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Protein

Histone deacetylase 4

Gene

hda-4

Organism
Caenorhabditis briggsae
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei628By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Gene namesi
Name:hda-4
ORF Names:CBG16328
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000008549 Componentsi: Chromosome X, Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG16328 ; CBP46312 ; WBGene00036299 ; Cbr-hda-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147411 – 892Histone deacetylase 4Add BLAST892

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi6238.CBG16328

Structurei

3D structure databases

ProteinModelPortaliQ613L4
SMRiQ613L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni481 – 822Histone deacetylaseAdd BLAST342

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi60 – 106Gln-richAdd BLAST47
Compositional biasi877 – 892Gln-richAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
HOGENOMiHOG000112870
InParanoidiQ613L4
KOiK11406
OMAiNGFACIR
OrthoDBiEOG091G0EQO

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

Q613L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN
60 70 80 90 100
LEPERIAVLQ TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ
110 120 130 140 150
QLQSLQERSG INPMLISQTS EDATSGPAAP LSLANSLTNL LSSSNGNLSN
160 170 180 190 200
LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD LPRTNSTTIS QLTKDRLKNM
210 220 230 240 250
IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP HFEPYRLPTS
260 270 280 290 300
LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ
310 320 330 340 350
FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA
360 370 380 390 400
FQNLNLPIGQ DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS
410 420 430 440 450
SSASNSSLAS NASLGSHQYQ SLLKQQIRDL VLRRKSLVRE DPEGEGMAES
460 470 480 490 500
YNGLFSHAKL QQLTALAMES GFNPKLEPTF STGLGYDPLM ARHECVCSNN
510 520 530 540 550
SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ MVHSQTYTTF
560 570 580 590 600
FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA
610 620 630 640 650
GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL
660 670 680 690 700
QAKYPVQCAK IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG
710 720 730 740 750
TGSVTEIGKG AGKGFSVNIP FSGGVMKDAE YLAAWRTVVE PVLASFCPDF
760 770 780 790 800
ILVSAGFDAC HGHVNALGGY EITPEMFGYM TKCLLSYANG KVVLALEGGY
810 820 830 840 850
NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL ETLQKVIAIH
860 870 880 890
KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ
Length:892
Mass (Da):97,039
Last modified:November 23, 2004 - v1
Checksum:i0BF5A1AABCF1106A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE600961 Genomic DNA Translation: CAP34128.1
RefSeqiXP_002643599.1, XM_002643553.1

Genome annotation databases

GeneIDi8585593
KEGGicbr:CBG16328

Similar proteinsi

Entry informationi

Entry nameiHDA4_CAEBR
AccessioniPrimary (citable) accession number: Q613L4
Secondary accession number(s): A8XNN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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