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Q61468

- MSLN_MOUSE

UniProt

Q61468 - MSLN_MOUSE

Protein

Mesothelin

Gene

Msln

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Membrane-anchored forms may play a role in cellular adhesion.2 Publications
    Megakaryocyte-potentiating factor (MPF) may potentiate megakaryocyte colony formation.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. pancreas development Source: Ensembl

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mesothelin
    Alternative name(s):
    Pre-pro-megakaryocyte-potentiating factor
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Msln
    Synonyms:Mes, Mpf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1888992. Msln.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity. Golgi apparatus By similarity

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. cell surface Source: Ensembl
    3. extracellular space Source: Ensembl
    4. Golgi apparatus Source: UniProtKB-SubCell
    5. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Golgi apparatus, Membrane, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Mice have normal growth and reproductive function, and normal platelet counts.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3535Sequence AnalysisAdd
    BLAST
    Chaini36 – 600565MesothelinPRO_0000253562Add
    BLAST
    Chaini36 – 288253Megakaryocyte-potentiating factorPRO_0000253563Add
    BLAST
    Chaini298 – 600303Mesothelin, cleaved formPRO_0000253564Add
    BLAST
    Propeptidei601 – 62525Removed in mature formSequence AnalysisPRO_0000253565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi304 ↔ 328By similarity
    Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi488 – 4881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Lipidationi600 – 6001GPI-anchor amidated serineSequence Analysis

    Post-translational modificationi

    Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PaxDbiQ61468.
    PRIDEiQ61468.

    PTM databases

    PhosphoSiteiQ61468.

    Expressioni

    Tissue specificityi

    Highly expressed in lung and heart. Expressed at low levels in spleen, liver, kidney and testis. Present in lung (at protein level).1 Publication

    Developmental stagei

    Expressed at E7, down-regulated at E11, re-expressed at E15 and peaks at E17. Present in embryonic diaphragm (at protein level).2 Publications

    Inductioni

    By WNT1 but not by WNT5A in mammary epithelial cells.1 Publication

    Gene expression databases

    BgeeiQ61468.
    CleanExiMM_MSLN.
    GenevestigatoriQ61468.

    Interactioni

    Subunit structurei

    Interacts with MUC16.1 Publication

    Protein-protein interaction databases

    IntActiQ61468. 1 interaction.
    MINTiMINT-4109628.
    STRINGi10090.ENSMUSP00000075279.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61468.
    SMRiQ61468. Positions 304-360.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the mesothelin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40535.
    GeneTreeiENSGT00530000064019.
    HOGENOMiHOG000113666.
    HOVERGENiHBG081988.
    InParanoidiQ61468.
    OMAiCDLPGRF.
    OrthoDBiEOG7M3HZW.
    PhylomeDBiQ61468.
    TreeFamiTF331713.

    Family and domain databases

    InterProiIPR010335. Mesothelin.
    IPR026664. Stereocilin_related.
    [Graphical view]
    PANTHERiPTHR23412. PTHR23412. 1 hit.
    PfamiPF06060. Mesothelin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61468-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPTARPLL GSCGSPICSR SFLLLLLSLG WIPRLQTQTT KTSQEATLLH    50
    AVNGAADFAS LPTGLFLGLT CEEVSDLSME QAKGLAMAVR QKNITLRGHQ 100
    LRCLARRLPR HLTDEELNAL PLDLLLFLNP AMFPGQQACA HFFSLISKAN 150
    VDVLPRRSLE RQRLLMEALK CQGVYGFQVS EADVRALGGL ACDLPGKFVA 200
    RSSEVLLPWL AGCQGPLDQS QEKAVREVLR SGRTQYGPPS KWSVSTLDAL 250
    QSLVAVLDES IVQSIPKDVK AEWLQHISRD PSRLGSKLTV IHPRFRRDAE 300
    QKACPPGKEP YKVDEDLIFY QNWELEACVD GTMLARQMDL VNEIPFTYEQ 350
    LSIFKHKLDK TYPQGYPESL IQQLGHFFRY VSPEDIHQWN VTSPDTVKTL 400
    LKVSKGQKMN AQAIALVACY LRGGGQLDED MVKALGDIPL SYLCDFSPQD 450
    LHSVPSSVMW LVGPQDLDKC SQRHLGLLYQ KACSAFQNVS GLEYFEKIKT 500
    FLGGASVKDL RALSQHNVSM DIATFKRLQV DSLVGLSVAE VQKLLGPNIV 550
    DLKTEEDKSP VRDWLFRQHQ KDLDRLGLGL QGGIPNGYLV LDFNVREAFS 600
    SRASLLGPGF VLIWIPALLP ALRLS 625
    Length:625
    Mass (Da):69,423
    Last modified:November 1, 1996 - v1
    Checksum:i9A5E9C3222C6983F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86370 mRNA. Translation: BAA13077.1.
    AK146799 mRNA. Translation: BAE27441.1.
    AK144391 mRNA. Translation: BAE25864.1.
    BC023753 mRNA. Translation: AAH23753.1.
    CCDSiCCDS28526.1.
    RefSeqiNP_061345.1. NM_018857.1.
    XP_006524713.1. XM_006524650.1.
    UniGeneiMm.17510.

    Genome annotation databases

    EnsembliENSMUST00000075884; ENSMUSP00000075279; ENSMUSG00000063011.
    GeneIDi56047.
    KEGGimmu:56047.
    UCSCiuc008bbo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86370 mRNA. Translation: BAA13077.1 .
    AK146799 mRNA. Translation: BAE27441.1 .
    AK144391 mRNA. Translation: BAE25864.1 .
    BC023753 mRNA. Translation: AAH23753.1 .
    CCDSi CCDS28526.1.
    RefSeqi NP_061345.1. NM_018857.1.
    XP_006524713.1. XM_006524650.1.
    UniGenei Mm.17510.

    3D structure databases

    ProteinModelPortali Q61468.
    SMRi Q61468. Positions 304-360.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61468. 1 interaction.
    MINTi MINT-4109628.
    STRINGi 10090.ENSMUSP00000075279.

    PTM databases

    PhosphoSitei Q61468.

    Proteomic databases

    PaxDbi Q61468.
    PRIDEi Q61468.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000075884 ; ENSMUSP00000075279 ; ENSMUSG00000063011 .
    GeneIDi 56047.
    KEGGi mmu:56047.
    UCSCi uc008bbo.1. mouse.

    Organism-specific databases

    CTDi 10232.
    MGIi MGI:1888992. Msln.

    Phylogenomic databases

    eggNOGi NOG40535.
    GeneTreei ENSGT00530000064019.
    HOGENOMi HOG000113666.
    HOVERGENi HBG081988.
    InParanoidi Q61468.
    OMAi CDLPGRF.
    OrthoDBi EOG7M3HZW.
    PhylomeDBi Q61468.
    TreeFami TF331713.

    Miscellaneous databases

    NextBioi 311824.
    PROi Q61468.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61468.
    CleanExi MM_MSLN.
    Genevestigatori Q61468.

    Family and domain databases

    InterProi IPR010335. Mesothelin.
    IPR026664. Stereocilin_related.
    [Graphical view ]
    PANTHERi PTHR23412. PTHR23412. 1 hit.
    Pfami PF06060. Mesothelin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse megakaryocyte potentiating factor cDNA."
      Kojima T., Taniguchi Y., Hattori K., Oh-eda M.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Seminal vesicle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    4. "Mesothelin is not required for normal mouse development or reproduction."
      Bera T.K., Pastan I.
      Mol. Cell. Biol. 20:2902-2906(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    5. "Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells."
      Prieve M.G., Moon R.T.
      BMC Dev. Biol. 3:2-2(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY WNT1.
    6. "Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion."
      Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M., Miyajima A.
      J. Biol. Chem. 279:9190-9198(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MUC16, DEVELOPMENTAL STAGE, FUNCTION.

    Entry informationi

    Entry nameiMSLN_MOUSE
    AccessioniPrimary (citable) accession number: Q61468
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3