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Protein

Complement decay-accelerating factor, GPI-anchored

Gene

Cd55

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protection of cells from complement-mediated damage.By similarity

GO - Molecular functioni

GO - Biological processi

  • complement activation, classical pathway Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • regulation of complement activation, classical pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Complement pathway, Immunity, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-977606. Regulation of Complement cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement decay-accelerating factor, GPI-anchored
Short name:
DAF-GPI
Alternative name(s):
CD_antigen: CD55
Gene namesi
Name:Cd55
Synonyms:Cd55a, Daf, Daf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104850. Cd55.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000000600435 – 362Complement decay-accelerating factor, GPI-anchoredAdd BLAST328
PropeptideiPRO_0000006005363 – 390Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 81PROSITE-ProRule annotation
Disulfide bondi65 ↔ 94PROSITE-ProRule annotation
Disulfide bondi98 ↔ 145PROSITE-ProRule annotation
Disulfide bondi129 ↔ 158PROSITE-ProRule annotation
Disulfide bondi163 ↔ 204PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi190 ↔ 220PROSITE-ProRule annotation
Disulfide bondi225 ↔ 267PROSITE-ProRule annotation
Disulfide bondi253 ↔ 284PROSITE-ProRule annotation
Glycosylationi262N-linked (GlcNAc...)Sequence analysis1
Lipidationi362GPI-anchor amidated glycineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ61475.
PaxDbiQ61475.
PeptideAtlasiQ61475.
PRIDEiQ61475.

PTM databases

PhosphoSitePlusiQ61475.

Expressioni

Tissue specificityi

Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.

Gene expression databases

BgeeiENSMUSG00000026399.
CleanExiMM_CD55.
ExpressionAtlasiQ61475. baseline and differential.
GenevisibleiQ61475. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027650.

Structurei

3D structure databases

ProteinModelPortaliQ61475.
SMRiQ61475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 96Sushi 1PROSITE-ProRule annotationAdd BLAST62
Domaini97 – 160Sushi 2PROSITE-ProRule annotationAdd BLAST64
Domaini161 – 222Sushi 3PROSITE-ProRule annotationAdd BLAST62
Domaini223 – 286Sushi 4PROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi288 – 362Ser/Thr-richAdd BLAST75

Domaini

The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 (By similarity).By similarity

Sequence similaritiesi

Contains 4 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IEGQ. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00860000133887.
HOVERGENiHBG001406.
InParanoidiQ61475.
KOiK04006.
OMAiCLENLEW.
OrthoDBiEOG091G0HW4.
PhylomeDBiQ61475.
TreeFamiTF334137.

Family and domain databases

CDDicd00033. CCP. 4 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRGRAPRTR PSPPPPLLPL LSLSLLLLSP TVRGDCGPPP DIPNARPILG
60 70 80 90 100
RHSKFAEQSK VAYSCNNGFK QVPDKSNIVV CLENGQWSSH ETFCEKSCVA
110 120 130 140 150
PERLSFASLK KEYLNMNFFP VGTIVEYECR PGFRKQPPLP GKATCLEDLV
160 170 180 190 200
WSPVAQFCKK KSCPNPKDLD NGHINIPTGI LFGSEINFSC NPGYRLVGVS
210 220 230 240 250
STFCSVTGNT VDWDDEFPVC TEIHCPEPPK INNGIMRGES DSYTYSQVVT
260 270 280 290 300
YSCDKGFILV GNASIYCTVS KSDVGQWSSP PPRCIEKSKV PTKKPTINVP
310 320 330 340 350
STGTPSTPQK PTTESVPNPG DQPTPQKPST VKVSATQHVP VTKTTVRHPI
360 370 380 390
RTSTDKGEPN TGGDRYIYGH TCLITLTVLH VMLSLIGYLT
Length:390
Mass (Da):42,618
Last modified:February 26, 2008 - v2
Checksum:iB4B872186947F8E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 9PRT → ARA in BAA09830 (PubMed:8671624).Curated3
Sequence conflicti83E → G in BAA09830 (PubMed:8671624).Curated1
Sequence conflicti91E → G in BAA09830 (PubMed:8671624).Curated1
Sequence conflicti98C → L in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti115N → H in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti135K → E in AAB00091 (PubMed:7545711).Curated1
Sequence conflicti143A → S in CAJ18536 (Ref. 3) Curated1
Sequence conflicti143A → S in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti173H → L in BAA09830 (PubMed:8671624).Curated1
Sequence conflicti180I → T in BAA09830 (PubMed:8671624).Curated1
Sequence conflicti258I → V in CAJ18536 (Ref. 3) Curated1
Sequence conflicti258I → V in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti313T → L in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti381V → A in CAJ18536 (Ref. 3) Curated1
Sequence conflicti381V → A in AAH11314 (PubMed:15489334).Curated1
Sequence conflicti381V → A in AAD51449 (PubMed:10417349).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41366 mRNA. Translation: AAB00091.1.
AK160994 mRNA. Translation: BAE36139.1.
CT010328 mRNA. Translation: CAJ18536.1.
BC011314 mRNA. Translation: AAH11314.1.
D63679 mRNA. Translation: BAA09830.1.
AB003320 Genomic DNA. Translation: BAA22908.1.
AF143541 mRNA. Translation: AAD51449.1.
CCDSiCCDS15256.1.
RefSeqiNP_034146.2. NM_010016.3.
XP_017169792.1. XM_017314303.1.
UniGeneiMm.101591.

Genome annotation databases

EnsembliENSMUST00000027650; ENSMUSP00000027650; ENSMUSG00000026399.
GeneIDi13136.
KEGGimmu:13136.
UCSCiuc007cly.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41366 mRNA. Translation: AAB00091.1.
AK160994 mRNA. Translation: BAE36139.1.
CT010328 mRNA. Translation: CAJ18536.1.
BC011314 mRNA. Translation: AAH11314.1.
D63679 mRNA. Translation: BAA09830.1.
AB003320 Genomic DNA. Translation: BAA22908.1.
AF143541 mRNA. Translation: AAD51449.1.
CCDSiCCDS15256.1.
RefSeqiNP_034146.2. NM_010016.3.
XP_017169792.1. XM_017314303.1.
UniGeneiMm.101591.

3D structure databases

ProteinModelPortaliQ61475.
SMRiQ61475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027650.

PTM databases

PhosphoSitePlusiQ61475.

Proteomic databases

MaxQBiQ61475.
PaxDbiQ61475.
PeptideAtlasiQ61475.
PRIDEiQ61475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027650; ENSMUSP00000027650; ENSMUSG00000026399.
GeneIDi13136.
KEGGimmu:13136.
UCSCiuc007cly.1. mouse.

Organism-specific databases

CTDi1604.
MGIiMGI:104850. Cd55.

Phylogenomic databases

eggNOGiENOG410IEGQ. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00860000133887.
HOVERGENiHBG001406.
InParanoidiQ61475.
KOiK04006.
OMAiCLENLEW.
OrthoDBiEOG091G0HW4.
PhylomeDBiQ61475.
TreeFamiTF334137.

Enzyme and pathway databases

ReactomeiR-MMU-373080. Class B/2 (Secretin family receptors).
R-MMU-6798695. Neutrophil degranulation.
R-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-977606. Regulation of Complement cascade.

Miscellaneous databases

PROiQ61475.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026399.
CleanExiMM_CD55.
ExpressionAtlasiQ61475. baseline and differential.
GenevisibleiQ61475. MM.

Family and domain databases

CDDicd00033. CCP. 4 hits.
InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 4 hits.
[Graphical view]
SMARTiSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 4 hits.
PROSITEiPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDAF1_MOUSE
AccessioniPrimary (citable) accession number: Q61475
Secondary accession number(s): P97732
, Q3TU32, Q4FJS4, Q61397, Q76N72, Q921P0, Q9R1C1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.