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Q613L4

- HDA4_CAEBR

UniProt

Q613L4 - HDA4_CAEBR

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Protein

Histone deacetylase 4

Gene

hda-4

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei628 – 6281By similarity

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 4 (EC:3.5.1.98)
Gene namesi
Name:hda-4
ORF Names:CBG16328
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome X, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG16328; CBP23360; WBGene00036299; Cbr-hda-4.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Histone deacetylase 4PRO_0000114741Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG16328.

Structurei

3D structure databases

ProteinModelPortaliQ613L4.
SMRiQ613L4. Positions 478-866.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni481 – 822342Histone deacetylaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 10647Gln-richAdd
BLAST
Compositional biasi877 – 89216Gln-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
HOGENOMiHOG000112870.
InParanoidiQ613L4.
KOiK11406.
OMAiNGFACIR.
OrthoDBiEOG7RFTH5.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q613L4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAFFSSSSSS FPVVFARMEE ASSSTGSTGG AMAGIPVIPS TSAALLANTN
60 70 80 90 100
LEPERIAVLQ TQLQEYRQKQ MDLIGHFQRA QQELSVQHMH NLYTALQQQQ
110 120 130 140 150
QLQSLQERSG INPMLISQTS EDATSGPAAP LSLANSLTNL LSSSNGNLSN
160 170 180 190 200
LSVPQTPTKE HHPTLPPQQP SAPTSSRKSD LPRTNSTTIS QLTKDRLKNM
210 220 230 240 250
IANRSKGESN SQSNLMSNVN GHDNSRRLKN SNSQMNVSSP HFEPYRLPTS
260 270 280 290 300
LANAHNLQQA SEFQLRKVNS EPNLKMKIRA KLLSKGNSPV QHVQQTNNSQ
310 320 330 340 350
FSFTHPQLKR SDSETSNMPI DMLPSGSHSN IPHLMLPSPS LPNLAAATGA
360 370 380 390 400
FQNLNLPIGQ DLTAFMAVAN LSPFLSLPSL LNKKLELGGM TDEGDRNGFS
410 420 430 440 450
SSASNSSLAS NASLGSHQYQ SLLKQQIRDL VLRRKSLVRE DPEGEGMAES
460 470 480 490 500
YNGLFSHAKL QQLTALAMES GFNPKLEPTF STGLGYDPLM ARHECVCSNN
510 520 530 540 550
SNHVENGERI QRIWSKLTEE GHVAKCERIT AKKASLEQLQ MVHSQTYTTF
560 570 580 590 600
FAVSPTACLK IDANALPLKR FLQLPCGGIG IDSDTYFNDA STQIAARLAA
610 620 630 640 650
GTLIELSSQV AEGRLKNGFA CIRPPGHHAE AEQALGFCFF NNVAVTAKVL
660 670 680 690 700
QAKYPVQCAK IAIIDWDVHH GNGTQLSFDD DPNVLYMSLH RHDNGNFFPG
710 720 730 740 750
TGSVTEIGKG AGKGFSVNIP FSGGVMKDAE YLAAWRTVVE PVLASFCPDF
760 770 780 790 800
ILVSAGFDAC HGHVNALGGY EITPEMFGYM TKCLLSYANG KVVLALEGGY
810 820 830 840 850
NLDSISAAAE QCVQALIGES DDAGRLCTDS LENLPNQSAL ETLQKVIAIH
860 870 880 890
KGFWPALHGQ EAAINTTEMQ WRNVKLQVQM QQQQQLQQQL QQ
Length:892
Mass (Da):97,039
Last modified:November 23, 2004 - v1
Checksum:i0BF5A1AABCF1106A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600961 Genomic DNA. Translation: CAP34128.1.
RefSeqiXP_002643599.1. XM_002643553.1.

Genome annotation databases

EnsemblMetazoaiCBG16328; CBG16328; CBG16328.
GeneIDi8585593.
KEGGicbr:CBG16328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600961 Genomic DNA. Translation: CAP34128.1 .
RefSeqi XP_002643599.1. XM_002643553.1.

3D structure databases

ProteinModelPortali Q613L4.
SMRi Q613L4. Positions 478-866.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG16328.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG16328 ; CBG16328 ; CBG16328 .
GeneIDi 8585593.
KEGGi cbr:CBG16328.

Organism-specific databases

CTDi 8585593.
WormBasei CBG16328 ; CBP23360 ; WBGene00036299 ; Cbr-hda-4.

Phylogenomic databases

eggNOGi COG0123.
HOGENOMi HOG000112870.
InParanoidi Q613L4.
KOi K11406.
OMAi NGFACIR.
OrthoDBi EOG7RFTH5.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiHDA4_CAEBR
AccessioniPrimary (citable) accession number: Q613L4
Secondary accession number(s): A8XNN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3