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Q61483 (DLL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Delta-like protein 1
Alternative name(s):
Drosophila Delta homolog 1
Short name=Delta1
Gene names
Name:Dll1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length722 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in cell-to-cell communication in mammalian embryos. May have a role in cellular interactions underlying somitogenesis and development of the nervous system.

Subunit structure

Interacts with Notch receptors.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung.

Developmental stage

Expressed until day 15 in the embryo. Expression then decreases and increases again in the adult.

Post-translational modification

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation By similarity.

Sequence similarities

Contains 1 DSL domain.

Contains 8 EGF-like domains.

Ontologies

Keywords
   Biological processDifferentiation
Notch signaling pathway
   Cellular componentMembrane
   DomainEGF-like domain
Repeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNotch signaling involved in heart development

Inferred by curator PubMed 12730124. Source: BHF-UCL

Notch signaling pathway

Traceable author statement PubMed 15821257. Source: UniProtKB

auditory receptor cell differentiation

Non-traceable author statement PubMed 9858718. Source: UniProtKB

auditory receptor cell fate commitment

Non-traceable author statement PubMed 10473135PubMed 10704388. Source: UniProtKB

cell-cell signaling

Inferred from direct assay PubMed 16621992. Source: MGI

compartment pattern specification

Inferred from mutant phenotype PubMed 12001066. Source: MGI

determination of left/right symmetry

Inferred from mutant phenotype PubMed 12730124. Source: MGI

heart looping

Inferred from mutant phenotype PubMed 12730124. Source: BHF-UCL

in utero embryonic development

Non-traceable author statement PubMed 10473134. Source: UniProtKB

inner ear development

Inferred from mutant phenotype PubMed 16495313. Source: MGI

inner ear morphogenesis

Non-traceable author statement PubMed 9858718. Source: UniProtKB

left/right axis specification

Inferred from mutant phenotype PubMed 12730124. Source: BHF-UCL

loop of Henle development

Inferred from expression pattern PubMed 15821257. Source: UniProtKB

negative regulation of auditory receptor cell differentiation

Inferred from mutant phenotype PubMed 16495313. Source: MGI

negative regulation of cell differentiation

Inferred from mutant phenotype PubMed 10476967PubMed 16495313. Source: MGI

negative regulation of myeloid cell differentiation

Inferred from direct assay PubMed 16621992. Source: MGI

negative regulation of neuron differentiation

Inferred from mutant phenotype PubMed 20081190. Source: MGI

nervous system development

Non-traceable author statement PubMed 10473134. Source: UniProtKB

neuronal stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

odontogenesis of dentin-containing tooth

Non-traceable author statement PubMed 9882480. Source: UniProtKB

organ morphogenesis

Non-traceable author statement PubMed 10473134. Source: UniProtKB

positive regulation of Notch signaling pathway

Inferred from direct assay PubMed 15574878. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 12730124. Source: BHF-UCL

proximal tubule development

Inferred from expression pattern PubMed 15821257. Source: UniProtKB

regulation of neurogenesis

Inferred from mutant phenotype PubMed 19389377. Source: MGI

somite specification

Inferred from mutant phenotype PubMed 14960495. Source: MGI

somitogenesis

Inferred from genetic interaction PubMed 15902259. Source: MGI

   Cellular_componentcytoplasmic vesicle

Inferred from direct assay PubMed 16000382. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 16000382. Source: MGI

   Molecular_functionNotch binding

Inferred from physical interaction PubMed 10958687. Source: UniProtKB

calcium ion binding

Inferred from electronic annotation. Source: InterPro

protein binding

Inferred from physical interaction PubMed 14529612. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Magi2Q9WVQ12EBI-297125,EBI-297151

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 722705Delta-like protein 1
PRO_0000007507

Regions

Topological domain18 – 545528Extracellular Potential
Transmembrane546 – 56823Helical; Potential
Topological domain569 – 722154Cytoplasmic Potential
Domain176 – 22045DSL
Domain225 – 25329EGF-like 1
Domain256 – 28429EGF-like 2
Domain291 – 32434EGF-like 3
Domain331 – 36232EGF-like 4; calcium-binding Potential
Domain369 – 40133EGF-like 5
Domain408 – 43932EGF-like 6
Domain446 – 47732EGF-like 7; calcium-binding Potential
Domain484 – 51532EGF-like 8

Amino acid modifications

Glycosylation4761N-linked (GlcNAc...) Potential
Disulfide bond178 ↔ 187 By similarity
Disulfide bond191 ↔ 203 By similarity
Disulfide bond211 ↔ 220 By similarity
Disulfide bond225 ↔ 236 By similarity
Disulfide bond229 ↔ 242 By similarity
Disulfide bond244 ↔ 253 By similarity
Disulfide bond256 ↔ 267 By similarity
Disulfide bond262 ↔ 273 By similarity
Disulfide bond275 ↔ 284 By similarity
Disulfide bond291 ↔ 303 By similarity
Disulfide bond297 ↔ 313 By similarity
Disulfide bond315 ↔ 324 By similarity
Disulfide bond331 ↔ 342 By similarity
Disulfide bond336 ↔ 351 By similarity
Disulfide bond353 ↔ 362 By similarity
Disulfide bond369 ↔ 380 By similarity
Disulfide bond374 ↔ 390 By similarity
Disulfide bond392 ↔ 401 By similarity
Disulfide bond408 ↔ 419 By similarity
Disulfide bond413 ↔ 428 By similarity
Disulfide bond430 ↔ 439 By similarity
Disulfide bond446 ↔ 457 By similarity
Disulfide bond451 ↔ 466 By similarity
Disulfide bond468 ↔ 477 By similarity
Disulfide bond484 ↔ 495 By similarity
Disulfide bond489 ↔ 504 By similarity
Disulfide bond506 ↔ 515 By similarity

Experimental info

Sequence conflict6281E → K in CAA56865. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61483 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9D570B9DC7EEC75E

FASTA72278,449
        10         20         30         40         50         60 
MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG PPCACRTFFR 

        70         80         90        100        110        120 
VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID PAFSNPIRFP FGFTWPGTFS 

       130        140        150        160        170        180 
LIIEALHTDS PDDLATENPE RLISRLTTQR HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE 

       190        200        210        220        230        240 
HYYGEGCSVF CRPRDDAFGH FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG 

       250        260        270        280        290        300 
ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG 

       310        320        330        340        350        360 
ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS CTCPPGFYGK 

       370        380        390        400        410        420 
VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN CEKKMDLCGS SPCSNGAKCV 

       430        440        450        460        470        480 
DLGNSYLCRC QAGFSGRYCE DNVDDCASSP CANGGTCRDS VNDFSCTCPP GYTGKNCSAP 

       490        500        510        520        530        540 
VSRCEHAPCH NGATCHQRGQ RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG 

       550        560        570        580        590        600 
GPFPWVAVCA GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK 

       610        620        630        640        650        660 
DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD EATVRDTHSK 

       670        680        690        700        710        720 
RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD TKYQSVYVLS AEKDECVIAT 


EV 

« Hide

References

« Hide 'large scale' references
[1]"Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta."
Bettenhausen B., de Angelis M.H., Simon D., Guenet J.-L., Gossler A.
Development 121:2407-2418(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6 X BALB/c.
Tissue: Embryo.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Embryonic brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X80903 mRNA. Translation: CAA56865.1.
AY497019 Genomic DNA. Translation: AAR30869.1.
CH466630 Genomic DNA. Translation: EDL20466.1.
BC057400 mRNA. Translation: AAH57400.1.
BC065063 mRNA. Translation: AAH65063.1.
CCDSCCDS37452.1.
PIRI48324.
RefSeqNP_031891.2. NM_007865.3.
UniGeneMm.4875.

3D structure databases

ProteinModelPortalQ61483.
SMRQ61483. Positions 22-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199232. 7 interactions.
DIPDIP-32600N.
IntActQ61483. 3 interactions.
MINTMINT-8187263.
STRING10090.ENSMUSP00000014917.

PTM databases

PhosphoSiteQ61483.

Proteomic databases

PRIDEQ61483.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773.
GeneID13388.
KEGGmmu:13388.
UCSCuc008aoi.2. mouse.

Organism-specific databases

CTD28514.
MGIMGI:104659. Dll1.

Phylogenomic databases

eggNOGNOG249767.
GeneTreeENSGT00750000117649.
HOGENOMHOG000267024.
HOVERGENHBG007139.
InParanoidQ6PFV7.
KOK06051.
OMARCTDNPD.
OrthoDBEOG7GQXZ5.
TreeFamTF351835.

Enzyme and pathway databases

ReactomeREACT_188257. Signal Transduction.

Gene expression databases

BgeeQ61483.
CleanExMM_DLL1.
GenevestigatorQ61483.

Family and domain databases

InterProIPR001774. DSL.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTSM00051. DSL. 1 hit.
SM00181. EGF. 4 hits.
SM00179. EGF_CA. 4 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 7 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio283748.
PMAP-CutDBQ6PFV7.
PROQ61483.
SOURCESearch...

Entry information

Entry nameDLL1_MOUSE
AccessionPrimary (citable) accession number: Q61483
Secondary accession number(s): Q6PFV7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot