SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61475

- DAF1_MOUSE

UniProt

Q61475 - DAF1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Complement decay-accelerating factor, GPI-anchored

Gene
Cd55, Cd55a, Daf, Daf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Protection of cells from complement-mediated damage By similarity.

GO - Biological processi

  1. complement activation, classical pathway Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. regulation of complement activation, classical pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_198562. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement decay-accelerating factor, GPI-anchored
Short name:
DAF-GPI
Alternative name(s):
CD_antigen: CD55
Gene namesi
Name:Cd55
Synonyms:Cd55a, Daf, Daf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104850. Cd55.

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. external side of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed predictionAdd
BLAST
Chaini35 – 362328Complement decay-accelerating factor, GPI-anchoredPRO_0000006004Add
BLAST
Propeptidei363 – 39028Removed in mature form Reviewed predictionPRO_0000006005Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 81 By similarity
Disulfide bondi65 ↔ 94 By similarity
Disulfide bondi98 ↔ 145 By similarity
Disulfide bondi129 ↔ 158 By similarity
Disulfide bondi163 ↔ 204 By similarity
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi190 ↔ 220 By similarity
Disulfide bondi225 ↔ 267 By similarity
Disulfide bondi253 ↔ 284 By similarity
Glycosylationi262 – 2621N-linked (GlcNAc...) Reviewed prediction
Lipidationi362 – 3621GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ61475.
PRIDEiQ61475.

PTM databases

PhosphoSiteiQ61475.

Expressioni

Tissue specificityi

Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.

Gene expression databases

BgeeiQ61475.
CleanExiMM_CD55.
GenevestigatoriQ61475.

Structurei

3D structure databases

ProteinModelPortaliQ61475.
SMRiQ61475. Positions 35-285.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 9662Sushi 1Add
BLAST
Domaini97 – 16064Sushi 2Add
BLAST
Domaini161 – 22262Sushi 3Add
BLAST
Domaini223 – 28664Sushi 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi288 – 36275Ser/Thr-richAdd
BLAST

Domaini

The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 By similarity.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG150769.
GeneTreeiENSGT00750000117418.
HOVERGENiHBG001406.
InParanoidiQ61475.
KOiK04006.
OMAiGHTCLIT.
OrthoDBiEOG78WKS7.
PhylomeDBiQ61475.
TreeFamiTF334137.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61475-1 [UniParc]FASTAAdd to Basket

« Hide

MIRGRAPRTR PSPPPPLLPL LSLSLLLLSP TVRGDCGPPP DIPNARPILG    50
RHSKFAEQSK VAYSCNNGFK QVPDKSNIVV CLENGQWSSH ETFCEKSCVA 100
PERLSFASLK KEYLNMNFFP VGTIVEYECR PGFRKQPPLP GKATCLEDLV 150
WSPVAQFCKK KSCPNPKDLD NGHINIPTGI LFGSEINFSC NPGYRLVGVS 200
STFCSVTGNT VDWDDEFPVC TEIHCPEPPK INNGIMRGES DSYTYSQVVT 250
YSCDKGFILV GNASIYCTVS KSDVGQWSSP PPRCIEKSKV PTKKPTINVP 300
STGTPSTPQK PTTESVPNPG DQPTPQKPST VKVSATQHVP VTKTTVRHPI 350
RTSTDKGEPN TGGDRYIYGH TCLITLTVLH VMLSLIGYLT 390
Length:390
Mass (Da):42,618
Last modified:February 26, 2008 - v2
Checksum:iB4B872186947F8E4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 93PRT → ARA in BAA09830. 1 Publication
Sequence conflicti83 – 831E → G in BAA09830. 1 Publication
Sequence conflicti91 – 911E → G in BAA09830. 1 Publication
Sequence conflicti98 – 981C → L in AAH11314. 1 Publication
Sequence conflicti115 – 1151N → H in AAH11314. 1 Publication
Sequence conflicti135 – 1351K → E in AAB00091. 1 Publication
Sequence conflicti143 – 1431A → S in CAJ18536. 1 Publication
Sequence conflicti143 – 1431A → S in AAH11314. 1 Publication
Sequence conflicti173 – 1731H → L in BAA09830. 1 Publication
Sequence conflicti180 – 1801I → T in BAA09830. 1 Publication
Sequence conflicti258 – 2581I → V in CAJ18536. 1 Publication
Sequence conflicti258 – 2581I → V in AAH11314. 1 Publication
Sequence conflicti313 – 3131T → L in AAH11314. 1 Publication
Sequence conflicti381 – 3811V → A in CAJ18536. 1 Publication
Sequence conflicti381 – 3811V → A in AAH11314. 1 Publication
Sequence conflicti381 – 3811V → A in AAD51449. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41366 mRNA. Translation: AAB00091.1.
AK160994 mRNA. Translation: BAE36139.1.
CT010328 mRNA. Translation: CAJ18536.1.
BC011314 mRNA. Translation: AAH11314.1.
D63679 mRNA. Translation: BAA09830.1.
AB003320 Genomic DNA. Translation: BAA22908.1.
AF143541 mRNA. Translation: AAD51449.1.
CCDSiCCDS15256.1.
RefSeqiNP_034146.2. NM_010016.2.
UniGeneiMm.101591.

Genome annotation databases

EnsembliENSMUST00000027650; ENSMUSP00000027650; ENSMUSG00000026399.
GeneIDi13136.
KEGGimmu:13136.
UCSCiuc007cly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41366 mRNA. Translation: AAB00091.1 .
AK160994 mRNA. Translation: BAE36139.1 .
CT010328 mRNA. Translation: CAJ18536.1 .
BC011314 mRNA. Translation: AAH11314.1 .
D63679 mRNA. Translation: BAA09830.1 .
AB003320 Genomic DNA. Translation: BAA22908.1 .
AF143541 mRNA. Translation: AAD51449.1 .
CCDSi CCDS15256.1.
RefSeqi NP_034146.2. NM_010016.2.
UniGenei Mm.101591.

3D structure databases

ProteinModelPortali Q61475.
SMRi Q61475. Positions 35-285.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61475.

Proteomic databases

PaxDbi Q61475.
PRIDEi Q61475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027650 ; ENSMUSP00000027650 ; ENSMUSG00000026399 .
GeneIDi 13136.
KEGGi mmu:13136.
UCSCi uc007cly.1. mouse.

Organism-specific databases

CTDi 1604.
MGIi MGI:104850. Cd55.

Phylogenomic databases

eggNOGi NOG150769.
GeneTreei ENSGT00750000117418.
HOVERGENi HBG001406.
InParanoidi Q61475.
KOi K04006.
OMAi GHTCLIT.
OrthoDBi EOG78WKS7.
PhylomeDBi Q61475.
TreeFami TF334137.

Enzyme and pathway databases

Reactomei REACT_198562. Regulation of Complement cascade.

Miscellaneous databases

NextBioi 283202.
PROi Q61475.
SOURCEi Search...

Gene expression databases

Bgeei Q61475.
CleanExi MM_CD55.
Genevestigatori Q61475.

Family and domain databases

InterProi IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00084. Sushi. 4 hits.
[Graphical view ]
SMARTi SM00032. CCP. 4 hits.
[Graphical view ]
SUPFAMi SSF57535. SSF57535. 4 hits.
PROSITEi PS50923. SUSHI. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms."
    Spicer A.P., Seldin M.F., Gendler S.J.
    J. Immunol. 155:3079-3091(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  5. "Molecular cloning of murine decay accelerating factor by immunoscreening."
    Fukuoka Y., Yasui A., Okada N., Okada H.
    Int. Immunol. 8:379-385(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-390.
    Strain: BALB/c.
    Tissue: Spleen.
  6. "A new repetitive sequence uniquely present in the decay-accelerating factor genes."
    Nonaka M., Nonaka M., Takenaka O., Okada N., Okada H.
    Immunogenetics 47:246-255(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 315-353.
    Strain: BALB/c.
  7. "Molecular and functional analysis of mouse decay accelerating factor (CD55)."
    Harris C.L., Rushmere N.K., Morgan B.P.
    Biochem. J. 341:821-829(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 369-390.
    Strain: BALB/c.

Entry informationi

Entry nameiDAF1_MOUSE
AccessioniPrimary (citable) accession number: Q61475
Secondary accession number(s): P97732
, Q3TU32, Q4FJS4, Q61397, Q76N72, Q921P0, Q9R1C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi