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Q61457 (CCNE1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G1/S-specific cyclin-E1
Gene names
Name:Ccne1
Synonyms:Ccne
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for the control of the cell cycle at the G1/S (start) transition.

Subunit structure

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Part of a complex consisting of UHRF2, CDK2 and CCNE1 By similarity. Interacts with retinoblastoma binding protein 3 and retinoblastoma-like protein 1. Found in a complex with CDK2, CABLES1 and CCNA1.

Subcellular location

Nucleus By similarity.

Tissue specificity

Found in adult spleen, and to a lesser extent in adult testis and brain.

Post-translational modification

Phosphorylation of Thr-393 and Ser-397 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR By similarity.

Sequence similarities

Belongs to the cyclin family. Cyclin E subfamily.

Sequence caution

The sequence CAA53482.1 differs from that shown. Reason: Frameshift at position 401.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408G1/S-specific cyclin-E1
PRO_0000080450

Amino acid modifications

Modified residue561Phosphoserine By similarity
Modified residue741Phosphothreonine By similarity
Modified residue1011Phosphoserine By similarity
Modified residue3791Phosphoserine By similarity
Modified residue3851Phosphoserine By similarity
Modified residue3931Phosphothreonine By similarity
Modified residue3971Phosphoserine By similarity

Experimental info

Sequence conflict21P → Q in AAH84588. Ref.2
Sequence conflict1791H → Q in CAA53482. Ref.1
Sequence conflict1791H → Q in AAH62152. Ref.2
Sequence conflict1791H → Q in AAH84588. Ref.2
Sequence conflict290 – 2912LE → FR in AAH62152. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q61457 [UniParc].

Last modified November 13, 2007. Version 2.
Checksum: 4916B5D7117ADA69

FASTA40846,986
        10         20         30         40         50         60 
MPRERDSTDH SNMKEEGGSD LSVRSRKRKA NVAVFLQDPD EEIAKIDKTV KSEDSSQPWD 

        70         80         90        100        110        120 
DNSACVDPCS FIPTPNKEED NELEYPRTAF QPRKIRPPRA SPLPVLNWGN REEVWRIMLN 

       130        140        150        160        170        180 
KEKTYLRDEH FLQRHPLLQA RMRAVLLDWL MEVCEVYKLH RETFYLAQDF FDRYMASQHN 

       190        200        210        220        230        240 
IIKTLLQLIG ISALFIASKL EEIYPPKLHQ FAYVTDGACS GDEILTMELM MMKALKWRLS 

       250        260        270        280        290        300 
PLTIVSWLNV YVQVAYVNDT GEVLMPQYPQ QVFVQIAELL DLCVLDVGCL EFPYGVLAAS 

       310        320        330        340        350        360 
ALYHFSSLEL MQKVSGYQWC DIEKCVKWMV PFAMVIREMG SSKLKHFRGV PMEDSHNIQT 

       370        380        390        400 
HTNSLDLLDK AQAKKAILSE QNRISPPPSV VLTPPPSSKK QSSEQETE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of murine cyclin E."
Damjanov I., Shan J., Wang R.F., Damjanov A., Deloia J.A.
Biochem. Biophys. Res. Commun. 201:994-1000(1994) [PubMed: 8003041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Limb.
[3]"Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
Cancer Res. 61:7325-7332(2001) [PubMed: 11585773] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH CDK2; CCNA1 AND CABLES1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75888 mRNA. Translation: CAA53482.1. Frameshift.
BC062152 mRNA. Translation: AAH62152.1.
BC084588 mRNA. Translation: AAH84588.1.
BC106191 mRNA. Translation: AAI06192.1.
IPIIPI00121227.
PIRJC2497.
RefSeqNP_031659.2. NM_007633.2.
UniGeneMm.16110.

3D structure databases

ProteinModelPortalQ61457.
SMRQ61457. Positions 101-370.
ModBaseSearch...

Protein-protein interaction databases

IntActQ61457. 3 interactions.
STRINGQ61457.

PTM databases

PhosphoSiteQ61457.

Proteomic databases

PRIDEQ61457.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108023; ENSMUSP00000103658; ENSMUSG00000002068.
GeneID12447.
KEGGmmu:12447.
UCSCuc009gkr.1. mouse.

Organism-specific databases

CTD898.
MGIMGI:88316. Ccne1.

Phylogenomic databases

GeneTreeENSGT00560000076942.
HOVERGENHBG050834.
OrthoDBEOG45756T.

Gene expression databases

ArrayExpressQ61457.
BgeeQ61457.
CleanExMM_CCNE1.
GenevestigatorQ61457.
GermOnlineENSMUSG00000002068. Mus musculus.

Family and domain databases

InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E.
IPR004367. Cyclin_C.
IPR006671. Cyclin_N.
[Graphical view]
Gene3DG3DSA:1.10.472.10. Cyclin_related. 2 hits.
KOK06626.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. Cyclin_like. 1 hit.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281272.
SOURCESearch...

Entry information

Entry nameCCNE1_MOUSE
AccessionPrimary (citable) accession number: Q61457
Secondary accession number(s): Q05BA1, Q05BA6, Q05BB7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 13, 2007
Last modified: November 16, 2011
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families