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Q61456

- CCNA1_MOUSE

UniProt

Q61456 - CCNA1_MOUSE

Protein

Cyclin-A1

Gene

Ccna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Jul 2008)
      Previous versions | rss
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    Functioni

    May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.2 Publications

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. meiotic nuclear division Source: UniProtKB-KW
    3. mitotic nuclear division Source: UniProtKB-KW
    4. multicellular organismal development Source: UniProtKB-KW
    5. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    6. regulation of G2/M transition of mitotic cell cycle Source: InterPro
    7. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Cyclin, Developmental protein

    Keywords - Biological processi

    Cell cycle, Cell division, Differentiation, Meiosis, Mitosis, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_188819. DNA Damage/Telomere Stress Induced Senescence.
    REACT_198608. G1/S-Specific Transcription.
    REACT_199110. G0 and Early G1.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_206830. E2F mediated regulation of DNA replication.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
    REACT_227891. G2 Phase.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-A1
    Gene namesi
    Name:Ccna1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:108042. Ccna1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonspindle
    Note: In oocytes at least, it associates with the spindle during metaphase.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-SubCell
    3. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Cyclin-A1PRO_0000080334Add
    BLAST

    Post-translational modificationi

    Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PRIDEiQ61456.

    Expressioni

    Tissue specificityi

    Testis and ovaries.

    Developmental stagei

    In male germ cells just prior to or during the first, but not the second meiotic division.

    Gene expression databases

    BgeeiQ61456.
    CleanExiMM_CCNA1.
    GenevestigatoriQ61456.

    Interactioni

    Subunit structurei

    Interacts with INCA1 and KLHDC9 By similarity. Interacts with the CDK2 and CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNE1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi198544. 4 interactions.
    STRINGi10090.ENSMUSP00000029368.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61456.
    SMRiQ61456. Positions 166-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG5024.
    GeneTreeiENSGT00740000115500.
    HOGENOMiHOG000167672.
    HOVERGENiHBG106244.
    InParanoidiQ61456.
    KOiK06627.
    OMAiAEIRHRP.
    OrthoDBiEOG7G7KQ0.
    PhylomeDBiQ61456.
    TreeFamiTF101002.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    InterProiIPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR015453. Cyclin_A_chordates.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view]
    PANTHERiPTHR10177:SF68. PTHR10177:SF68. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    PROSITEiPS00292. CYCLINS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61456-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHRQSSKSGV ALPPVGQGPD ACQMLSRAQL GQDPPQRTVL GVLTENEQYR    50
    RTCGQEITAI RCFSGSENVF PAAGKKVLSD HGVNEPAKRG FDIYMDDPEQ 100
    GDRDTCSGKE GIIFEDVYEV DTSMLKSDLH FLLDFNTVSP MLVDPTTHAQ 150
    SEEATDFGSD VINVTEYAEE IHRYLREAEV RHRPKAHYMR KQPDITEGMR 200
    AILVDWLVEV GEEYKLRTET LYLAVNFLDR FLSCMSVLRG KLQLVGTAAI 250
    LLASKYEEIY PPDVDEFVYI TDDTYTKRQL LRMEHLLLKV LAFDLTVPTT 300
    NQFLLQYLRR QGVCIRTENL AKYVAELSLL EADPFLKYLP SLVAAAAYCL 350
    ANYIVNRHFW PETLAAFTGY SLNEIVPCLS ELHKACLSIP HRPQQAIREK 400
    YKASKYLHVS LMEPPVVLPL Q 421
    Length:421
    Mass (Da):47,772
    Last modified:July 1, 2008 - v2
    Checksum:iFF717D0065B954E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti176 – 1761R → P in CAA59053. (PubMed:8565853)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84311 mRNA. Translation: CAA59053.1.
    AK077114 mRNA. Translation: BAC36619.1.
    BC120518 mRNA. Translation: AAI20519.1.
    BC125436 mRNA. Translation: AAI25437.1.
    CCDSiCCDS17356.1.
    RefSeqiNP_031654.2. NM_007628.3.
    XP_006501011.1. XM_006500948.1.
    XP_006501012.1. XM_006500949.1.
    XP_006501013.1. XM_006500950.1.
    XP_006501014.1. XM_006500951.1.
    XP_006501015.1. XM_006500952.1.
    UniGeneiMm.4815.

    Genome annotation databases

    EnsembliENSMUST00000029368; ENSMUSP00000029368; ENSMUSG00000027793.
    GeneIDi12427.
    KEGGimmu:12427.
    UCSCiuc008pfy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84311 mRNA. Translation: CAA59053.1 .
    AK077114 mRNA. Translation: BAC36619.1 .
    BC120518 mRNA. Translation: AAI20519.1 .
    BC125436 mRNA. Translation: AAI25437.1 .
    CCDSi CCDS17356.1.
    RefSeqi NP_031654.2. NM_007628.3.
    XP_006501011.1. XM_006500948.1.
    XP_006501012.1. XM_006500949.1.
    XP_006501013.1. XM_006500950.1.
    XP_006501014.1. XM_006500951.1.
    XP_006501015.1. XM_006500952.1.
    UniGenei Mm.4815.

    3D structure databases

    ProteinModelPortali Q61456.
    SMRi Q61456. Positions 166-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198544. 4 interactions.
    STRINGi 10090.ENSMUSP00000029368.

    Proteomic databases

    PRIDEi Q61456.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029368 ; ENSMUSP00000029368 ; ENSMUSG00000027793 .
    GeneIDi 12427.
    KEGGi mmu:12427.
    UCSCi uc008pfy.2. mouse.

    Organism-specific databases

    CTDi 8900.
    MGIi MGI:108042. Ccna1.

    Phylogenomic databases

    eggNOGi COG5024.
    GeneTreei ENSGT00740000115500.
    HOGENOMi HOG000167672.
    HOVERGENi HBG106244.
    InParanoidi Q61456.
    KOi K06627.
    OMAi AEIRHRP.
    OrthoDBi EOG7G7KQ0.
    PhylomeDBi Q61456.
    TreeFami TF101002.

    Enzyme and pathway databases

    Reactomei REACT_188819. DNA Damage/Telomere Stress Induced Senescence.
    REACT_198608. G1/S-Specific Transcription.
    REACT_199110. G0 and Early G1.
    REACT_206033. Senescence-Associated Secretory Phenotype (SASP).
    REACT_206803. Cyclin A/B1 associated events during G2/M transition.
    REACT_206830. E2F mediated regulation of DNA replication.
    REACT_220647. SCF(Skp2)-mediated degradation of p27/p21.
    REACT_223647. Cyclin A:Cdk2-associated events at S phase entry.
    REACT_227891. G2 Phase.

    Miscellaneous databases

    NextBioi 281240.
    PROi Q61456.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61456.
    CleanExi MM_CCNA1.
    Genevestigatori Q61456.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    InterProi IPR013763. Cyclin-like.
    IPR014400. Cyclin_A/B/D/E/F.
    IPR015453. Cyclin_A_chordates.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    [Graphical view ]
    PANTHERi PTHR10177:SF68. PTHR10177:SF68. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001771. Cyclin_A_B_D_E. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    PROSITEi PS00292. CYCLINS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A distinct cyclin A is expressed in germ cells in the mouse."
      Sweeney C., Murphy M., Kubelka M., Ravnik S.E., Hawkins C.F., Wolgemuth D.J., Carrington M.
      Development 122:53-64(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Testis.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Cyclin A1 is required for meiosis in the male mouse."
      Liu D., Matzuk M.M., Sung W.K., Guo Q., Wang P., Wolgemuth D.J.
      Nat. Genet. 20:377-380(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage."
      Ravnik S.E., Wolgemuth D.J.
      Dev. Biol. 207:408-418(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
      Strain: Swiss Webster.
    6. "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
      Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
      Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH CDK2; CABLES1 AND CCNE1.

    Entry informationi

    Entry nameiCCNA1_MOUSE
    AccessioniPrimary (citable) accession number: Q61456
    Secondary accession number(s): Q8C5U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 1, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    CCNA1 -/- males are sterile due to a block of spermatogenesis before the first meiotic division, whereas females are normal.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3