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Q61361

- PGCB_MOUSE

UniProt

Q61361 - PGCB_MOUSE

Protein

Brevican core protein

Gene

Bcan

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. hyaluronic acid binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell adhesion Source: InterPro
    2. hippocampus development Source: MGI

    Keywords - Ligandi

    Hyaluronic acid, Lectin

    Enzyme and pathway databases

    ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196514. Chondroitin sulfate biosynthesis.
    REACT_196540. Dermatan sulfate biosynthesis.
    REACT_196606. ECM proteoglycans.
    REACT_198981. CS/DS degradation.
    REACT_199052. Degradation of the extracellular matrix.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Brevican core protein
    Gene namesi
    Name:Bcan
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1096385. Bcan.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 883861Brevican core proteinPRO_0000017512Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 136By similarity
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 249By similarity
    Disulfide bondi202 ↔ 223By similarity
    Disulfide bondi276 ↔ 351By similarity
    Disulfide bondi300 ↔ 321By similarity
    Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi626 ↔ 637By similarity
    Disulfide bondi631 ↔ 646By similarity
    Disulfide bondi648 ↔ 657By similarity
    Disulfide bondi664 ↔ 675By similarity
    Disulfide bondi692 ↔ 784By similarity
    Disulfide bondi760 ↔ 776By similarity
    Disulfide bondi791 ↔ 834By similarity
    Disulfide bondi820 ↔ 847By similarity

    Post-translational modificationi

    Contains mostly chondroitin sulfate.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan

    Proteomic databases

    MaxQBiQ61361.
    PaxDbiQ61361.
    PRIDEiQ61361.

    PTM databases

    PhosphoSiteiQ61361.

    Expressioni

    Tissue specificityi

    Brain.

    Gene expression databases

    BgeeiQ61361.
    CleanExiMM_BCAN.
    GenevestigatoriQ61361.

    Interactioni

    Subunit structurei

    Interacts with TNR.By similarity

    Protein-protein interaction databases

    IntActiQ61361. 2 interactions.
    MINTiMINT-4107305.
    STRINGi10090.ENSMUSP00000088491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61361.
    SMRiQ61361. Positions 42-142, 160-250, 266-356, 626-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 154120Ig-like V-typeAdd
    BLAST
    Domaini156 – 25196Link 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini256 – 35398Link 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini622 – 65837EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini658 – 786129C-type lectinPROSITE-ProRule annotationAdd
    BLAST
    Domaini789 – 84961SushiPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation
    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 2 Link domains.PROSITE-ProRule annotation
    Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

    Phylogenomic databases

    eggNOGiNOG136696.
    GeneTreeiENSGT00750000117316.
    HOGENOMiHOG000115520.
    HOVERGENiHBG008175.
    InParanoidiQ80WT7.
    KOiK06795.
    OMAiYAFSFAG.
    OrthoDBiEOG7PS1F3.
    TreeFamiTF332134.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.100.10. 3 hits.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000538. Link.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 1 hit.
    PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view]
    PRINTSiPR01265. LINKMODULE.
    SMARTiSM00032. CCP. 1 hit.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    SM00406. IGv. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 3 hits.
    SSF57535. SSF57535. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    PS50923. SUSHI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61361-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG    50
    ALAIPCHVHH LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN 100
    EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE 150
    VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE 200
    QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG PDDLYDVYCY 250
    AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC 300
    SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY 350
    CFRDSAHPSA SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI 400
    YSIPISEDGG GGSSTPEDPA EAPRTPLESE TQSIAPPTES SEEEGVALEE 450
    EERFKDLEAL EEEKEQEDLW VWPRELSSPL PTGSETEHSL SQVSPPAQAV 500
    LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV GGETGSPELS 550
    GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS 600
    VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP 650
    GYGGDLCDVG LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT 700
    SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGAPL LYENWNPGQP 750
    DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA 800
    QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR 850
    RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL 883
    Length:883
    Mass (Da):95,815
    Last modified:July 27, 2011 - v2
    Checksum:i64DDE4D951D2042A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421T → A in CAA60575. (PubMed:9286696)Curated
    Sequence conflicti65 – 651H → R in CAA60575. (PubMed:9286696)Curated
    Sequence conflicti504 – 5041G → D in CAA60575. (PubMed:9286696)Curated
    Sequence conflicti514 – 5141V → F in CAA60575. (PubMed:9286696)Curated
    Sequence conflicti528 – 5303GSP → WSA in CAA60575. (PubMed:9286696)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87096 mRNA. Translation: CAA60575.1.
    CH466547 Genomic DNA. Translation: EDL15323.1.
    BC052032 mRNA. Translation: AAH52032.1.
    CCDSiCCDS17462.1.
    PIRiS57653.
    RefSeqiNP_001103228.1. NM_001109758.1.
    NP_031555.2. NM_007529.2.
    XP_006500999.1. XM_006500936.1.
    XP_006501000.1. XM_006500937.1.
    UniGeneiMm.4598.

    Genome annotation databases

    EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
    GeneIDi12032.
    KEGGimmu:12032.
    UCSCiuc008pto.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Brevican

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87096 mRNA. Translation: CAA60575.1 .
    CH466547 Genomic DNA. Translation: EDL15323.1 .
    BC052032 mRNA. Translation: AAH52032.1 .
    CCDSi CCDS17462.1.
    PIRi S57653.
    RefSeqi NP_001103228.1. NM_001109758.1.
    NP_031555.2. NM_007529.2.
    XP_006500999.1. XM_006500936.1.
    XP_006501000.1. XM_006500937.1.
    UniGenei Mm.4598.

    3D structure databases

    ProteinModelPortali Q61361.
    SMRi Q61361. Positions 42-142, 160-250, 266-356, 626-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61361. 2 interactions.
    MINTi MINT-4107305.
    STRINGi 10090.ENSMUSP00000088491.

    PTM databases

    PhosphoSitei Q61361.

    Proteomic databases

    MaxQBi Q61361.
    PaxDbi Q61361.
    PRIDEi Q61361.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000090971 ; ENSMUSP00000088491 ; ENSMUSG00000004892 .
    GeneIDi 12032.
    KEGGi mmu:12032.
    UCSCi uc008pto.2. mouse.

    Organism-specific databases

    CTDi 63827.
    MGIi MGI:1096385. Bcan.

    Phylogenomic databases

    eggNOGi NOG136696.
    GeneTreei ENSGT00750000117316.
    HOGENOMi HOG000115520.
    HOVERGENi HBG008175.
    InParanoidi Q80WT7.
    KOi K06795.
    OMAi YAFSFAG.
    OrthoDBi EOG7PS1F3.
    TreeFami TF332134.

    Enzyme and pathway databases

    Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
    REACT_196514. Chondroitin sulfate biosynthesis.
    REACT_196540. Dermatan sulfate biosynthesis.
    REACT_196606. ECM proteoglycans.
    REACT_198981. CS/DS degradation.
    REACT_199052. Degradation of the extracellular matrix.

    Miscellaneous databases

    ChiTaRSi BCAN. mouse.
    NextBioi 280271.
    PROi Q61361.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61361.
    CleanExi MM_BCAN.
    Genevestigatori Q61361.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.100.10. 3 hits.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013106. Ig_V-set.
    IPR003596. Ig_V-set_subgr.
    IPR000538. Link.
    IPR000436. Sushi_SCR_CCP.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00059. Lectin_C. 1 hit.
    PF00084. Sushi. 1 hit.
    PF07686. V-set. 1 hit.
    PF00193. Xlink. 2 hits.
    [Graphical view ]
    PRINTSi PR01265. LINKMODULE.
    SMARTi SM00032. CCP. 1 hit.
    SM00034. CLECT. 1 hit.
    SM00181. EGF. 1 hit.
    SM00406. IGv. 1 hit.
    SM00445. LINK. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 3 hits.
    SSF57535. SSF57535. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    PS01241. LINK_1. 2 hits.
    PS50963. LINK_2. 2 hits.
    PS50923. SUSHI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and chromosomal localization of the mouse brevican gene."
      Rauch U., Meyer H., Brakebusch C., Seidenbecher C., Gundelfinger E.D., Beier D.R., Fassler R.
      Genomics 44:15-21(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.

    Entry informationi

    Entry nameiPGCB_MOUSE
    AccessioniPrimary (citable) accession number: Q61361
    Secondary accession number(s): Q80WT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3