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Protein

CMP-sialic acid transporter

Gene

Slc35a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transport CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.
R-MMU-727802. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-sialic acid transporter
Short name:
CMP-SA-Tr
Short name:
CMP-Sia-Tr
Alternative name(s):
Solute carrier family 35 member A1
Gene namesi
Name:Slc35a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1345622. Slc35a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9CytoplasmicSequence analysis9
Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 45LumenalSequence analysisAdd BLAST15
Transmembranei46 – 64HelicalSequence analysisAdd BLAST19
Topological domaini65 – 87CytoplasmicSequence analysisAdd BLAST23
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 113LumenalSequence analysis5
Transmembranei114 – 135HelicalSequence analysisAdd BLAST22
Topological domaini136 – 141CytoplasmicSequence analysis6
Transmembranei142 – 160HelicalSequence analysisAdd BLAST19
Topological domaini161 – 175LumenalSequence analysisAdd BLAST15
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 212CytoplasmicSequence analysisAdd BLAST16
Transmembranei213 – 228HelicalSequence analysisAdd BLAST16
Topological domaini229 – 243LumenalSequence analysisAdd BLAST15
Transmembranei244 – 262HelicalSequence analysisAdd BLAST19
Topological domaini263 – 272CytoplasmicSequence analysis10
Transmembranei273 – 291HelicalSequence analysisAdd BLAST19
Topological domaini292 – 296LumenalSequence analysis5
Transmembranei297 – 315HelicalSequence analysisAdd BLAST19
Topological domaini316 – 336CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002133521 – 336CMP-sialic acid transporterAdd BLAST336

Proteomic databases

MaxQBiQ61420.
PaxDbiQ61420.
PRIDEiQ61420.

PTM databases

iPTMnetiQ61420.
PhosphoSitePlusiQ61420.

Expressioni

Tissue specificityi

Found in all the tissues examined including skeletal muscle, brain, heart, liver, kidney and spleen.

Gene expression databases

BgeeiENSMUSG00000028293.
ExpressionAtlasiQ61420. baseline and differential.
GenevisibleiQ61420. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029970.

Structurei

3D structure databases

ProteinModelPortaliQ61420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000216649.
HOVERGENiHBG054025.
InParanoidiQ61420.
KOiK15272.
OMAiVCIAEVI.
OrthoDBiEOG091G0CHS.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPARENVSL FFKLYCLTVM TLVAAAYTVA LRYTRTTAEE LYFSTTAVCI
60 70 80 90 100
TEVIKLLISV GLLAKETGSL GRFKASLSEN VLGSPKELAK LSVPSLVYAV
110 120 130 140 150
QNNMAFLALS NLDAAVYQVT YQLKIPCTAL CTVLMLNRTL SKLQWISVFM
160 170 180 190 200
LCGGVTLVQW KPAQATKVVV AQNPLLGFGA IAIAVLCSGF AGVYFEKVLK
210 220 230 240 250
SSDTSLWVRN IQMYLSGIVV TLAGTYLSDG AEIQEKGFFY GYTYYVWFVI
260 270 280 290 300
FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVLL FGLQITLSFA
310 320 330
LGALLVCVSI YLYGLPRQDT TSIQQEATSK ERIIGV
Length:336
Mass (Da):36,453
Last modified:July 27, 2011 - v2
Checksum:iA396528233904451
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18T → A in CAA95855 (PubMed:8755516).Curated1
Sequence conflicti18T → A in AAH12252 (PubMed:15489334).Curated1
Sequence conflicti166T → S in CAA95855 (PubMed:8755516).Curated1
Sequence conflicti166T → S in AAH12252 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71268 mRNA. Translation: CAA95855.1.
AL928738 Genomic DNA. Translation: CAM26875.1.
BC012252 mRNA. Translation: AAH12252.1.
CCDSiCCDS18030.1.
RefSeqiNP_036025.2. NM_011895.3.
UniGeneiMm.281885.

Genome annotation databases

EnsembliENSMUST00000029970; ENSMUSP00000029970; ENSMUSG00000028293.
GeneIDi24060.
KEGGimmu:24060.
UCSCiuc012dbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71268 mRNA. Translation: CAA95855.1.
AL928738 Genomic DNA. Translation: CAM26875.1.
BC012252 mRNA. Translation: AAH12252.1.
CCDSiCCDS18030.1.
RefSeqiNP_036025.2. NM_011895.3.
UniGeneiMm.281885.

3D structure databases

ProteinModelPortaliQ61420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029970.

Protein family/group databases

TCDBi2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ61420.
PhosphoSitePlusiQ61420.

Proteomic databases

MaxQBiQ61420.
PaxDbiQ61420.
PRIDEiQ61420.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029970; ENSMUSP00000029970; ENSMUSG00000028293.
GeneIDi24060.
KEGGimmu:24060.
UCSCiuc012dbo.1. mouse.

Organism-specific databases

CTDi10559.
MGIiMGI:1345622. Slc35a1.

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000216649.
HOVERGENiHBG054025.
InParanoidiQ61420.
KOiK15272.
OMAiVCIAEVI.
OrthoDBiEOG091G0CHS.
TreeFamiTF315345.

Enzyme and pathway databases

ReactomeiR-MMU-4085001. Sialic acid metabolism.
R-MMU-727802. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSiSlc35a1. mouse.
PROiQ61420.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028293.
ExpressionAtlasiQ61420. baseline and differential.
GenevisibleiQ61420. MM.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS35A1_MOUSE
AccessioniPrimary (citable) accession number: Q61420
Secondary accession number(s): A2AT44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.