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Q61456

- CCNA1_MOUSE

UniProt

Q61456 - CCNA1_MOUSE

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Protein

Cyclin-A1

Gene

Ccna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.2 Publications

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. meiotic nuclear division Source: UniProtKB-KW
  3. mitotic nuclear division Source: UniProtKB-KW
  4. multicellular organismal development Source: UniProtKB-KW
  5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  6. regulation of G2/M transition of mitotic cell cycle Source: InterPro
  7. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cyclin, Developmental protein

Keywords - Biological processi

Cell cycle, Cell division, Differentiation, Meiosis, Mitosis, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_198608. G1/S-Specific Transcription.
REACT_199110. G0 and Early G1.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_206830. E2F mediated regulation of DNA replication.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
REACT_227891. G2 Phase.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-A1
Gene namesi
Name:Ccna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:108042. Ccna1.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonspindle
Note: In oocytes at least, it associates with the spindle during metaphase.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. microtubule cytoskeleton Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Cyclin-A1PRO_0000080334Add
BLAST

Post-translational modificationi

Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PRIDEiQ61456.

Expressioni

Tissue specificityi

Testis and ovaries.

Developmental stagei

In male germ cells just prior to or during the first, but not the second meiotic division.

Gene expression databases

BgeeiQ61456.
CleanExiMM_CCNA1.
GenevestigatoriQ61456.

Interactioni

Subunit structurei

Interacts with INCA1 and KLHDC9 (By similarity). Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNE1.By similarity1 Publication

Protein-protein interaction databases

BioGridi198544. 4 interactions.
STRINGi10090.ENSMUSP00000029368.

Structurei

3D structure databases

ProteinModelPortaliQ61456.
SMRiQ61456. Positions 166-418.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiCOG5024.
GeneTreeiENSGT00760000118939.
HOGENOMiHOG000167672.
HOVERGENiHBG106244.
InParanoidiQ61456.
KOiK06627.
OMAiAEIRHRP.
OrthoDBiEOG7G7KQ0.
PhylomeDBiQ61456.
TreeFamiTF101002.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
InterProiIPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR015453. Cyclin_A_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR10177:SF68. PTHR10177:SF68. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
PROSITEiPS00292. CYCLINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61456-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR
60 70 80 90 100
RTCGQEITAI RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ
110 120 130 140 150
GDRDTCSGKE GIIFEDVYEV DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ
160 170 180 190 200
SEEATDFGSD VINVTEYAEE IHRYLREAEV RHRPKAHYMR KQPDITEGMR
210 220 230 240 250
AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG KLQLVGTAAI
260 270 280 290 300
LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT
310 320 330 340 350
NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL
360 370 380 390 400
ANYIVNRHFW PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK
410 420
YKASKYLHVS LMEPPVVLPL Q
Length:421
Mass (Da):47,772
Last modified:July 1, 2008 - v2
Checksum:iFF717D0065B954E9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti176 – 1761R → P in CAA59053. (PubMed:8565853)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84311 mRNA. Translation: CAA59053.1.
AK077114 mRNA. Translation: BAC36619.1.
BC120518 mRNA. Translation: AAI20519.1.
BC125436 mRNA. Translation: AAI25437.1.
CCDSiCCDS17356.1.
RefSeqiNP_031654.2. NM_007628.3.
XP_006501011.1. XM_006500948.1.
XP_006501012.1. XM_006500949.1.
XP_006501013.1. XM_006500950.1.
XP_006501014.1. XM_006500951.1.
XP_006501015.1. XM_006500952.1.
UniGeneiMm.4815.

Genome annotation databases

EnsembliENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793.
GeneIDi12427.
KEGGimmu:12427.
UCSCiuc008pfy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84311 mRNA. Translation: CAA59053.1 .
AK077114 mRNA. Translation: BAC36619.1 .
BC120518 mRNA. Translation: AAI20519.1 .
BC125436 mRNA. Translation: AAI25437.1 .
CCDSi CCDS17356.1.
RefSeqi NP_031654.2. NM_007628.3.
XP_006501011.1. XM_006500948.1.
XP_006501012.1. XM_006500949.1.
XP_006501013.1. XM_006500950.1.
XP_006501014.1. XM_006500951.1.
XP_006501015.1. XM_006500952.1.
UniGenei Mm.4815.

3D structure databases

ProteinModelPortali Q61456.
SMRi Q61456. Positions 166-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198544. 4 interactions.
STRINGi 10090.ENSMUSP00000029368.

Proteomic databases

PRIDEi Q61456.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029368 ; ENSMUSP00000029368 ; ENSMUSG00000027793 .
GeneIDi 12427.
KEGGi mmu:12427.
UCSCi uc008pfy.2. mouse.

Organism-specific databases

CTDi 8900.
MGIi MGI:108042. Ccna1.

Phylogenomic databases

eggNOGi COG5024.
GeneTreei ENSGT00760000118939.
HOGENOMi HOG000167672.
HOVERGENi HBG106244.
InParanoidi Q61456.
KOi K06627.
OMAi AEIRHRP.
OrthoDBi EOG7G7KQ0.
PhylomeDBi Q61456.
TreeFami TF101002.

Enzyme and pathway databases

Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
REACT_198608. G1/S-Specific Transcription.
REACT_199110. G0 and Early G1.
REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
REACT_206803. Cyclin A/B1 associated events during G2/M transition.
REACT_206830. E2F mediated regulation of DNA replication.
REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
REACT_227891. G2 Phase.

Miscellaneous databases

NextBioi 281240.
PROi Q61456.
SOURCEi Search...

Gene expression databases

Bgeei Q61456.
CleanExi MM_CCNA1.
Genevestigatori Q61456.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
InterProi IPR013763. Cyclin-like.
IPR014400. Cyclin_A/B/D/E/F.
IPR015453. Cyclin_A_chordates.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
[Graphical view ]
PANTHERi PTHR10177:SF68. PTHR10177:SF68. 1 hit.
Pfami PF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
PROSITEi PS00292. CYCLINS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A distinct cyclin A is expressed in germ cells in the mouse."
    Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F., Wolgemuth D.J., Carrington M.
    Development 122:53-64(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Testis.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Cyclin A1 is required for meiosis in the male mouse."
    Liu D., Matzuk M.M., Sung W.K., Guo Q., Wang P., Wolgemuth D.J.
    Nat. Genet. 20:377-380(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage."
    Ravnik S.E., Wolgemuth D.J.
    Dev. Biol. 207:408-418(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: Swiss Webster.
  6. "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
    Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
    Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH CDK2; CABLES1 AND CCNE1.

Entry informationi

Entry nameiCCNA1_MOUSE
AccessioniPrimary (citable) accession number: Q61456
Secondary accession number(s): Q8C5U1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 2008
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

CCNA1 -/- males are sterile due to a block of spermatogenesis before the first meiotic division, whereas females are normal.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3