Q613L4 (HDA4_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone deacetylase 4
EC=3.5.1.98

Gene names

Name:	hda-4
ORF Names:	CBG16328

Organism

Caenorhabditis briggsae

Taxonomic identifier

6238 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	892 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.
Catalytic activity	Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone deacetylase family. HD type 2 subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Molecular function	Chromatin regulator Hydrolase Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H3-K9 specific) Inferred from electronic annotation. Source: EC NAD-dependent histone deacetylase activity (H4-K16 specific) Inferred from electronic annotation. Source: EC histone deacetylase activity (H3-K16 specific) Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 892	892	Histone deacetylase 4		PRO_0000114741
Regions
	Region	481 – 822	342	Histone deacetylase
	Compositional bias	60 – 106	47	Gln-rich
	Compositional bias	877 – 892	16	Gln-rich
Sites
	Active site	628	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q613L4 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 0BF5A1AABCF1106A	FASTA	892	97,039
	10 20 30 40 50 60 MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN LEPERIAVLQ 70 80 90 100 110 120 TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ QLQSLQERSG INPMLISQTS 130 140 150 160 170 180 EDATSGPAAP LSLANSLTNL LSSSNGNLSN LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD 190 200 210 220 230 240 LPRTNSTTIS QLTKDRLKNM IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP 250 260 270 280 290 300 HFEPYRLPTS LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ 310 320 330 340 350 360 FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA FQNLNLPIGQ 370 380 390 400 410 420 DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS SSASNSSLAS NASLGSHQYQ 430 440 450 460 470 480 SLLKQQIRDL VLRRKSLVRE DPEGEGMAES YNGLFSHAKL QQLTALAMES GFNPKLEPTF 490 500 510 520 530 540 STGLGYDPLM ARHECVCSNN SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ 550 560 570 580 590 600 MVHSQTYTTF FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA 610 620 630 640 650 660 GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL QAKYPVQCAK 670 680 690 700 710 720 IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG TGSVTEIGKG AGKGFSVNIP 730 740 750 760 770 780 FSGGVMKDAE YLAAWRTVVE PVLASFCPDF ILVSAGFDAC HGHVNALGGY EITPEMFGYM 790 800 810 820 830 840 TKCLLSYANG KVVLALEGGY NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL 850 860 870 880 890 ETLQKVIAIH KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ

References

[1]

"The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics." Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N., Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P., Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W., Hillier L.W. , Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A., Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E., Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K., Durbin R.M., Waterston R.H. PLoS Biol. 1:166-192(2003) [PubMed: 14624247] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AF16.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CAAC02000532 Genomic DNA. Translation: CAP34128.1.
RefSeq	XP_002643599.1. XM_002643553.1.
3D structure databases
ProteinModelPortal	Q613L4.
SMR	Q613L4. Positions 478-866.
ModBase	Search...
Protein-protein interaction databases
STRING	Q613L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8585593.
KEGG	cbr:CBG16328.
Organism-specific databases
CTD	8585593.
WormBase	CBG16328; CBP23360; WBGene00036299.
Phylogenomic databases
HOGENOM	HBG388504.
OMA	NGFACIR.
PhylomeDB	Q613L4.
Family and domain databases
InterPro	IPR000286. His_deacetylse. IPR023801. His_deacetylse_dom. [Graphical view]
Gene3D	G3DSA:3.40.800.20. His_deacetylse. 1 hit.
KO	K11406.
PANTHER	PTHR10625. His_deacetylse. 1 hit.
Pfam	PF00850. Hist_deacetyl. 1 hit. [Graphical view]
PRINTS	PR01270. HDASUPER.
ProtoNet	Search...

Entry information

Entry name

HDA4_CAEBR

Accession

Primary (citable) accession number: Q613L4
Secondary accession number(s): A8XNN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project