Reviewed, UniProtKB/Swiss-Prot Q61476 (DAF2_MOUSE)

Names and origin

Protein names

Recommended name:
    Complement decay-accelerating factor transmembrane isoform
      Short name=DAF-TM
Alternative name(s):
    CD_antigen=CD55

Gene names

Name:	Cd55b
Synonyms:	Daf2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	407 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Protection of cells from complement-mediated damage By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Testis, spleen and lymph node.
Domain	The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 By similarity.
Sequence similarities	Belongs to the receptors of complement activation (RCA) family. Contains 4 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Biological process	Complement pathway Immune response Innate immunity
Cellular component	Membrane
Domain	Repeat Signal Sushi Transmembrane
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Biological process	complement activation, classical pathway Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 39	39	Potential
	Chain	40 – 407	368	Complement decay-accelerating factor transmembrane isoform		PRO_0000006006
Regions
	Topological domain	40 – 368	329	Extracellular Potential
	Transmembrane	369 – 389	21	Potential
	Topological domain	390 – 407	18	Cytoplasmic Potential
	Domain	40 – 101	62	Sushi 1
	Domain	102 – 165	64	Sushi 2
	Domain	166 – 227	62	Sushi 3
	Domain	228 – 291	64	Sushi 4
	Compositional bias	291 – 363	73	Ser/Thr-rich
Amino acid modifications
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	267	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 86		By similarity
	Disulfide bond	70 ↔ 99		By similarity
	Disulfide bond	103 ↔ 150		By similarity
	Disulfide bond	134 ↔ 163		By similarity
	Disulfide bond	168 ↔ 209		By similarity
	Disulfide bond	195 ↔ 225		By similarity
	Disulfide bond	230 ↔ 272		By similarity
	Disulfide bond	258 ↔ 289		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q61476-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: DDD82F2D72CEAD40	FASTA	407	44,469
	10 20 30 40 50 60 MVSSTWGYDP RAGAGDLVIT TTAAGAVTIA VLLFQTVCGD CGPPPDIPNA RPILGRHSKF 70 80 90 100 110 120 AEQSKVAYSC NNGFKQVPDK SNIVVCLENG QWSSHETFCE KSCDTPERLS FASLKKEYFN 130 140 150 160 170 180 MNFFPVGTIV EYECRPGFRK QPSLSGKSTC LEDLVWSPVA QFCKKKSCPN PKDLDNGHIN 190 200 210 220 230 240 IPTGILFGSE INFSCNPGYR LVGITSILCT ITGNAVDWDD EFPVCTEIFC PDPPKINDGI 250 260 270 280 290 300 MRGESDSYKY SQVVIYSCDK GFILFGNSTI YCTVSKSDVG QWSSPPPQCI EESKVPIKKP 310 320 330 340 350 360 VVNVPSTGIP STPQKPTTES VPNPGDQPTP QKPSTVKVPA TQHEPDTTTR TSTDKGESNS 370 380 390 400 GGDRYIYGFV AVIAMIDSLI IVKTLWTILS PNRRSDFQGK ERKDVSK

References

[1]	"Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms." Spicer A.P., Seldin M.F., Gendler S.J. J. Immunol. 155:3079-3091(1995) [PubMed: 7545711] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L41365 mRNA. Translation: AAB00092.1.
IPI	IPI00121307.
UniGene	Mm.436759
3D structure databases
HSSP	HSSP built from PDB template 1NWV based on UniProtKB P08174.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000026401. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:104849. Daf2.
Phylogenomic databases
HOGENOM	Q61476.
HOVERGEN	Q61476.
Gene expression databases
ArrayExpress	Q61476.
Bgee	Q61476.
CleanEx	MM_DAF2.
GermOnline	ENSMUSG00000026401. Mus musculus.
Family and domain databases
InterPro	IPR016060. Complement_control_module. IPR000436. Sushi_SCR_CCP. [Graphical view]
Gene3D	G3DSA:2.10.70.10. Complement_control_module. 4 hits.
Pfam	PF00084. Sushi. 4 hits. [Graphical view]
SMART	SM00032. CCP. 4 hits. [Graphical view]
PROSITE	PS50923. SUSHI. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

DAF2_MOUSE

Accession

Primary (citable) accession number: Q61476

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	March 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)