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Q61423

- KCNA4_MOUSE

UniProt

Q61423 - KCNA4_MOUSE

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Protein

Potassium voltage-gated channel subfamily A member 4

Gene

Kcna4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

GO - Molecular functioni

  1. potassium ion binding Source: InterPro
  2. voltage-gated potassium channel activity Source: InterPro

GO - Biological processi

  1. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_199077. Voltage gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily A member 4
Alternative name(s):
Voltage-gated potassium channel subunit Kv1.4
Gene namesi
Name:Kcna4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96661. Kcna4.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: MGI
  2. voltage-gated potassium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 654654Potassium voltage-gated channel subfamily A member 4PRO_0000053982Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi353 – 3531N-linked (GlcNAc...)Sequence Analysis
Modified residuei600 – 6001Phosphoserine; by PKASequence Analysis
Glycosylationi643 – 6431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ61423.
PRIDEiQ61423.

PTM databases

PhosphoSiteiQ61423.

Expressioni

Gene expression databases

BgeeiQ61423.
GenevestigatoriQ61423.

Interactioni

Subunit structurei

Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4. Interacts with SIGMAR1 By similarity. Part of a complex containing KCNA1, KCNAB1 and LGI1 By similarity.By similarity

Protein-protein interaction databases

BioGridi200879. 1 interaction.
IntActiQ61423. 1 interaction.
MINTiMINT-1780501.
STRINGi10090.ENSMUSP00000106689.

Structurei

3D structure databases

ProteinModelPortaliQ61423.
SMRiQ61423. Positions 1-75, 176-572.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei309 – 32719Helical; Name=Segment S1Sequence AnalysisAdd
BLAST
Transmembranei372 – 39322Helical; Name=Segment S2Sequence AnalysisAdd
BLAST
Transmembranei405 – 42521Helical; Name=Segment S3Sequence AnalysisAdd
BLAST
Transmembranei444 – 46219Helical; Voltage-sensor; Name=Segment S4Sequence AnalysisAdd
BLAST
Transmembranei479 – 49820Helical; Name=Segment S5Sequence AnalysisAdd
BLAST
Transmembranei540 – 56223Helical; Name=Segment S6Sequence AnalysisAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi525 – 5306Selectivity filterBy similarity
Motifi652 – 6543PDZ-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi38 – 5013Poly-AlaAdd
BLAST
Compositional biasi62 – 654Poly-His
Compositional biasi83 – 897Poly-Arg
Compositional biasi123 – 13715Poly-GluAdd
BLAST
Compositional biasi162 – 1665Poly-Gly
Compositional biasi434 – 4374Poly-Gln

Domaini

The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
GeneTreeiENSGT00760000118846.
HOGENOMiHOG000231015.
HOVERGENiHBG052230.
InParanoidiQ61423.
KOiK04877.
OMAiKKAHHRQ.
OrthoDBiEOG7M0NRD.
TreeFamiTF313103.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
1.20.5.600. 1 hit.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR020467. K_chnl_volt-dep_Kv1.4.
IPR012897. K_chnl_volt-dep_Kv1.4_TID.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF07941. K_channel_TID. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01511. KV14CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61423-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVAMVSAES SGCNSHMPYG YAAQARARER ERLAHSRAAA AAAVAAATAA
60 70 80 90 100
VEGTGGSGGG PHHHHQTRGA YSSHDPQGSR GSRRRRRQRT EKKKLHHRQS
110 120 130 140 150
SFPHCSDLMP SGSEEKILRE LSEEEEDEEE EEEEEEEGRF YYSEEDHGDG
160 170 180 190 200
CSYTDLLPQD DGGGGGYSSV RYSDCCERVV INVSGLRFET QMKTLAQFPE
210 220 230 240 250
TLLGDPEKRT QYFDPLRNEY FFDRNRPSFD AILYYYQSGG RLKRPVNVPF
260 270 280 290 300
DIFTEEVKFY QLGEEALLKF REDEGFVREE EDRALPENEF KKQIWLLFEY
310 320 330 340 350
PESSSPARGI AIVSVLVILI SIVIFCLETL PEFRDDRDLI MALSAGGHSR
360 370 380 390 400
LLNDTSAPHL ENSGHTIFND PFFIVETVCI VWFSFEFVVR CFACPSQALF
410 420 430 440 450
FKNIMNIIDI VSILPYFITL GTDLAQQQGG GNGQQQQAMS FAILRIIRLV
460 470 480 490 500
RVFRIFKLSR HSKGLQILGH TLRASMRELG LLIFFLFIGV ILFSSAVYFA
510 520 530 540 550
EADEPTTHFQ SIPDAFWWAV VTMTTVGYGD MKPITVGGKI VGSLCAIAGV
560 570 580 590 600
LTIALPVPVI VSNFNYFYHR ETENEEQTQL TQNAVSCPYL PSNLLKKFRS
610 620 630 640 650
STSSSLGDKS EYLEMEEGVK ESLCGKEEKC QGKGDESETD KNNCSNAKAV

ETDV
Length:654
Mass (Da):73,470
Last modified:July 27, 2011 - v2
Checksum:i9322A3DC9CBA2AC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601D → E in AAB60668. (PubMed:8020965)Curated
Sequence conflicti395 – 3951P → T in AAB60668. (PubMed:8020965)Curated
Sequence conflicti636 – 6361E → D in AAB60668. (PubMed:8020965)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03723 Genomic DNA. Translation: AAB60668.1.
AK036112 mRNA. Translation: BAC29309.1.
BX293548 Genomic DNA. Translation: CAM23761.1.
CH466519 Genomic DNA. Translation: EDL27774.1.
BC109014 mRNA. Translation: AAI09015.1.
CCDSiCCDS16505.1.
PIRiS09045.
RefSeqiNP_067250.2. NM_021275.4.
XP_006498875.1. XM_006498812.1.
UniGeneiMm.142718.

Genome annotation databases

EnsembliENSMUST00000037012; ENSMUSP00000037958; ENSMUSG00000042604.
GeneIDi16492.
KEGGimmu:16492.
UCSCiuc008llu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03723 Genomic DNA. Translation: AAB60668.1 .
AK036112 mRNA. Translation: BAC29309.1 .
BX293548 Genomic DNA. Translation: CAM23761.1 .
CH466519 Genomic DNA. Translation: EDL27774.1 .
BC109014 mRNA. Translation: AAI09015.1 .
CCDSi CCDS16505.1.
PIRi S09045.
RefSeqi NP_067250.2. NM_021275.4.
XP_006498875.1. XM_006498812.1.
UniGenei Mm.142718.

3D structure databases

ProteinModelPortali Q61423.
SMRi Q61423. Positions 1-75, 176-572.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200879. 1 interaction.
IntActi Q61423. 1 interaction.
MINTi MINT-1780501.
STRINGi 10090.ENSMUSP00000106689.

Chemistry

GuidetoPHARMACOLOGYi 541.

PTM databases

PhosphoSitei Q61423.

Proteomic databases

PaxDbi Q61423.
PRIDEi Q61423.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037012 ; ENSMUSP00000037958 ; ENSMUSG00000042604 .
GeneIDi 16492.
KEGGi mmu:16492.
UCSCi uc008llu.2. mouse.

Organism-specific databases

CTDi 3739.
MGIi MGI:96661. Kcna4.

Phylogenomic databases

eggNOGi COG1226.
GeneTreei ENSGT00760000118846.
HOGENOMi HOG000231015.
HOVERGENi HBG052230.
InParanoidi Q61423.
KOi K04877.
OMAi KKAHHRQ.
OrthoDBi EOG7M0NRD.
TreeFami TF313103.

Enzyme and pathway databases

Reactomei REACT_199077. Voltage gated Potassium channels.

Miscellaneous databases

NextBioi 289795.
PROi Q61423.
SOURCEi Search...

Gene expression databases

Bgeei Q61423.
Genevestigatori Q61423.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
1.20.5.600. 1 hit.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003091. K_chnl.
IPR003968. K_chnl_volt-dep_Kv.
IPR003972. K_chnl_volt-dep_Kv1.
IPR020467. K_chnl_volt-dep_Kv1.4.
IPR012897. K_chnl_volt-dep_Kv1.4_TID.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view ]
PANTHERi PTHR11537. PTHR11537. 1 hit.
Pfami PF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF07941. K_channel_TID. 1 hit.
[Graphical view ]
PRINTSi PR00169. KCHANNEL.
PR01511. KV14CHANNEL.
PR01491. KVCHANNEL.
PR01496. SHAKERCHANEL.
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13."
    Wymore R.S., Korenberg J.R., Kinoshita K.D., Aiyar J., Coyne C., Chen X.N., Hustad C.M., Copeland N.G., Gutman G.A., Jenkins N.A., Chandy K.G.
    Genomics 20:191-202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: AKR.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiKCNA4_MOUSE
AccessioniPrimary (citable) accession number: Q61423
Secondary accession number(s): Q8CBF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3