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Delta-like protein 1



Mus musculus (Mouse)
Reviewed-Annotation score: -Experimental evidence at protein leveli


Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner (PubMed:21985982, PubMed:10958687). Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD) (PubMed:10958687, PubMed:18676613). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signaling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation (PubMed:17194759, PubMed:19562077, PubMed:18997111, PubMed:23695674, PubMed:16495313, PubMed:21238454, PubMed:22282195, PubMed:7671806, PubMed:17960184, PubMed:22529374, PubMed:19389377, PubMed:23699523, PubMed:19144989, PubMed:23688253, PubMed:23806616, PubMed:26114479, PubMed:22940113, PubMed:25220152, PubMed:20081190, PubMed:21572390, PubMed:22096075). Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner (PubMed:7671806, PubMed:18997111). During neocortex development, Dll1-Notch signaling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries (PubMed:23699523). During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signaling pathway (PubMed:23688253). At the retina and spinal cord level, regulates neurogenesis by preventing the premature differentiation of neural progenitors and also by maintaining progenitors in spinal cord through Notch signaling pathway (PubMed:19389377, PubMed:26114479). Also controls neurogenesis of the neural tube in a progenitor domain-specific fashion along the dorsoventral axis (PubMed:20081190). Maintains quiescence of neural stem cells and plays a role as a fate determinant that segregates asymmetrically to one daughter cell during neural stem cells mitosis, resulting in neuronal differentiation in Dll1-inheriting cell (PubMed:23695674). Plays a role in immune systeme development, namely the development of all T-cells and marginal zone (MZ) B cells (PubMed:15146182, PubMed:19217325). Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor (By similarity). Upon MMP14 cleavage, negatively regulates Notch signaling in haematopoietic progenitor cells to specifically maintain normal B-cell development in bone marrow (PubMed:21572390). Also plays a role during muscle development. During early development, inhibits myoblasts differentiation from the medial dermomyotomal lip and later regulates progenitor cell differentiation (PubMed:17194759). Directly modulates cell adhesion and basal lamina formation in satellite cells through Notch signaling. Maintains myogenic progenitors pool by suppressing differentiation through down-regulation of MYOD1 and is required for satellite cell homing and PAX7 expression (PubMed:22940113). During craniofacial and trunk myogenesis suppresses differentiation of cranial mesoderm-derived and somite-derived muscle via MYOD1 regulation but in cranial mesoderm-derived progenitors, is neither required for satellite cell homing nor for PAX7 expression (PubMed:25220152). Also plays a role during pancreatic cell development. During type B pancreatic cell development, may be involved in the initiation of proximodistal patterning in the early pancreatic epithelium (PubMed:22529374). Stimulates multipotent pancreatic progenitor cells proliferation and pancreatic growth by maintaining HES1 expression and PTF1A protein levels (PubMed:22096075). During fetal stages of development, is required to maintain arterial identity and the responsiveness of arterial endothelial cells for VEGFA through regulation of KDR activation and NRP1 expression (PubMed:19144989). Controls sprouting angiogenesis and subsequent vertical branch formation througth regulation on tip cell differentiation (PubMed:22282195). Negatively regulates goblet cell differentiation in intestine and controls secretory fat commitment through lateral inhibition in small intestine (PubMed:21238454, PubMed:21915337). Plays a role during inner ear development; negatively regulates auditory hair cell differentiation (PubMed:16495313). Plays a role during nephron development through Notch signaling pathway (PubMed:23806616). Regulates growth, blood pressure and energy homeostasis (PubMed:19562077).By similarity27 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: UniProtKB
  • scaffold protein binding Source: UniProtKB
  • Tat protein binding Source: MGI

GO - Biological processi

  • animal organ morphogenesis Source: UniProtKB
  • astrocyte development Source: UniProtKB
  • auditory receptor cell fate commitment Source: UniProtKB
  • cell-cell signaling Source: MGI
  • cerebellar molecular layer formation Source: UniProtKB
  • cerebellar Purkinje cell layer structural organization Source: UniProtKB
  • clathrin-dependent endocytosis Source: UniProtKB
  • compartment pattern specification Source: MGI
  • determination of left/right symmetry Source: MGI
  • endothelial tip cell fate specification Source: UniProtKB
  • energy homeostasis Source: UniProtKB
  • heart looping Source: BHF-UCL
  • inner ear auditory receptor cell differentiation Source: UniProtKB
  • inner ear development Source: MGI
  • inner ear morphogenesis Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • lateral inhibition Source: UniProtKB
  • left/right axis specification Source: BHF-UCL
  • loop of Henle development Source: UniProtKB
  • marginal zone B cell differentiation Source: UniProtKB
  • negative regulation of cardiac muscle cell differentiation Source: BHF-UCL
  • negative regulation of cell differentiation Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of epidermal cell differentiation Source: UniProtKB
  • negative regulation of epithelial cell differentiation Source: UniProtKB
  • negative regulation of glial cell apoptotic process Source: UniProtKB
  • negative regulation of inner ear auditory receptor cell differentiation Source: MGI
  • negative regulation of interleukin-10 production Source: MGI
  • negative regulation of myeloid cell differentiation Source: MGI
  • negative regulation of myoblast differentiation Source: UniProtKB
  • negative regulation of neuron differentiation Source: UniProtKB
  • nephron development Source: UniProtKB
  • nervous system development Source: UniProtKB
  • neuronal stem cell population maintenance Source: UniProtKB
  • neuron fate specification Source: UniProtKB
  • Notch signaling involved in heart development Source: BHF-UCL
  • Notch signaling pathway Source: UniProtKB
  • Notch signaling pathway involved in arterial endothelial cell fate commitment Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: UniProtKB
  • organ growth Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of endocytosis Source: UniProtKB
  • positive regulation of gene expression Source: MGI
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • positive regulation of skeletal muscle tissue growth Source: UniProtKB
  • positive regulation of sprouting angiogenesis Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • proximal/distal pattern formation Source: UniProtKB
  • proximal tubule development Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of cell adhesion Source: UniProtKB
  • regulation of cell division Source: UniProtKB
  • regulation of growth Source: UniProtKB
  • regulation of neurogenesis Source: UniProtKB
  • regulation of skeletal muscle tissue growth Source: UniProtKB
  • regulation of somitogenesis Source: UniProtKB
  • regulation of vascular endothelial growth factor signaling pathway Source: UniProtKB
  • retina development in camera-type eye Source: UniProtKB
  • retina morphogenesis in camera-type eye Source: UniProtKB
  • skeletal muscle tissue growth Source: UniProtKB
  • skin epidermis development Source: UniProtKB
  • somite specification Source: MGI
  • somitogenesis Source: UniProtKB
  • spinal cord development Source: UniProtKB
  • type B pancreatic cell development Source: UniProtKB


Molecular functionDevelopmental protein
Biological processDifferentiation, Notch signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-1980150 Signaling by NOTCH4
R-MMU-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein 1Curated
Alternative name(s):
Drosophila Delta homolog 1
Short name:
Delta11 Publication
Cleaved into the following 3 chains:
Dll1-soluble form1 Publication
Short name:
Dll1-EC1 Publication
Short name:
Shed form1 Publication
Dll1-derived cell-associated form1 Publication
Short name:
Dll1-TMIC1 Publication
Short name:
Membrane-associated fragment1 Publication
Dll1-intracellular form1 Publication
Short name:
Dll1-IC1 Publication
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:104659 Dll1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 545ExtracellularSequence analysisAdd BLAST528
Transmembranei546 – 568HelicalSequence analysisAdd BLAST23
Topological domaini569 – 722CytoplasmicSequence analysisAdd BLAST154

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Heterozygous Dll1 mice mutants are lighter and smaller, with altered fat to lean ratio and have increased blood pressure and a slight bradycardia. The animals have reduced cholesterol and triglyceride levels in blood (PubMed:19562077). Heterozygous Dll1 mice mutants and hypomorphic Dll1 mice mutants survive until birth, despite significantly reduced Notch activity (PubMed:17194759). Conditional knockout in inner ear leads to an early and excessive production of hair cells and have vestibular defects (PubMed:16495313). Conditional knockout in a small proportion of neural precursor cells reduces neurogenesis, whereas conditional knockout in a large proportion promotes premature neurogenesis (PubMed:18997111). Hypomorph Dll1 pups mutant survive until birth but are smaller. Conditional knockout Dll1 mice mutant in epidermis, survive and have no gross abnormalities (PubMed:17960184). Hypomorph Dll1 mice mutant survive until birth and have severe skeletal muscle defects (PubMed:19144989). Heterozygous Dll1 mutant embryos show disrupted muscle growth (PubMed:25220152). Conditional knockout Dll1 mice mutant show disorganization of Bergmann fibers, ectopic localization of Bergmann glia in the molecular layer and a reduction in the number of Bergmann glia (PubMed:23688253).8 Publications


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi613 – 618KNTNKK → RNTNRR: Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis interaction with NOTCH1. 1 Publication6
Mutagenesisi613K → R: Highly decreases Notch signaling pathway. Multi-ubiquitination pattern is reduced, although it does appear to be mono-ubiquitinated. Interacts with MIB1. Loss of cis and trans interaction with NOTCH1. Increases its association with lipid raft microdomains. 1 Publication1
Mutagenesisi638T → V: Not phosphorylated; when associated with A-693 and A-696. Not phosphorylated and doesn't prevent phosphorylation at S-693 and S-696. Reduces NOTCH1 transactivation; when associated with A-693 and A-696. Reduces cell surface levels of proteins; when associated with A-693 and A-696. Increases ectodomain shedding; when associated with A-693 and A-696. 1 Publication1
Mutagenesisi689K → R: Decreases Notch signaling pathway. 1 Publication1
Mutagenesisi693S → A: Not phosphorylated; when associated with V-638 and A-696. Not phosphorylated and prevents phosphorylation at S-696. Reduces NOTCH1 transactivation; when associated with V-638 and A-696. Reduces cell surface levels of proteins; when associated with V-638 and A-696. Increases ectodomain shedding; when associated with V-638 and A-696. 1 Publication1
Mutagenesisi696S → A: Not phosphorylated; when associated with V-638 and A-693. Not phosphorylated and doesn't prevent phosphorylation at T-638 and S-693, Reduces NOTCH1 transactivation; when associated with V-638 and A-693. Reduces cell surface levels of proteins; when associated with V-638 and A-693. Increases ectodomain shedding; when associated with V-638 and A-693. 1 Publication1
Mutagenesisi699K → R: Decreases Notch signaling pathway. 1 Publication1
Mutagenesisi713K → R: Decreases Notch signaling pathway. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000434832? – 722Dll1-intracellular form1 Publication
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000750718 – 722Delta-like protein 1Add BLAST705
ChainiPRO_000043483018 – 535Dll1-soluble form1 PublicationAdd BLAST518
ChainiPRO_0000434831536 – 722Dll1-derived cell-associated form1 PublicationAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi178 ↔ 187By similarity
Disulfide bondi191 ↔ 203By similarity
Disulfide bondi211 ↔ 220By similarity
Disulfide bondi225 ↔ 236By similarity
Disulfide bondi229 ↔ 242By similarity
Disulfide bondi244 ↔ 253By similarity
Disulfide bondi256 ↔ 267By similarity
Disulfide bondi262 ↔ 273By similarity
Disulfide bondi275 ↔ 284By similarity
Disulfide bondi291 ↔ 303By similarity
Disulfide bondi297 ↔ 313By similarity
Disulfide bondi315 ↔ 324By similarity
Disulfide bondi331 ↔ 342By similarity
Disulfide bondi336 ↔ 351By similarity
Disulfide bondi353 ↔ 362By similarity
Disulfide bondi369 ↔ 380By similarity
Disulfide bondi374 ↔ 390By similarity
Disulfide bondi392 ↔ 401By similarity
Disulfide bondi408 ↔ 419By similarity
Disulfide bondi413 ↔ 428By similarity
Disulfide bondi430 ↔ 439By similarity
Disulfide bondi446 ↔ 457By similarity
Disulfide bondi451 ↔ 466By similarity
Disulfide bondi468 ↔ 477By similarity
Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi484 ↔ 495By similarity
Disulfide bondi489 ↔ 504By similarity
Disulfide bondi506 ↔ 515By similarity
Cross-linki613Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei638Phosphothreonine1 Publication1
Modified residuei693Phosphoserine; by PKB1 Publication1
Modified residuei696Phosphoserine1 Publication1

Post-translational modificationi

Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. Ubiquitinated; promotes recycling back to the plasma membrane and confers a strong affinity for NOTCH1 (PubMed:18676613). Multi-ubiquitination of LYS-613 by MIB1 promotes both cis and trans-interaction with NOTCH1, as well as activation of Notch signaling (PubMed:21985982). Ubiquitinated by NEURL1B (PubMed:17003037).By similarity3 Publications
Phosphorylated in a membrane association-dependent manner. Phosphorylation at Ser-696 requires the presence of Ser-693, whereas phosphorylation at Thr-638 and Ser-693 occurs independently of the other sites. Phosphorylation is required for full ligand activity in vitro and affects surface presentation, ectodomain shedding, and endocytosis.1 Publication
Cleaved by MMP14; negatively regulates DLL1-induced Notch signaling in HPCs, modulating B-lymphocyte differentiation in bone marrow (PubMed:21572390). Undergoes two consecutive processing events: a shedding event, partially by ADAM10, that generates a soluble extracellular form and an intracellular membrane-anchored form, followed by a gamma-secretase cleavage releasing an intracellular fragment (PubMed:12794186).2 Publications
O-fucosylated. Can be elongated to a disaccharide by MFNG.By similarity


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei527 – 528Cleavage; by MMP141 Publication2
Sitei535 – 536Cleavage; by ADAM protease1 Publication2

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases


PTM databases


Miscellaneous databases



Tissue specificityi

In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung. Highly expressed in satellite cells from masseter and tongue than in satellite cells from leg and extraocular muscle.? (PubMed:25220152).2 Publications

Developmental stagei

Expressed until E15. Expression then decreases and increases again in the adult. In differentiating somites, is expressed at low levels in cells emerging from the dorsomedial lip and subsequently throughout myotomes. In the limb buds, is found in myoblasts and myocytes but not in the progenitor cells (PubMed:17194759). Highly expressed in the endothelium and in the smooth muscle layer starting at E13.5 in arterial vessels, but not in veins. At E12.5, there is no detectable expression in arteries or veins. This pattern persists until E18.5 (PubMed:19144989). Strongly expressed in developing muscle of tongue, cheek, and in extraocular muscle at E11.5. Found at E18 and P21 in head muscle (PubMed:25220152). Detected in a subset of cells in the ventricular zone (VZ), the intermediate zone (IZ) and the cortical plate (CP) of neocortex and in the ganglionic eminences at E13.5. At later stages, such as at E16.5, found in the VZ and IZ, but at very low levels in the CP of the neocortex (PubMed:18997111). Highly expressed in embryonic cells located in the ventricular zone (VZ) of the retinal neuroepithelium that form clusters; is first detected in cells located in the central retina. As the retina grows, expression spreads peripherally along the expanding neurogenic region, being always absent from the ciliary margin zone (CMZ) (PubMed:19389377).6 Publications


Induced by PTF1A in multipotent pancreatic progenitor cells (PubMed:22096075). Induced by CDX1 and CDX2 during somitogenesis and goblet cell differentiation (PubMed:22015720).2 Publications

Gene expression databases

GenevisibleiQ61483 MM


Subunit structurei

Homodimer (PubMed:12794186). Interacts with TJP1 (PubMed:24715457). Interacts with MMP14; inhibits DLL1-induced Notch signaling (PubMed:21572390). Interacts with MAGI1 (via PDZ domain); forms a complex with CTNNB1 and CDH2 and promotes recruitment to the adherens junction and stabilization on the cell surface (PubMed:15908431). Interacts with PSEN1; undergoes a presenilin-dependent gamma-secretase cleavage that releases a Dll1-intracellular form (PubMed:12794186). Interacts with MFAP5 (PubMed:15788413). Interacts with MIB1 (PubMed:21985982). Interacts with NEURL1B; leads to ubiquitination (PubMed:17003037, PubMed:19723503). Interacts with NEURL1 (PubMed:19723503). Interacts with SYNJ2BP; enhances DLL1 protein stability, and promotes Notch signaling in endothelial cells (By similarity). Interacts with MAGI1, MAGI2, MAGI3 and MPDZ (By similarity). Interacts (via ubiquitin) with EPN1 (via IUM domain); binding with NOTCH1 attached to neighboring cell, promotes ligand ubiquitination and EPN1 interaction, leading to NECD transendocytosis and Notch signaling. Interacts with NOTCH1 (By similarity).By similarity8 Publications

Binary interactionsi


GO - Molecular functioni

  • Notch binding Source: UniProtKB
  • scaffold protein binding Source: UniProtKB
  • Tat protein binding Source: MGI

Protein-protein interaction databases

BioGridi199232, 7 interactors
IntActiQ61483, 8 interactors


3D structure databases


Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 220DSLPROSITE-ProRule annotationAdd BLAST45
Domaini225 – 253EGF-like 1PROSITE-ProRule annotationAdd BLAST29
Domaini256 – 284EGF-like 2PROSITE-ProRule annotationAdd BLAST29
Domaini291 – 324EGF-like 3PROSITE-ProRule annotationAdd BLAST34
Domaini331 – 362EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST32
Domaini369 – 401EGF-like 5PROSITE-ProRule annotationAdd BLAST33
Domaini408 – 439EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini446 – 477EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST32
Domaini484 – 515EGF-like 8PROSITE-ProRule annotationAdd BLAST32


Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni719 – 722Interaction with MAGI11 Publication4

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR7B Eukaryota

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR011651 Notch_ligand_N
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 5 hits
PF07645 EGF_CA, 1 hit
PF07657 MNNL, 1 hit
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 8 hits
SM00179 EGF_CA, 6 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 8 hits
PS01186 EGF_2, 8 hits
PS50026 EGF_3, 7 hits
PS01187 EGF_CA, 2 hits


Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61483-1 [UniParc]FASTAAdd to basket

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Mass (Da):78,449
Last modified:July 27, 2011 - v2

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti628E → K in CAA56865 (PubMed:7671806).Curated1

Sequence databases

Select the link destinations:
Links Updated
X80903 mRNA Translation: CAA56865.1
AY497019 Genomic DNA Translation: AAR30869.1
CH466630 Genomic DNA Translation: EDL20466.1
BC057400 mRNA Translation: AAH57400.1
BC065063 mRNA Translation: AAH65063.1
RefSeqiNP_031891.2, NM_007865.3

Genome annotation databases

EnsembliENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773
UCSCiuc008aoi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiDLL1_MOUSE
AccessioniPrimary (citable) accession number: Q61483
Secondary accession number(s): Q6PFV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program


Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome


  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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