGREM 

       670        680        690        700        710        720 
QDLGGGERTT GFELMDGVKT SAAPEICQEY SGTLRRNSMR ECRDGGLNMN FMESYFCQKA 

       730        740        750        760        770        780 
YAYADEDEGR PSNDCLLIYD IEGVGSPAGS VGCCSFIGED LDESFLDTLG PKFKKLADIS 

       790        800        810        820        830        840 
LGKEIDSYPD SDPSWPPQST EPMCPQHTEP LGSGHPPISP HFGTTTVISE NAYHSGPGVQ 

       850        860        870        880        890        900 
HPVPIPDPLG YGNVTVRESY TTSGTLKPSV HFHDNQQASN VVVTERVVGP ISGADLHGML 

       910        920        930        940        950        960 
EIPDLRGGAN VIVTERVIAP GSSLPTSLTI PNPQETSNVV VTERVIQPTS GMIGNLSMTP 

       970        980        990       1000       1010       1020 
ELSSAHNVIV TERVVSGAGM SEIAGTAGLG GVGGIGSSGL VSTTMGASGT GLNMGGTATI 

      1030       1040       1050 
GHMRSSSDHH FSQTVGSASP SMARSRITKY NTVQYSK 

« Hide

References

« Hide 'large scale' references
[1]"Interspecies conservation and differential expression of mouse desmoglein gene family."
Mahoney M.G., Simpson A., Aho S., Uitto J., Pulkkinen L.
Exp. Dermatol. 11:115-125(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Keratinocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 734-1057.
Strain: C57BL/6J.
Tissue: Head.
[4]"Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18."
Buxton R.S., Wheeler G.N., Pidsley S.C., Marsden M.D., Adams M.J., Jenkins N.A., Gilbert D.J., Copeland N.G.
Genomics 21:510-516(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 748-974.
[5]"Novel member of the mouse desmoglein gene family: Dsg1-beta."
Pulkkinen L., Choi Y.W., Kljuic A., Uitto J., Mahoney M.G.
Exp. Dermatol. 12:11-19(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC154410 mRNA. Translation: AAI54411.1.
AK029294 mRNA. Translation: BAC26378.1. Frameshift.
X74335 mRNA. Translation: CAA52382.1.
CCDSCCDS50231.1.
PIRB54742.
RefSeqNP_034209.2. NM_010079.2.
UniGeneMm.37953.

3D structure databases

ProteinModelPortalQ61495.
SMRQ61495. Positions 47-483.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199323. 6 interactions.
IntActQ61495. 4 interactions.
STRING10090.ENSMUSP00000076393.

PTM databases

PhosphoSiteQ61495.

Proteomic databases

PaxDbQ61495.
PRIDEQ61495.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077146; ENSMUSP00000076393; ENSMUSG00000069441.
GeneID13510.
KEGGmmu:13510.
UCSCuc008eel.2. mouse.

Organism-specific databases

CTD13510.
MGIMGI:94930. Dsg1a.

Phylogenomic databases

eggNOGNOG283402.
GeneTreeENSGT00740000114904.
HOGENOMHOG000236266.
HOVERGENHBG005532.
InParanoidA8WFQ4.
KOK07596.
OMADSDPSWP.
OrthoDBEOG7VTDM9.
PhylomeDBQ61495.
TreeFamTF331809.

Gene expression databases

BgeeQ61495.
CleanExMM_DSG1A.
GenevestigatorQ61495.

Family and domain databases

Gene3D2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERPTHR24025. PTHR24025. 1 hit.
PfamPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTSM00112. CA. 4 hits.
[Graphical view]
SUPFAMSSF49313. SSF49313. 4 hits.
PROSITEPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio284060.
PROQ61495.
SOURCESearch...

Entry information

Entry nameDSG1A_MOUSE
AccessionPrimary (citable) accession number: Q61495
Secondary accession number(s): A8WFQ4, Q8CE03
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: July 9, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot