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Protein

Leukocyte surface antigen CD53

Gene

Cd53

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte surface antigen CD53
Alternative name(s):
Cell surface glycoprotein CD53
CD_antigen: CD53
Gene namesi
Name:Cd53
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:88341. Cd53.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 11CytoplasmicSequence analysis10
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 54ExtracellularSequence analysisAdd BLAST22
Transmembranei55 – 69HelicalSequence analysisAdd BLAST15
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 106HelicalSequence analysisAdd BLAST26
Topological domaini107 – 181ExtracellularSequence analysisAdd BLAST75
Transmembranei182 – 206HelicalSequence analysisAdd BLAST25
Topological domaini207 – 219CytoplasmicSequence analysisAdd BLAST13

GO - Cellular componenti

  • cell-cell junction Source: UniProtKB
  • cell surface Source: Ensembl
  • extracellular exosome Source: MGI
  • immunological synapse Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002192132 – 219Leukocyte surface antigen CD53Add BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ61451.
PRIDEiQ61451.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040747.
CleanExiMM_CD53.
ExpressionAtlasiQ61451. baseline and differential.
GenevisibleiQ61451. MM.

Interactioni

Subunit structurei

Interacts with SCIMP.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035781.

Structurei

3D structure databases

ProteinModelPortaliQ61451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00880000137858.
HOGENOMiHOG000230651.
HOVERGENiHBG002324.
InParanoidiQ61451.
KOiK06489.
OMAiVCVIQVL.
OrthoDBiEOG091G0CQO.
PhylomeDBiQ61451.
TreeFamiTF352892.

Family and domain databases

Gene3Di1.10.1450.10. 1 hit.
InterProiView protein in InterPro
IPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
PfamiView protein in Pfam
PF00335. Tetraspannin. 1 hit.
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiView protein in PROSITE
PS00421. TM4_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61451-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSSLKLLK YVLFIFNLLF WVCGCCILGF GIYFLVQNTY GVLFRNLPFL
60 70 80 90 100
TLGNILVIVG SIIMVVAFLG CMGSIKENKC LLMSFFVLLL IILLAEVTIA
110 120 130 140 150
ILLFVYEQKL NTLVAEGLND SIQHYHSDNS TMKAWDFIQT QLQCCGVNGS
160 170 180 190 200
SDWTSGPPSS CPSGADVQGC YNKAKSWFHS NFLYIGIITI CVCVIQVLGM
210
SFALTLNCQI DKTSQALGL
Length:219
Mass (Da):24,164
Last modified:January 23, 2007 - v2
Checksum:i7995D2E745A17AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97227 mRNA. Translation: CAA65864.1.
Z16078 Genomic DNA. Translation: CAA78892.1.
BC021310 mRNA. Translation: AAH21310.1.
BC052905 mRNA. Translation: AAH52905.1.
CCDSiCCDS17728.1.
RefSeqiNP_031677.1. NM_007651.3.
UniGeneiMm.316861.

Genome annotation databases

EnsembliENSMUST00000038845; ENSMUSP00000035781; ENSMUSG00000040747.
GeneIDi12508.
KEGGimmu:12508.
UCSCiuc008qwm.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD53_MOUSE
AccessioniPrimary (citable) accession number: Q61451
Secondary accession number(s): Q61721
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families