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Protein

Zinc finger protein ZIC 4

Gene

Zic4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to DNA.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 16935C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20528C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23525C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29525C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZIC 4
Alternative name(s):
Zinc finger protein of the cerebellum 4
Gene namesi
Name:Zic4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107201. Zic4.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Zinc finger protein ZIC 4PRO_0000047254Add
BLAST

Proteomic databases

PaxDbiQ61467.
PRIDEiQ61467.

PTM databases

iPTMnetiQ61467.
PhosphoSiteiQ61467.

Expressioni

Tissue specificityi

Exclusively expressed in the cerebellum.1 Publication

Developmental stagei

First expressed in embryo at 9 dpc. Expressed in the dorsal midline of the forebrain at 10.5 dpc at the boundary between the diencephalon and telencephalon, the septum, and the lamina terminalis. Expressed in the choroid plexus of the third ventricle, the dorsal part of the spinal neural tube, the dorsal sclerotome and the dorsomedial lip of the dermomyotome between 10.5 and 12.5 dpc. Expressed in the midline of the forebrain and in the dorsal spinal neural tube at 12.5 dpc.2 Publications

Gene expression databases

BgeeiQ61467.
CleanExiMM_ZIC4.
ExpressionAtlasiQ61467. baseline and differential.
GenevisibleiQ61467. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133958.

Structurei

3D structure databases

ProteinModelPortaliQ61467.
SMRiQ61467. Positions 129-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri135 – 16935C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri178 – 20528C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri211 – 23525C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri241 – 26525C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29525C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ61467.
KOiK09225.
OMAiPSSDFGR.
PhylomeDBiQ61467.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGRVCPRG PGKVRSPRHR FSCTLFVSTT GSSCGHHGPQ LAASSNPSVL
60 70 80 90 100
PGLHEQPPQA SHSRPLNGLL RLGIPGDMYA RSEPFAPGPM ARSDTLATAT
110 120 130 140 150
ALHGYGGMNL TMNLTAPHGP GAFFRYMRQP IKQELICKWL GDDSPMSPRP
160 170 180 190 200
CSKTFSTMHE LVTHVTVEHV GGPEQANHIC FWEECPRQGK PFKAKYKLVN
210 220 230 240 250
HIRVHTGEKP FPCPFPGCGK VFARSENLKI HKRTHTGEKP FRCEFEGCER
260 270 280 290 300
RFANSSDRKK HSHVHTSDKP YMCKVRGCDK CYTHPSSLRK HMKVHGRSPP
310 320 330 340
PSSGYDSAIT SALASPSLES GREPSVACSA AVVVRGTDVS E
Length:341
Mass (Da):37,437
Last modified:January 24, 2006 - v2
Checksum:iB4BB10DE736230CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78174 mRNA. Translation: BAA11240.1. Different termination.
AK028305 mRNA. Translation: BAC25871.1.
AK035908 mRNA. Translation: BAC29239.1.
PIRiJC4875.
RefSeqiNP_033602.2. NM_009576.2.
XP_011241029.1. XM_011242727.1.
UniGeneiMm.434835.
Mm.8062.

Genome annotation databases

EnsembliENSMUST00000066384; ENSMUSP00000069568; ENSMUSG00000036972.
GeneIDi22774.
KEGGimmu:22774.
UCSCiuc009rak.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78174 mRNA. Translation: BAA11240.1. Different termination.
AK028305 mRNA. Translation: BAC25871.1.
AK035908 mRNA. Translation: BAC29239.1.
PIRiJC4875.
RefSeqiNP_033602.2. NM_009576.2.
XP_011241029.1. XM_011242727.1.
UniGeneiMm.434835.
Mm.8062.

3D structure databases

ProteinModelPortaliQ61467.
SMRiQ61467. Positions 129-296.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000133958.

PTM databases

iPTMnetiQ61467.
PhosphoSiteiQ61467.

Proteomic databases

PaxDbiQ61467.
PRIDEiQ61467.

Protocols and materials databases

DNASUi22774.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066384; ENSMUSP00000069568; ENSMUSG00000036972.
GeneIDi22774.
KEGGimmu:22774.
UCSCiuc009rak.1. mouse.

Organism-specific databases

CTDi84107.
MGIiMGI:107201. Zic4.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000118771.
HOGENOMiHOG000232057.
HOVERGENiHBG007135.
InParanoidiQ61467.
KOiK09225.
OMAiPSSDFGR.
PhylomeDBiQ61467.

Miscellaneous databases

PROiQ61467.
SOURCEiSearch...

Gene expression databases

BgeeiQ61467.
CleanExiMM_ZIC4.
ExpressionAtlasiQ61467. baseline and differential.
GenevisibleiQ61467. MM.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of Zic4, a new member of the mouse Zic gene family."
    Aruga J., Yozu A., Hayashizaki Y., Okazaki Y., Chapman V.M., Mikoshiba K.
    Gene 172:291-294(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
    Tissue: Cerebellum.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family."
    Ishiguro A., Inoue T., Mikoshiba K., Aruga J.
    Biochem. Biophys. Res. Commun. 324:302-307(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, SUBCELLULAR LOCATION.
  4. "Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system."
    Gaston-Massuet C., Henderson D.J., Greene N.D., Copp A.J.
    Dev. Dyn. 233:1110-1115(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiZIC4_MOUSE
AccessioniPrimary (citable) accession number: Q61467
Secondary accession number(s): Q8BG91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 24, 2006
Last modified: June 8, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.