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Protein

Interleukin-17A

Gene

Il17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Induces stromal cells to produce proinflammatory and hematopoietic cytokines.By similarity

GO - Molecular functioni

  1. cytokine activity Source: RGD

GO - Biological processi

  1. cellular response to glucocorticoid stimulus Source: RGD
  2. inflammatory response Source: InterPro
  3. positive regulation of necrotic cell death Source: RGD
  4. positive regulation of transcription from RNA polymerase II promoter Source: RGD
  5. response to amino acid Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17A
Short name:
IL-17
Short name:
IL-17A
Alternative name(s):
Cytotoxic T-lymphocyte-associated antigen 8
Short name:
CTLA-8
Gene namesi
Name:Il17a
Synonyms:Ctla8, Il17
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2888. Il17a.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 150133Interleukin-17APRO_0000015425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 139By similarity
Disulfide bondi94 ↔ 141By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ61453.

Expressioni

Gene expression databases

GenevestigatoriQ61453.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016664.

Structurei

3D structure databases

ProteinModelPortaliQ61453.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-17 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42989.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ61453.
PhylomeDBiQ61453.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61453-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCLMLLLLLN LEATVKAAVL IPQSSVCPNA EANNFLQNVK VNLKVINSLS
60 70 80 90 100
SKASSRRPSD YLNRSTSPWT LSRNEDPDRY PSVIWEAQCR HQRCVNAEGK
110 120 130 140 150
LDHHMNSVLI QQEILVLKRE PEKCPFTFRV EKMLVGVGCT CVSSIVRHAS
Length:150
Mass (Da):16,877
Last modified:November 1, 1996 - v1
Checksum:iEF13F33EDF9D689F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461I → L(PubMed:8877732)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13839 mRNA. Translation: AAA37490.1.
UniGeneiRn.218513.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13839 mRNA. Translation: AAA37490.1.
UniGeneiRn.218513.

3D structure databases

ProteinModelPortaliQ61453.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016664.

Proteomic databases

PRIDEiQ61453.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi2888. Il17a.

Phylogenomic databases

eggNOGiNOG42989.
HOGENOMiHOG000064520.
HOVERGENiHBG006143.
InParanoidiQ61453.
PhylomeDBiQ61453.

Gene expression databases

GenevestigatoriQ61453.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR020440. IL-17_chr.
IPR010345. IL-17_fam.
[Graphical view]
PANTHERiPTHR21295. PTHR21295. 1 hit.
PfamiPF06083. IL17. 1 hit.
[Graphical view]
PRINTSiPR01932. INTRLEUKIN17.
SUPFAMiSSF57501. SSF57501. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene."
    Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., Golstein P.
    J. Immunol. 150:5445-5456(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete nucleotide sequence of the mouse CTLA8 gene."
    Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.
    Gene 168:223-225(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: ORGANISM IDENTIFICATION.
  3. "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells."
    Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A.
    J. Interferon Cytokine Res. 16:611-617(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ORGANISM IDENTIFICATION.

Entry informationi

Entry nameiIL17_RAT
AccessioniPrimary (citable) accession number: Q61453
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to be from mouse but, on the basis of subsequent work (PubMed:8654948 and PubMed:8877732) has been shown to be of rat origin.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.