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Q61362

- CH3L1_MOUSE

UniProt

Q61362 - CH3L1_MOUSE

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Protein

Chitinase-3-like protein 1

Gene

Chi3l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.6 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei150 – 1501ChitooligosaccharideBy similarity
Binding sitei361 – 3611ChitooligosaccharideBy similarity

GO - Molecular functioni

  1. chitinase activity Source: InterPro
  2. chitin binding Source: UniProtKB

GO - Biological processi

  1. activation of NF-kappaB-inducing kinase activity Source: UniProtKB
  2. apoptotic process Source: UniProtKB-KW
  3. carbohydrate metabolic process Source: InterPro
  4. cellular response to tumor necrosis factor Source: UniProtKB
  5. chitin catabolic process Source: InterPro
  6. inflammatory response Source: UniProtKB
  7. interleukin-8 secretion Source: UniProtKB
  8. lung development Source: UniProtKB
  9. positive regulation of angiogenesis Source: UniProtKB
  10. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  11. positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
  12. positive regulation of protein kinase B signaling Source: UniProtKB
  13. response to interleukin-1 Source: UniProtKB
  14. response to interleukin-6 Source: UniProtKB
  15. response to mechanical stimulus Source: UniProtKB
  16. response to tumor necrosis factor Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial

Keywords - Biological processi

Apoptosis, Inflammatory response

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitinase-3-like protein 1
Alternative name(s):
BRP39 protein
Breast regression protein 39
Cartilage glycoprotein 39
Short name:
CGP-39
Short name:
GP-39
Gene namesi
Name:Chi3l1
Synonyms:Brp39, Chil1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1340899. Chil1.

Subcellular locationi

Secretedextracellular space. Cytoplasm. Endoplasmic reticulum
Note: Detected in bronchoalveolar lavage (BAL) fluids. Localizes mainly to endoplasmic reticulum when overexpressed in cells, with some protein also detected throughout the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endoplasmic reticulum Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Secreted

Pathology & Biotechi

Disruption phenotypei

Mice are viable, fertile and appear normal, but have defective antigen-induced Th2 inflammatory responses and defective IL-13-induced responses, displaying accelerated cell death responses and diminished M2 macrophage differentiation. Mutant mice are more sensitive to S.pneumoniae infection, displaying enhanced mortality, exacerbated lung injury and decreased bacterial clearance compared to wild-type mice. Mutant mice also have an exacerbated response to hyperoxia, displaying enhanced protein leak, tissue inflammation and chemokine production and premature death.3 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi136 – 1361L → E: No effect on chiting-binding. No restoration of chitinase activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929By similarityAdd
BLAST
Chaini30 – 389360Chitinase-3-like protein 1PRO_0000011966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 59By similarity
Glycosylationi68 – 681N-linked (GlcNAc...)By similarity
Disulfide bondi309 ↔ 372By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61362.
PaxDbiQ61362.
PRIDEiQ61362.

PTM databases

PhosphoSiteiQ61362.

Expressioni

Tissue specificityi

Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon.4 Publications

Inductioni

Up-regulated in colon under several inflammatory conditions. Up-regulated upon pulmonary inflammation elicited by sensitization and challenge with the chitin-free aeroallergen ovalbumin or with chitin-containing antigen house dust mite (HDM) extract. Up-regulated in lungs after S.pneumoniae infection. Up-regulated in splenic cells of mammary tumor-bearing animals. Down-regulated by hyperoxia in lung.5 Publications

Gene expression databases

BgeeiQ61362.
CleanExiMM_CHI3L1.
ExpressionAtlasiQ61362. baseline and differential.
GenevestigatoriQ61362.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ61362. 1 interaction.
MINTiMINT-4090719.
STRINGi10090.ENSMUSP00000080717.

Structurei

3D structure databases

ProteinModelPortaliQ61362.
SMRiQ61362. Positions 30-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni79 – 802Chitooligosaccharide bindingBy similarity
Regioni106 – 1094Chitooligosaccharide bindingBy similarity
Regioni213 – 2164Chitooligosaccharide bindingBy similarity
Regioni333 – 34715Important for AKT1 activation and IL8 productionAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 18 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3325.
GeneTreeiENSGT00550000074323.
HOVERGENiHBG011684.
InParanoidiQ61362.
KOiK17523.
TreeFamiTF315610.

Family and domain databases

Gene3Di3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProiIPR028538. CHI3L1.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR11177:SF81. PTHR11177:SF81. 1 hit.
PfamiPF00704. Glyco_hydro_18. 1 hit.
[Graphical view]
SMARTiSM00636. Glyco_18. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform 1 (identifier: Q61362-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTSTEARMG MRAALTGFAV LMLLQSCSAY KLVCYFTSWS QYREGVGSFL
60 70 80 90 100
PDAIQPFLCT HIIYSFANIS SDNMLSTWEW NDESNYDKLN KLKTRNTNLK
110 120 130 140 150
TLLSVGGWKF GEKRFSEIAS NTERRTAFVR SVAPFLRSYG FDGLDLAWLY
160 170 180 190 200
PRLRDKQYFS TLIKELNAEF TKEVQPGREK LLLSAALSAG KVAIDTGYDI
210 220 230 240 250
AQIAQHLDFI NLMTYDFHGV WRQITGHHSP LFQGQKDTRF DRYSNVNYAV
260 270 280 290 300
QYMIRLGAQA SKLLMGIPTF GKSFTLASSE NQLGAPISGE GLPGRFTKEA
310 320 330 340 350
GTLAYYEICD FLKGAEVHRL SNEKVPFATK GNQWVGYEDK ESVKNKVGFL
360 370 380
KEKKLAGAMV WALDLDDFQG TCQPKEFFPL TNAIKDALA
Length:389
Mass (Da):43,893
Last modified:May 14, 2014 - v3
Checksum:i9E7D66069B233834
GO
Isoform 2 (identifier: Q61362-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Note: Produced by alternative initiation at Met-9 of isoform 1.

Show »
Length:381
Mass (Da):42,979
Checksum:iEF6588C5AE9D4450
GO
Isoform 3 (identifier: Q61362-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MHTSTEARMGMRAALT → MTLQLA

Note: May be produced by alternative splicing of isoform 1. Gene prediction based on EST data.

Show »
Length:379
Mass (Da):42,805
Checksum:i289A0DCD41EE5E9D
GO

Sequence cautioni

The sequence AAH03780.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH04734.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH05611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA63603.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti112 – 1121E → G in ABY53363. 1 PublicationCurated
Sequence conflicti258 – 2581A → V in BAE33251. (PubMed:16141072)Curated
Sequence conflicti339 – 3391D → H in CAA63603. (PubMed:7970700)Curated
Sequence conflicti348 – 3481G → R in ABY53363. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616MHTST…RAALT → MTLQLA in isoform 3. CuratedVSP_054523Add
BLAST
Alternative sequencei1 – 88Missing in isoform 2. 2 PublicationsVSP_054524

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93035 mRNA. Translation: CAA63603.1. Different initiation.
EU313768 mRNA. Translation: ABY53363.1.
AK051475 mRNA. Translation: BAC34654.1.
AK155412 mRNA. Translation: BAE33251.1.
CT010283 mRNA. Translation: CAJ18491.1.
AC137104 Genomic DNA. No translation available.
BC003780 mRNA. Translation: AAH03780.1. Different initiation.
BC004734 mRNA. Translation: AAH04734.1. Different initiation.
BC005611 mRNA. Translation: AAH05611.1. Different initiation.
CCDSiCCDS48368.1. [Q61362-1]
PIRiS61551.
RefSeqiNP_031721.2. NM_007695.3. [Q61362-1]
XP_006529174.1. XM_006529111.1. [Q61362-3]
UniGeneiMm.38274.

Genome annotation databases

EnsembliENSMUST00000082060; ENSMUSP00000080717; ENSMUSG00000064246. [Q61362-1]
ENSMUST00000153856; ENSMUSP00000117117; ENSMUSG00000064246. [Q61362-2]
ENSMUST00000156873; ENSMUSP00000119205; ENSMUSG00000064246. [Q61362-3]
GeneIDi12654.
KEGGimmu:12654.
UCSCiuc007crg.2. mouse. [Q61362-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X93035 mRNA. Translation: CAA63603.1 . Different initiation.
EU313768 mRNA. Translation: ABY53363.1 .
AK051475 mRNA. Translation: BAC34654.1 .
AK155412 mRNA. Translation: BAE33251.1 .
CT010283 mRNA. Translation: CAJ18491.1 .
AC137104 Genomic DNA. No translation available.
BC003780 mRNA. Translation: AAH03780.1 . Different initiation.
BC004734 mRNA. Translation: AAH04734.1 . Different initiation.
BC005611 mRNA. Translation: AAH05611.1 . Different initiation.
CCDSi CCDS48368.1. [Q61362-1 ]
PIRi S61551.
RefSeqi NP_031721.2. NM_007695.3. [Q61362-1 ]
XP_006529174.1. XM_006529111.1. [Q61362-3 ]
UniGenei Mm.38274.

3D structure databases

ProteinModelPortali Q61362.
SMRi Q61362. Positions 30-389.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61362. 1 interaction.
MINTi MINT-4090719.
STRINGi 10090.ENSMUSP00000080717.

Protein family/group databases

CAZyi GH18. Glycoside Hydrolase Family 18.

PTM databases

PhosphoSitei Q61362.

Proteomic databases

MaxQBi Q61362.
PaxDbi Q61362.
PRIDEi Q61362.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000082060 ; ENSMUSP00000080717 ; ENSMUSG00000064246 . [Q61362-1 ]
ENSMUST00000153856 ; ENSMUSP00000117117 ; ENSMUSG00000064246 . [Q61362-2 ]
ENSMUST00000156873 ; ENSMUSP00000119205 ; ENSMUSG00000064246 . [Q61362-3 ]
GeneIDi 12654.
KEGGi mmu:12654.
UCSCi uc007crg.2. mouse. [Q61362-1 ]

Organism-specific databases

CTDi 12654.
MGIi MGI:1340899. Chil1.

Phylogenomic databases

eggNOGi COG3325.
GeneTreei ENSGT00550000074323.
HOVERGENi HBG011684.
InParanoidi Q61362.
KOi K17523.
TreeFami TF315610.

Miscellaneous databases

NextBioi 281872.
PROi Q61362.
SOURCEi Search...

Gene expression databases

Bgeei Q61362.
CleanExi MM_CHI3L1.
ExpressionAtlasi Q61362. baseline and differential.
Genevestigatori Q61362.

Family and domain databases

Gene3Di 3.10.50.10. 1 hit.
3.20.20.80. 2 hits.
InterProi IPR028538. CHI3L1.
IPR011583. Chitinase_II.
IPR029070. Chitinase_insertion.
IPR001223. Glyco_hydro18cat.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR11177:SF81. PTHR11177:SF81. 1 hit.
Pfami PF00704. Glyco_hydro_18. 1 hit.
[Graphical view ]
SMARTi SM00636. Glyco_18. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 2 hits.
SSF54556. SSF54556. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors."
    Morrison B.W., Leder P.
    Oncogene 9:3417-3426(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary gland.
  2. "Cloning, expression, characterization and crystallization of BRP39, a signalling glycoprotein expressed during mammary gland apoptosis."
    Mohanty A.K., Fisher A.J., Yu Z., Pradeep M.A., Janjanam J., Kaushik J.K.
    Protein Expr. Purif. 64:213-218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, MUTAGENESIS OF LEU-136, CRYSTALLIZATION.
    Tissue: Mammary gland.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J and NOD.
    Tissue: Dendritic cell and Spinal ganglion.
  4. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  7. "Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells."
    Mizoguchi E.
    Gastroenterology 130:398-411(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION.
  8. "Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis."
    Lee C.G., Hartl D., Lee G.R., Koller B., Matsuura H., Da Silva C.A., Sohn M.H., Cohn L., Homer R.J., Kozhich A.A., Humbles A., Kearley J., Coyle A., Chupp G., Reed J., Flavell R.A., Elias J.A.
    J. Exp. Med. 206:1149-1166(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
  9. "The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury."
    Sohn M.H., Kang M.J., Matsuura H., Bhandari V., Chen N.Y., Lee C.G., Elias J.A.
    Am. J. Respir. Crit. Care Med. 182:918-928(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, DISRUPTION PHENOTYPE.
  10. "Carbohydrate-binding motif in chitinase 3-like 1 (CHI3L1/YKL-40) specifically activates Akt signaling pathway in colonic epithelial cells."
    Chen C.C., Llado V., Eurich K., Tran H.T., Mizoguchi E.
    Clin. Immunol. 140:268-275(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, REGION.
  11. "Chitinase 3-like-1 promotes Streptococcus pneumoniae killing and augments host tolerance to lung antibacterial responses."
    Dela Cruz C.S., Liu W., He C.H., Jacoby A., Gornitzky A., Ma B., Flavell R., Lee C.G., Elias J.A.
    Cell Host Microbe 12:34-46(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION, DISRUPTION PHENOTYPE.
  12. "Induction of proinflammatory mediators by CHI3L1 is reduced by chitin treatment: decreased tumor metastasis in a breast cancer model."
    Libreros S., Garcia-Areas R., Shibata Y., Carrio R., Torroella-Kouri M., Iragavarapu-Charyulu V.
    Int. J. Cancer 131:377-386(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiCH3L1_MOUSE
AccessioniPrimary (citable) accession number: Q61362
Secondary accession number(s): B0FEU7
, D3Z2P2, Q3U291, Q4FJW9, Q8BKL8, Q99J84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 14, 2014
Last modified: October 29, 2014
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3