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Protein

Desmoglein-1-alpha

Gene

Dsg1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-351906. Apoptotic cleavage of cell adhesion proteins.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Desmoglein-1-alpha
Short name:
Desmoglein-1
Short name:
Dsg1-alpha
Alternative name(s):
DG1
DGI
Desmosomal glycoprotein I
Gene namesi
Name:Dsg1a
Synonyms:Dsg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:94930. Dsg1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini50 – 564ExtracellularSequence analysisAdd BLAST515
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Topological domaini586 – 1057CytoplasmicSequence analysisAdd BLAST472

GO - Cellular componenti

  • cytoplasmic side of plasma membrane Source: MGI
  • desmosome Source: MGI
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000383924 – 49Sequence analysisAdd BLAST26
ChainiPRO_000000384050 – 1057Desmoglein-1-alphaAdd BLAST1008

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

MaxQBiQ61495.
PaxDbiQ61495.
PRIDEiQ61495.

PTM databases

iPTMnetiQ61495.
PhosphoSitePlusiQ61495.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Developmental stagei

Expressed in embryo at 17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000069441.
CleanExiMM_DSG1A.
GenevisibleiQ61495. MM.

Interactioni

Subunit structurei

Binds to JUP/plakoglobin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199323. 6 interactors.
IntActiQ61495. 4 interactors.
STRINGi10090.ENSMUSP00000076393.

Structurei

3D structure databases

ProteinModelPortaliQ61495.
SMRiQ61495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 157Cadherin 1PROSITE-ProRule annotationAdd BLAST108
Domaini158 – 269Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini270 – 389Cadherin 3PROSITE-ProRule annotationAdd BLAST120
Domaini386 – 493Cadherin 4PROSITE-ProRule annotationAdd BLAST108
Repeati832 – 858Desmoglein repeat 1Add BLAST27
Repeati859 – 888Desmoglein repeat 2Add BLAST30
Repeati889 – 918Desmoglein repeat 3Add BLAST30
Repeati919 – 946Desmoglein repeat 4Add BLAST28
Repeati947 – 975Desmoglein repeat 5Add BLAST29

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ61495.
KOiK07596.
OMAiNLENGGW.
OrthoDBiEOG091G01PF.
PhylomeDBiQ61495.
TreeFamiTF331809.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61495-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWHSFRIAA LLLTSLVVLE VNSEFQIQVR DHNAKNGTIK WHSIRRQKRE
60 70 80 90 100
WIKFAAACRE GEDNSKRNPI AKIHSDCAAN QPVTYRISGV GIDQPPYGIF
110 120 130 140 150
IINQKTGEIN ITSIVDREVT PFFIIYCRAL NAQGQDLENP LELRVRVMDI
160 170 180 190 200
NDNPPVFSMT TFLGQIEENS NANTLVMKLN ATDADEPNNL NSMIAFKIIR
210 220 230 240 250
QEPSDSPMFI INRKTGEIRT MNNFLDREQY SQYSLVVRGS DRDGGADGMS
260 270 280 290 300
AESECSITIL DVNDNIPYLE QSSYDITIEE NALHSQLVQI RVIDLDEEFS
310 320 330 340 350
DNWKAIIFFI SGNEGNWFEI EMNERTNVGT LKVVKPLDYE AMKNLQLSIG
360 370 380 390 400
VRNVAEFHQS IISQYRLTAT MVTVTVLNVI EGSVFRPGSK TFVVDSRMEA
410 420 430 440 450
NHRVGEFVAT DLDTGRASTN VRYEMGNNPE NLLVVDSRTG IITLRNRVTM
460 470 480 490 500
EQYQRLNGEY KGTVLSIDDS LQRTCTGTIV IELSGTGWVT GSESGGSSSG
510 520 530 540 550
SGDDRDRVTN GYQGTSSTEN PQRVTGSWGG SGIDGTRPNT NPFQGDPDET
560 570 580 590 600
LETPLYGDNV HFGPAGIGLL IMGFLVLGLV PFLLICCDCG GAPGGGAGFE
610 620 630 640 650
PVPECSDGAI HTWAVEGPQP EPHEGITTIC VPQMPPGNAN VIEYIDNSGV
660 670 680 690 700
YTNEYCGREM QDLGGGERTT GFELMDGVKT SAAPEICQEY SGTLRRNSMR
710 720 730 740 750
ECRDGGLNMN FMESYFCQKA YAYADEDEGR PSNDCLLIYD IEGVGSPAGS
760 770 780 790 800
VGCCSFIGED LDESFLDTLG PKFKKLADIS LGKEIDSYPD SDPSWPPQST
810 820 830 840 850
EPMCPQHTEP LGSGHPPISP HFGTTTVISE NAYHSGPGVQ HPVPIPDPLG
860 870 880 890 900
YGNVTVRESY TTSGTLKPSV HFHDNQQASN VVVTERVVGP ISGADLHGML
910 920 930 940 950
EIPDLRGGAN VIVTERVIAP GSSLPTSLTI PNPQETSNVV VTERVIQPTS
960 970 980 990 1000
GMIGNLSMTP ELSSAHNVIV TERVVSGAGM SEIAGTAGLG GVGGIGSSGL
1010 1020 1030 1040 1050
VSTTMGASGT GLNMGGTATI GHMRSSSDHH FSQTVGSASP SMARSRITKY

NTVQYSK
Length:1,057
Mass (Da):114,597
Last modified:March 1, 2005 - v2
Checksum:iEEF6AF26E57051A0
GO

Sequence cautioni

The sequence BAC26378 differs from that shown. Reason: Frameshift at position 748.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti749 – 750GS → EG in CAA52382 (PubMed:7959727).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC154410 mRNA. Translation: AAI54411.1.
AK029294 mRNA. Translation: BAC26378.1. Frameshift.
X74335 mRNA. Translation: CAA52382.1.
CCDSiCCDS50231.1.
PIRiB54742.
RefSeqiNP_034209.2. NM_010079.2.
UniGeneiMm.37953.

Genome annotation databases

EnsembliENSMUST00000077146; ENSMUSP00000076393; ENSMUSG00000069441.
GeneIDi13510.
KEGGimmu:13510.
UCSCiuc008eel.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC154410 mRNA. Translation: AAI54411.1.
AK029294 mRNA. Translation: BAC26378.1. Frameshift.
X74335 mRNA. Translation: CAA52382.1.
CCDSiCCDS50231.1.
PIRiB54742.
RefSeqiNP_034209.2. NM_010079.2.
UniGeneiMm.37953.

3D structure databases

ProteinModelPortaliQ61495.
SMRiQ61495.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199323. 6 interactors.
IntActiQ61495. 4 interactors.
STRINGi10090.ENSMUSP00000076393.

PTM databases

iPTMnetiQ61495.
PhosphoSitePlusiQ61495.

Proteomic databases

MaxQBiQ61495.
PaxDbiQ61495.
PRIDEiQ61495.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077146; ENSMUSP00000076393; ENSMUSG00000069441.
GeneIDi13510.
KEGGimmu:13510.
UCSCiuc008eel.2. mouse.

Organism-specific databases

CTDi13510.
MGIiMGI:94930. Dsg1a.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00760000118906.
HOGENOMiHOG000236266.
HOVERGENiHBG005532.
InParanoidiQ61495.
KOiK07596.
OMAiNLENGGW.
OrthoDBiEOG091G01PF.
PhylomeDBiQ61495.
TreeFamiTF331809.

Enzyme and pathway databases

ReactomeiR-MMU-351906. Apoptotic cleavage of cell adhesion proteins.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ61495.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069441.
CleanExiMM_DSG1A.
GenevisibleiQ61495. MM.

Family and domain databases

Gene3Di2.60.40.60. 4 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
IPR009123. Desmoglein.
IPR009122. Desmosomal_cadherin.
[Graphical view]
PANTHERiPTHR24025. PTHR24025. 1 hit.
PfamiPF00028. Cadherin. 3 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
PR01818. DESMOCADHERN.
PR01819. DESMOGLEIN.
SMARTiSM00112. CA. 4 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 4 hits.
PROSITEiPS00232. CADHERIN_1. 2 hits.
PS50268. CADHERIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDSG1A_MOUSE
AccessioniPrimary (citable) accession number: Q61495
Secondary accession number(s): A8WFQ4, Q8CE03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.