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Q61361

- PGCB_MOUSE

UniProt

Q61361 - PGCB_MOUSE

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Protein

Brevican core protein

Gene

Bcan

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. hippocampus development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Gene namesi
Name:Bcan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1096385. Bcan.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 883861Brevican core proteinPRO_0000017512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 136By similarity
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi178 ↔ 249By similarity
Disulfide bondi202 ↔ 223By similarity
Disulfide bondi276 ↔ 351By similarity
Disulfide bondi300 ↔ 321By similarity
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 657By similarity
Disulfide bondi664 ↔ 675By similarity
Disulfide bondi692 ↔ 784By similarity
Disulfide bondi760 ↔ 776By similarity
Disulfide bondi791 ↔ 834By similarity
Disulfide bondi820 ↔ 847By similarity

Post-translational modificationi

Contains mostly chondroitin sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61361.
PaxDbiQ61361.
PRIDEiQ61361.

PTM databases

PhosphoSiteiQ61361.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiQ61361.
CleanExiMM_BCAN.
ExpressionAtlasiQ61361. baseline and differential.
GenevestigatoriQ61361.

Interactioni

Subunit structurei

Interacts with TNR.By similarity

Protein-protein interaction databases

IntActiQ61361. 2 interactions.
MINTiMINT-4107305.
STRINGi10090.ENSMUSP00000088491.

Structurei

3D structure databases

ProteinModelPortaliQ61361.
SMRiQ61361. Positions 160-250, 266-356, 623-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 154120Ig-like V-typeAdd
BLAST
Domaini156 – 25196Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 35398Link 2PROSITE-ProRule annotationAdd
BLAST
Domaini622 – 65837EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini658 – 786129C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini789 – 84961SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Link domains.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG136696.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000115520.
HOVERGENiHBG008175.
InParanoidiQ61361.
KOiK06795.
OMAiYAFSFAG.
OrthoDBiEOG7PS1F3.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61361-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG
60 70 80 90 100
ALAIPCHVHH LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN
110 120 130 140 150
EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE
160 170 180 190 200
VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE
210 220 230 240 250
QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG PDDLYDVYCY
260 270 280 290 300
AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC
310 320 330 340 350
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY
360 370 380 390 400
CFRDSAHPSA SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI
410 420 430 440 450
YSIPISEDGG GGSSTPEDPA EAPRTPLESE TQSIAPPTES SEEEGVALEE
460 470 480 490 500
EERFKDLEAL EEEKEQEDLW VWPRELSSPL PTGSETEHSL SQVSPPAQAV
510 520 530 540 550
LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV GGETGSPELS
560 570 580 590 600
GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS
610 620 630 640 650
VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP
660 670 680 690 700
GYGGDLCDVG LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT
710 720 730 740 750
SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGAPL LYENWNPGQP
760 770 780 790 800
DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA
810 820 830 840 850
QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR
860 870 880
RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL
Length:883
Mass (Da):95,815
Last modified:July 27, 2011 - v2
Checksum:i64DDE4D951D2042A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421T → A in CAA60575. (PubMed:9286696)Curated
Sequence conflicti65 – 651H → R in CAA60575. (PubMed:9286696)Curated
Sequence conflicti504 – 5041G → D in CAA60575. (PubMed:9286696)Curated
Sequence conflicti514 – 5141V → F in CAA60575. (PubMed:9286696)Curated
Sequence conflicti528 – 5303GSP → WSA in CAA60575. (PubMed:9286696)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87096 mRNA. Translation: CAA60575.1.
CH466547 Genomic DNA. Translation: EDL15323.1.
BC052032 mRNA. Translation: AAH52032.1.
CCDSiCCDS17462.1.
PIRiS57653.
RefSeqiNP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGeneiMm.4598.

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
GeneIDi12032.
KEGGimmu:12032.
UCSCiuc008pto.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87096 mRNA. Translation: CAA60575.1 .
CH466547 Genomic DNA. Translation: EDL15323.1 .
BC052032 mRNA. Translation: AAH52032.1 .
CCDSi CCDS17462.1.
PIRi S57653.
RefSeqi NP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGenei Mm.4598.

3D structure databases

ProteinModelPortali Q61361.
SMRi Q61361. Positions 160-250, 266-356, 623-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61361. 2 interactions.
MINTi MINT-4107305.
STRINGi 10090.ENSMUSP00000088491.

PTM databases

PhosphoSitei Q61361.

Proteomic databases

MaxQBi Q61361.
PaxDbi Q61361.
PRIDEi Q61361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090971 ; ENSMUSP00000088491 ; ENSMUSG00000004892 .
GeneIDi 12032.
KEGGi mmu:12032.
UCSCi uc008pto.2. mouse.

Organism-specific databases

CTDi 63827.
MGIi MGI:1096385. Bcan.

Phylogenomic databases

eggNOGi NOG136696.
GeneTreei ENSGT00760000119025.
HOGENOMi HOG000115520.
HOVERGENi HBG008175.
InParanoidi Q61361.
KOi K06795.
OMAi YAFSFAG.
OrthoDBi EOG7PS1F3.
TreeFami TF332134.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.

Miscellaneous databases

ChiTaRSi BCAN. mouse.
NextBioi 280271.
PROi Q61361.
SOURCEi Search...

Gene expression databases

Bgeei Q61361.
CleanExi MM_BCAN.
ExpressionAtlasi Q61361. baseline and differential.
Genevestigatori Q61361.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and chromosomal localization of the mouse brevican gene."
    Rauch U., Meyer H., Brakebusch C., Seidenbecher C., Gundelfinger E.D., Beier D.R., Fassler R.
    Genomics 44:15-21(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPGCB_MOUSE
AccessioniPrimary (citable) accession number: Q61361
Secondary accession number(s): Q80WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3