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Reviewed, UniProtKB/Swiss-Prot Q61481 (PDE1A_MOUSE)

Last modified October 13, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
      Short name=Cam-PDE 1A
    EC=3.1.4.17
Alternative name(s):
    61 kDa Cam-PDE
Gene names
Name: Pde1a
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length565 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Has a higher affinity for cGMP than for cAMP.

Catalytic activity

Nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate.

Enzyme regulation

Type I PDE are activated by the binding of calmodulin in the presence of Ca2+.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

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Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   LigandCalmodulin-binding
cAMP
cGMP
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity

Inferred from electronic annotation. Source: EC

calmodulin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform PDE1A2 (identifier: Q61481-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PDE1A1 (identifier: Q61481-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-54: MVGSSTSSSHVWIAPVRNIIMGSTDTDIEELENATYKYLIGEQTEKMWQRLKGI → MDEYVTIRKKHLQRPIFR

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 565565Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
PRO_0000198786

Regions

Region44 – 6421Calmodulin-binding
Region213 – 535323Catalytic By similarity

Natural variations

Alternative sequence1 – 5454MVGSS…RLKGI → MDEYVTIRKKHLQRPIFR in isoform PDE1A1.
VSP_004551

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Sequences

Sequence LengthMass (Da)Tools
Isoform PDE1A2 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 66A0749774967FE6

FASTA56564,470
        10         20         30         40         50         60 
MVGSSTSSSH VWIAPVRNII MGSTDTDIEE LENATYKYLI GEQTEKMWQR LKGILRCLVK 

        70         80         90        100        110        120 
QLEKGDVNVV DLKKNIEYAA SVLEAVYIDE TRRLLDTEDE LSDIQTDSVP SEVRDWLAST 

       130        140        150        160        170        180 
FTRKMGMMKK KPEEKPKFRS IVHAVQAGIF VERMYRKNYH MVGLTYPAAV IVTLKEVDKW 

       190        200        210        220        230        240 
SFDVFALNEA SGEHSLKFMI YELFTRYDLI NRFKIPVSCL IAFAEALEVG YSKHKNPYHN 

       250        260        270        280        290        300 
LVHAADVTQT VHYIMLHTGI MHWLTELEIL AMVFAAAIHD YEHTGTTNNF HIQTRSDVAI 

       310        320        330        340        350        360 
LYNDRSVLEN HHVSAAYRLM QEEEMNILVN LSKDDWRDLR NLVIEMVLAT DMSGHFQQIK 

       370        380        390        400        410        420 
NIRNSLQQPE GIDRAKTMSL ILHAADISHP AKTWKLHYRW TMALMEEFFL QGDKEAELGL 

       430        440        450        460        470        480 
PFSPLCDRKS TMVAQSQIGF IDFIVEPTFS LLTDSTEKIV IPLIEEASKS QSSNYGASSS 

       490        500        510        520        530        540 
STMIGFHVAD SLRRSNTKGS VCDGSYAPDY SLSAVDLKSF KNNLVDIIQQ NKERWKELAA 

       550        560 
QGELDLHKNS EELGNTEEKH ADTRP

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Isoform PDE1A1.

Checksum: F7C02D4DF7B290E6
Show »

FASTA52960,685

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References

[1]Yan C., Sonnenburg W.K., Zhao A.Z., Kwak K.S., Beavo J.A.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PDE1A2).
Strain: BALB/c.
Tissue: Brain.
[2]Sonnenburg W.K., Rybalkin S.D., Bornfeldt K.E., Kwak K.S., Rybalkina I., Beavo J.A.
Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-262 (ISOFORM PDE1A1).
Tissue: Heart.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U56649 mRNA. Translation: AAB03319.1.
AF023529 mRNA. Translation: AAB81952.1.
IPIIPI00121336.
IPI00223497.
UniGeneMm.40678

3D structure databases

HSSPHSSP built from PDB template 1OYN based on UniProtKB Q08499.
SMRQ61481. Positions 162-491.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ61481.

PTM databases

PhosphoSiteQ61481.

Proteomic databases

PRIDEQ61481.

Genome annotation databases

EnsemblENSMUST00000102653; ENSMUSP00000099713; ENSMUSG00000059173; Mus musculus. [Genome view]
ENSMUST00000102654; ENSMUSP00000099714; ENSMUSG00000059173; Mus musculus. [Genome view]
ENSMUST00000102655; ENSMUSP00000099715; ENSMUSG00000059173; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:1201792. Pde1a.

Phylogenomic databases

HOGENOMQ61481.
HOVERGENQ61481.

Enzyme and pathway databases

BRENDA3.1.4.17. 244.

Gene expression databases

ArrayExpressQ61481.
BgeeQ61481.
CleanExMM_PDE1A.
GenevestigatorQ61481.
GermOnlineENSMUSG00000059173. Mus musculus.

Family and domain databases

InterProIPR003607. Met-dep_phosphohydro_HD.
IPR002073. PDEase.
IPR013706. PDEase_N.
[Graphical view]
PfamPF00233. PDEase_I. 1 hit.
PF08499. PDEase_I_N. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00471. HDc. 1 hit.
[Graphical view]
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry namePDE1A_MOUSE
AccessionPrimary (citable) accession number: Q61481
Secondary accession number(s): O35388
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 13, 2009
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents