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Q613L4

- HDA4_CAEBR

UniProt

Q613L4 - HDA4_CAEBR

Protein

Histone deacetylase 4

Gene

hda-4

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.By similarity

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei628 – 6281By similarity

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylase 4 (EC:3.5.1.98)
    Gene namesi
    Name:hda-4
    ORF Names:CBG16328
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG16328; CBP23360; WBGene00036299; Cbr-hda-4.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Histone deacetylase 4PRO_0000114741Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG16328.

    Structurei

    3D structure databases

    ProteinModelPortaliQ613L4.
    SMRiQ613L4. Positions 478-866.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni481 – 822342Histone deacetylaseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi60 – 10647Gln-richAdd
    BLAST
    Compositional biasi877 – 89216Gln-richAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0123.
    HOGENOMiHOG000112870.
    KOiK11406.
    OMAiNGFACIR.
    OrthoDBiEOG7RFTH5.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q613L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN    50
    LEPERIAVLQ TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ 100
    QLQSLQERSG INPMLISQTS EDATSGPAAP LSLANSLTNL LSSSNGNLSN 150
    LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD LPRTNSTTIS QLTKDRLKNM 200
    IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP HFEPYRLPTS 250
    LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ 300
    FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA 350
    FQNLNLPIGQ DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS 400
    SSASNSSLAS NASLGSHQYQ SLLKQQIRDL VLRRKSLVRE DPEGEGMAES 450
    YNGLFSHAKL QQLTALAMES GFNPKLEPTF STGLGYDPLM ARHECVCSNN 500
    SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ MVHSQTYTTF 550
    FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA 600
    GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL 650
    QAKYPVQCAK IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG 700
    TGSVTEIGKG AGKGFSVNIP FSGGVMKDAE YLAAWRTVVE PVLASFCPDF 750
    ILVSAGFDAC HGHVNALGGY EITPEMFGYM TKCLLSYANG KVVLALEGGY 800
    NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL ETLQKVIAIH 850
    KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ 892
    Length:892
    Mass (Da):97,039
    Last modified:November 23, 2004 - v1
    Checksum:i0BF5A1AABCF1106A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600961 Genomic DNA. Translation: CAP34128.1.
    RefSeqiXP_002643599.1. XM_002643553.1.

    Genome annotation databases

    EnsemblMetazoaiCBG16328; CBG16328; CBG16328.
    GeneIDi8585593.
    KEGGicbr:CBG16328.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600961 Genomic DNA. Translation: CAP34128.1 .
    RefSeqi XP_002643599.1. XM_002643553.1.

    3D structure databases

    ProteinModelPortali Q613L4.
    SMRi Q613L4. Positions 478-866.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG16328.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG16328 ; CBG16328 ; CBG16328 .
    GeneIDi 8585593.
    KEGGi cbr:CBG16328.

    Organism-specific databases

    CTDi 8585593.
    WormBasei CBG16328 ; CBP23360 ; WBGene00036299 ; Cbr-hda-4.

    Phylogenomic databases

    eggNOGi COG0123.
    HOGENOMi HOG000112870.
    KOi K11406.
    OMAi NGFACIR.
    OrthoDBi EOG7RFTH5.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiHDA4_CAEBR
    AccessioniPrimary (citable) accession number: Q613L4
    Secondary accession number(s): A8XNN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3