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Q61490

- CD166_MOUSE

UniProt

Q61490 - CD166_MOUSE

Protein

CD166 antigen

Gene

Alcam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 3 (24 May 2004)
      Previous versions | rss
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    Functioni

    Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. cell adhesion Source: UniProtKB-KW
    3. motor neuron axon guidance Source: MGI

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_219680. L1CAM interactions.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD166 antigen
    Alternative name(s):
    Activated leukocyte cell adhesion molecule
    Protein DM-GRASP
    CD_antigen: CD166
    Gene namesi
    Name:Alcam
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1313266. Alcam.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. external side of plasma membrane Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. neuronal cell body Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 583556CD166 antigenPRO_0000014660Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 113PROSITE-ProRule annotation
    Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication
    Disulfide bondi157 ↔ 220PROSITE-ProRule annotation
    Glycosylationi167 – 1671N-linked (GlcNAc...)1 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi270 ↔ 313PROSITE-ProRule annotation
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi354 ↔ 392PROSITE-ProRule annotation
    Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi435 ↔ 485PROSITE-ProRule annotation
    Glycosylationi457 – 4571N-linked (GlcNAc...)1 Publication
    Glycosylationi466 – 4661N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi496 – 4961N-linked (GlcNAc...); atypical1 Publication
    Glycosylationi499 – 4991N-linked (GlcNAc...)1 Publication
    Glycosylationi518 – 5181N-linked (GlcNAc...); atypical1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ61490.
    PaxDbiQ61490.
    PRIDEiQ61490.

    PTM databases

    PhosphoSiteiQ61490.

    Expressioni

    Tissue specificityi

    Expressed at high levels in the brain, and lung, and at lower levels in the liver, and the kidney, as well as by activated leukocytes and a number of cell lines.

    Gene expression databases

    ArrayExpressiQ61490.
    BgeeiQ61490.
    CleanExiMM_ALCAM.
    GenevestigatoriQ61490.

    Interactioni

    Protein-protein interaction databases

    IntActiQ61490. 1 interaction.
    MINTiMINT-4997271.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61490.
    SMRiQ61490. Positions 36-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 527500ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini550 – 58334CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei528 – 54922HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 12093Ig-like V-type 1Add
    BLAST
    Domaini125 – 234110Ig-like V-type 2Add
    BLAST
    Domaini245 – 32884Ig-like C2-type 1Add
    BLAST
    Domaini333 – 40977Ig-like C2-type 2Add
    BLAST
    Domaini416 – 50186Ig-like C2-type 3Add
    BLAST

    Domaini

    The CD6 binding site is located in the N-terminal Ig-like domain.

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG148902.
    GeneTreeiENSGT00530000063457.
    HOGENOMiHOG000070101.
    HOVERGENiHBG050847.
    InParanoidiQ61490.
    KOiK06547.
    OMAiDIYYPTE.
    OrthoDBiEOG74J97B.
    PhylomeDBiQ61490.
    TreeFamiTF321859.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61490-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKVSPSCR LVFCLLISAA VLRPGLGWYT VNSAYGDTIV MPCRLDVPQN    50
    LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL SLSENYTLSI 100
    ANAKISDEKR FVCMLVTEDN VFEAPTLVKV FKQPSKPEIV NKAPFLETDQ 150
    LKKLGDCISR DSYPDGNITW YRNGKVLQPV EGEVAILFKK EIDPGTQLYT 200
    VTSSLEYKTT RSDIQMPFTC SVTYYGPSGQ KTIYSEQEIF DIYYPTEQVT 250
    IQVLPPKNAI KEGDNITLQC LGNGNPPPEE FMFYLPGQPE GIRSSNTYTL 300
    TDVRRNATGD YKCSLIDKRN MAASTTITVH YLDLSLNPSG EVTKQIGDTL 350
    PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE 400
    GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIHWTIT 450
    GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV 500
    SAISIPEHDE ADDISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY 550
    MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA 583
    Length:583
    Mass (Da):65,092
    Last modified:May 24, 2004 - v3
    Checksum:i570AFA8FCAF888F8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81S → C in BAC27159. (PubMed:16141072)Curated
    Sequence conflicti227 – 2326PSGQKT → AAGIPA in AAA37528. (PubMed:8089660)Curated
    Sequence conflicti339 – 3391S → R(PubMed:9209500)Curated
    Sequence conflicti339 – 3391S → R(PubMed:8089660)Curated
    Sequence conflicti451 – 4511G → S in BAC27159. (PubMed:16141072)Curated
    Sequence conflicti454 – 4541S → F in AAA37528. (PubMed:8089660)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95030 mRNA. Translation: AAC06342.1.
    AK030851 mRNA. Translation: BAC27159.1.
    AK031391 mRNA. Translation: BAC27382.1.
    BC027280 mRNA. Translation: AAH27280.1.
    L25274 mRNA. Translation: AAA37528.1.
    CCDSiCCDS37356.1.
    RefSeqiNP_033785.1. NM_009655.2.
    UniGeneiMm.288282.

    Genome annotation databases

    EnsembliENSMUST00000023312; ENSMUSP00000023312; ENSMUSG00000022636.
    GeneIDi11658.
    KEGGimmu:11658.
    UCSCiuc007zli.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U95030 mRNA. Translation: AAC06342.1 .
    AK030851 mRNA. Translation: BAC27159.1 .
    AK031391 mRNA. Translation: BAC27382.1 .
    BC027280 mRNA. Translation: AAH27280.1 .
    L25274 mRNA. Translation: AAA37528.1 .
    CCDSi CCDS37356.1.
    RefSeqi NP_033785.1. NM_009655.2.
    UniGenei Mm.288282.

    3D structure databases

    ProteinModelPortali Q61490.
    SMRi Q61490. Positions 36-378.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61490. 1 interaction.
    MINTi MINT-4997271.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q61490.

    Proteomic databases

    MaxQBi Q61490.
    PaxDbi Q61490.
    PRIDEi Q61490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023312 ; ENSMUSP00000023312 ; ENSMUSG00000022636 .
    GeneIDi 11658.
    KEGGi mmu:11658.
    UCSCi uc007zli.2. mouse.

    Organism-specific databases

    CTDi 214.
    MGIi MGI:1313266. Alcam.

    Phylogenomic databases

    eggNOGi NOG148902.
    GeneTreei ENSGT00530000063457.
    HOGENOMi HOG000070101.
    HOVERGENi HBG050847.
    InParanoidi Q61490.
    KOi K06547.
    OMAi DIYYPTE.
    OrthoDBi EOG74J97B.
    PhylomeDBi Q61490.
    TreeFami TF321859.

    Enzyme and pathway databases

    Reactomei REACT_219680. L1CAM interactions.

    Miscellaneous databases

    NextBioi 279279.
    PROi Q61490.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61490.
    Bgeei Q61490.
    CleanExi MM_ALCAM.
    Genevestigatori Q61490.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of mouse ALCAM (CD166): the CD6 binding domain is conserved in different homologs and mediates cross-species binding."
      Bowen M.A., Bajorath J., D'Egidio M., Whitney G.S., Palmer D., Kobarg J., Starling G.C., Siadak A.W., Aruffo A.
      Eur. J. Immunol. 27:1469-1478(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NFS.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse."
      Kanki J.P., Chang S., Kuwada J.Y.
      J. Neurobiol. 25:831-845(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 227-583.
      Strain: BALB/c.
      Tissue: Brain.
    5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
      Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
      Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-95; ASN-167; ASN-457; ASN-466; ASN-496; ASN-499 AND ASN-518.
      Tissue: Myoblast.

    Entry informationi

    Entry nameiCD166_MOUSE
    AccessioniPrimary (citable) accession number: Q61490
    Secondary accession number(s): O70136, Q8CDA5, Q8R2T0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 120 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3