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Q61453

- IL17_RAT

UniProt

Q61453 - IL17_RAT

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Protein
Interleukin-17A
Gene
Il17a, Ctla8, Il17
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Induces stromal cells to produce proinflammatory and hematopoietic cytokines By similarity.

GO - Biological processi

  1. cellular response to glucocorticoid stimulus Source: RGD
  2. inflammatory response Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:Il17a
Synonyms:Ctla8, Il17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2888. Il17a.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 150133Interleukin-17A
PRO_0000015425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi89 ↔ 139 By similarity
Disulfide bondi94 ↔ 141 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61453.

Expressioni

Gene expression databases

GenevestigatoriQ61453.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016664.

Structurei

3D structure databases

ProteinModelPortaliQ61453.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42989.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ61453.
PhylomeDBiQ61453.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61453-1 [UniParc]FASTAAdd to Basket

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MCLMLLLLLN LEATVKAAVL IPQSSVCPNA EANNFLQNVK VNLKVINSLS    50
SKASSRRPSD YLNRSTSPWT LSRNEDPDRY PSVIWEAQCR HQRCVNAEGK 100
LDHHMNSVLI QQEILVLKRE PEKCPFTFRV EKMLVGVGCT CVSSIVRHAS 150
Length:150
Mass (Da):16,877
Last modified:November 1, 1996 - v1
Checksum:iEF13F33EDF9D689F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461I → L1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13839 mRNA. Translation: AAA37490.1.
UniGeneiRn.218513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13839 mRNA. Translation: AAA37490.1 .
UniGenei Rn.218513.

3D structure databases

ProteinModelPortali Q61453.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000016664.

Proteomic databases

PRIDEi Q61453.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 2888. Il17a.

Phylogenomic databases

eggNOGi NOG42989.
HOGENOMi HOG000064520.
HOVERGENi HBG006143.
InParanoidi Q61453.
PhylomeDBi Q61453.

Gene expression databases

Genevestigatori Q61453.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view ]
PANTHERi PTHR21295. PTHR21295. 1 hit.
Pfami PF06083. IL17. 1 hit.
[Graphical view ]
PRINTSi PR01932. INTRLEUKIN17.
SUPFAMi SSF57501. SSF57501. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene."
    Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., Golstein P.
    J. Immunol. 150:5445-5456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete nucleotide sequence of the mouse CTLA8 gene."
    Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.
    Gene 168:223-225(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ORGANISM IDENTIFICATION.
  3. "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells."
    Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A.
    J. Interferon Cytokine Res. 16:611-617(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ORGANISM IDENTIFICATION.

Entry informationi

Entry nameiIL17_RAT
AccessioniPrimary (citable) accession number: Q61453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally (1 Publication) thought to be from mouse but, on the basis of subsequent work (1 Publication and 1 Publication) has been shown to be of rat origin.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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