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Q61475 (DAF1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement decay-accelerating factor, GPI-anchored

Short name=DAF-GPI
Alternative name(s):
CD_antigen=CD55
Gene names
Name:Cd55
Synonyms:Cd55a, Daf, Daf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protection of cells from complement-mediated damage By similarity.

Subcellular location

Cell membrane; Lipid-anchorGPI-anchor By similarity.

Tissue specificity

Brain, secretory epithelia, skeletal muscle, liver, testes, thymus, spleen and lymph node.

Domain

The first Sushi domain (SCR1) is not necessary for function. SCR2 and SCR4 provide the proper conformation for the active site on SCR3 By similarity.

Sequence similarities

Belongs to the receptors of complement activation (RCA) family.

Contains 4 Sushi (CCP/SCR) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 362328Complement decay-accelerating factor, GPI-anchored
PRO_0000006004
Propeptide363 – 39028Removed in mature form Potential
PRO_0000006005

Regions

Domain35 – 9662Sushi 1
Domain97 – 16064Sushi 2
Domain161 – 22262Sushi 3
Domain223 – 28664Sushi 4
Compositional bias288 – 36275Ser/Thr-rich

Amino acid modifications

Lipidation3621GPI-anchor amidated glycine Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Glycosylation2621N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 81 By similarity
Disulfide bond65 ↔ 94 By similarity
Disulfide bond98 ↔ 145 By similarity
Disulfide bond129 ↔ 158 By similarity
Disulfide bond163 ↔ 204 By similarity
Disulfide bond190 ↔ 220 By similarity
Disulfide bond225 ↔ 267 By similarity
Disulfide bond253 ↔ 284 By similarity

Experimental info

Sequence conflict7 – 93PRT → ARA in BAA09830. Ref.5
Sequence conflict831E → G in BAA09830. Ref.5
Sequence conflict911E → G in BAA09830. Ref.5
Sequence conflict981C → L in AAH11314. Ref.4
Sequence conflict1151N → H in AAH11314. Ref.4
Sequence conflict1351K → E in AAB00091. Ref.1
Sequence conflict1431A → S in CAJ18536. Ref.3
Sequence conflict1431A → S in AAH11314. Ref.4
Sequence conflict1731H → L in BAA09830. Ref.5
Sequence conflict1801I → T in BAA09830. Ref.5
Sequence conflict2581I → V in CAJ18536. Ref.3
Sequence conflict2581I → V in AAH11314. Ref.4
Sequence conflict3131T → L in AAH11314. Ref.4
Sequence conflict3811V → A in CAJ18536. Ref.3
Sequence conflict3811V → A in AAH11314. Ref.4
Sequence conflict3811V → A in AAD51449. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q61475 [UniParc].

Last modified February 26, 2008. Version 2.
Checksum: B4B872186947F8E4

FASTA39042,618
        10         20         30         40         50         60 
MIRGRAPRTR PSPPPPLLPL LSLSLLLLSP TVRGDCGPPP DIPNARPILG RHSKFAEQSK 

        70         80         90        100        110        120 
VAYSCNNGFK QVPDKSNIVV CLENGQWSSH ETFCEKSCVA PERLSFASLK KEYLNMNFFP 

       130        140        150        160        170        180 
VGTIVEYECR PGFRKQPPLP GKATCLEDLV WSPVAQFCKK KSCPNPKDLD NGHINIPTGI 

       190        200        210        220        230        240 
LFGSEINFSC NPGYRLVGVS STFCSVTGNT VDWDDEFPVC TEIHCPEPPK INNGIMRGES 

       250        260        270        280        290        300 
DSYTYSQVVT YSCDKGFILV GNASIYCTVS KSDVGQWSSP PPRCIEKSKV PTKKPTINVP 

       310        320        330        340        350        360 
STGTPSTPQK PTTESVPNPG DQPTPQKPST VKVSATQHVP VTKTTVRHPI RTSTDKGEPN 

       370        380        390 
TGGDRYIYGH TCLITLTVLH VMLSLIGYLT 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and chromosomal localization of the mouse decay-accelerating factor genes. Duplicated genes encode glycosylphosphatidylinositol-anchored and transmembrane forms."
Spicer A.P., Seldin M.F., Gendler S.J.
J. Immunol. 155:3079-3091(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head.
[3]"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[5]"Molecular cloning of murine decay accelerating factor by immunoscreening."
Fukuoka Y., Yasui A., Okada N., Okada H.
Int. Immunol. 8:379-385(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-390.
Strain: BALB/c.
Tissue: Spleen.
[6]"A new repetitive sequence uniquely present in the decay-accelerating factor genes."
Nonaka M., Nonaka M., Takenaka O., Okada N., Okada H.
Immunogenetics 47:246-255(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 315-353.
Strain: BALB/c.
[7]"Molecular and functional analysis of mouse decay accelerating factor (CD55)."
Harris C.L., Rushmere N.K., Morgan B.P.
Biochem. J. 341:821-829(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 369-390.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41366 mRNA. Translation: AAB00091.1.
AK160994 mRNA. Translation: BAE36139.1.
CT010328 mRNA. Translation: CAJ18536.1.
BC011314 mRNA. Translation: AAH11314.1.
D63679 mRNA. Translation: BAA09830.1.
AB003320 Genomic DNA. Translation: BAA22908.1.
AF143541 mRNA. Translation: AAD51449.1.
CCDSCCDS15256.1.
RefSeqNP_034146.2. NM_010016.2.
UniGeneMm.101591.

3D structure databases

ProteinModelPortalQ61475.
SMRQ61475. Positions 35-285.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ61475.

Proteomic databases

PaxDbQ61475.
PRIDEQ61475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027650; ENSMUSP00000027650; ENSMUSG00000026399.
GeneID13136.
KEGGmmu:13136.
UCSCuc007cly.1. mouse.

Organism-specific databases

CTD1604.
MGIMGI:104850. Cd55.

Phylogenomic databases

eggNOGNOG150769.
GeneTreeENSGT00750000117418.
HOVERGENHBG001406.
InParanoidQ61475.
KOK04006.
OMAGHTCLIT.
OrthoDBEOG78WKS7.
PhylomeDBQ61475.
TreeFamTF334137.

Gene expression databases

BgeeQ61475.
CleanExMM_CD55.
GenevestigatorQ61475.

Family and domain databases

InterProIPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00084. Sushi. 4 hits.
[Graphical view]
SMARTSM00032. CCP. 4 hits.
[Graphical view]
SUPFAMSSF57535. SSF57535. 4 hits.
PROSITEPS50923. SUSHI. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio283202.
PROQ61475.
SOURCESearch...

Entry information

Entry nameDAF1_MOUSE
AccessionPrimary (citable) accession number: Q61475
Secondary accession number(s): P97732 expand/collapse secondary AC list , Q3TU32, Q4FJS4, Q61397, Q76N72, Q921P0, Q9R1C1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot