Delta-like protein 1 precursor - Mus musculus (Mouse)

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Q61483 (DLL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 114. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Delta-like protein 1

Alternative name(s):
Drosophila Delta homolog 1
Short name=Delta1

Gene names

Name:

Dll1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	722 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in cell-to-cell communication in mammalian embryos. May have a role in cellular interactions underlying somitogenesis and development of the nervous system.
Subunit structure	Interacts with Notch receptors.
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	In the embryo, expressed in the paraxial mesoderm and nervous system. Expressed at high levels in adult heart and at lower levels, in adult lung.
Developmental stage	Expressed until day 15 in the embryo. Expression then decreases and increases again in the adult.
Post-translational modification	Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation By similarity.
Sequence similarities	Contains 1 DSL domain. Contains 8 EGF-like domains.

Ontologies

Keywords
Biological process	Differentiation Notch signaling pathway
Cellular component	Membrane
Domain	EGF-like domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	Notch signaling pathway Traceable author statement. Source: UniProtKB auditory receptor cell fate commitment Non-traceable author statement. Source: UniProtKB cell-cell signaling Inferred from direct assay. Source: MGI compartment pattern specification Inferred from mutant phenotype. Source: MGI determination of left/right symmetry Inferred from mutant phenotype. Source: MGI in utero embryonic development Non-traceable author statement. Source: UniProtKB inner ear morphogenesis Non-traceable author statement. Source: UniProtKB loop of Henle development Inferred from expression pattern. Source: UniProtKB negative regulation of auditory receptor cell differentiation Inferred from mutant phenotype. Source: MGI negative regulation of myeloid cell differentiation Inferred from direct assay. Source: MGI odontogenesis of dentin-containing tooth Non-traceable author statement. Source: UniProtKB proximal tubule development Inferred from expression pattern. Source: UniProtKB somite specification Inferred from mutant phenotype. Source: MGI
Cellular component	cytoplasmic vesicle Inferred from direct assay. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: MGI
Molecular function	Notch binding Inferred from physical interaction. Source: UniProtKB calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Magi2	Q9WVQ1	2	EBI-297125,EBI-297151

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

Potential

Chain

18 – 722

705

Delta-like protein 1

PRO_0000007507

Regions

Topological domain

18 – 545

528

Extracellular Potential

Transmembrane

546 – 568

Helical; Potential

Topological domain

569 – 722

154

Cytoplasmic Potential

Domain

176 – 220

DSL

Domain

225 – 253

EGF-like 1

Domain

256 – 284

EGF-like 2

Domain

291 – 324

EGF-like 3

Domain

331 – 362

EGF-like 4; calcium-binding Potential

Domain

369 – 401

EGF-like 5

Domain

408 – 439

EGF-like 6

Domain

446 – 477

EGF-like 7; calcium-binding Potential

Domain

484 – 515

EGF-like 8

Amino acid modifications

Glycosylation

476

N-linked (GlcNAc...) Potential

Disulfide bond

178 ↔ 187

By similarity

Disulfide bond

191 ↔ 203

By similarity

Disulfide bond

211 ↔ 220

By similarity

Disulfide bond

225 ↔ 236

By similarity

Disulfide bond

229 ↔ 242

By similarity

Disulfide bond

244 ↔ 253

By similarity

Disulfide bond

256 ↔ 267

By similarity

Disulfide bond

262 ↔ 273

By similarity

Disulfide bond

275 ↔ 284

By similarity

Disulfide bond

291 ↔ 303

By similarity

Disulfide bond

297 ↔ 313

By similarity

Disulfide bond

315 ↔ 324

By similarity

Disulfide bond

331 ↔ 342

By similarity

Disulfide bond

336 ↔ 351

By similarity

Disulfide bond

353 ↔ 362

By similarity

Disulfide bond

369 ↔ 380

By similarity

Disulfide bond

374 ↔ 390

By similarity

Disulfide bond

392 ↔ 401

By similarity

Disulfide bond

408 ↔ 419

By similarity

Disulfide bond

413 ↔ 428

By similarity

Disulfide bond

430 ↔ 439

By similarity

Disulfide bond

446 ↔ 457

By similarity

Disulfide bond

451 ↔ 466

By similarity

Disulfide bond

468 ↔ 477

By similarity

Disulfide bond

484 ↔ 495

By similarity

Disulfide bond

489 ↔ 504

By similarity

Disulfide bond

506 ↔ 515

By similarity

Experimental info

Sequence conflict

628

E → K in CAA56865. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q61483 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 9D570B9DC7EEC75E
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FASTA

722

78,449

        10         20         30         40         50         60 
MGRRSALALA VVSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGSG PPCACRTFFR 

        70         80         90        100        110        120 
VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGAGID PAFSNPIRFP FGFTWPGTFS 

       130        140        150        160        170        180 
LIIEALHTDS PDDLATENPE RLISRLTTQR HLTVGEEWSQ DLHSSGRTDL RYSYRFVCDE 

       190        200        210        220        230        240 
HYYGEGCSVF CRPRDDAFGH FTCGDRGEKM CDPGWKGQYC TDPICLPGCD DQHGYCDKPG 

       250        260        270        280        290        300 
ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCRNG 

       310        320        330        340        350        360 
ATCTNTGQGS YTCSCRPGYT GANCELEVDE CAPSPCKNGA SCTDLEDSFS CTCPPGFYGK 

       370        380        390        400        410        420 
VCELSAMTCA DGPCFNGGRC SDNPDGGYTC HCPLGFSGFN CEKKMDLCGS SPCSNGAKCV 

       430        440        450        460        470        480 
DLGNSYLCRC QAGFSGRYCE DNVDDCASSP CANGGTCRDS VNDFSCTCPP GYTGKNCSAP 

       490        500        510        520        530        540 
VSRCEHAPCH NGATCHQRGQ RYMCECAQGY GGPNCQFLLP EPPPGPMVVD LSERHMESQG 

       550        560        570        580        590        600 
GPFPWVAVCA GVVLVLLLLL GCAAVVVCVR LKLQKHQPPP EPCGGETETM NNLANCQREK 

       610        620        630        640        650        660 
DVSVSIIGAT QIKNTNKKAD FHGDHGAEKS SFKVRYPTVD YNLVRDLKGD EATVRDTHSK 

       670        680        690        700        710        720 
RDTKCQSQSS AGEEKIAPTL RGGEIPDRKR PESVYSTSKD TKYQSVYVLS AEKDECVIAT 


EV

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta." Bettenhausen B., de Angelis M.H., Simon D., Guenet J.-L., Gossler A. Development 121:2407-2418(1995) [PubMed: 7671806] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X BALB/c. Tissue: Embryo.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[3]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Embryonic brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X80903 mRNA. Translation: CAA56865.1. AY497019 Genomic DNA. Translation: AAR30869.1. CH466630 Genomic DNA. Translation: EDL20466.1. BC057400 mRNA. Translation: AAH57400.1. BC065063 mRNA. Translation: AAH65063.1.
IPI	IPI00121340.
PIR	I48324.
RefSeq	NP_031891.2. NM_007865.3.
UniGene	Mm.4875.
3D structure databases
ProteinModelPortal	Q61483.
SMR	Q61483. Positions 177-548.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-32600N.
IntAct	Q61483. 1 interaction.
STRING	Q61483.
Proteomic databases
PRIDE	Q61483.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000014917; ENSMUSP00000014917; ENSMUSG00000014773.
GeneID	13388.
KEGG	mmu:13388.
Organism-specific databases
CTD	28514.
MGI	MGI:104659. Dll1.
Phylogenomic databases
eggNOG	maNOG11925.
HOGENOM	HBG403082.
HOVERGEN	HBG007139.
InParanoid	Q61483.
OrthoDB	EOG469QT9.
Gene expression databases
ArrayExpress	Q61483.
Bgee	Q61483.
CleanEx	MM_DLL1.
Genevestigator	Q61483.
GermOnline	ENSMUSG00000014773. Mus musculus.
Family and domain databases
InterPro	IPR001774. DSL. IPR006209. EGF. IPR006210. EGF-like. IPR001881. EGF-like_Ca-bd. IPR013032. EGF-like_reg_CS. IPR000152. EGF-type_Asp/Asn_hydroxyl_site. IPR000742. EGF_3. IPR018097. EGF_Ca-bd_CS. IPR011651. Notch_ligand_N. [Graphical view]
KO	K06051.
Pfam	PF01414. DSL. 1 hit. PF00008. EGF. 6 hits. PF07657. MNNL. 1 hit. [Graphical view]
SMART	SM00051. DSL. 1 hit. SM00181. EGF. 4 hits. SM00179. EGF_CA. 4 hits. [Graphical view]
PROSITE	PS00010. ASX_HYDROXYL. 3 hits. PS51051. DSL. 1 hit. PS00022. EGF_1. 8 hits. PS01186. EGF_2. 8 hits. PS50026. EGF_3. 7 hits. PS01187. EGF_CA. 2 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

DLL1_MOUSE

Accession

Primary (citable) accession number: Q61483
Secondary accession number(s): Q6PFV7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents