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Q61456 (CCNA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-A1
Gene names
Name:Ccna1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. Ref.4 Ref.5

Subunit structure

Interacts with INCA1 and KLHDC9 By similarity. Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNE1. Ref.6

Subcellular location

Nucleus By similarity. Cytoplasmcytoskeletonspindle. Note: In oocytes at least, it associates with the spindle during metaphase.

Tissue specificity

Testis and ovaries.

Developmental stage

In male germ cells just prior to or during the first, but not the second meiotic division.

Post-translational modification

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase By similarity.

Miscellaneous

CCNA1 -/- males are sterile due to a block of spermatogenesis before the first meiotic division, whereas females are normal.

Sequence similarities

Belongs to the cyclin family. Cyclin AB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Cyclin-A1
PRO_0000080334

Experimental info

Sequence conflict1761R → P in CAA59053. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61456 [UniParc].

Last modified July 1, 2008. Version 2.
Checksum: FF717D0065B954E9

FASTA42147,772
        10         20         30         40         50         60 
MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR RTCGQEITAI 

        70         80         90        100        110        120 
RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ GDRDTCSGKE GIIFEDVYEV 

       130        140        150        160        170        180 
DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ SEEATDFGSD VINVTEYAEE IHRYLREAEV 

       190        200        210        220        230        240 
RHRPKAHYMR KQPDITEGMR AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG 

       250        260        270        280        290        300 
KLQLVGTAAI LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT 

       310        320        330        340        350        360 
NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL ANYIVNRHFW 

       370        380        390        400        410        420 
PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK YKASKYLHVS LMEPPVVLPL 


Q 

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References

« Hide 'large scale' references
[1]"A distinct cyclin A is expressed in germ cells in the mouse."
Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F., Wolgemuth D.J., Carrington M.
Development 122:53-64(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Testis.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Cyclin A1 is required for meiosis in the male mouse."
Liu D., Matzuk M.M., Sung W.K., Guo Q., Wang P., Wolgemuth D.J.
Nat. Genet. 20:377-380(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage."
Ravnik S.E., Wolgemuth D.J.
Dev. Biol. 207:408-418(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
Strain: Swiss Webster.
[6]"Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH CDK2; CABLES1 AND CCNE1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X84311 mRNA. Translation: CAA59053.1.
AK077114 mRNA. Translation: BAC36619.1.
BC120518 mRNA. Translation: AAI20519.1.
BC125436 mRNA. Translation: AAI25437.1.
CCDSCCDS17356.1.
RefSeqNP_031654.2. NM_007628.3.
XP_006501011.1. XM_006500948.1.
XP_006501012.1. XM_006500949.1.
XP_006501013.1. XM_006500950.1.
XP_006501014.1. XM_006500951.1.
XP_006501015.1. XM_006500952.1.
UniGeneMm.4815.

3D structure databases

ProteinModelPortalQ61456.
SMRQ61456. Positions 166-418.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198544. 4 interactions.
STRING10090.ENSMUSP00000029368.

Proteomic databases

PRIDEQ61456.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793.
GeneID12427.
KEGGmmu:12427.
UCSCuc008pfy.2. mouse.

Organism-specific databases

CTD8900.
MGIMGI:108042. Ccna1.

Phylogenomic databases

eggNOGCOG5024.
GeneTreeENSGT00740000115500.
HOGENOMHOG000167672.
HOVERGENHBG106244.
InParanoidQ61456.
KOK06627.
OMAAEIRHRP.
OrthoDBEOG7G7KQ0.
PhylomeDBQ61456.
TreeFamTF101002.

Enzyme and pathway databases

ReactomeREACT_188804. Cell Cycle.

Gene expression databases

BgeeQ61456.
CleanExMM_CCNA1.
GenevestigatorQ61456.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
InterProIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR015453. Cyclin_A_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERPTHR10177:SF68. PTHR10177:SF68. 1 hit.
PfamPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
PROSITEPS00292. CYCLINS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio281240.
PROQ61456.
SOURCESearch...

Entry information

Entry nameCCNA1_MOUSE
AccessionPrimary (citable) accession number: Q61456
Secondary accession number(s): Q8C5U1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 2008
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot