Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q61420

- S35A1_MOUSE

UniProt

Q61420 - S35A1_MOUSE

Protein

CMP-sialic acid transporter

Gene

Slc35a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transport CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function.

    GO - Molecular functioni

    1. nucleotide-sugar transmembrane transporter activity Source: InterPro
    2. sugar:proton symporter activity Source: InterPro

    GO - Biological processi

    1. nucleotide-sugar transport Source: InterPro

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_202500. Sialic acid metabolism.
    REACT_203051. Transport of nucleotide sugars.

    Protein family/group databases

    TCDBi2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CMP-sialic acid transporter
    Short name:
    CMP-SA-Tr
    Short name:
    CMP-Sia-Tr
    Alternative name(s):
    Solute carrier family 35 member A1
    Gene namesi
    Name:Slc35a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1345622. Slc35a1.

    Subcellular locationi

    Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 336336CMP-sialic acid transporterPRO_0000213352Add
    BLAST

    Proteomic databases

    MaxQBiQ61420.
    PaxDbiQ61420.
    PRIDEiQ61420.

    Expressioni

    Tissue specificityi

    Found in all the tissues examined including skeletal muscle, brain, heart, liver, kidney and spleen.

    Gene expression databases

    BgeeiQ61420.
    GenevestigatoriQ61420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61420.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini31 – 4515LumenalSequence AnalysisAdd
    BLAST
    Topological domaini65 – 8723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 1135LumenalSequence Analysis
    Topological domaini136 – 1416CytoplasmicSequence Analysis
    Topological domaini161 – 17515LumenalSequence AnalysisAdd
    BLAST
    Topological domaini197 – 21216CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini229 – 24315LumenalSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27210CytoplasmicSequence Analysis
    Topological domaini292 – 2965LumenalSequence Analysis
    Topological domaini316 – 33621CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 3021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13522HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei213 – 22816HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei273 – 29119HelicalSequence AnalysisAdd
    BLAST
    Transmembranei297 – 31519HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00550000074563.
    HOGENOMiHOG000216649.
    HOVERGENiHBG054025.
    KOiK15272.
    OMAiFYGYTHY.
    OrthoDBiEOG7NCV4D.
    TreeFamiTF315345.

    Family and domain databases

    InterProiIPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view]
    PANTHERiPTHR10231. PTHR10231. 1 hit.
    PfamiPF04142. Nuc_sug_transp. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsiTIGR00803. nst. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q61420-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPARENVSL FFKLYCLTVM TLVAAAYTVA LRYTRTTAEE LYFSTTAVCI    50
    TEVIKLLISV GLLAKETGSL GRFKASLSEN VLGSPKELAK LSVPSLVYAV 100
    QNNMAFLALS NLDAAVYQVT YQLKIPCTAL CTVLMLNRTL SKLQWISVFM 150
    LCGGVTLVQW KPAQATKVVV AQNPLLGFGA IAIAVLCSGF AGVYFEKVLK 200
    SSDTSLWVRN IQMYLSGIVV TLAGTYLSDG AEIQEKGFFY GYTYYVWFVI 250
    FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVLL FGLQITLSFA 300
    LGALLVCVSI YLYGLPRQDT TSIQQEATSK ERIIGV 336
    Length:336
    Mass (Da):36,453
    Last modified:July 27, 2011 - v2
    Checksum:iA396528233904451
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181T → A in CAA95855. (PubMed:8755516)Curated
    Sequence conflicti18 – 181T → A in AAH12252. (PubMed:15489334)Curated
    Sequence conflicti166 – 1661T → S in CAA95855. (PubMed:8755516)Curated
    Sequence conflicti166 – 1661T → S in AAH12252. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71268 mRNA. Translation: CAA95855.1.
    AL928738 Genomic DNA. Translation: CAM26875.1.
    BC012252 mRNA. Translation: AAH12252.1.
    CCDSiCCDS18030.1.
    RefSeqiNP_036025.2. NM_011895.3.
    UniGeneiMm.281885.

    Genome annotation databases

    EnsembliENSMUST00000029970; ENSMUSP00000029970; ENSMUSG00000028293.
    GeneIDi24060.
    KEGGimmu:24060.
    UCSCiuc012dbo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z71268 mRNA. Translation: CAA95855.1 .
    AL928738 Genomic DNA. Translation: CAM26875.1 .
    BC012252 mRNA. Translation: AAH12252.1 .
    CCDSi CCDS18030.1.
    RefSeqi NP_036025.2. NM_011895.3.
    UniGenei Mm.281885.

    3D structure databases

    ProteinModelPortali Q61420.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

    Proteomic databases

    MaxQBi Q61420.
    PaxDbi Q61420.
    PRIDEi Q61420.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029970 ; ENSMUSP00000029970 ; ENSMUSG00000028293 .
    GeneIDi 24060.
    KEGGi mmu:24060.
    UCSCi uc012dbo.1. mouse.

    Organism-specific databases

    CTDi 10559.
    MGIi MGI:1345622. Slc35a1.

    Phylogenomic databases

    eggNOGi COG0697.
    GeneTreei ENSGT00550000074563.
    HOGENOMi HOG000216649.
    HOVERGENi HBG054025.
    KOi K15272.
    OMAi FYGYTHY.
    OrthoDBi EOG7NCV4D.
    TreeFami TF315345.

    Enzyme and pathway databases

    Reactomei REACT_202500. Sialic acid metabolism.
    REACT_203051. Transport of nucleotide sugars.

    Miscellaneous databases

    ChiTaRSi SLC35A1. mouse.
    NextBioi 304021.
    PROi Q61420.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61420.
    Genevestigatori Q61420.

    Family and domain databases

    InterProi IPR007271. Nuc_sug_transpt.
    IPR021189. UDP/CMP-sugar_transptr.
    IPR004689. UDPgal_transpt.
    [Graphical view ]
    PANTHERi PTHR10231. PTHR10231. 1 hit.
    Pfami PF04142. Nuc_sug_transp. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
    TIGRFAMsi TIGR00803. nst. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    4. "Membrane topology of the mammalian CMP-sialic acid transporter."
      Eckhardt M., Gotza B., Gerardy-Schahn R.
      J. Biol. Chem. 274:8779-8787(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

    Entry informationi

    Entry nameiS35A1_MOUSE
    AccessioniPrimary (citable) accession number: Q61420
    Secondary accession number(s): A2AT44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3