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Protein

Protein Tob1

Gene

Tob1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay.By similarity

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • SMAD binding Source: MGI
  • transcription corepressor activity Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Tob1
Alternative name(s):
Transducer of erbB-2 1
Gene namesi
Name:Tob1
Synonyms:Tob, Trob
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349721 Tob1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi22 – 24RRR → QQQ: Localizes to cytoplasm; when associated with 37-NNN-39. 1 Publication3
Mutagenesisi37 – 39KKK → NNN: Localizes to cytoplasm; when associated with 22-QQQ-24. 1 Publication3
Mutagenesisi234L → A: Not exported to the cytoplasm; when associated with A-236. 1 Publication1
Mutagenesisi236L → A: Not exported to the cytoplasm; when associated with A-234. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001438131 – 362Protein Tob1Add BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei204PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated on Ser and Thr residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61471
PRIDEiQ61471

PTM databases

iPTMnetiQ61471
PhosphoSitePlusiQ61471

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000037573
CleanExiMM_TOB1
GenevisibleiQ61471 MM

Interactioni

Subunit structurei

Interacts with ERBB2. Interacts with CNOT7. Interacts with CPEB3 (via C-terminal RNA-binding region); recruits CNOT7 to CPEB3 to form a ternary complex required for mRNA deadenylation and decay. Interacts with CNOT8. Interacts with CPEB4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CORO7P577373EBI-8527498,EBI-6916167From Homo sapiens.

GO - Molecular functioni

  • receptor tyrosine kinase binding Source: UniProtKB
  • SMAD binding Source: MGI

Protein-protein interaction databases

BioGridi204322, 2 interactors
IntActiQ61471, 1 interactor
MINTiQ61471
STRINGi10090.ENSMUSP00000036039

Structurei

3D structure databases

ProteinModelPortaliQ61471
SMRiQ61471
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 92Important for nuclear localizationAdd BLAST11
Regioni161 – 220Required for interaction with CPEB3By similarityAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 39Bipartite nuclear localization signalAdd BLAST18
Motifi228 – 236Nuclear export signal9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi243 – 253Poly-GlnAdd BLAST11
Compositional biasi259 – 264Poly-Pro6
Compositional biasi265 – 280Poly-GlnAdd BLAST16

Sequence similaritiesi

Belongs to the BTG family.Curated

Phylogenomic databases

eggNOGiKOG4006 Eukaryota
ENOG410ZZC0 LUCA
GeneTreeiENSGT00550000074461
HOGENOMiHOG000253939
HOVERGENiHBG006617
InParanoidiQ61471
KOiK14443
OMAiGLGPLQY
OrthoDBiEOG091G0LEQ
TreeFamiTF105274

Family and domain databases

Gene3Di1.20.120.1120, 1 hit
InterProiView protein in InterPro
IPR002087 Anti_prolifrtn
IPR036054 BTG-like_sf
IPR015677 Tob1
IPR015676 Tob1/2
PANTHERiPTHR17537 PTHR17537, 1 hit
PTHR17537:SF6 PTHR17537:SF6, 1 hit
PfamiView protein in Pfam
PF07742 BTG, 1 hit
PRINTSiPR00310 ANTIPRLFBTG1
SMARTiView protein in SMART
SM00099 btg1, 1 hit
SUPFAMiSSF160696 SSF160696, 1 hit
PROSITEiView protein in PROSITE
PS00960 BTG_1, 1 hit
PS01203 BTG_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q61471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY
60 70 80 90 100
KGSGFRCIHV GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS
110 120 130 140 150
YQIGEKGPVK VLYVDDSSET GCELDKEIKN SFNPEAQVFM PISDPASSVS
160 170 180 190 200
SSPSPPFGHS AAVSPTFMPR STQPLTFTTA TFAATKFGST KMKNSGRSSK
210 220 230 240 250
VARTSPINLG LTVNVNDLLK QKAISSSVHS LYGLGLGSQQ QPQPQPQQQQ
260 270 280 290 300
QQQPSSSQPP PPLPQQQQQQ PQQQQQQQQQ TSALSPNAKE FIFPNMQGQG
310 320 330 340 350
SSTNGMFPGD SPLNLSPLQY SNAFDVFAAY GGLNEKSFVD GLNFSLNNMQ
360
YSNQQFQPVM AN
Length:362
Mass (Da):40,056
Last modified:September 18, 2013 - v2
Checksum:i4D4F1F492A7CA6FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti136A → P in BAA11384 (PubMed:9210596).Curated1
Sequence conflicti217D → H in BAA11384 (PubMed:9210596).Curated1
Sequence conflicti271P → PQ in BAA11384 (PubMed:9210596).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78382 Genomic DNA Translation: BAA11384.1
AL645846 Genomic DNA No translation available.
BC082588 mRNA Translation: AAH82588.1
CCDSiCCDS25250.1
RefSeqiNP_033453.2, NM_009427.2
UniGeneiMm.259673

Genome annotation databases

EnsembliENSMUST00000041589; ENSMUSP00000036039; ENSMUSG00000037573
GeneIDi22057
KEGGimmu:22057
UCSCiuc007kyf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTOB1_MOUSE
AccessioniPrimary (citable) accession number: Q61471
Secondary accession number(s): Q640M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 18, 2013
Last modified: March 28, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health