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Protein

Keratin, type I cytoskeletal 15

Gene

Krt15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5.2 Publications

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 15
Alternative name(s):
Cytokeratin-15
Short name:
CK-15
Keratin-15
Short name:
K15
Gene namesi
Name:Krt15
Synonyms:Krt1-15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96689. Krt15.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636581 – 452Keratin, type I cytoskeletal 15Add BLAST452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei294PhosphothreonineBy similarity1
Modified residuei316PhosphothreonineBy similarity1
Modified residuei425PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ61414.
PRIDEiQ61414.

PTM databases

iPTMnetiQ61414.
PhosphoSitePlusiQ61414.

Expressioni

Tissue specificityi

Expressed strongly in the basal cell layer at the tips of rete-like prominences (RLPs) of adult dorsal tongue, outer root sheath (ORS) of hair follicle and skin epidermis (at protein level).2 Publications

Developmental stagei

In neonatal mice, additional expression seen in the basal layer of the cornea, forestomach and esophagus (at protein level).1 Publication

Inductioni

During wound healing expression is suppressed by TGF-beta, TNF-alpha and to a lesser extent by epidermal and keratinocyte growth factors (EGF and KGF respectively).1 Publication

Gene expression databases

BgeeiENSMUSG00000054146.
CleanExiMM_KRT15.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201020. 5 interactors.
IntActiQ61414. 1 interactor.
MINTiMINT-1866664.
STRINGi10090.ENSMUSP00000103034.

Structurei

3D structure databases

ProteinModelPortaliQ61414.
SMRiQ61414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97HeadAdd BLAST97
Regioni98 – 406RodAdd BLAST309
Regioni98 – 133Coil 1AAdd BLAST36
Regioni134 – 152Linker 1Add BLAST19
Regioni153 – 244Coil 1BAdd BLAST92
Regioni245 – 264Linker 12Add BLAST20
Regioni265 – 406Coil 2Add BLAST142
Regioni407 – 452TailAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 39Poly-Gly4
Compositional biasi421 – 424Poly-Gly4
Compositional biasi425 – 430Poly-Ser6

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61414.
KOiK07604.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTFLQTSS TFGGSSTRGA SLRAGGGSFG GGSLYGGGGS RSISASSARF
60 70 80 90 100
VSSGAGGGFG GGMSCGFGGG FGGGFGGGFG GGFGDFGGGD GGLLSGNEKV
110 120 130 140 150
TMQNLNDRLA SYLDKVRALE QANTELEVKI RDWYQKQSPA SPDRDYSHYF
160 170 180 190 200
KTMEEIRDKI LAATIDNSRV VLEIDNARLA ADDFRLKYEN ELTLRQGVEA
210 220 230 240 250
DINGLRRVLD ELTLARTDLE MQIEQLNEEL AYLKKNHEEE MKEFSSQLAG
260 270 280 290 300
QVNVEMDAAP GVDLTRMLAE MREQYEAIAE KNRRDVEAWF FSKTEELNKE
310 320 330 340 350
VASNTEMIQT SKTEITDLRR TLQGLEIELQ SQLSMKAGLE NSLAEVECRY
360 370 380 390 400
ATQLQQIQGV ITGLETQLSE LRCEMEAQNQ EYNMLLDIKT RLEQEIATYR
410 420 430 440 450
NLLEGQDAKM AGIGVREGSS GGGGSSSSSS NFHISVEESV DGKVVSSRKR

EI
Length:452
Mass (Da):49,138
Last modified:December 6, 2005 - v2
Checksum:i4FFBE25AC60E79BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti372 – 374RCE → HSQ in BAA03821 (PubMed:7510260).Curated3
Sequence conflicti405G → D in BAA03821 (PubMed:7510260).Curated1
Sequence conflicti417E → EVSLG in AAH57934 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16313 Genomic DNA. Translation: BAA03821.1.
BC057934 mRNA. Translation: AAH57934.1.
PIRiI49595.
RefSeqiNP_032495.2. NM_008469.2.
UniGeneiMm.440010.

Genome annotation databases

GeneIDi16665.
KEGGimmu:16665.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16313 Genomic DNA. Translation: BAA03821.1.
BC057934 mRNA. Translation: AAH57934.1.
PIRiI49595.
RefSeqiNP_032495.2. NM_008469.2.
UniGeneiMm.440010.

3D structure databases

ProteinModelPortaliQ61414.
SMRiQ61414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201020. 5 interactors.
IntActiQ61414. 1 interactor.
MINTiMINT-1866664.
STRINGi10090.ENSMUSP00000103034.

PTM databases

iPTMnetiQ61414.
PhosphoSitePlusiQ61414.

Proteomic databases

PaxDbiQ61414.
PRIDEiQ61414.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16665.
KEGGimmu:16665.

Organism-specific databases

CTDi3866.
MGIiMGI:96689. Krt15.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ61414.
KOiK07604.

Miscellaneous databases

PROiQ61414.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054146.
CleanExiMM_KRT15.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C15_MOUSE
AccessioniPrimary (citable) accession number: Q61414
Secondary accession number(s): Q6PEQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.