Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mesothelin

Gene

Msln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-anchored forms may play a role in cellular adhesion.2 Publications
Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Mesothelin
Alternative name(s):
Pre-pro-megakaryocyte-potentiating factor
Cleaved into the following 2 chains:
Gene namesi
Name:Msln
Synonyms:Mes, Mpf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1888992. Msln.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice have normal growth and reproductive function, and normal platelet counts.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000025356236 – 600MesothelinAdd BLAST565
ChainiPRO_000025356336 – 288Megakaryocyte-potentiating factorAdd BLAST253
ChainiPRO_0000253564298 – 600Mesothelin, cleaved formAdd BLAST303
PropeptideiPRO_0000253565601 – 625Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Modified residuei202PhosphoserineBy similarity1
Disulfide bondi304 ↔ 328By similarity
Glycosylationi390N-linked (GlcNAc...)Sequence analysis1
Glycosylationi488N-linked (GlcNAc...)Sequence analysis1
Glycosylationi517N-linked (GlcNAc...)Sequence analysis1
Lipidationi600GPI-anchor amidated serineSequence analysis1

Post-translational modificationi

Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61468.
PaxDbiQ61468.
PeptideAtlasiQ61468.
PRIDEiQ61468.

PTM databases

PhosphoSitePlusiQ61468.

Expressioni

Tissue specificityi

Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).1 Publication

Developmental stagei

Expressed at E7, down-regulated at E11, re-expressed at E15 and peaks at E17. Present in embryonic diaphragm (at protein level).2 Publications

Inductioni

By WNT1 but not by WNT5A in mammary epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000063011.
CleanExiMM_MSLN.
GenevisibleiQ61468. MM.

Interactioni

Subunit structurei

Interacts with MUC16.1 Publication

Protein-protein interaction databases

IntActiQ61468. 2 interactors.
MINTiMINT-4109628.
STRINGi10090.ENSMUSP00000075279.

Structurei

3D structure databases

ProteinModelPortaliQ61468.
SMRiQ61468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the mesothelin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIJH. Eukaryota.
ENOG4111HFW. LUCA.
GeneTreeiENSGT00530000064019.
HOGENOMiHOG000113666.
HOVERGENiHBG081988.
InParanoidiQ61468.
KOiK20733.
OMAiCDLPGRF.
OrthoDBiEOG091G04V4.
PhylomeDBiQ61468.
TreeFamiTF331713.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61468-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTARPLL GSCGSPICSR SFLLLLLSLG WIPRLQTQTT KTSQEATLLH
60 70 80 90 100
AVNGAADFAS LPTGLFLGLT CEEVSDLSME QAKGLAMAVR QKNITLRGHQ
110 120 130 140 150
LRCLARRLPR HLTDEELNAL PLDLLLFLNP AMFPGQQACA HFFSLISKAN
160 170 180 190 200
VDVLPRRSLE RQRLLMEALK CQGVYGFQVS EADVRALGGL ACDLPGKFVA
210 220 230 240 250
RSSEVLLPWL AGCQGPLDQS QEKAVREVLR SGRTQYGPPS KWSVSTLDAL
260 270 280 290 300
QSLVAVLDES IVQSIPKDVK AEWLQHISRD PSRLGSKLTV IHPRFRRDAE
310 320 330 340 350
QKACPPGKEP YKVDEDLIFY QNWELEACVD GTMLARQMDL VNEIPFTYEQ
360 370 380 390 400
LSIFKHKLDK TYPQGYPESL IQQLGHFFRY VSPEDIHQWN VTSPDTVKTL
410 420 430 440 450
LKVSKGQKMN AQAIALVACY LRGGGQLDED MVKALGDIPL SYLCDFSPQD
460 470 480 490 500
LHSVPSSVMW LVGPQDLDKC SQRHLGLLYQ KACSAFQNVS GLEYFEKIKT
510 520 530 540 550
FLGGASVKDL RALSQHNVSM DIATFKRLQV DSLVGLSVAE VQKLLGPNIV
560 570 580 590 600
DLKTEEDKSP VRDWLFRQHQ KDLDRLGLGL QGGIPNGYLV LDFNVREAFS
610 620
SRASLLGPGF VLIWIPALLP ALRLS
Length:625
Mass (Da):69,423
Last modified:November 1, 1996 - v1
Checksum:i9A5E9C3222C6983F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86370 mRNA. Translation: BAA13077.1.
AK146799 mRNA. Translation: BAE27441.1.
AK144391 mRNA. Translation: BAE25864.1.
BC023753 mRNA. Translation: AAH23753.1.
CCDSiCCDS28526.1.
RefSeqiNP_061345.1. NM_018857.1.
XP_006524713.1. XM_006524650.3.
UniGeneiMm.17510.

Genome annotation databases

EnsembliENSMUST00000075884; ENSMUSP00000075279; ENSMUSG00000063011.
GeneIDi56047.
KEGGimmu:56047.
UCSCiuc008bbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86370 mRNA. Translation: BAA13077.1.
AK146799 mRNA. Translation: BAE27441.1.
AK144391 mRNA. Translation: BAE25864.1.
BC023753 mRNA. Translation: AAH23753.1.
CCDSiCCDS28526.1.
RefSeqiNP_061345.1. NM_018857.1.
XP_006524713.1. XM_006524650.3.
UniGeneiMm.17510.

3D structure databases

ProteinModelPortaliQ61468.
SMRiQ61468.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61468. 2 interactors.
MINTiMINT-4109628.
STRINGi10090.ENSMUSP00000075279.

PTM databases

PhosphoSitePlusiQ61468.

Proteomic databases

MaxQBiQ61468.
PaxDbiQ61468.
PeptideAtlasiQ61468.
PRIDEiQ61468.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075884; ENSMUSP00000075279; ENSMUSG00000063011.
GeneIDi56047.
KEGGimmu:56047.
UCSCiuc008bbo.1. mouse.

Organism-specific databases

CTDi10232.
MGIiMGI:1888992. Msln.

Phylogenomic databases

eggNOGiENOG410IIJH. Eukaryota.
ENOG4111HFW. LUCA.
GeneTreeiENSGT00530000064019.
HOGENOMiHOG000113666.
HOVERGENiHBG081988.
InParanoidiQ61468.
KOiK20733.
OMAiCDLPGRF.
OrthoDBiEOG091G04V4.
PhylomeDBiQ61468.
TreeFamiTF331713.

Miscellaneous databases

PROiQ61468.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063011.
CleanExiMM_MSLN.
GenevisibleiQ61468. MM.

Family and domain databases

InterProiIPR010335. Mesothelin.
IPR026664. Stereocilin-rel.
[Graphical view]
PANTHERiPTHR23412. PTHR23412. 1 hit.
PfamiPF06060. Mesothelin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSLN_MOUSE
AccessioniPrimary (citable) accession number: Q61468
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.