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Q61453

- IL17_RAT

UniProt

Q61453 - IL17_RAT

Protein

Interleukin-17A

Gene

Il17a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Induces stromal cells to produce proinflammatory and hematopoietic cytokines.By similarity

    GO - Biological processi

    1. cellular response to glucocorticoid stimulus Source: RGD
    2. inflammatory response Source: InterPro

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-17A
    Short name:
    IL-17
    Short name:
    IL-17A
    Alternative name(s):
    Cytotoxic T-lymphocyte-associated antigen 8
    Short name:
    CTLA-8
    Gene namesi
    Name:Il17a
    Synonyms:Ctla8, Il17
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2888. Il17a.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 150133Interleukin-17APRO_0000015425Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi63 – 631N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 139By similarity
    Disulfide bondi94 ↔ 141By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ61453.

    Expressioni

    Gene expression databases

    GenevestigatoriQ61453.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000016664.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61453.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-17 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42989.
    HOGENOMiHOG000064520.
    HOVERGENiHBG006143.
    InParanoidiQ61453.
    PhylomeDBiQ61453.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view]
    PANTHERiPTHR21295. PTHR21295. 1 hit.
    PfamiPF06083. IL17. 1 hit.
    [Graphical view]
    PRINTSiPR01932. INTRLEUKIN17.
    SUPFAMiSSF57501. SSF57501. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61453-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCLMLLLLLN LEATVKAAVL IPQSSVCPNA EANNFLQNVK VNLKVINSLS    50
    SKASSRRPSD YLNRSTSPWT LSRNEDPDRY PSVIWEAQCR HQRCVNAEGK 100
    LDHHMNSVLI QQEILVLKRE PEKCPFTFRV EKMLVGVGCT CVSSIVRHAS 150
    Length:150
    Mass (Da):16,877
    Last modified:November 1, 1996 - v1
    Checksum:iEF13F33EDF9D689F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461I → L(PubMed:8877732)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13839 mRNA. Translation: AAA37490.1.
    UniGeneiRn.218513.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13839 mRNA. Translation: AAA37490.1 .
    UniGenei Rn.218513.

    3D structure databases

    ProteinModelPortali Q61453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000016664.

    Proteomic databases

    PRIDEi Q61453.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 2888. Il17a.

    Phylogenomic databases

    eggNOGi NOG42989.
    HOGENOMi HOG000064520.
    HOVERGENi HBG006143.
    InParanoidi Q61453.
    PhylomeDBi Q61453.

    Gene expression databases

    Genevestigatori Q61453.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR020440. IL-17_chr.
    IPR010345. IL-17_fam.
    [Graphical view ]
    PANTHERi PTHR21295. PTHR21295. 1 hit.
    Pfami PF06083. IL17. 1 hit.
    [Graphical view ]
    PRINTSi PR01932. INTRLEUKIN17.
    SUPFAMi SSF57501. SSF57501. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene."
      Rouvier E., Luciani M.-F., Mattei M.-G., Denizot F., Golstein P.
      J. Immunol. 150:5445-5456(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete nucleotide sequence of the mouse CTLA8 gene."
      Yao Z., Timour M., Painter S., Fanslow W., Spriggs M.K.
      Gene 168:223-225(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: ORGANISM IDENTIFICATION.
    3. "Mouse IL-17: a cytokine preferentially expressed by alpha beta TCR + CD4-CD8-T cells."
      Kennedy J., Rossi D.L., Zurawski S.M., Vega F. Jr., Kastelein R.A., Wagner J.L., Hannum C.H., Zlotnik A.
      J. Interferon Cytokine Res. 16:611-617(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ORGANISM IDENTIFICATION.

    Entry informationi

    Entry nameiIL17_RAT
    AccessioniPrimary (citable) accession number: Q61453
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    Was originally thought to be from mouse but, on the basis of subsequent work (PubMed:8654948 and PubMed:8877732) has been shown to be of rat origin.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3