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Protein

Visual system homeobox 2

Gene

Vsx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi148 – 20760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: MGI
  • cell fate commitment Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • retinal bipolar neuron differentiation Source: MGI
  • retina morphogenesis in camera-type eye Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Visual system homeobox 2
Alternative name(s):
Ceh-10 homeodomain-containing homolog
Homeobox protein CHX10
Gene namesi
Name:Vsx2
Synonyms:Chx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88401. Vsx2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • intracellular Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Vsx2 are the cause of ocular retardation (OR(J)), a mouse disease characterized by microphthalmia, progressive destruction of the retina, and absence of the optic nerve. The OR(J) mutation is due to an OCHR (STOP) mutation.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Visual system homeobox 2PRO_0000049363Add
BLAST

Proteomic databases

PaxDbiQ61412.
PRIDEiQ61412.

PTM databases

iPTMnetiQ61412.
PhosphoSiteiQ61412.

Expressioni

Tissue specificityi

Expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup. In the mature retina Is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin. Also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord.

Developmental stagei

Detected by embryonic day 25, by which time the optic cup has formed and the ganglion cell layer can be distinguished. A rapid increase to levels 3- to 4-fold greater than those seen in adult retina occurs in the period from birth (P0) to postnatal day 6 (P6). During this interval, the horizontal, bipolar, amacrine, and cone cells arise from the neuroretinal layer, the inner nuclear layer, and outer nuclear layer separate, and the outer plexiform layer begins to form. Levels begin to decrease by P8, when the rod outer segments are Still differentiating, and reaches its lowest levels in adult retina.

Gene expression databases

BgeeiENSMUSG00000021239.
CleanExiMM_VSX2.
ExpressionAtlasiQ61412. baseline and differential.
GenevisibleiQ61412. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Rb1P134052EBI-1208174,EBI-971782
RBL2Q089994EBI-1208174,EBI-971439From a different organism.

Protein-protein interaction databases

BioGridi198710. 2 interactions.
IntActiQ61412. 3 interactions.
STRINGi10090.ENSMUSP00000021665.

Structurei

3D structure databases

ProteinModelPortaliQ61412.
SMRiQ61412. Positions 155-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini208 – 26154CVCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi304 – 31714OARPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 114103Pro-richAdd
BLAST
Compositional biasi117 – 13822Ser/Thr-richAdd
BLAST
Compositional biasi335 – 34612Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 CVC domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0494. Eukaryota.
ENOG410ZN24. LUCA.
HOVERGENiHBG036251.
InParanoidiQ61412.
KOiK09336.
PhylomeDBiQ61412.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR023339. CVC.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51496. CVC. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR
60 70 80 90 100
AALDGLAPGH LLAARSVLSP AGVGSMGLLG PGGLPGFYTQ PTFLEVLSDP
110 120 130 140 150
QSVHLQPLGR ASGPLDTSQT ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR
160 170 180 190 200
HRTIFTSYQL EELEKAFNEA HYPDVYAREM LAMKTELPED RIQVWFQNRR
210 220 230 240 250
AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA KDGIMDSCAP
260 270 280 290 300
WLLGMHKKSL EAAAESGRKP EVERQALPKL DKMEQEERAP EAQAAISQEE
310 320 330 340 350
LRENSIAALR AKAQEHSTKV LGTVSGPDSL ARNAEKPEEE DATEEDRPAE
360
KLSPPQLEDM A
Length:361
Mass (Da):39,436
Last modified:November 1, 1996 - v1
Checksum:i2DB7FF7F8C7BE0AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34808 mRNA. Translation: AAA60431.1.
BC031869 mRNA. Translation: AAH31869.1.
CCDSiCCDS36493.1.
PIRiI49594.
RefSeqiNP_031727.1. NM_007701.3.
UniGeneiMm.4405.

Genome annotation databases

EnsembliENSMUST00000021665; ENSMUSP00000021665; ENSMUSG00000021239.
GeneIDi12677.
KEGGimmu:12677.
UCSCiuc007ofm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34808 mRNA. Translation: AAA60431.1.
BC031869 mRNA. Translation: AAH31869.1.
CCDSiCCDS36493.1.
PIRiI49594.
RefSeqiNP_031727.1. NM_007701.3.
UniGeneiMm.4405.

3D structure databases

ProteinModelPortaliQ61412.
SMRiQ61412. Positions 155-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198710. 2 interactions.
IntActiQ61412. 3 interactions.
STRINGi10090.ENSMUSP00000021665.

PTM databases

iPTMnetiQ61412.
PhosphoSiteiQ61412.

Proteomic databases

PaxDbiQ61412.
PRIDEiQ61412.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021665; ENSMUSP00000021665; ENSMUSG00000021239.
GeneIDi12677.
KEGGimmu:12677.
UCSCiuc007ofm.2. mouse.

Organism-specific databases

CTDi338917.
MGIiMGI:88401. Vsx2.

Phylogenomic databases

eggNOGiKOG0494. Eukaryota.
ENOG410ZN24. LUCA.
HOVERGENiHBG036251.
InParanoidiQ61412.
KOiK09336.
PhylomeDBiQ61412.

Miscellaneous databases

ChiTaRSiVsx2. mouse.
PROiQ61412.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021239.
CleanExiMM_VSX2.
ExpressionAtlasiQ61412. baseline and differential.
GenevisibleiQ61412. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR023339. CVC.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51496. CVC. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVSX2_MOUSE
AccessioniPrimary (citable) accession number: Q61412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.