Transcription factor SOX-17 - Mus musculus (Mouse)

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Protein attributes

General annotation (Comments)

Ontologies

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Reviewed, UniProtKB/Swiss-Prot Q61473 (SOX17_MOUSE)

Last modified February 9, 2010. Version 78. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Protein names

Recommended name:
Transcription factor SOX-17

Gene names

Name:	Sox17
Synonyms:	Sox-17

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Sequence length	419 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

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Function	Probable transcriptional activator in the premeiotic germ cells. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. The short form (T-SOX17) shows no DNA-binding activity.
Subcellular location	Nucleus Potential.
Tissue specificity	Testis. Detected in lung.
Developmental stage	Expressed in spermatogonia. The expression clearly declines from the early pachytene spermatocyte stage onward. In contrast, expression of form T-SOX17 began at the pachytene spermatocyte stage and was highly accumulated in round spermatids.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

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Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Activator
Technical term	3D-structure
Gene Ontology (GO)
Biological process	angiogenesis Inferred from genetic interaction. Source: MGI embryonic heart tube development Inferred from genetic interaction. Source: MGI endocardial cell differentiation Inferred from genetic interaction. Source: MGI endocardium formation Inferred from genetic interaction. Source: MGI heart looping Inferred from mutant phenotype. Source: MGI negative regulation of Wnt receptor signaling pathway Inferred from mutant phenotype. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW vasculogenesis Inferred from genetic interaction. Source: MGI
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA polymerase II transcription factor activity, enhancer binding Inferred from direct assay. Source: MGI promoter binding Inferred from direct assay. Source: MGI
Complete GO annotation...

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Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 419

419

Transcription factor SOX-17

PRO_0000048766

DNA binding

68 – 136

HMG box

Compositional bias

312 – 346

Gln/Pro-rich

Compositional bias

322 – 326

Poly-Pro

Alternative sequence

1 – 128

128

Missing in isoform 2.

VSP_002204

419

Helix Strand Turn

Details...

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Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 14233EED2CCDD69D Show »	FASTA	419	44,646
10 20 30 40 50 60 MSSPDAGYAS DDQSQPRSAQ PAVMAGLGPC PWAESLSPLG DVKVKGEVVA SSGAPAGTSG 70 80 90 100 110 120 RAKAESRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKALT LAEKRPFVEE 130 140 150 160 170 180 AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR VEGGFLHALV EPQAGALGPE GGRVAMDGLG 190 200 210 220 230 240 LPFPEPGYPA GPPLMSPHMG PHYRDCQGLG APALDGYPLP TPDTSPLDGV EQDPAFFAAP 250 260 270 280 290 300 LPGDCPAAGT YTYAPVSDYA VSVEPPAGPM RVGPDPSGPA MPGILAPPSA LHLYYGAMGS 310 320 330 340 350 360 PAASAGRGFH AQPQQPLQPQ APPPPPQQQH PAHGPGQPSP PPEALPCRDG TESNQPTELL 370 380 390 400 410 GEVDRTEFEQ YLPFVYKPEM GLPYQGHDCG VNLSDSHGAI SSVVSDASSA VYYCNYPDI « Hide
Isoform 2 (T-SOX17). Checksum: 2298C8A3EC02F44C Show »	FASTA	291	30,782
10 20 30 40 50 60 MQDHPNYKYR PRRRKQVKRM KRVEGGFLHA LVEPQAGALG PEGGRVAMDG LGLPFPEPGY 70 80 90 100 110 120 PAGPPLMSPH MGPHYRDCQG LGAPALDGYP LPTPDTSPLD GVEQDPAFFA APLPGDCPAA 130 140 150 160 170 180 GTYTYAPVSD YAVSVEPPAG PMRVGPDPSG PAMPGILAPP SALHLYYGAM GSPAASAGRG 190 200 210 220 230 240 FHAQPQQPLQ PQAPPPPPQQ QHPAHGPGQP SPPPEALPCR DGTESNQPTE LLGEVDRTEF 250 260 270 280 290 EQYLPFVYKP EMGLPYQGHD CGVNLSDSHG AISSVVSDAS SAVYYCNYPD I « Hide

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	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis." Kanai Y., Kanai-Azuma M., Noce T., Saido T.C., Shiroishi T., Hayashi Y., Yazaki K. J. Cell Biol. 133:667-681(1996) [PubMed: 8636240] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Strain: C57BL/6. Tissue: Testis.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6J. Tissue: Lung.
[3]	Layfield R., Mynett-Johnson L., Yarwood P.J., Muscat G.E.O., Koopman P.A., Hume D.A. Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 76-132 (ISOFORM 1). Strain: BALB/c. Tissue: Heart muscle.
+	Additional computationally mapped references.

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EMBL
GenBank
DDBJ

D49474 mRNA. Translation: BAA08444.1.
D49473 mRNA. Translation: BAA08443.1.
AK004781 mRNA. Translation: BAB23559.1.
L29085 mRNA. Translation: AAA56843.1.

IPI

IPI00121298.
IPI00230012.

RefSeq

NP_035571.1.

UniGene

Mm.279103

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3F27	X-ray	2.75	D	66-144	[»]

ModBase

Search...

STRING

Q61473.

PRIDE

Q61473.

Ensembl

ENSMUST00000027035; ENSMUSP00000027035; ENSMUSG00000025902; Mus musculus. [Genome view]
ENSMUST00000116652; ENSMUSP00000112351; ENSMUSG00000025902; Mus musculus. [Genome view]

GeneID

20671.

KEGG

mmu:20671.

UCSC

uc007aey.1. mouse.
uc007afb.1. mouse.

CTD

20671.

MGI

MGI:107543. Sox17.

eggNOG

roNOG06795.

HOGENOM

HBG507069.

HOVERGEN

Q61473.

InParanoid

Q61473.

OMA

ALPCRDG.

OrthoDB

EOG96T5M7.

PhylomeDB

Q61473.

ArrayExpress

Q61473.

Bgee

Q61473.

CleanEx

MM_SOX17.

Genevestigator

Q61473.

GermOnline

ENSMUSG00000025902. Mus musculus.

InterPro

IPR000910. HMG_HMG1/HMG2.
IPR009071. HMG_superfamily.
[Graphical view]

Gene3D

G3DSA:1.10.30.10. HMG-box. 1 hit.

Pfam

PF00505. HMG_box. 1 hit.
[Graphical view]

SMART

SM00398. HMG. 1 hit.
[Graphical view]

PROSITE

PS50118. HMG_BOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

NextBio

299151.

SOURCE

Search...

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Entry name

SOX17_MOUSE

Accession

Primary (citable) accession number: Q61473
Secondary accession number(s): Q61472, Q62248

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q61473-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q61473-2)

Also known as: T-SOX17;

The sequence of this isoform differs from the canonical sequence as follows:
1-128: Missing.

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families