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Q61468

- MSLN_MOUSE

UniProt

Q61468 - MSLN_MOUSE

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Protein

Mesothelin

Gene

Msln

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Membrane-anchored forms may play a role in cellular adhesion.2 Publications
Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. pancreas development Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Mesothelin
Alternative name(s):
Pre-pro-megakaryocyte-potentiating factor
Cleaved into the following 2 chains:
Gene namesi
Name:Msln
Synonyms:Mes, Mpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1888992. Msln.

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity. Golgi apparatus By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. cell surface Source: Ensembl
  3. extracellular space Source: Ensembl
  4. Golgi apparatus Source: UniProtKB-KW
  5. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have normal growth and reproductive function, and normal platelet counts.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535Sequence AnalysisAdd
BLAST
Chaini36 – 600565MesothelinPRO_0000253562Add
BLAST
Chaini36 – 288253Megakaryocyte-potentiating factorPRO_0000253563Add
BLAST
Chaini298 – 600303Mesothelin, cleaved formPRO_0000253564Add
BLAST
Propeptidei601 – 62525Removed in mature formSequence AnalysisPRO_0000253565Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi304 ↔ 328By similarity
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Lipidationi600 – 6001GPI-anchor amidated serineSequence Analysis

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ61468.
PRIDEiQ61468.

PTM databases

PhosphoSiteiQ61468.

Expressioni

Tissue specificityi

Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).1 Publication

Developmental stagei

Expressed at E7, down-regulated at E11, re-expressed at E15 and peaks at E17. Present in embryonic diaphragm (at protein level).2 Publications

Inductioni

By WNT1 but not by WNT5A in mammary epithelial cells.1 Publication

Gene expression databases

BgeeiQ61468.
CleanExiMM_MSLN.
GenevestigatoriQ61468.

Interactioni

Subunit structurei

Interacts with MUC16.1 Publication

Protein-protein interaction databases

IntActiQ61468. 1 interaction.
MINTiMINT-4109628.
STRINGi10090.ENSMUSP00000075279.

Structurei

3D structure databases

ProteinModelPortaliQ61468.
SMRiQ61468. Positions 304-360.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mesothelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40535.
GeneTreeiENSGT00530000064019.
HOGENOMiHOG000113666.
HOVERGENiHBG081988.
InParanoidiQ61468.
OMAiCDLPGRF.
OrthoDBiEOG7M3HZW.
PhylomeDBiQ61468.
TreeFamiTF331713.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin_related.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61468-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALPTARPLL GSCGSPICSR SFLLLLLSLG WIPRLQTQTT KTSQEATLLH
60 70 80 90 100
AVNGAADFAS LPTGLFLGLT CEEVSDLSME QAKGLAMAVR QKNITLRGHQ
110 120 130 140 150
LRCLARRLPR HLTDEELNAL PLDLLLFLNP AMFPGQQACA HFFSLISKAN
160 170 180 190 200
VDVLPRRSLE RQRLLMEALK CQGVYGFQVS EADVRALGGL ACDLPGKFVA
210 220 230 240 250
RSSEVLLPWL AGCQGPLDQS QEKAVREVLR SGRTQYGPPS KWSVSTLDAL
260 270 280 290 300
QSLVAVLDES IVQSIPKDVK AEWLQHISRD PSRLGSKLTV IHPRFRRDAE
310 320 330 340 350
QKACPPGKEP YKVDEDLIFY QNWELEACVD GTMLARQMDL VNEIPFTYEQ
360 370 380 390 400
LSIFKHKLDK TYPQGYPESL IQQLGHFFRY VSPEDIHQWN VTSPDTVKTL
410 420 430 440 450
LKVSKGQKMN AQAIALVACY LRGGGQLDED MVKALGDIPL SYLCDFSPQD
460 470 480 490 500
LHSVPSSVMW LVGPQDLDKC SQRHLGLLYQ KACSAFQNVS GLEYFEKIKT
510 520 530 540 550
FLGGASVKDL RALSQHNVSM DIATFKRLQV DSLVGLSVAE VQKLLGPNIV
560 570 580 590 600
DLKTEEDKSP VRDWLFRQHQ KDLDRLGLGL QGGIPNGYLV LDFNVREAFS
610 620
SRASLLGPGF VLIWIPALLP ALRLS
Length:625
Mass (Da):69,423
Last modified:November 1, 1996 - v1
Checksum:i9A5E9C3222C6983F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86370 mRNA. Translation: BAA13077.1.
AK146799 mRNA. Translation: BAE27441.1.
AK144391 mRNA. Translation: BAE25864.1.
BC023753 mRNA. Translation: AAH23753.1.
CCDSiCCDS28526.1.
RefSeqiNP_061345.1. NM_018857.1.
XP_006524713.1. XM_006524650.1.
UniGeneiMm.17510.

Genome annotation databases

EnsembliENSMUST00000075884; ENSMUSP00000075279; ENSMUSG00000063011.
GeneIDi56047.
KEGGimmu:56047.
UCSCiuc008bbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86370 mRNA. Translation: BAA13077.1 .
AK146799 mRNA. Translation: BAE27441.1 .
AK144391 mRNA. Translation: BAE25864.1 .
BC023753 mRNA. Translation: AAH23753.1 .
CCDSi CCDS28526.1.
RefSeqi NP_061345.1. NM_018857.1.
XP_006524713.1. XM_006524650.1.
UniGenei Mm.17510.

3D structure databases

ProteinModelPortali Q61468.
SMRi Q61468. Positions 304-360.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61468. 1 interaction.
MINTi MINT-4109628.
STRINGi 10090.ENSMUSP00000075279.

PTM databases

PhosphoSitei Q61468.

Proteomic databases

PaxDbi Q61468.
PRIDEi Q61468.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000075884 ; ENSMUSP00000075279 ; ENSMUSG00000063011 .
GeneIDi 56047.
KEGGi mmu:56047.
UCSCi uc008bbo.1. mouse.

Organism-specific databases

CTDi 10232.
MGIi MGI:1888992. Msln.

Phylogenomic databases

eggNOGi NOG40535.
GeneTreei ENSGT00530000064019.
HOGENOMi HOG000113666.
HOVERGENi HBG081988.
InParanoidi Q61468.
OMAi CDLPGRF.
OrthoDBi EOG7M3HZW.
PhylomeDBi Q61468.
TreeFami TF331713.

Miscellaneous databases

NextBioi 311824.
PROi Q61468.
SOURCEi Search...

Gene expression databases

Bgeei Q61468.
CleanExi MM_MSLN.
Genevestigatori Q61468.

Family and domain databases

InterProi IPR010335. Mesothelin.
IPR026664. Stereocilin_related.
[Graphical view ]
PANTHERi PTHR23412. PTHR23412. 1 hit.
Pfami PF06060. Mesothelin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse megakaryocyte potentiating factor cDNA."
    Kojima T., Taniguchi Y., Hattori K., Oh-eda M.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Seminal vesicle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "Mesothelin is not required for normal mouse development or reproduction."
    Bera T.K., Pastan I.
    Mol. Cell. Biol. 20:2902-2906(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  5. "Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells."
    Prieve M.G., Moon R.T.
    BMC Dev. Biol. 3:2-2(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY WNT1.
  6. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
    Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
    J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUC16, DEVELOPMENTAL STAGE, FUNCTION.

Entry informationi

Entry nameiMSLN_MOUSE
AccessioniPrimary (citable) accession number: Q61468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3