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Q613L4 (HDA4_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 4

EC=3.5.1.98
Gene names
Name:hda-4
ORF Names:CBG16328
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length892 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 892892Histone deacetylase 4
PRO_0000114741

Regions

Region481 – 822342Histone deacetylase
Compositional bias60 – 10647Gln-rich
Compositional bias877 – 89216Gln-rich

Sites

Active site6281 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q613L4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 0BF5A1AABCF1106A

FASTA89297,039
        10         20         30         40         50         60 
MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN LEPERIAVLQ 

        70         80         90        100        110        120 
TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ QLQSLQERSG INPMLISQTS 

       130        140        150        160        170        180 
EDATSGPAAP LSLANSLTNL LSSSNGNLSN LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD 

       190        200        210        220        230        240 
LPRTNSTTIS QLTKDRLKNM IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP 

       250        260        270        280        290        300 
HFEPYRLPTS LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ 

       310        320        330        340        350        360 
FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA FQNLNLPIGQ 

       370        380        390        400        410        420 
DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS SSASNSSLAS NASLGSHQYQ 

       430        440        450        460        470        480 
SLLKQQIRDL VLRRKSLVRE DPEGEGMAES YNGLFSHAKL QQLTALAMES GFNPKLEPTF 

       490        500        510        520        530        540 
STGLGYDPLM ARHECVCSNN SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ 

       550        560        570        580        590        600 
MVHSQTYTTF FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA 

       610        620        630        640        650        660 
GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL QAKYPVQCAK 

       670        680        690        700        710        720 
IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG TGSVTEIGKG AGKGFSVNIP 

       730        740        750        760        770        780 
FSGGVMKDAE YLAAWRTVVE PVLASFCPDF ILVSAGFDAC HGHVNALGGY EITPEMFGYM 

       790        800        810        820        830        840 
TKCLLSYANG KVVLALEGGY NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL 

       850        860        870        880        890 
ETLQKVIAIH KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600961 Genomic DNA. Translation: CAP34128.1.
RefSeqXP_002643599.1. XM_002643553.1.

3D structure databases

ProteinModelPortalQ613L4.
SMRQ613L4. Positions 478-866.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG16328.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG16328; CBG16328; CBG16328.
GeneID8585593.
KEGGcbr:CBG16328.

Organism-specific databases

CTD8585593.
WormBaseCBG16328; CBP23360; WBGene00036299; Cbr-hda-4.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000112870.
KOK11406.
OMANGFACIR.
OrthoDBEOG7RFTH5.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Entry information

Entry nameHDA4_CAEBR
AccessionPrimary (citable) accession number: Q613L4
Secondary accession number(s): A8XNN9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families