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Q61483

- DLL1_MOUSE

UniProt

Q61483 - DLL1_MOUSE

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Protein

Delta-like protein 1

Gene

Dll1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in cell-to-cell communication in mammalian embryos. May have a role in cellular interactions underlying somitogenesis and development of the nervous system.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. Notch binding Source: UniProtKB

GO - Biological processi

  1. auditory receptor cell differentiation Source: UniProtKB
  2. auditory receptor cell fate commitment Source: UniProtKB
  3. cell-cell signaling Source: MGI
  4. compartment pattern specification Source: MGI
  5. determination of left/right symmetry Source: MGI
  6. heart looping Source: BHF-UCL
  7. inner ear development Source: MGI
  8. inner ear morphogenesis Source: UniProtKB
  9. in utero embryonic development Source: UniProtKB
  10. left/right axis specification Source: BHF-UCL
  11. loop of Henle development Source: UniProtKB
  12. negative regulation of auditory receptor cell differentiation Source: MGI
  13. negative regulation of cell differentiation Source: MGI
  14. negative regulation of interleukin-10 production Source: Ensembl
  15. negative regulation of myeloid cell differentiation Source: MGI
  16. negative regulation of neuron differentiation Source: MGI
  17. nervous system development Source: UniProtKB
  18. neuronal stem cell maintenance Source: Ensembl
  19. Notch signaling involved in heart development Source: BHF-UCL
  20. Notch signaling pathway Source: UniProtKB
  21. odontogenesis of dentin-containing tooth Source: UniProtKB
  22. organ morphogenesis Source: UniProtKB
  23. positive regulation of Notch signaling pathway Source: MGI
  24. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. proximal tubule development Source: UniProtKB
  26. regulation of neurogenesis Source: MGI
  27. somite specification Source: MGI
  28. somitogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Notch signaling pathway

Enzyme and pathway databases

ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein 1
Alternative name(s):
Drosophila Delta homolog 1
Short name:
Delta1
Gene namesi
Name:Dll1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:104659. Dll1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 722705Delta-like protein 1PRO_0000007507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi178 ↔ 187By similarity
Disulfide bondi191 ↔ 203By similarity
Disulfide bondi211 ↔ 220By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi229 ↔ 242By similarity
Disulfide bondi244 ↔ 253By similarity
Disulfide bondi256 ↔ 267By similarity
Disulfide bondi262 ↔ 273By similarity
Disulfide bondi275 ↔ 284By similarity
Disulfide bondi291 ↔ 303By similarity
Disulfide bondi297 ↔ 313By similarity
Disulfide bondi315 ↔ 324By similarity
Disulfide bondi331 ↔ 342By similarity
Disulfide bondi336 ↔ 351By similarity
Disulfide bondi353 ↔ 362By similarity
Disulfide bondi369 ↔ 380By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi392 ↔ 401By similarity
Disulfide bondi408 ↔ 419By similarity
Disulfide bondi413 ↔ 428By similarity
Disulfide bondi430 ↔ 439By similarity
Disulfide bondi446 ↔ 457By similarity
Disulfide bondi451 ↔ 466By similarity
Disulfide bondi468 ↔ 477By similarity
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi484 ↔ 495By similarity
Disulfide bondi489 ↔ 504By similarity
Disulfide bondi506 ↔ 515By similarity

Post-translational modificationi

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ61483.

PTM databases

PhosphoSiteiQ61483.

Miscellaneous databases

PMAP-CutDBQ6PFV7.

Expressioni

Tissue specificityi

In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung.

Developmental stagei

Expressed until day 15 in the embryo. Expression then decreases and increases again in the adult.

Gene expression databases

BgeeiQ61483.
CleanExiMM_DLL1.
GenevestigatoriQ61483.

Interactioni

Subunit structurei

Interacts with Notch receptors.

Binary interactionsi

WithEntry#Exp.IntActNotes
Magi2Q9WVQ12EBI-297125,EBI-297151

Protein-protein interaction databases

BioGridi199232. 7 interactions.
DIPiDIP-32600N.
IntActiQ61483. 3 interactions.
MINTiMINT-8187263.
STRINGi10090.ENSMUSP00000014917.

Structurei

3D structure databases

ProteinModelPortaliQ61483.
SMRiQ61483. Positions 22-551.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 545528ExtracellularSequence AnalysisAdd
BLAST
Topological domaini569 – 722154CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei546 – 56823HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini176 – 22045DSLPROSITE-ProRule annotationAdd
BLAST
Domaini225 – 25329EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 28429EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini291 – 32434EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 36232EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini369 – 40133EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini408 – 43932EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini446 – 47732EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini484 – 51532EGF-like 8PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249767.
GeneTreeiENSGT00760000118786.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiQ61483.
KOiK06051.
OMAiRCTDNPD.
OrthoDBiEOG7GQXZ5.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61483 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG
60 70 80 90 100
PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID
110 120 130 140 150
PAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLTTQR
160 170 180 190 200
HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE HYYGEGCSVF CRPRDDAFGH
210 220 230 240 250
FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG ECKCRVGWQG
260 270 280 290 300
RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG
310 320 330 340 350
ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS
360 370 380 390 400
CTCPPGFYGK VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN
410 420 430 440 450
CEKKMDLCGS SPCSNGAKCV DLGNSYLCRC QAGFSGRYCE DNVDDCASSP
460 470 480 490 500
CANGGTCRDS VNDFSCTCPP GYTGKNCSAP VSRCEHAPCH NGATCHQRGQ
510 520 530 540 550
RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG GPFPWVAVCA
560 570 580 590 600
GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK
610 620 630 640 650
DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD
660 670 680 690 700
EATVRDTHSK RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD
710 720
TKYQSVYVLS AEKDECVIAT EV
Length:722
Mass (Da):78,449
Last modified:July 27, 2011 - v2
Checksum:i9D570B9DC7EEC75E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti628 – 6281E → K in CAA56865. (PubMed:7671806)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80903 mRNA. Translation: CAA56865.1.
AY497019 Genomic DNA. Translation: AAR30869.1.
CH466630 Genomic DNA. Translation: EDL20466.1.
BC057400 mRNA. Translation: AAH57400.1.
BC065063 mRNA. Translation: AAH65063.1.
CCDSiCCDS37452.1.
PIRiI48324.
RefSeqiNP_031891.2. NM_007865.3.
UniGeneiMm.4875.

Genome annotation databases

EnsembliENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773.
GeneIDi13388.
KEGGimmu:13388.
UCSCiuc008aoi.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X80903 mRNA. Translation: CAA56865.1 .
AY497019 Genomic DNA. Translation: AAR30869.1 .
CH466630 Genomic DNA. Translation: EDL20466.1 .
BC057400 mRNA. Translation: AAH57400.1 .
BC065063 mRNA. Translation: AAH65063.1 .
CCDSi CCDS37452.1.
PIRi I48324.
RefSeqi NP_031891.2. NM_007865.3.
UniGenei Mm.4875.

3D structure databases

ProteinModelPortali Q61483.
SMRi Q61483. Positions 22-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199232. 7 interactions.
DIPi DIP-32600N.
IntActi Q61483. 3 interactions.
MINTi MINT-8187263.
STRINGi 10090.ENSMUSP00000014917.

PTM databases

PhosphoSitei Q61483.

Proteomic databases

PRIDEi Q61483.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000014917 ; ENSMUSP00000014917 ; ENSMUSG00000014773 .
GeneIDi 13388.
KEGGi mmu:13388.
UCSCi uc008aoi.2. mouse.

Organism-specific databases

CTDi 28514.
MGIi MGI:104659. Dll1.

Phylogenomic databases

eggNOGi NOG249767.
GeneTreei ENSGT00760000118786.
HOGENOMi HOG000267024.
HOVERGENi HBG007139.
InParanoidi Q61483.
KOi K06051.
OMAi RCTDNPD.
OrthoDBi EOG7GQXZ5.
TreeFami TF351835.

Enzyme and pathway databases

Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
REACT_199404. Signaling by NOTCH4.
REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
REACT_199413. Signaling by NOTCH3.

Miscellaneous databases

NextBioi 283748.
PMAP-CutDB Q6PFV7.
PROi Q61483.
SOURCEi Search...

Gene expression databases

Bgeei Q61483.
CleanExi MM_DLL1.
Genevestigatori Q61483.

Family and domain databases

InterProi IPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011651. Notch_ligand_N.
[Graphical view ]
Pfami PF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07657. MNNL. 1 hit.
[Graphical view ]
SMARTi SM00051. DSL. 1 hit.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta."
    Bettenhausen B., de Angelis M.H., Simon D., Guenet J.-L., Gossler A.
    Development 121:2407-2418(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X BALB/c.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Embryonic brain.

Entry informationi

Entry nameiDLL1_MOUSE
AccessioniPrimary (citable) accession number: Q61483
Secondary accession number(s): Q6PFV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3