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Q61420 (S35A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CMP-sialic acid transporter

Short name=CMP-SA-Tr
Short name=CMP-Sia-Tr
Alternative name(s):
Solute carrier family 35 member A1
Gene names
Name:Slc35a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length336 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transport CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function.

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein Ref.4.

Tissue specificity

Found in all the tissues examined including skeletal muscle, brain, heart, liver, kidney and spleen.

Sequence similarities

Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 336336CMP-sialic acid transporter
PRO_0000213352

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 4515Lumenal Potential
Transmembrane46 – 6419Helical; Potential
Topological domain65 – 8723Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 1135Lumenal Potential
Transmembrane114 – 13522Helical; Potential
Topological domain136 – 1416Cytoplasmic Potential
Transmembrane142 – 16019Helical; Potential
Topological domain161 – 17515Lumenal Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 21216Cytoplasmic Potential
Transmembrane213 – 22816Helical; Potential
Topological domain229 – 24315Lumenal Potential
Transmembrane244 – 26219Helical; Potential
Topological domain263 – 27210Cytoplasmic Potential
Transmembrane273 – 29119Helical; Potential
Topological domain292 – 2965Lumenal Potential
Transmembrane297 – 31519Helical; Potential
Topological domain316 – 33621Cytoplasmic Potential

Experimental info

Sequence conflict181T → A in CAA95855. Ref.1
Sequence conflict181T → A in AAH12252. Ref.3
Sequence conflict1661T → S in CAA95855. Ref.1
Sequence conflict1661T → S in AAH12252. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q61420 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: A396528233904451

FASTA33636,453
        10         20         30         40         50         60 
MAPARENVSL FFKLYCLTVM TLVAAAYTVA LRYTRTTAEE LYFSTTAVCI TEVIKLLISV 

        70         80         90        100        110        120 
GLLAKETGSL GRFKASLSEN VLGSPKELAK LSVPSLVYAV QNNMAFLALS NLDAAVYQVT 

       130        140        150        160        170        180 
YQLKIPCTAL CTVLMLNRTL SKLQWISVFM LCGGVTLVQW KPAQATKVVV AQNPLLGFGA 

       190        200        210        220        230        240 
IAIAVLCSGF AGVYFEKVLK SSDTSLWVRN IQMYLSGIVV TLAGTYLSDG AEIQEKGFFY 

       250        260        270        280        290        300 
GYTYYVWFVI FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVLL FGLQITLSFA 

       310        320        330 
LGALLVCVSI YLYGLPRQDT TSIQQEATSK ERIIGV 

« Hide

References

« Hide 'large scale' references
[1]"Expression cloning of the Golgi CMP-sialic acid transporter."
Eckhardt M., Muehlenhoff M., Bethe A., Gerardy-Schahn R.
Proc. Natl. Acad. Sci. U.S.A. 93:7572-7576(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[4]"Membrane topology of the mammalian CMP-sialic acid transporter."
Eckhardt M., Gotza B., Gerardy-Schahn R.
J. Biol. Chem. 274:8779-8787(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z71268 mRNA. Translation: CAA95855.1.
AL928738 Genomic DNA. Translation: CAM26875.1.
BC012252 mRNA. Translation: AAH12252.1.
CCDSCCDS18030.1.
RefSeqNP_036025.2. NM_011895.3.
UniGeneMm.281885.

3D structure databases

ProteinModelPortalQ61420.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

MaxQBQ61420.
PaxDbQ61420.
PRIDEQ61420.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029970; ENSMUSP00000029970; ENSMUSG00000028293.
GeneID24060.
KEGGmmu:24060.
UCSCuc012dbo.1. mouse.

Organism-specific databases

CTD10559.
MGIMGI:1345622. Slc35a1.

Phylogenomic databases

eggNOGCOG0697.
GeneTreeENSGT00550000074563.
HOGENOMHOG000216649.
HOVERGENHBG054025.
KOK15272.
OMAFYGYTHY.
OrthoDBEOG7NCV4D.
TreeFamTF315345.

Gene expression databases

BgeeQ61420.
GenevestigatorQ61420.

Family and domain databases

InterProIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERPTHR10231. PTHR10231. 1 hit.
PfamPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsTIGR00803. nst. 1 hit.
ProtoNetSearch...

Other

ChiTaRSSLC35A1. mouse.
NextBio304021.
PROQ61420.
SOURCESearch...

Entry information

Entry nameS35A1_MOUSE
AccessionPrimary (citable) accession number: Q61420
Secondary accession number(s): A2AT44
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot