Q61470 (CD37_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte antigen CD37

Alternative name(s):
CD_antigen=CD37

Gene names

Name:

Cd37

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Interacts with SCIMP By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the tetraspanin (TM4SF) family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to protozoan Inferred from genetic interaction PubMed 20709950. Source: MGI negative regulation of cell proliferation Inferred from genetic interaction PubMed 20709950. Source: MGI negative regulation of myeloid dendritic cell activation Inferred from genetic interaction PubMed 20709950. Source: MGI positive regulation of immunoglobulin production Inferred from mutant phenotype PubMed 10891477. Source: MGI regulation of defense response to virus Inferred from genetic interaction PubMed 20709950. Source: MGI regulation of humoral immune response Inferred from mutant phenotype PubMed 10891477PubMed 20709950. Source: MGI
Cellular_component	immunological synapse Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Leukocyte antigen CD37		PRO_0000219210
Regions
	Topological domain	1 – 17	17	Cytoplasmic Potential
	Transmembrane	18 – 38	21	Helical; Potential
	Topological domain	39 – 59	21	Extracellular Potential
	Transmembrane	60 – 74	15	Helical; Potential
	Topological domain	75 – 85	11	Cytoplasmic Potential
	Transmembrane	86 – 111	26	Helical; Potential
	Topological domain	112 – 241	130	Extracellular Potential
	Transmembrane	242 – 266	25	Helical; Potential
	Topological domain	267 – 281	15	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	170	1	N-linked (GlcNAc...) Potential
	Glycosylation	183	1	N-linked (GlcNAc...) Potential
	Glycosylation	188	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61470 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 5B0E11B3B9CCA22D	FASTA	281	31,852
	10 20 30 40 50 60 MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS FVPLQTWSKV 70 80 90 100 110 120 LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRVRLERRVQ 130 140 150 160 170 180 ELVLRTIQSY RTNPDETAAE ESWDYAQFQL RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS 190 200 210 220 230 240 CYNSTATNDS TVFDKLFFSQ LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN 250 260 270 280 NIISIVGICL GVGLLELGFM TLSIFLCRNL DHVYDRLARY R

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterisation of mouse CD37: cDNA and genomic cloning." Tomlinson M.G., Wright M.D. Mol. Immunol. 33:867-872(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/Sv. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18372 , U18367, U18368, U18369, U18370, U18371 Genomic DNA. Translation: AAB39500.1. BC019402 mRNA. Translation: AAH19402.1.
IPI	IPI00762742.
RefSeq	NP_031671.1. NM_007645.4.
UniGene	Mm.3689.
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q61470.
Proteomic databases
PRIDE	Q61470.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798.
GeneID	12493.
KEGG	mmu:12493.
Organism-specific databases
CTD	951.
MGI	MGI:88330. Cd37.
Phylogenomic databases
eggNOG	NOG246498.
GeneTree	ENSGT00680000099759.
HOGENOM	HOG000230651.
HOVERGEN	HBG002324.
InParanoid	Q61470.
KO	K06475.
OrthoDB	EOG4T7841.
Gene expression databases
ArrayExpress	Q61470.
Bgee	Q61470.
CleanEx	MM_CD37.
Genevestigator	Q61470.
GermOnline	ENSMUSG00000030798. Mus musculus.
Family and domain databases
InterPro	IPR000301. Tetraspanin. IPR018499. Tetraspanin/Peripherin. IPR018503. Tetraspanin_CS. IPR008952. Tetraspanin_EC2. [Graphical view]
Pfam	PF00335. Tetraspannin. 1 hit. [Graphical view]
PIRSF	PIRSF002419. Tetraspanin. 1 hit.
PRINTS	PR00259. TMFOUR.
SUPFAM	SSF48652. Tetraspanin. 1 hit.
PROSITE	PS00421. TM4_1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	281420.
SOURCE	Search...

Entry information

Entry name

CD37_MOUSE

Accession

Primary (citable) accession number: Q61470

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program