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Protein

Zinc finger protein 638

Gene

Znf638

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Early regulator of adipogenesis that works as a transcription cofactor of CEBPs, controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1 (PubMed:21602272). Binds to cytidine clusters in double-stranded DNA (By similarity). May also regulate alternative splicing of target genes during adipogenesis (PubMed:25024404).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 638Imported
Alternative name(s):
Nuclear protein 2201 Publication
Zinc finger matrin-like proteinBy similarity
Gene namesi
Name:Znf638By similarity
Synonyms:Np220Imported, ZfmlImported, Zfp638Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1203484. Zfp638.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820121 – 1960Zinc finger protein 638Add BLAST1960

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47Asymmetric dimethylarginineBy similarity1
Modified residuei49Asymmetric dimethylarginineBy similarity1
Modified residuei54Asymmetric dimethylarginineBy similarity1
Modified residuei128PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Modified residuei298PhosphoserineBy similarity1
Modified residuei367PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei418PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei606PhosphoserineBy similarity1
Modified residuei615PhosphoserineBy similarity1
Modified residuei637PhosphoserineBy similarity1
Modified residuei1099PhosphoserineBy similarity1
Modified residuei1400PhosphoserineBy similarity1
Modified residuei1635PhosphoserineCombined sources1
Modified residuei1661PhosphoserineBy similarity1
Modified residuei1864PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ61464.
PaxDbiQ61464.
PeptideAtlasiQ61464.
PRIDEiQ61464.

PTM databases

iPTMnetiQ61464.
PhosphoSitePlusiQ61464.

Expressioni

Developmental stagei

In an vitro adipocyte differentiation system, induced at the protein and RNA levels shortly after exposure to the induction mixture. Levels peak before PPARG induction and rapidly decrease during later stages of differentiation.1 Publication

Gene expression databases

BgeeiENSMUSG00000030016.
CleanExiMM_ZFML.
ExpressionAtlasiQ61464. baseline and differential.
GenevisibleiQ61464. MM.

Interactioni

Subunit structurei

Interacts with FHL2 (By similarity). Interacts with CEBPA, CEBPD and CEBPG.By similarity1 Publication

Protein-protein interaction databases

BioGridi201815. 2 interactors.
IntActiQ61464. 1 interactor.
MINTiMINT-4109575.
STRINGi10090.ENSMUSP00000032088.

Structurei

3D structure databases

ProteinModelPortaliQ61464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini676 – 751RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini902 – 976RRM 2PROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni470 – 573Involved in localization to nuclear speckles1 PublicationAdd BLAST104

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi470 – 575Arg-richAdd BLAST106
Compositional biasi1577 – 1582Poly-Lys6

Domaini

The matrin-type zinc finger domain is required for localization to nuclear speckles.1 Publication

Sequence similaritiesi

Contains 1 matrin-type zinc finger.PROSITE-ProRule annotation
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1876 – 1906Matrin-typePROSITE-ProRule annotationAdd BLAST31

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IN3N. Eukaryota.
ENOG4111GCE. LUCA.
GeneTreeiENSGT00850000132416.
HOGENOMiHOG000082488.
HOVERGENiHBG094186.
InParanoidiQ61464.
PhylomeDBiQ61464.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR033096. ZNF638.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
PANTHERiPTHR15592:SF1. PTHR15592:SF1. 2 hits.
SMARTiSM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61464-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRPRFNPRG TFPLQRPRAP NPPGMRPPGP FVRPGSMGLP RFYPAGRARG
60 70 80 90 100
IPHRFPGHGS YQNMGPQRMN VQVTQHRTDP RLTKEKLDFP EAQQKKGKPH
110 120 130 140 150
GSRWDDESHI TPPVEVKQSS VTQVTEQSPK VQSRYTKESA SSILASFGLS
160 170 180 190 200
NEDLEELSRY PDEQLTPENM PLILRDIRMR KMSRRLPNLP SHSRNKETLS
210 220 230 240 250
NETVSSNVID YGHASKYGYT EDPLEVRIYD PEIPTDEVKN EFQPQQSISA
260 270 280 290 300
TVSTPNVICN SVFPGGDMFR QMDFPGESSS QSFFPVESGT KMSGLHISGQ
310 320 330 340 350
SVLEPVKSIS QSISQTVSQT TSQSLNPPSM NQVPFTFELD AVLRQQERIS
360 370 380 390 400
QKSVISSADA HGGPTESKKD YQSEADLPIR SPFGIVKASW LPKFTQAGAQ
410 420 430 440 450
KMKRLPTPSM MNDYYAASPR IFPHLCSLCN VECSHLKDWI QHQNTSTHIE
460 470 480 490 500
SCRQLRQQYP DWNPEILPSR RNESNRKENE TPRRRSHSPS PRHSRRSSSG
510 520 530 540 550
HRIRRSRSPV RYIYRPRSRS PRICHRFISK YRSRSRSRSR SRSPYRSRNL
560 570 580 590 600
LRRSPKSYRS ASPERTSRKS VRSDRKKALE DGGQRSVHGT EVTKQKHTET
610 620 630 640 650
VDKGLSPAQK PKLASGTKPS AKSLSSVKSD SHLGAYSAHK SENLEDDTLP
660 670 680 690 700
EGKQESGKSA LAQRKPQKDQ SLSSNSILLV SELPEDGFTE EDIRKAFLPF
710 720 730 740 750
GKISDVLLVP CRNEAYLEME LRKAVTSIMK YIETMPLVIK GKSVKVCVPG
760 770 780 790 800
KKKPQNKEMK KKPSDIKKSS ASALKKETDA SKTMETVSSS SSAKSGQIKS
810 820 830 840 850
STVKVNKCAG KSAGSVKSVV TVAAKGKASI KTAKSGKKSL EAKKSGNIKN
860 870 880 890 900
KDSNKPVTVP ANSEIKASSE DKATGKSAEE SPSGTLEATE KEPVNKESEE
910 920 930 940 950
MSVVFISNLP NKGYSTEEIY NLAKPFGALK DILVLSSHKK AYIEINKKSA
960 970 980 990 1000
DSMVKFYTCF PISMDGNQLS ISMAPEHVDL KDEEALFTTL IQENDPEANI
1010 1020 1030 1040 1050
DKIYNRFVHL DNLPEDGLQC VLCVGHQFGK VDRYMFMSNK NKVILQLESP
1060 1070 1080 1090 1100
ESALSMYNFL KQNPQNIGEH VLTCTLSPKT DSEVQRKNDL ELGKGSTFSP
1110 1120 1130 1140 1150
DLKNSPVDES EVQTAADSSS VKPSEVEEET TSNIGTETSV HQEELGKEEP
1160 1170 1180 1190 1200
KQALCESDFA IQTLELEAQG AEVSIEIPLV ASTPANIELF SENIDESALN
1210 1220 1230 1240 1250
QQMYTSDFEK EEAEVTNPET ELAVSDSVFI EERNIKGIIE DSPSETEDIF
1260 1270 1280 1290 1300
SGIVQPMVDA IAEVDKHETV SEVLPSACNV TQAPGSYIED EKVVSKKDIA
1310 1320 1330 1340 1350
EKVILDEKEE DEFNVKETRM DLQVKTEKAE KNEAIIFKEK LEKIIAAIRE
1360 1370 1380 1390 1400
KPIESSVIKA DPTKGLDQTS KPDETGKSSV LTVSNVYSSK SSIKATVVSS
1410 1420 1430 1440 1450
PKAKSTPSKT ESHSTFPKPV LREQIKADKK VSAKEFGLLK NTRSGLAESN
1460 1470 1480 1490 1500
SKSKPTQIGV NRGCSGRISA LQCKDSKVDY KDITKQSQET ETKPPIMKRD
1510 1520 1530 1540 1550
DSNNKALALQ NTKNSKSTTD RSSKSKEEPL FTFNLDEFVT VDEVIEEVNP
1560 1570 1580 1590 1600
SQAKQNPLKG KRKEALKISP SPELNLKKKK GKTSVPHSVE GELSFVTLDE
1610 1620 1630 1640 1650
IGEEEDATVQ ALVTVDEVID EEELNMEEMV KNSNSLLTLD ELIDQDDCIP
1660 1670 1680 1690 1700
HSGPKDVTVL SMAEEQDLQQ ERLVTVDEIG EVEESADITF ATLNAKRDKR
1710 1720 1730 1740 1750
DSIGFISSQM PEDPSTLVTV DEIQDDSSDF HLMTLDEVTE EDENSLADFN
1760 1770 1780 1790 1800
NLKEELNFVT VDEVGDEEDG DNDSKVELAR GKIEHHTDKK GNRKRRAVDP
1810 1820 1830 1840 1850
KKSKLDSFSQ VGPGSETVTQ KDLKTMPERH LAAKTPMKRV RLGKSSPSQK
1860 1870 1880 1890 1900
VAEPTKGEEA FQMSEGVDDA ELKDSEPDEK RRKTQDSSVG KSMTSDVPGD
1910 1920 1930 1940 1950
LDFLVPKAGF FCPICSLFYS GEKAMANHCK STRHKQNTEK FMAKQRKEKE
1960
QNETEERSSR
Length:1,960
Mass (Da):218,134
Last modified:July 19, 2005 - v2
Checksum:i27DF6740BFE410ED
GO
Isoform 2 (identifier: Q61464-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-832: Missing.
     1147-1200: KEEPKQALCE...SENIDESALN → PGSETVTQKD...GEEAFQMSEG
     1201-1832: Missing.
     1833-1866: Missing.

Note: No experimental confirmation available.
Show »
Length:1,271
Mass (Da):142,198
Checksum:i342F546EFC525823
GO
Isoform 3 (identifier: Q61464-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     438-454: DWIQHQNTSTHIESCRQ → VSVFKRLLYNDAQCPGF
     456-1960: Missing.

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:455
Mass (Da):50,951
Checksum:i5B605A1F5153B1C3
GO
Isoform 4 (identifier: Q61464-4) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1833-1866: Missing.

Show »
Length:1,926
Mass (Da):214,460
Checksum:i3B2F3A7AF4580259
GO
Isoform 5 (identifier: Q61464-5) [UniParc]FASTAAdd to basket
Also known as: Gamma

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1832: Missing.

Show »
Length:1,274
Mass (Da):142,134
Checksum:i344E096A235A8168
GO
Isoform 6 (identifier: Q61464-7) [UniParc]FASTAAdd to basket
Also known as: Delta

The sequence of this isoform differs from the canonical sequence as follows:
     1147-1866: Missing.

Show »
Length:1,240
Mass (Da):138,461
Checksum:iF2BF9C3AA2F2883B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32V → L in AAH76615 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014807438 – 454DWIQH…ESCRQ → VSVFKRLLYNDAQCPGF in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_014808456 – 1960Missing in isoform 3. 1 PublicationAdd BLAST1505
Alternative sequenceiVSP_014809810 – 832Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0148101147 – 1866Missing in isoform 6. 1 PublicationAdd BLAST720
Alternative sequenceiVSP_0148111147 – 1832Missing in isoform 5. 1 PublicationAdd BLAST686
Alternative sequenceiVSP_0148121147 – 1200KEEPK…ESALN → PGSETVTQKDLKTMPERHLA AKTPMKRVRIGKSSPSQKVA EPTKGEEAFQMSEG in isoform 2. 1 PublicationAdd BLAST54
Alternative sequenceiVSP_0148131201 – 1832Missing in isoform 2. 1 PublicationAdd BLAST632
Alternative sequenceiVSP_0148141833 – 1866Missing in isoform 2 and isoform 4. 2 PublicationsAdd BLAST34

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83033 mRNA. Translation: BAA11749.1.
AK043029 mRNA. Translation: BAC31439.1.
BC076615 mRNA. Translation: AAH76615.1.
CCDSiCCDS20288.1. [Q61464-4]
CCDS51823.1. [Q61464-2]
PIRiJC4842.
RefSeqiNP_001159843.1. NM_001166371.1. [Q61464-2]
NP_032743.2. NM_008717.3.
UniGeneiMm.132392.

Genome annotation databases

EnsembliENSMUST00000113835; ENSMUSP00000109466; ENSMUSG00000030016. [Q61464-2]
GeneIDi18139.
KEGGimmu:18139.
UCSCiuc009coo.2. mouse. [Q61464-3]
uc009coq.2. mouse. [Q61464-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83033 mRNA. Translation: BAA11749.1.
AK043029 mRNA. Translation: BAC31439.1.
BC076615 mRNA. Translation: AAH76615.1.
CCDSiCCDS20288.1. [Q61464-4]
CCDS51823.1. [Q61464-2]
PIRiJC4842.
RefSeqiNP_001159843.1. NM_001166371.1. [Q61464-2]
NP_032743.2. NM_008717.3.
UniGeneiMm.132392.

3D structure databases

ProteinModelPortaliQ61464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201815. 2 interactors.
IntActiQ61464. 1 interactor.
MINTiMINT-4109575.
STRINGi10090.ENSMUSP00000032088.

PTM databases

iPTMnetiQ61464.
PhosphoSitePlusiQ61464.

Proteomic databases

EPDiQ61464.
PaxDbiQ61464.
PeptideAtlasiQ61464.
PRIDEiQ61464.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113835; ENSMUSP00000109466; ENSMUSG00000030016. [Q61464-2]
GeneIDi18139.
KEGGimmu:18139.
UCSCiuc009coo.2. mouse. [Q61464-3]
uc009coq.2. mouse. [Q61464-2]

Organism-specific databases

CTDi18139.
MGIiMGI:1203484. Zfp638.

Phylogenomic databases

eggNOGiENOG410IN3N. Eukaryota.
ENOG4111GCE. LUCA.
GeneTreeiENSGT00850000132416.
HOGENOMiHOG000082488.
HOVERGENiHBG094186.
InParanoidiQ61464.
PhylomeDBiQ61464.

Miscellaneous databases

PROiQ61464.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030016.
CleanExiMM_ZFML.
ExpressionAtlasiQ61464. baseline and differential.
GenevisibleiQ61464. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR033096. ZNF638.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR000690. Znf_C2H2_matrin.
IPR003604. Znf_U1.
[Graphical view]
PANTHERiPTHR15592:SF1. PTHR15592:SF1. 2 hits.
SMARTiSM00360. RRM. 2 hits.
SM00355. ZnF_C2H2. 2 hits.
SM00451. ZnF_U1. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 1 hit.
PS50171. ZF_MATRIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN638_MOUSE
AccessioniPrimary (citable) accession number: Q61464
Secondary accession number(s): Q6DFV9, Q8C941
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.