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Protein

Interleukin-17A

Gene

Il17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.By similarity

Caution

Was originally thought to be from mouse but, on the basis of subsequent work (PubMed:8654948 and PubMed:8877732) has been shown to be of rat origin.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to glucocorticoid stimulus Source: RGD
  • inflammatory response Source: InterPro
  • positive regulation of necrotic cell death Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: RGD
  • response to amino acid Source: RGD

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:Il17a
Synonyms:Ctla8, Il17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2888 Il17a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000001542518 – 150Interleukin-17AAdd BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 139By similarity
Disulfide bondi94 ↔ 141By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ61453
PRIDEiQ61453

Interactioni

Subunit structurei

Homodimer. Heterodimer with IL17F.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016664

Structurei

3D structure databases

ProteinModelPortaliQ61453
SMRiQ61453
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J12P Eukaryota
ENOG410YS4N LUCA
HOGENOMiHOG000064520
HOVERGENiHBG006143
InParanoidiQ61453
PhylomeDBiQ61453

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020440 IL-17_chr
IPR010345 IL-17_fam
PfamiView protein in Pfam
PF06083 IL17, 1 hit
PRINTSiPR01932 INTRLEUKIN17
SUPFAMiSSF57501 SSF57501, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61453-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLMLLLLLN LEATVKAAVL IPQSSVCPNA EANNFLQNVK VNLKVINSLS
60 70 80 90 100
SKASSRRPSD YLNRSTSPWT LSRNEDPDRY PSVIWEAQCR HQRCVNAEGK
110 120 130 140 150
LDHHMNSVLI QQEILVLKRE PEKCPFTFRV EKMLVGVGCT CVSSIVRHAS
Length:150
Mass (Da):16,877
Last modified:November 1, 1996 - v1
Checksum:iEF13F33EDF9D689F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46I → L (PubMed:8877732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13839 mRNA Translation: AAA37490.1
UniGeneiRn.218513

Similar proteinsi

Entry informationi

Entry nameiIL17_RAT
AccessioniPrimary (citable) accession number: Q61453
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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