SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q61361

- PGCB_MOUSE

UniProt

Q61361 - PGCB_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Brevican core protein
Gene
Bcan
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. hyaluronic acid binding Source: UniProtKB-KW

GO - Biological processi

  1. cell adhesion Source: InterPro
  2. hippocampus development Source: MGI
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Gene namesi
Name:Bcan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1096385. Bcan.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 883861Brevican core protein
PRO_0000017512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 136 By similarity
Glycosylationi129 – 1291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi178 ↔ 249 By similarity
Disulfide bondi202 ↔ 223 By similarity
Disulfide bondi276 ↔ 351 By similarity
Disulfide bondi300 ↔ 321 By similarity
Glycosylationi336 – 3361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi626 ↔ 637 By similarity
Disulfide bondi631 ↔ 646 By similarity
Disulfide bondi648 ↔ 657 By similarity
Disulfide bondi664 ↔ 675 By similarity
Disulfide bondi692 ↔ 784 By similarity
Disulfide bondi760 ↔ 776 By similarity
Disulfide bondi791 ↔ 834 By similarity
Disulfide bondi820 ↔ 847 By similarity

Post-translational modificationi

Contains mostly chondroitin sulfate By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61361.
PaxDbiQ61361.
PRIDEiQ61361.

PTM databases

PhosphoSiteiQ61361.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiQ61361.
CleanExiMM_BCAN.
GenevestigatoriQ61361.

Interactioni

Subunit structurei

Interacts with TNR By similarity.

Protein-protein interaction databases

IntActiQ61361. 2 interactions.
MINTiMINT-4107305.
STRINGi10090.ENSMUSP00000088491.

Structurei

3D structure databases

ProteinModelPortaliQ61361.
SMRiQ61361. Positions 42-142, 160-250, 266-356, 626-787.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 154120Ig-like V-type
Add
BLAST
Domaini156 – 25196Link 1
Add
BLAST
Domaini256 – 35398Link 2
Add
BLAST
Domaini622 – 65837EGF-like
Add
BLAST
Domaini658 – 786129C-type lectin
Add
BLAST
Domaini789 – 84961Sushi
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.
Contains 2 Link domains.

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG136696.
GeneTreeiENSGT00750000117316.
HOGENOMiHOG000115520.
HOVERGENiHBG008175.
InParanoidiQ80WT7.
KOiK06795.
OMAiYAFSFAG.
OrthoDBiEOG7PS1F3.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61361-1 [UniParc]FASTAAdd to Basket

« Hide

MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG    50
ALAIPCHVHH LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN 100
EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE 150
VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE 200
QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG PDDLYDVYCY 250
AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC 300
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY 350
CFRDSAHPSA SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI 400
YSIPISEDGG GGSSTPEDPA EAPRTPLESE TQSIAPPTES SEEEGVALEE 450
EERFKDLEAL EEEKEQEDLW VWPRELSSPL PTGSETEHSL SQVSPPAQAV 500
LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV GGETGSPELS 550
GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS 600
VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP 650
GYGGDLCDVG LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT 700
SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGAPL LYENWNPGQP 750
DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA 800
QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR 850
RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL 883
Length:883
Mass (Da):95,815
Last modified:July 27, 2011 - v2
Checksum:i64DDE4D951D2042A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421T → A in CAA60575. 1 Publication
Sequence conflicti65 – 651H → R in CAA60575. 1 Publication
Sequence conflicti504 – 5041G → D in CAA60575. 1 Publication
Sequence conflicti514 – 5141V → F in CAA60575. 1 Publication
Sequence conflicti528 – 5303GSP → WSA in CAA60575. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87096 mRNA. Translation: CAA60575.1.
CH466547 Genomic DNA. Translation: EDL15323.1.
BC052032 mRNA. Translation: AAH52032.1.
CCDSiCCDS17462.1.
PIRiS57653.
RefSeqiNP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGeneiMm.4598.

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
GeneIDi12032.
KEGGimmu:12032.
UCSCiuc008pto.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X87096 mRNA. Translation: CAA60575.1 .
CH466547 Genomic DNA. Translation: EDL15323.1 .
BC052032 mRNA. Translation: AAH52032.1 .
CCDSi CCDS17462.1.
PIRi S57653.
RefSeqi NP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGenei Mm.4598.

3D structure databases

ProteinModelPortali Q61361.
SMRi Q61361. Positions 42-142, 160-250, 266-356, 626-787.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61361. 2 interactions.
MINTi MINT-4107305.
STRINGi 10090.ENSMUSP00000088491.

PTM databases

PhosphoSitei Q61361.

Proteomic databases

MaxQBi Q61361.
PaxDbi Q61361.
PRIDEi Q61361.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000090971 ; ENSMUSP00000088491 ; ENSMUSG00000004892 .
GeneIDi 12032.
KEGGi mmu:12032.
UCSCi uc008pto.2. mouse.

Organism-specific databases

CTDi 63827.
MGIi MGI:1096385. Bcan.

Phylogenomic databases

eggNOGi NOG136696.
GeneTreei ENSGT00750000117316.
HOGENOMi HOG000115520.
HOVERGENi HBG008175.
InParanoidi Q80WT7.
KOi K06795.
OMAi YAFSFAG.
OrthoDBi EOG7PS1F3.
TreeFami TF332134.

Enzyme and pathway databases

Reactomei REACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.

Miscellaneous databases

ChiTaRSi BCAN. mouse.
NextBioi 280271.
PROi Q61361.
SOURCEi Search...

Gene expression databases

Bgeei Q61361.
CleanExi MM_BCAN.
Genevestigatori Q61361.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view ]
PRINTSi PR01265. LINKMODULE.
SMARTi SM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and chromosomal localization of the mouse brevican gene."
    Rauch U., Meyer H., Brakebusch C., Seidenbecher C., Gundelfinger E.D., Beier D.R., Fassler R.
    Genomics 44:15-21(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPGCB_MOUSE
AccessioniPrimary (citable) accession number: Q61361
Secondary accession number(s): Q80WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi