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Protein

Visual system homeobox 2

Gene

Vsx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi148 – 207HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: MGI
  • cell fate commitment Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • retinal bipolar neuron differentiation Source: MGI
  • retina morphogenesis in camera-type eye Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Visual system homeobox 2
Alternative name(s):
Ceh-10 homeodomain-containing homolog
Homeobox protein CHX10
Gene namesi
Name:Vsx2
Synonyms:Chx10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:88401. Vsx2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Vsx2 are the cause of ocular retardation (OR(J)), a mouse disease characterized by microphthalmia, progressive destruction of the retina, and absence of the optic nerve. The OR(J) mutation is due to an OCHR (STOP) mutation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493631 – 361Visual system homeobox 2Add BLAST361

Proteomic databases

PaxDbiQ61412.
PRIDEiQ61412.

PTM databases

iPTMnetiQ61412.
PhosphoSitePlusiQ61412.

Expressioni

Tissue specificityi

Expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup. In the mature retina Is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin. Also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord.

Developmental stagei

Detected by embryonic day 25, by which time the optic cup has formed and the ganglion cell layer can be distinguished. A rapid increase to levels 3- to 4-fold greater than those seen in adult retina occurs in the period from birth (P0) to postnatal day 6 (P6). During this interval, the horizontal, bipolar, amacrine, and cone cells arise from the neuroretinal layer, the inner nuclear layer, and outer nuclear layer separate, and the outer plexiform layer begins to form. Levels begin to decrease by P8, when the rod outer segments are Still differentiating, and reaches its lowest levels in adult retina.

Gene expression databases

BgeeiENSMUSG00000021239.
CleanExiMM_VSX2.
ExpressionAtlasiQ61412. baseline and differential.
GenevisibleiQ61412. MM.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi198710. 2 interactors.
IntActiQ61412. 3 interactors.
STRINGi10090.ENSMUSP00000021665.

Structurei

3D structure databases

ProteinModelPortaliQ61412.
SMRiQ61412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 261CVCPROSITE-ProRule annotationAdd BLAST54

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi304 – 317OARPROSITE-ProRule annotationAdd BLAST14

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 114Pro-richAdd BLAST103
Compositional biasi117 – 138Ser/Thr-richAdd BLAST22
Compositional biasi335 – 346Asp/Glu-rich (acidic)Add BLAST12

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0494. Eukaryota.
ENOG410ZN24. LUCA.
GeneTreeiENSGT00820000126963.
HOVERGENiHBG036251.
InParanoidiQ61412.
KOiK09336.
PhylomeDBiQ61412.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR023339. CVC.
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR003654. OAR_dom.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS51496. CVC. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q61412-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR
60 70 80 90 100
AALDGLAPGH LLAARSVLSP AGVGSMGLLG PGGLPGFYTQ PTFLEVLSDP
110 120 130 140 150
QSVHLQPLGR ASGPLDTSQT ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR
160 170 180 190 200
HRTIFTSYQL EELEKAFNEA HYPDVYAREM LAMKTELPED RIQVWFQNRR
210 220 230 240 250
AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA KDGIMDSCAP
260 270 280 290 300
WLLGMHKKSL EAAAESGRKP EVERQALPKL DKMEQEERAP EAQAAISQEE
310 320 330 340 350
LRENSIAALR AKAQEHSTKV LGTVSGPDSL ARNAEKPEEE DATEEDRPAE
360
KLSPPQLEDM A
Length:361
Mass (Da):39,436
Last modified:November 1, 1996 - v1
Checksum:i2DB7FF7F8C7BE0AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34808 mRNA. Translation: AAA60431.1.
BC031869 mRNA. Translation: AAH31869.1.
CCDSiCCDS36493.1.
PIRiI49594.
RefSeqiNP_031727.1. NM_007701.3.
UniGeneiMm.4405.

Genome annotation databases

EnsembliENSMUST00000021665; ENSMUSP00000021665; ENSMUSG00000021239.
GeneIDi12677.
KEGGimmu:12677.
UCSCiuc007ofm.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiVSX2_MOUSE
AccessioniPrimary (citable) accession number: Q61412
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families