Complement decay-accelerating factor, GPI-anchored precursor

Contribute

Send feedback

Read comments (?) or add your own

Q61475 (DAF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Complement decay-accelerating factor, GPI-anchored
Short name=DAF-GPI

Alternative name(s):
CD_antigen=CD55

Gene names

Name:	Cd55
Synonyms:	Cd55a, Daf, Daf1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protection of cells from complement-mediated damage By similarity.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor By similarity.
Tissue specificity	Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.
Domain	The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 By similarity.
Sequence similarities	Belongs to the receptors of complement activation (RCA) family. Contains 4 Sushi (CCP/SCR) domains.

Ontologies

Keywords
Biological process	Complement pathway Immunity Innate immunity
Cellular component	Cell membrane Membrane
Domain	Repeat Signal Sushi
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW regulation of complement activation, classical pathway Inferred from mutant phenotype PubMed 9892684. Source: MGI
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW external side of plasma membrane Inferred from direct assay PubMed 18947875. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 34

Potential

Chain

35 – 362

328

Complement decay-accelerating factor, GPI-anchored

PRO_0000006004

Propeptide

363 – 390

Removed in mature form Potential

PRO_0000006005

Regions

Domain

35 – 96

Sushi 1

Domain

97 – 160

Sushi 2

Domain

161 – 222

Sushi 3

Domain

223 – 286

Sushi 4

Compositional bias

288 – 362

Ser/Thr-rich

Amino acid modifications

Lipidation

362

GPI-anchor amidated glycine Potential

Glycosylation

187

N-linked (GlcNAc...) Potential

Glycosylation

262

N-linked (GlcNAc...) Potential

Disulfide bond

36 ↔ 81

By similarity

Disulfide bond

65 ↔ 94

By similarity

Disulfide bond

98 ↔ 145

By similarity

Disulfide bond

129 ↔ 158

By similarity

Disulfide bond

163 ↔ 204

By similarity

Disulfide bond

190 ↔ 220

By similarity

Disulfide bond

225 ↔ 267

By similarity

Disulfide bond

253 ↔ 284

By similarity

Experimental info

Sequence conflict

7 – 9

PRT → ARA in BAA09830. Ref.5

Sequence conflict

E → G in BAA09830. Ref.5

Sequence conflict

E → G in BAA09830. Ref.5

Sequence conflict

C → L in AAH11314. Ref.4

Sequence conflict

115

N → H in AAH11314. Ref.4

Sequence conflict

135

K → E in AAB00091. Ref.1

Sequence conflict

143

A → S in CAJ18536. Ref.3

Sequence conflict

143

A → S in AAH11314. Ref.4

Sequence conflict

173

H → L in BAA09830. Ref.5

Sequence conflict

180

I → T in BAA09830. Ref.5

Sequence conflict

258

I → V in CAJ18536. Ref.3

Sequence conflict

258

I → V in AAH11314. Ref.4

Sequence conflict

313

T → L in AAH11314. Ref.4

Sequence conflict

381

V → A in CAJ18536. Ref.3

Sequence conflict

381

V → A in AAH11314. Ref.4

Sequence conflict

381

V → A in AAD51449. Ref.7

Sequences

Sequence

Length

Mass (Da)

Tools

Q61475 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: B4B872186947F8E4
Show »

FASTA

390

42,618

        10         20         30         40         50         60 
MIRGRAPRTR PSPPPPLLPL LSLSLLLLSP TVRGDCGPPP DIPNARPILG RHSKFAEQSK 

        70         80         90        100        110        120 
VAYSCNNGFK QVPDKSNIVV CLENGQWSSH ETFCEKSCVA PERLSFASLK KEYLNMNFFP 

       130        140        150        160        170        180 
VGTIVEYECR PGFRKQPPLP GKATCLEDLV WSPVAQFCKK KSCPNPKDLD NGHINIPTGI 

       190        200        210        220        230        240 
LFGSEINFSC NPGYRLVGVS STFCSVTGNT VDWDDEFPVC TEIHCPEPPK INNGIMRGES 

       250        260        270        280        290        300 
DSYTYSQVVT YSCDKGFILV GNASIYCTVS KSDVGQWSSP PPRCIEKSKV PTKKPTINVP 

       310        320        330        340        350        360 
STGTPSTPQK PTTESVPNPG DQPTPQKPST VKVSATQHVP VTKTTVRHPI RTSTDKGEPN 

       370        380        390 
TGGDRYIYGH TCLITLTVLH VMLSLIGYLT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms." Spicer A.P., Seldin M.F., Gendler S.J. J. Immunol. 155:3079-3091(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6J. Tissue: Testis.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Head.
[3]	"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)." Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary tumor.
[5]	"Molecular cloning of murine decay accelerating factor by immunoscreening." Fukuoka Y., Yasui A., Okada N., Okada H. Int. Immunol. 8:379-385(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-390. Strain: BALB/c. Tissue: Spleen.
[6]	"A new repetitive sequence uniquely present in the decay-accelerating factor genes." Nonaka M., Nonaka M., Takenaka O., Okada N., Okada H. Immunogenetics 47:246-255(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 315-353. Strain: BALB/c.
[7]	"Molecular and functional analysis of mouse decay accelerating factor (CD55)." Harris C.L., Rushmere N.K., Morgan B.P. Biochem. J. 341:821-829(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 369-390. Strain: BALB/c.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41366 mRNA. Translation: AAB00091.1. AK160994 mRNA. Translation: BAE36139.1. CT010328 mRNA. Translation: CAJ18536.1. BC011314 mRNA. Translation: AAH11314.1. D63679 mRNA. Translation: BAA09830.1. AB003320 Genomic DNA. Translation: BAA22908.1. AF143541 mRNA. Translation: AAD51449.1.
IPI	IPI00322234.
RefSeq	NP_034146.2. NM_010016.2.
UniGene	Mm.101591.
3D structure databases
ProteinModelPortal	Q61475.
SMR	Q61475. Positions 35-284.
ModBase	Search...
PTM databases
PhosphoSite	Q61475.
Proteomic databases
PaxDb	Q61475.
PRIDE	Q61475.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000027650; ENSMUSP00000027650; ENSMUSG00000026399.
GeneID	13136.
KEGG	mmu:13136.
Organism-specific databases
CTD	1604.
MGI	MGI:104850. Cd55.
Phylogenomic databases
eggNOG	NOG150769.
GeneTree	ENSGT00680000099691.
HOVERGEN	HBG001406.
InParanoid	Q61475.
KO	K04006.
OMA	GHTCLIT.
OrthoDB	EOG4WSWB0.
Gene expression databases
Bgee	Q61475.
CleanEx	MM_CD55.
Genevestigator	Q61475.
GermOnline	ENSMUSG00000026399. Mus musculus.
Family and domain databases
InterPro	IPR000436. Sushi_SCR_CCP. [Graphical view]
Pfam	PF00084. Sushi. 4 hits. [Graphical view]
SMART	SM00032. CCP. 4 hits. [Graphical view]
SUPFAM	SSF57535. Complement_control_module. 4 hits.
PROSITE	PS50923. SUSHI. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	283202.
SOURCE	Search...

Entry information

Entry name

DAF1_MOUSE

Accession

Primary (citable) accession number: Q61475
Secondary accession number(s): P97732

Q9R1C1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 95 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents