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Q61420

- S35A1_MOUSE

UniProt

Q61420 - S35A1_MOUSE

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Protein

CMP-sialic acid transporter

Gene

Slc35a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Transport CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function.

GO - Molecular functioni

  1. nucleotide-sugar transmembrane transporter activity Source: InterPro
  2. sugar:proton symporter activity Source: InterPro

GO - Biological processi

  1. nucleotide-sugar transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_202500. Sialic acid metabolism.
REACT_203051. Transport of nucleotide sugars.

Protein family/group databases

TCDBi2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
CMP-sialic acid transporter
Short name:
CMP-SA-Tr
Short name:
CMP-Sia-Tr
Alternative name(s):
Solute carrier family 35 member A1
Gene namesi
Name:Slc35a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1345622. Slc35a1.

Subcellular locationi

Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 99CytoplasmicSequence Analysis
Transmembranei10 – 3021HelicalSequence AnalysisAdd
BLAST
Topological domaini31 – 4515LumenalSequence AnalysisAdd
BLAST
Transmembranei46 – 6419HelicalSequence AnalysisAdd
BLAST
Topological domaini65 – 8723CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence AnalysisAdd
BLAST
Topological domaini109 – 1135LumenalSequence Analysis
Transmembranei114 – 13522HelicalSequence AnalysisAdd
BLAST
Topological domaini136 – 1416CytoplasmicSequence Analysis
Transmembranei142 – 16019HelicalSequence AnalysisAdd
BLAST
Topological domaini161 – 17515LumenalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 21216CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei213 – 22816HelicalSequence AnalysisAdd
BLAST
Topological domaini229 – 24315LumenalSequence AnalysisAdd
BLAST
Transmembranei244 – 26219HelicalSequence AnalysisAdd
BLAST
Topological domaini263 – 27210CytoplasmicSequence Analysis
Transmembranei273 – 29119HelicalSequence AnalysisAdd
BLAST
Topological domaini292 – 2965LumenalSequence Analysis
Transmembranei297 – 31519HelicalSequence AnalysisAdd
BLAST
Topological domaini316 – 33621CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 336336CMP-sialic acid transporterPRO_0000213352Add
BLAST

Proteomic databases

MaxQBiQ61420.
PaxDbiQ61420.
PRIDEiQ61420.

Expressioni

Tissue specificityi

Found in all the tissues examined including skeletal muscle, brain, heart, liver, kidney and spleen.

Gene expression databases

BgeeiQ61420.
GenevestigatoriQ61420.

Structurei

3D structure databases

ProteinModelPortaliQ61420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000216649.
HOVERGENiHBG054025.
InParanoidiQ61420.
KOiK15272.
OMAiFYGYTHY.
OrthoDBiEOG7NCV4D.
TreeFamiTF315345.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 1 hit.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsiTIGR00803. nst. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61420-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPARENVSL FFKLYCLTVM TLVAAAYTVA LRYTRTTAEE LYFSTTAVCI
60 70 80 90 100
TEVIKLLISV GLLAKETGSL GRFKASLSEN VLGSPKELAK LSVPSLVYAV
110 120 130 140 150
QNNMAFLALS NLDAAVYQVT YQLKIPCTAL CTVLMLNRTL SKLQWISVFM
160 170 180 190 200
LCGGVTLVQW KPAQATKVVV AQNPLLGFGA IAIAVLCSGF AGVYFEKVLK
210 220 230 240 250
SSDTSLWVRN IQMYLSGIVV TLAGTYLSDG AEIQEKGFFY GYTYYVWFVI
260 270 280 290 300
FLASVGGLYT SVVVKYTDNI MKGFSAAAAI VLSTIASVLL FGLQITLSFA
310 320 330
LGALLVCVSI YLYGLPRQDT TSIQQEATSK ERIIGV
Length:336
Mass (Da):36,453
Last modified:July 27, 2011 - v2
Checksum:iA396528233904451
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181T → A in CAA95855. (PubMed:8755516)Curated
Sequence conflicti18 – 181T → A in AAH12252. (PubMed:15489334)Curated
Sequence conflicti166 – 1661T → S in CAA95855. (PubMed:8755516)Curated
Sequence conflicti166 – 1661T → S in AAH12252. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71268 mRNA. Translation: CAA95855.1.
AL928738 Genomic DNA. Translation: CAM26875.1.
BC012252 mRNA. Translation: AAH12252.1.
CCDSiCCDS18030.1.
RefSeqiNP_036025.2. NM_011895.3.
UniGeneiMm.281885.

Genome annotation databases

EnsembliENSMUST00000029970; ENSMUSP00000029970; ENSMUSG00000028293.
GeneIDi24060.
KEGGimmu:24060.
UCSCiuc012dbo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z71268 mRNA. Translation: CAA95855.1 .
AL928738 Genomic DNA. Translation: CAM26875.1 .
BC012252 mRNA. Translation: AAH12252.1 .
CCDSi CCDS18030.1.
RefSeqi NP_036025.2. NM_011895.3.
UniGenei Mm.281885.

3D structure databases

ProteinModelPortali Q61420.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.7.12.1. the drug/metabolite transporter (dmt) superfamily.

Proteomic databases

MaxQBi Q61420.
PaxDbi Q61420.
PRIDEi Q61420.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029970 ; ENSMUSP00000029970 ; ENSMUSG00000028293 .
GeneIDi 24060.
KEGGi mmu:24060.
UCSCi uc012dbo.1. mouse.

Organism-specific databases

CTDi 10559.
MGIi MGI:1345622. Slc35a1.

Phylogenomic databases

eggNOGi COG0697.
GeneTreei ENSGT00550000074563.
HOGENOMi HOG000216649.
HOVERGENi HBG054025.
InParanoidi Q61420.
KOi K15272.
OMAi FYGYTHY.
OrthoDBi EOG7NCV4D.
TreeFami TF315345.

Enzyme and pathway databases

Reactomei REACT_202500. Sialic acid metabolism.
REACT_203051. Transport of nucleotide sugars.

Miscellaneous databases

ChiTaRSi Slc35a1. mouse.
NextBioi 304021.
PROi Q61420.
SOURCEi Search...

Gene expression databases

Bgeei Q61420.
Genevestigatori Q61420.

Family and domain databases

InterProi IPR007271. Nuc_sug_transpt.
IPR021189. UDP/CMP-sugar_transptr.
IPR004689. UDPgal_transpt.
[Graphical view ]
PANTHERi PTHR10231. PTHR10231. 1 hit.
Pfami PF04142. Nuc_sug_transp. 1 hit.
[Graphical view ]
PIRSFi PIRSF005799. UDP-gal_transpt. 1 hit.
TIGRFAMsi TIGR00803. nst. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  4. "Membrane topology of the mammalian CMP-sialic acid transporter."
    Eckhardt M., Gotza B., Gerardy-Schahn R.
    J. Biol. Chem. 274:8779-8787(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MEMBRANE TOPOLOGY.

Entry informationi

Entry nameiS35A1_MOUSE
AccessioniPrimary (citable) accession number: Q61420
Secondary accession number(s): A2AT44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3