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Q61490

- CD166_MOUSE

UniProt

Q61490 - CD166_MOUSE

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Protein

CD166 antigen

Gene

Alcam

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

GO - Biological processi

  1. axon guidance Source: MGI
  2. cell adhesion Source: UniProtKB-KW
  3. motor neuron axon guidance Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_219680. L1CAM interactions.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
CD166 antigen
Alternative name(s):
Activated leukocyte cell adhesion molecule
Protein DM-GRASP
CD_antigen: CD166
Gene namesi
Name:Alcam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1313266. Alcam.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 527500ExtracellularSequence AnalysisAdd
BLAST
Transmembranei528 – 54922HelicalSequence AnalysisAdd
BLAST
Topological domaini550 – 58334CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. external side of plasma membrane Source: MGI
  3. extracellular vesicular exosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 583556CD166 antigenPRO_0000014660Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 113PROSITE-ProRule annotation
Glycosylationi95 – 951N-linked (GlcNAc...)1 Publication
Disulfide bondi157 ↔ 220PROSITE-ProRule annotation
Glycosylationi167 – 1671N-linked (GlcNAc...)1 Publication
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi270 ↔ 313PROSITE-ProRule annotation
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi354 ↔ 392PROSITE-ProRule annotation
Glycosylationi361 – 3611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi435 ↔ 485PROSITE-ProRule annotation
Glycosylationi457 – 4571N-linked (GlcNAc...)1 Publication
Glycosylationi466 – 4661N-linked (GlcNAc...); atypical1 Publication
Glycosylationi480 – 4801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi496 – 4961N-linked (GlcNAc...); atypical1 Publication
Glycosylationi499 – 4991N-linked (GlcNAc...)1 Publication
Glycosylationi518 – 5181N-linked (GlcNAc...); atypical1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61490.
PaxDbiQ61490.
PRIDEiQ61490.

PTM databases

PhosphoSiteiQ61490.

Expressioni

Tissue specificityi

Expressed at high levels in the brain, and lung, and at lower levels in the liver, and the kidney, as well as by activated leukocytes and a number of cell lines.

Gene expression databases

BgeeiQ61490.
CleanExiMM_ALCAM.
ExpressionAtlasiQ61490. baseline and differential.
GenevestigatoriQ61490.

Interactioni

Protein-protein interaction databases

IntActiQ61490. 1 interaction.
MINTiMINT-4997271.

Structurei

3D structure databases

ProteinModelPortaliQ61490.
SMRiQ61490. Positions 29-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 12093Ig-like V-type 1Add
BLAST
Domaini125 – 234110Ig-like V-type 2Add
BLAST
Domaini245 – 32884Ig-like C2-type 1Add
BLAST
Domaini333 – 40977Ig-like C2-type 2Add
BLAST
Domaini416 – 50186Ig-like C2-type 3Add
BLAST

Domaini

The CD6 binding site is located in the N-terminal Ig-like domain.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG148902.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000070101.
HOVERGENiHBG050847.
InParanoidiQ61490.
KOiK06547.
OMAiDIYYPTE.
OrthoDBiEOG74J97B.
PhylomeDBiQ61490.
TreeFamiTF321859.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61490-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKVSPSCR LVFCLLISAA VLRPGLGWYT VNSAYGDTIV MPCRLDVPQN
60 70 80 90 100
LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL SLSENYTLSI
110 120 130 140 150
ANAKISDEKR FVCMLVTEDN VFEAPTLVKV FKQPSKPEIV NKAPFLETDQ
160 170 180 190 200
LKKLGDCISR DSYPDGNITW YRNGKVLQPV EGEVAILFKK EIDPGTQLYT
210 220 230 240 250
VTSSLEYKTT RSDIQMPFTC SVTYYGPSGQ KTIYSEQEIF DIYYPTEQVT
260 270 280 290 300
IQVLPPKNAI KEGDNITLQC LGNGNPPPEE FMFYLPGQPE GIRSSNTYTL
310 320 330 340 350
TDVRRNATGD YKCSLIDKRN MAASTTITVH YLDLSLNPSG EVTKQIGDTL
360 370 380 390 400
PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE
410 420 430 440 450
GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIHWTIT
460 470 480 490 500
GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV
510 520 530 540 550
SAISIPEHDE ADDISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY
560 570 580
MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA
Length:583
Mass (Da):65,092
Last modified:May 24, 2004 - v3
Checksum:i570AFA8FCAF888F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81S → C in BAC27159. (PubMed:16141072)Curated
Sequence conflicti227 – 2326PSGQKT → AAGIPA in AAA37528. (PubMed:8089660)Curated
Sequence conflicti339 – 3391S → R(PubMed:9209500)Curated
Sequence conflicti339 – 3391S → R(PubMed:8089660)Curated
Sequence conflicti451 – 4511G → S in BAC27159. (PubMed:16141072)Curated
Sequence conflicti454 – 4541S → F in AAA37528. (PubMed:8089660)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95030 mRNA. Translation: AAC06342.1.
AK030851 mRNA. Translation: BAC27159.1.
AK031391 mRNA. Translation: BAC27382.1.
BC027280 mRNA. Translation: AAH27280.1.
L25274 mRNA. Translation: AAA37528.1.
CCDSiCCDS37356.1.
RefSeqiNP_033785.1. NM_009655.2.
UniGeneiMm.288282.

Genome annotation databases

EnsembliENSMUST00000023312; ENSMUSP00000023312; ENSMUSG00000022636.
GeneIDi11658.
KEGGimmu:11658.
UCSCiuc007zli.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U95030 mRNA. Translation: AAC06342.1 .
AK030851 mRNA. Translation: BAC27159.1 .
AK031391 mRNA. Translation: BAC27382.1 .
BC027280 mRNA. Translation: AAH27280.1 .
L25274 mRNA. Translation: AAA37528.1 .
CCDSi CCDS37356.1.
RefSeqi NP_033785.1. NM_009655.2.
UniGenei Mm.288282.

3D structure databases

ProteinModelPortali Q61490.
SMRi Q61490. Positions 29-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61490. 1 interaction.
MINTi MINT-4997271.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q61490.

Proteomic databases

MaxQBi Q61490.
PaxDbi Q61490.
PRIDEi Q61490.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023312 ; ENSMUSP00000023312 ; ENSMUSG00000022636 .
GeneIDi 11658.
KEGGi mmu:11658.
UCSCi uc007zli.2. mouse.

Organism-specific databases

CTDi 214.
MGIi MGI:1313266. Alcam.

Phylogenomic databases

eggNOGi NOG148902.
GeneTreei ENSGT00530000063457.
HOGENOMi HOG000070101.
HOVERGENi HBG050847.
InParanoidi Q61490.
KOi K06547.
OMAi DIYYPTE.
OrthoDBi EOG74J97B.
PhylomeDBi Q61490.
TreeFami TF321859.

Enzyme and pathway databases

Reactomei REACT_219680. L1CAM interactions.

Miscellaneous databases

ChiTaRSi Alcam. mouse.
NextBioi 279279.
PROi Q61490.
SOURCEi Search...

Gene expression databases

Bgeei Q61490.
CleanExi MM_ALCAM.
ExpressionAtlasi Q61490. baseline and differential.
Genevestigatori Q61490.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 3 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of mouse ALCAM (CD166): the CD6 binding domain is conserved in different homologs and mediates cross-species binding."
    Bowen M.A., Bajorath J., D'Egidio M., Whitney G.S., Palmer D., Kobarg J., Starling G.C., Siadak A.W., Aruffo A.
    Eur. J. Immunol. 27:1469-1478(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NFS.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse."
    Kanki J.P., Chang S., Kuwada J.Y.
    J. Neurobiol. 25:831-845(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 227-583.
    Strain: BALB/c.
    Tissue: Brain.
  5. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-95; ASN-167; ASN-457; ASN-466; ASN-496; ASN-499 AND ASN-518.
    Tissue: Myoblast.

Entry informationi

Entry nameiCD166_MOUSE
AccessioniPrimary (citable) accession number: Q61490
Secondary accession number(s): O70136, Q8CDA5, Q8R2T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2004
Last modified: November 26, 2014
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3