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Protein

T-complex protein 1 subunit zeta-2

Gene

Cct6b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). May have specific functions in the folding of testicular proteins and for interactions with testicular molecular chaperones.By similarity

GO - Molecular functioni

GO - Biological processi

  • protein folding Source: InterPro
  • toxin transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta-2
Short name:
TCP-1-zeta-2
Alternative name(s):
CCT-zeta-2
Short name:
Cctz-2
Gene namesi
Name:Cct6b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1329013. Cct6b.

Subcellular locationi

GO - Cellular componenti

  • chaperonin-containing T-complex Source: MGI
  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 531531T-complex protein 1 subunit zeta-2PRO_0000128364Add
BLAST

Proteomic databases

EPDiQ61390.
MaxQBiQ61390.
PaxDbiQ61390.
PRIDEiQ61390.

PTM databases

iPTMnetiQ61390.
PhosphoSiteiQ61390.

Expressioni

Tissue specificityi

Testis specific.

Gene expression databases

BgeeiQ61390.
CleanExiMM_CCT6B.
ExpressionAtlasiQ61390. baseline and differential.
GenevisibleiQ61390. MM.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.

Protein-protein interaction databases

IntActiQ61390. 1 interaction.
MINTiMINT-1863619.
STRINGi10090.ENSMUSP00000021040.

Structurei

3D structure databases

ProteinModelPortaliQ61390.
SMRiQ61390. Positions 4-525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ61390.
KOiK09498.
OMAiLFMVEIV.
OrthoDBiEOG7SN8C9.
PhylomeDBiQ61390.
TreeFamiTF106333.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61390-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIKIANPG AEVTRSQAAL AVNICAARGL QDVLRPTLGP KGALKMLVSG
60 70 80 90 100
AGDIKLTKDG NVLLHEMQIQ HPTASIIAKV AAAQDHVTGD GTTSNVLIIG
110 120 130 140 150
ELLKQADLYI SEGLHPRIIT EGFDVAKTKA LEVLDEIKVQ KEMKREILLD
160 170 180 190 200
VARTSLQTKV HAELADILTE AVVDSVLAIR RPGVPIDLFM VEIVEMRHKS
210 220 230 240 250
ETDTQLIRGL VLDHGARHPR MRKQVRDAYI LTCNVSLEYE KTEVSSGFFY
260 270 280 290 300
KTVEEKEKLV KAERKFIEDR VQKIIDLKQK VCAESNKGFV VINQKGIDPV
310 320 330 340 350
SLEMLAKHNI VALRRAKRRN LERLTLACGG LAVNSFEGLS EECLGHAGLV
360 370 380 390 400
FEYALGEEKF TFIEDCVNPL SVTLLVKGPN KHTLIQIKDA LRDGLRAVKN
410 420 430 440 450
AIEDGCVVPG AGAVEVAIAE ALVNYKHRVQ GRVRLGIQAF ADALLIIPKV
460 470 480 490 500
LAQNSGYDLQ ETLIKIQTKH AESKELLGID LNTGEPMAAA EAGIWDNYCV
510 520 530
KKHLLHSCTV IATNILLVDE IMRAGMSSLR D
Length:531
Mass (Da):58,185
Last modified:January 23, 2007 - v4
Checksum:i5B8C600231A1F6B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121E → K in CAA90574 (PubMed:9013858).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50192 mRNA. Translation: CAA90574.1.
AB022086 Genomic DNA. Translation: BAA81891.1.
CCDSiCCDS25145.1.
RefSeqiNP_033969.2. NM_009839.3.
UniGeneiMm.4126.

Genome annotation databases

EnsembliENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698.
GeneIDi12467.
KEGGimmu:12467.
UCSCiuc007kmx.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50192 mRNA. Translation: CAA90574.1.
AB022086 Genomic DNA. Translation: BAA81891.1.
CCDSiCCDS25145.1.
RefSeqiNP_033969.2. NM_009839.3.
UniGeneiMm.4126.

3D structure databases

ProteinModelPortaliQ61390.
SMRiQ61390. Positions 4-525.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61390. 1 interaction.
MINTiMINT-1863619.
STRINGi10090.ENSMUSP00000021040.

PTM databases

iPTMnetiQ61390.
PhosphoSiteiQ61390.

Proteomic databases

EPDiQ61390.
MaxQBiQ61390.
PaxDbiQ61390.
PRIDEiQ61390.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021040; ENSMUSP00000021040; ENSMUSG00000020698.
GeneIDi12467.
KEGGimmu:12467.
UCSCiuc007kmx.3. mouse.

Organism-specific databases

CTDi10693.
MGIiMGI:1329013. Cct6b.

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
GeneTreeiENSGT00550000074743.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ61390.
KOiK09498.
OMAiLFMVEIV.
OrthoDBiEOG7SN8C9.
PhylomeDBiQ61390.
TreeFamiTF106333.

Miscellaneous databases

PROiQ61390.
SOURCEiSearch...

Gene expression databases

BgeeiQ61390.
CleanExiMM_CCT6B.
ExpressionAtlasiQ61390. baseline and differential.
GenevisibleiQ61390. MM.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-specific subunit of the mouse cytosolic chaperonin-containing TCP-1."
    Kubota H., Hynes G.M., Kerr S.M., Willison K.R.
    FEBS Lett. 402:53-56(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Sv.
    Tissue: Testis.
  2. "Structures and co-regulated expression of the genes encoding mouse cytosolic chaperonin CCT subunits."
    Kubota H., Yokota S., Yanagi H., Yura T.
    Eur. J. Biochem. 262:492-500(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Testis.

Entry informationi

Entry nameiTCPW_MOUSE
AccessioniPrimary (citable) accession number: Q61390
Secondary accession number(s): Q9R1U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 131 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.