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Q61483

- DLL1_MOUSE

UniProt

Q61483 - DLL1_MOUSE

Protein

Delta-like protein 1

Gene

Dll1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be involved in cell-to-cell communication in mammalian embryos. May have a role in cellular interactions underlying somitogenesis and development of the nervous system.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. Notch binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. auditory receptor cell differentiation Source: UniProtKB
    2. auditory receptor cell fate commitment Source: UniProtKB
    3. cell-cell signaling Source: MGI
    4. compartment pattern specification Source: MGI
    5. determination of left/right symmetry Source: MGI
    6. heart looping Source: BHF-UCL
    7. inner ear development Source: MGI
    8. inner ear morphogenesis Source: UniProtKB
    9. in utero embryonic development Source: UniProtKB
    10. left/right axis specification Source: BHF-UCL
    11. loop of Henle development Source: UniProtKB
    12. negative regulation of auditory receptor cell differentiation Source: MGI
    13. negative regulation of cell differentiation Source: MGI
    14. negative regulation of myeloid cell differentiation Source: MGI
    15. negative regulation of neuron differentiation Source: MGI
    16. nervous system development Source: UniProtKB
    17. neuronal stem cell maintenance Source: Ensembl
    18. Notch signaling involved in heart development Source: BHF-UCL
    19. Notch signaling pathway Source: UniProtKB
    20. odontogenesis of dentin-containing tooth Source: UniProtKB
    21. organ morphogenesis Source: UniProtKB
    22. positive regulation of Notch signaling pathway Source: MGI
    23. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    24. proximal tubule development Source: UniProtKB
    25. regulation of neurogenesis Source: MGI
    26. somite specification Source: MGI
    27. somitogenesis Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Notch signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Delta-like protein 1
    Alternative name(s):
    Drosophila Delta homolog 1
    Short name:
    Delta1
    Gene namesi
    Name:Dll1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:104659. Dll1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 722705Delta-like protein 1PRO_0000007507Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi178 ↔ 187By similarity
    Disulfide bondi191 ↔ 203By similarity
    Disulfide bondi211 ↔ 220By similarity
    Disulfide bondi225 ↔ 236By similarity
    Disulfide bondi229 ↔ 242By similarity
    Disulfide bondi244 ↔ 253By similarity
    Disulfide bondi256 ↔ 267By similarity
    Disulfide bondi262 ↔ 273By similarity
    Disulfide bondi275 ↔ 284By similarity
    Disulfide bondi291 ↔ 303By similarity
    Disulfide bondi297 ↔ 313By similarity
    Disulfide bondi315 ↔ 324By similarity
    Disulfide bondi331 ↔ 342By similarity
    Disulfide bondi336 ↔ 351By similarity
    Disulfide bondi353 ↔ 362By similarity
    Disulfide bondi369 ↔ 380By similarity
    Disulfide bondi374 ↔ 390By similarity
    Disulfide bondi392 ↔ 401By similarity
    Disulfide bondi408 ↔ 419By similarity
    Disulfide bondi413 ↔ 428By similarity
    Disulfide bondi430 ↔ 439By similarity
    Disulfide bondi446 ↔ 457By similarity
    Disulfide bondi451 ↔ 466By similarity
    Disulfide bondi468 ↔ 477By similarity
    Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi484 ↔ 495By similarity
    Disulfide bondi489 ↔ 504By similarity
    Disulfide bondi506 ↔ 515By similarity

    Post-translational modificationi

    Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ61483.

    PTM databases

    PhosphoSiteiQ61483.

    Miscellaneous databases

    PMAP-CutDBQ6PFV7.

    Expressioni

    Tissue specificityi

    In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung.

    Developmental stagei

    Expressed until day 15 in the embryo. Expression then decreases and increases again in the adult.

    Gene expression databases

    BgeeiQ61483.
    CleanExiMM_DLL1.
    GenevestigatoriQ61483.

    Interactioni

    Subunit structurei

    Interacts with Notch receptors.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Magi2Q9WVQ12EBI-297125,EBI-297151

    Protein-protein interaction databases

    BioGridi199232. 7 interactions.
    DIPiDIP-32600N.
    IntActiQ61483. 3 interactions.
    MINTiMINT-8187263.
    STRINGi10090.ENSMUSP00000014917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61483.
    SMRiQ61483. Positions 22-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 545528ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini569 – 722154CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 56823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini176 – 22045DSLPROSITE-ProRule annotationAdd
    BLAST
    Domaini225 – 25329EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 28429EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 32434EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 36232EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini369 – 40133EGF-like 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini408 – 43932EGF-like 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini446 – 47732EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini484 – 51532EGF-like 8PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 DSL domain.PROSITE-ProRule annotation
    Contains 8 EGF-like domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249767.
    GeneTreeiENSGT00750000117649.
    HOGENOMiHOG000267024.
    HOVERGENiHBG007139.
    InParanoidiQ6PFV7.
    KOiK06051.
    OMAiRCTDNPD.
    OrthoDBiEOG7GQXZ5.
    TreeFamiTF351835.

    Family and domain databases

    InterProiIPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011651. Notch_ligand_N.
    [Graphical view]
    PfamiPF01414. DSL. 1 hit.
    PF00008. EGF. 6 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view]
    SMARTiSM00051. DSL. 1 hit.
    SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 4 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61483-1 [UniParc]FASTAAdd to Basket

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    MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG    50
    PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID 100
    PAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLTTQR 150
    HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE HYYGEGCSVF CRPRDDAFGH 200
    FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG ECKCRVGWQG 250
    RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG 300
    ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS 350
    CTCPPGFYGK VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN 400
    CEKKMDLCGS SPCSNGAKCV DLGNSYLCRC QAGFSGRYCE DNVDDCASSP 450
    CANGGTCRDS VNDFSCTCPP GYTGKNCSAP VSRCEHAPCH NGATCHQRGQ 500
    RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG GPFPWVAVCA 550
    GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK 600
    DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD 650
    EATVRDTHSK RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD 700
    TKYQSVYVLS AEKDECVIAT EV 722
    Length:722
    Mass (Da):78,449
    Last modified:July 27, 2011 - v2
    Checksum:i9D570B9DC7EEC75E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti628 – 6281E → K in CAA56865. (PubMed:7671806)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80903 mRNA. Translation: CAA56865.1.
    AY497019 Genomic DNA. Translation: AAR30869.1.
    CH466630 Genomic DNA. Translation: EDL20466.1.
    BC057400 mRNA. Translation: AAH57400.1.
    BC065063 mRNA. Translation: AAH65063.1.
    CCDSiCCDS37452.1.
    PIRiI48324.
    RefSeqiNP_031891.2. NM_007865.3.
    UniGeneiMm.4875.

    Genome annotation databases

    EnsembliENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773.
    GeneIDi13388.
    KEGGimmu:13388.
    UCSCiuc008aoi.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80903 mRNA. Translation: CAA56865.1 .
    AY497019 Genomic DNA. Translation: AAR30869.1 .
    CH466630 Genomic DNA. Translation: EDL20466.1 .
    BC057400 mRNA. Translation: AAH57400.1 .
    BC065063 mRNA. Translation: AAH65063.1 .
    CCDSi CCDS37452.1.
    PIRi I48324.
    RefSeqi NP_031891.2. NM_007865.3.
    UniGenei Mm.4875.

    3D structure databases

    ProteinModelPortali Q61483.
    SMRi Q61483. Positions 22-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199232. 7 interactions.
    DIPi DIP-32600N.
    IntActi Q61483. 3 interactions.
    MINTi MINT-8187263.
    STRINGi 10090.ENSMUSP00000014917.

    PTM databases

    PhosphoSitei Q61483.

    Proteomic databases

    PRIDEi Q61483.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000014917 ; ENSMUSP00000014917 ; ENSMUSG00000014773 .
    GeneIDi 13388.
    KEGGi mmu:13388.
    UCSCi uc008aoi.2. mouse.

    Organism-specific databases

    CTDi 28514.
    MGIi MGI:104659. Dll1.

    Phylogenomic databases

    eggNOGi NOG249767.
    GeneTreei ENSGT00750000117649.
    HOGENOMi HOG000267024.
    HOVERGENi HBG007139.
    InParanoidi Q6PFV7.
    KOi K06051.
    OMAi RCTDNPD.
    OrthoDBi EOG7GQXZ5.
    TreeFami TF351835.

    Enzyme and pathway databases

    Reactomei REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_196638. Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.
    REACT_196643. Constitutive Signaling by NOTCH1 HD Domain Mutants.
    REACT_199384. Activated NOTCH1 Transmits Signal to the Nucleus.
    REACT_199404. Signaling by NOTCH4.
    REACT_199411. NOTCH2 Activation and Transmission of Signal to the Nucleus.
    REACT_199413. Signaling by NOTCH3.

    Miscellaneous databases

    NextBioi 283748.
    PMAP-CutDB Q6PFV7.
    PROi Q61483.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61483.
    CleanExi MM_DLL1.
    Genevestigatori Q61483.

    Family and domain databases

    InterProi IPR001774. DSL.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011651. Notch_ligand_N.
    [Graphical view ]
    Pfami PF01414. DSL. 1 hit.
    PF00008. EGF. 6 hits.
    PF07657. MNNL. 1 hit.
    [Graphical view ]
    SMARTi SM00051. DSL. 1 hit.
    SM00181. EGF. 4 hits.
    SM00179. EGF_CA. 4 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS51051. DSL. 1 hit.
    PS00022. EGF_1. 8 hits.
    PS01186. EGF_2. 8 hits.
    PS50026. EGF_3. 7 hits.
    PS01187. EGF_CA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta."
      Bettenhausen B., de Angelis M.H., Simon D., Guenet J.-L., Gossler A.
      Development 121:2407-2418(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X BALB/c.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Embryonic brain.

    Entry informationi

    Entry nameiDLL1_MOUSE
    AccessioniPrimary (citable) accession number: Q61483
    Secondary accession number(s): Q6PFV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3