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Q61495

- DSG1A_MOUSE

UniProt

Q61495 - DSG1A_MOUSE

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Protein
Desmoglein-1-alpha
Gene
Dsg1a, Dsg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. protein binding Source: MGI

GO - Biological processi

  1. homophilic cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_212869. Apoptotic cleavage of cell adhesion proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-1-alpha
Short name:
Desmoglein-1
Short name:
Dsg1-alpha
Alternative name(s):
DG1
DGI
Desmosomal glycoprotein I
Gene namesi
Name:Dsg1a
Synonyms:Dsg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:94930. Dsg1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini50 – 564515Extracellular Reviewed prediction
Add
BLAST
Transmembranei565 – 58521Helical; Reviewed prediction
Add
BLAST
Topological domaini586 – 1057472Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. desmosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Propeptidei24 – 4926 Reviewed prediction
PRO_0000003839Add
BLAST
Chaini50 – 10571008Desmoglein-1-alpha
PRO_0000003840Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ61495.
PRIDEiQ61495.

PTM databases

PhosphoSiteiQ61495.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Developmental stagei

Expressed in embryo at 17 dpc.1 Publication

Gene expression databases

BgeeiQ61495.
CleanExiMM_DSG1A.
GenevestigatoriQ61495.

Interactioni

Subunit structurei

Binds to JUP/plakoglobin By similarity.

Protein-protein interaction databases

BioGridi199323. 6 interactions.
IntActiQ61495. 4 interactions.
STRINGi10090.ENSMUSP00000076393.

Structurei

3D structure databases

ProteinModelPortaliQ61495.
SMRiQ61495. Positions 47-483.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 157108Cadherin 1
Add
BLAST
Domaini158 – 269112Cadherin 2
Add
BLAST
Domaini270 – 389120Cadherin 3
Add
BLAST
Domaini386 – 493108Cadherin 4
Add
BLAST
Repeati832 – 85827Desmoglein repeat 1
Add
BLAST
Repeati859 – 88830Desmoglein repeat 2
Add
BLAST
Repeati889 – 91830Desmoglein repeat 3
Add
BLAST
Repeati919 – 94628Desmoglein repeat 4
Add
BLAST
Repeati947 – 97529Desmoglein repeat 5
Add
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain By similarity.

Sequence similaritiesi

Contains 4 cadherin domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283402.
GeneTreeiENSGT00740000114904.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiA8WFQ4.
KOiK07596.
OMAiDSDPSWP.
OrthoDBiEOG7VTDM9.
PhylomeDBiQ61495.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61495-1 [UniParc]FASTAAdd to Basket

« Hide

MDWHSFRIAA LLLTSLVVLE VNSEFQIQVR DHNAKNGTIK WHSIRRQKRE     50
WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QPVTYRISGV GIDQPPYGIF 100
IINQKTGEIN ITSIVDREVT PFFIIYCRAL NAQGQDLENP LELRVRVMDI 150
NDNPPVFSMT TFLGQIEENS NANTLVMKLN ATDADEPNNL NSMIAFKIIR 200
QEPSDSPMFI INRKTGEIRT MNNFLDREQY SQYSLVVRGS DRDGGADGMS 250
AESECSITIL DVNDNIPYLE QSSYDITIEE NALHSQLVQI RVIDLDEEFS 300
DNWKAIIFFI SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMKNLQLSIG 350
VRNVAEFHQS IISQYRLTAT MVTVTVLNVI EGSVFRPGSK TFVVDSRMEA 400
NHRVGEFVAT DLDTGRASTN VRYEMGNNPE NLLVVDSRTG IITLRNRVTM 450
EQYQRLNGEY KGTVLSIDDS LQRTCTGTIV IELSGTGWVT GSESGGSSSG 500
SGDDRDRVTN GYQGTSSTEN PQRVTGSWGG SGIDGTRPNT NPFQGDPDET 550
LETPLYGDNV HFGPAGIGLL IMGFLVLGLV PFLLICCDCG GAPGGGAGFE 600
PVPECSDGAI HTWAVEGPQP EPHEGITTIC VPQMPPGNAN VIEYIDNSGV 650
YTNEYCGREM QDLGGGERTT GFELMDGVKT SAAPEICQEY SGTLRRNSMR 700
ECRDGGLNMN FMESYFCQKA YAYADEDEGR PSNDCLLIYD IEGVGSPAGS 750
VGCCSFIGED LDESFLDTLG PKFKKLADIS LGKEIDSYPD SDPSWPPQST 800
EPMCPQHTEP LGSGHPPISP HFGTTTVISE NAYHSGPGVQ HPVPIPDPLG 850
YGNVTVRESY TTSGTLKPSV HFHDNQQASN VVVTERVVGP ISGADLHGML 900
EIPDLRGGAN VIVTERVIAP GSSLPTSLTI PNPQETSNVV VTERVIQPTS 950
GMIGNLSMTP ELSSAHNVIV TERVVSGAGM SEIAGTAGLG GVGGIGSSGL 1000
VSTTMGASGT GLNMGGTATI GHMRSSSDHH FSQTVGSASP SMARSRITKY 1050
NTVQYSK 1057
Length:1,057
Mass (Da):114,597
Last modified:March 1, 2005 - v2
Checksum:iEEF6AF26E57051A0
GO

Sequence cautioni

The sequence BAC26378.1 differs from that shown. Reason: Frameshift at position 748.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti749 – 7502GS → EG in CAA52382. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC154410 mRNA. Translation: AAI54411.1.
AK029294 mRNA. Translation: BAC26378.1. Frameshift.
X74335 mRNA. Translation: CAA52382.1.
CCDSiCCDS50231.1.
PIRiB54742.
RefSeqiNP_034209.2. NM_010079.2.
UniGeneiMm.37953.

Genome annotation databases

EnsembliENSMUST00000077146; ENSMUSP00000076393; ENSMUSG00000069441.
GeneIDi13510.
KEGGimmu:13510.
UCSCiuc008eel.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC154410 mRNA. Translation: AAI54411.1 .
AK029294 mRNA. Translation: BAC26378.1 . Frameshift.
X74335 mRNA. Translation: CAA52382.1 .
CCDSi CCDS50231.1.
PIRi B54742.
RefSeqi NP_034209.2. NM_010079.2.
UniGenei Mm.37953.

3D structure databases

ProteinModelPortali Q61495.
SMRi Q61495. Positions 47-483.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199323. 6 interactions.
IntActi Q61495. 4 interactions.
STRINGi 10090.ENSMUSP00000076393.

PTM databases

PhosphoSitei Q61495.

Proteomic databases

PaxDbi Q61495.
PRIDEi Q61495.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077146 ; ENSMUSP00000076393 ; ENSMUSG00000069441 .
GeneIDi 13510.
KEGGi mmu:13510.
UCSCi uc008eel.2. mouse.

Organism-specific databases

CTDi 13510.
MGIi MGI:94930. Dsg1a.

Phylogenomic databases

eggNOGi NOG283402.
GeneTreei ENSGT00740000114904.
HOGENOMi HOG000236266.
HOVERGENi HBG005532.
InParanoidi A8WFQ4.
KOi K07596.
OMAi DSDPSWP.
OrthoDBi EOG7VTDM9.
PhylomeDBi Q61495.
TreeFami TF331809.

Enzyme and pathway databases

Reactomei REACT_212869. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

NextBioi 284060.
PROi Q61495.
SOURCEi Search...

Gene expression databases

Bgeei Q61495.
CleanExi MM_DSG1A.
Genevestigatori Q61495.

Family and domain databases

Gene3Di 2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProi IPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view ]
PANTHERi PTHR24025. PTHR24025. 1 hit.
Pfami PF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view ]
PRINTSi PR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTi SM00112. CA. 4 hits.
[Graphical view ]
SUPFAMi SSF49313. SSF49313. 4 hits.
PROSITEi PS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interspecies conservation and differential expression of mouse desmoglein gene family."
    Mahoney M.G., Simpson A., Aho S., Uitto J., Pulkkinen L.
    Exp. Dermatol. 11:115-125(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Keratinocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 734-1057.
    Strain: C57BL/6J.
    Tissue: Head.
  4. "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18."
    Buxton R.S., Wheeler G.N., Pidsley S.C., Marsden M.D., Adams M.J., Jenkins N.A., Gilbert D.J., Copeland N.G.
    Genomics 21:510-516(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 748-974.
  5. "Novel member of the mouse desmoglein gene family: Dsg1-beta."
    Pulkkinen L., Choi Y.W., Kljuic A., Uitto J., Mahoney M.G.
    Exp. Dermatol. 12:11-19(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDSG1A_MOUSE
AccessioniPrimary (citable) accession number: Q61495
Secondary accession number(s): A8WFQ4, Q8CE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: September 3, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi