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Protein

Cytochrome c oxidase subunit 7A-related protein, mitochondrial

Gene

Cox7a2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of oxidative phosphorylation and energy metabolism (PubMed:23857330, PubMed:23812712). Necessary for the assembly of mitochondrial respiratory supercomplex (PubMed:23857330, PubMed:23812712).2 Publications

GO - Molecular functioni

GO - Biological processi

  • mitochondrial respiratory chain supercomplex assembly Source: UniProtKB
  • regulation of oxidative phosphorylation Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7A-related protein, mitochondrial
Alternative name(s):
Cytochrome c oxidase subunit VIIa-related protein
Silica-induced gene 81 protein
Short name:
SIG-81
Supercomplex assembly factor I1 Publication
Gene namesi
Name:Cox7a2l
Synonyms:Cox7rp, Scaf1, Silg811 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:106015. Cox7a2l.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain Source: InterPro
  • mitochondrial respiratory chain supercomplex Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Knockout homozygous mice manifest decreased mitochondrial respiratory activities and impaired formation of mitochondrial supercomplexes in muscles. KO animals have muscle weakness and exhibit heat production failure in the cold.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5454MitochondrionAdd
BLAST
Chaini55 – 11157Cytochrome c oxidase subunit 7A-related protein, mitochondrialPRO_0000006155Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei68 – 681N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ61387.
MaxQBiQ61387.
PRIDEiQ61387.

PTM databases

iPTMnetiQ61387.

Expressioni

Inductioni

By estrogen and silica.1 Publication

Gene expression databases

BgeeiQ61387.
ExpressionAtlasiQ61387. baseline and differential.
GenevisibleiQ61387. MM.

Interactioni

Subunit structurei

Interacts with the mitochondrial respiratory supercomplex.1 Publication

Protein-protein interaction databases

BioGridi203253. 1 interaction.
IntActiQ61387. 2 interactions.
MINTiMINT-1846999.

Structurei

3D structure databases

ProteinModelPortaliQ61387.
SMRiQ61387. Positions 56-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIa family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00400000022054.
HOVERGENiHBG051095.
InParanoidiQ61387.
KOiK02270.
PhylomeDBiQ61387.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
IPR017267. Cyt_c_oxidase_su7a-rel_mt.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PTHR10510:SF2. PTHR10510:SF2. 1 hit.
PIRSFiPIRSF037710. COX7A-rel_mt. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61387-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYYKFSSFTQ KLAGAWASEA YTPQGLKPVS TEAPPIIFAT PTKLTSSVTA
60 70 80 90 100
YDYSGKNKVP ELQKFFQKAD GFHLKRGLPD QMLYRTTMAL TLGGTIYCLI
110
ALYMASQPRN K
Length:111
Mass (Da):12,399
Last modified:November 1, 1996 - v1
Checksum:i542F20F0ADD9F4E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80899 mRNA. Translation: CAA56861.1.
CCDSiCCDS28995.1.
RefSeqiNP_033213.1. NM_009187.3.
UniGeneiMm.30072.

Genome annotation databases

EnsembliENSMUST00000025095; ENSMUSP00000025095; ENSMUSG00000024248.
GeneIDi20463.
KEGGimmu:20463.
UCSCiuc008dsc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80899 mRNA. Translation: CAA56861.1.
CCDSiCCDS28995.1.
RefSeqiNP_033213.1. NM_009187.3.
UniGeneiMm.30072.

3D structure databases

ProteinModelPortaliQ61387.
SMRiQ61387. Positions 56-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203253. 1 interaction.
IntActiQ61387. 2 interactions.
MINTiMINT-1846999.

PTM databases

iPTMnetiQ61387.

Proteomic databases

EPDiQ61387.
MaxQBiQ61387.
PRIDEiQ61387.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025095; ENSMUSP00000025095; ENSMUSG00000024248.
GeneIDi20463.
KEGGimmu:20463.
UCSCiuc008dsc.2. mouse.

Organism-specific databases

CTDi9167.
MGIiMGI:106015. Cox7a2l.

Phylogenomic databases

GeneTreeiENSGT00400000022054.
HOVERGENiHBG051095.
InParanoidiQ61387.
KOiK02270.
PhylomeDBiQ61387.

Miscellaneous databases

ChiTaRSiCox7a2l. mouse.
PROiQ61387.
SOURCEiSearch...

Gene expression databases

BgeeiQ61387.
ExpressionAtlasiQ61387. baseline and differential.
GenevisibleiQ61387. MM.

Family and domain databases

Gene3Di4.10.91.10. 1 hit.
InterProiIPR003177. Cyt_c_oxidase_su7a.
IPR017267. Cyt_c_oxidase_su7a-rel_mt.
[Graphical view]
PANTHERiPTHR10510. PTHR10510. 1 hit.
PTHR10510:SF2. PTHR10510:SF2. 1 hit.
PIRSFiPIRSF037710. COX7A-rel_mt. 1 hit.
SUPFAMiSSF81419. SSF81419. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of nine gene sequences induced by silica in murine macrophages."
    Segade F., Claudio E., Wrobel K., Ramos S., Lazo P.S.
    J. Immunol. 154:2384-2392(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Tissue: Macrophage.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  3. "A stabilizing factor for mitochondrial respiratory supercomplex assembly regulates energy metabolism in muscle."
    Ikeda K., Shiba S., Horie-Inoue K., Shimokata K., Inoue S.
    Nat. Commun. 4:2147-2147(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  4. Cited for: FUNCTION, INTERACTION WITH MITOCHONDRIAL RESPIRATORY SUPERCOMPLEX.

Entry informationi

Entry nameiCOX7R_MOUSE
AccessioniPrimary (citable) accession number: Q61387
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.