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Q61453 (IL17_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17A

Short name=IL-17
Short name=IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name=CTLA-8
Gene names
Name:Il17a
Synonyms:Ctla8, Il17
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Induces stromal cells to produce proinflammatory and hematopoietic cytokines By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the IL-17 family.

Caution

Was originally (Ref.1) thought to be from mouse but, on the basis of subsequent work (Ref.2 and Ref.3) has been shown to be of rat origin.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to glucocorticoid stimulus

Inferred from mutant phenotype PubMed 20003332. Source: RGD

inflammatory response

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from direct assay PubMed 21043049. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 150133Interleukin-17A
PRO_0000015425

Amino acid modifications

Glycosylation631N-linked (GlcNAc...) Potential
Disulfide bond89 ↔ 139 By similarity
Disulfide bond94 ↔ 141 By similarity

Experimental info

Sequence conflict461I → L Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61453 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: EF13F33EDF9D689F

FASTA15016,877
        10         20         30         40         50         60 
MCLMLLLLLN LEATVKAAVL IPQSSVCPNA EANNFLQNVK VNLKVINSLS SKASSRRPSD 

        70         80         90        100        110        120 
YLNRSTSPWT LSRNEDPDRY PSVIWEAQCR HQRCVNAEGK LDHHMNSVLI QQEILVLKRE 

       130        140        150 
PEKCPFTFRV EKMLVGVGCT CVSSIVRHAS 

« Hide

References

[1]"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene."
Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., Golstein P.
J. Immunol. 150:5445-5456(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete nucleotide sequence of the mouse CTLA8 gene."
Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.
Gene 168:223-225(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: ORGANISM IDENTIFICATION.
[3]"Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells."
Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A.
J. Interferon Cytokine Res. 16:611-617(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], ORGANISM IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L13839 mRNA. Translation: AAA37490.1.
UniGeneRn.218513.

3D structure databases

ProteinModelPortalQ61453.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016664.

Proteomic databases

PRIDEQ61453.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

RGD2888. Il17a.

Phylogenomic databases

eggNOGNOG42989.
HOGENOMHOG000064520.
HOVERGENHBG006143.
InParanoidQ61453.
PhylomeDBQ61453.

Gene expression databases

GenevestigatorQ61453.

Family and domain databases

InterProIPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERPTHR21295. PTHR21295. 1 hit.
PfamPF06083. IL17. 1 hit.
[Graphical view]
PRINTSPR01932. INTRLEUKIN17.
ProtoNetSearch...

Entry information

Entry nameIL17_RAT
AccessionPrimary (citable) accession number: Q61453
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families