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Q613L4

- HDA4_CAEBR

UniProt

Q613L4 - HDA4_CAEBR

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Protein

Histone deacetylase 4

Gene
hda-4, CBG16328
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei628 – 6281 By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Gene namesi
Name:hda-4
ORF Names:CBG16328
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG16328; CBP23360; WBGene00036299; Cbr-hda-4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Histone deacetylase 4PRO_0000114741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG16328.

Structurei

3D structure databases

ProteinModelPortaliQ613L4.
SMRiQ613L4. Positions 478-866.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni481 – 822342Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 10647Gln-richAdd
BLAST
Compositional biasi877 – 89216Gln-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000112870.
KOiK11406.
OMAiNGFACIR.
OrthoDBiEOG7RFTH5.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q613L4-1 [UniParc]FASTAAdd to Basket

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MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN    50
LEPERIAVLQ TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ 100
QLQSLQERSG INPMLISQTS EDATSGPAAP LSLANSLTNL LSSSNGNLSN 150
LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD LPRTNSTTIS QLTKDRLKNM 200
IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP HFEPYRLPTS 250
LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ 300
FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA 350
FQNLNLPIGQ DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS 400
SSASNSSLAS NASLGSHQYQ SLLKQQIRDL VLRRKSLVRE DPEGEGMAES 450
YNGLFSHAKL QQLTALAMES GFNPKLEPTF STGLGYDPLM ARHECVCSNN 500
SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ MVHSQTYTTF 550
FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA 600
GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL 650
QAKYPVQCAK IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG 700
TGSVTEIGKG AGKGFSVNIP FSGGVMKDAE YLAAWRTVVE PVLASFCPDF 750
ILVSAGFDAC HGHVNALGGY EITPEMFGYM TKCLLSYANG KVVLALEGGY 800
NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL ETLQKVIAIH 850
KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ 892
Length:892
Mass (Da):97,039
Last modified:November 23, 2004 - v1
Checksum:i0BF5A1AABCF1106A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600961 Genomic DNA. Translation: CAP34128.1.
RefSeqiXP_002643599.1. XM_002643553.1.

Genome annotation databases

EnsemblMetazoaiCBG16328; CBG16328; CBG16328.
GeneIDi8585593.
KEGGicbr:CBG16328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600961 Genomic DNA. Translation: CAP34128.1 .
RefSeqi XP_002643599.1. XM_002643553.1.

3D structure databases

ProteinModelPortali Q613L4.
SMRi Q613L4. Positions 478-866.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG16328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG16328 ; CBG16328 ; CBG16328 .
GeneIDi 8585593.
KEGGi cbr:CBG16328.

Organism-specific databases

CTDi 8585593.
WormBasei CBG16328 ; CBP23360 ; WBGene00036299 ; Cbr-hda-4.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000112870.
KOi K11406.
OMAi NGFACIR.
OrthoDBi EOG7RFTH5.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiHDA4_CAEBR
AccessioniPrimary (citable) accession number: Q613L4
Secondary accession number(s): A8XNN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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