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Protein

Brevican core protein

Gene

Bcan

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
  2. extracellular matrix structural constituent Source: GO_Central
  3. hyaluronic acid binding Source: GO_Central

GO - Biological processi

  1. cell adhesion Source: GO_Central
  2. hippocampus development Source: MGI
  3. skeletal system development Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Hyaluronic acid, Lectin

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_268957. Defective CHSY1 causes TPBS.
REACT_269050. Defective CHST3 causes SEDCJD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_271176. Defective CHST14 causes EDS, musculocontractural type.

Names & Taxonomyi

Protein namesi
Recommended name:
Brevican core protein
Gene namesi
Name:Bcan
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1096385. Bcan.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 883861Brevican core proteinPRO_0000017512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 136By similarity
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi178 ↔ 249By similarity
Disulfide bondi202 ↔ 223By similarity
Disulfide bondi276 ↔ 351By similarity
Disulfide bondi300 ↔ 321By similarity
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi626 ↔ 637By similarity
Disulfide bondi631 ↔ 646By similarity
Disulfide bondi648 ↔ 657By similarity
Disulfide bondi664 ↔ 675By similarity
Disulfide bondi692 ↔ 784By similarity
Disulfide bondi760 ↔ 776By similarity
Disulfide bondi791 ↔ 834By similarity
Disulfide bondi820 ↔ 847By similarity

Post-translational modificationi

Contains mostly chondroitin sulfate.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

MaxQBiQ61361.
PaxDbiQ61361.
PRIDEiQ61361.

PTM databases

PhosphoSiteiQ61361.

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiQ61361.
CleanExiMM_BCAN.
ExpressionAtlasiQ61361. baseline and differential.
GenevestigatoriQ61361.

Interactioni

Subunit structurei

Interacts with TNR.By similarity

Protein-protein interaction databases

IntActiQ61361. 2 interactions.
MINTiMINT-4107305.
STRINGi10090.ENSMUSP00000088491.

Structurei

3D structure databases

ProteinModelPortaliQ61361.
SMRiQ61361. Positions 40-144, 160-250, 266-356, 664-787.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 154120Ig-like V-typeAdd
BLAST
Domaini156 – 25196Link 1PROSITE-ProRule annotationAdd
BLAST
Domaini256 – 35398Link 2PROSITE-ProRule annotationAdd
BLAST
Domaini622 – 65837EGF-likePROSITE-ProRule annotationAdd
BLAST
Domaini658 – 786129C-type lectinPROSITE-ProRule annotationAdd
BLAST
Domaini789 – 84961SushiPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.PROSITE-ProRule annotation
Contains 2 Link domains.PROSITE-ProRule annotation
Contains 1 Sushi (CCP/SCR) domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Immunoglobulin domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiNOG136696.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000115520.
HOVERGENiHBG008175.
InParanoidiQ61361.
KOiK06795.
OMAiDVGLRFC.
OrthoDBiEOG7PS1F3.
TreeFamiTF332134.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61361-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG
60 70 80 90 100
ALAIPCHVHH LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN
110 120 130 140 150
EAYRFRVALP AYPASLTDVS LVLSELRPND SGVYRCEVQH GIDDSSDAVE
160 170 180 190 200
VKVKGVVFLY REGSARYAFS FAGAQEACAR IGARIATPEQ LYAAYLGGYE
210 220 230 240 250
QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG PDDLYDVYCY
260 270 280 290 300
AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC
310 320 330 340 350
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY
360 370 380 390 400
CFRDSAHPSA SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI
410 420 430 440 450
YSIPISEDGG GGSSTPEDPA EAPRTPLESE TQSIAPPTES SEEEGVALEE
460 470 480 490 500
EERFKDLEAL EEEKEQEDLW VWPRELSSPL PTGSETEHSL SQVSPPAQAV
510 520 530 540 550
LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV GGETGSPELS
560 570 580 590 600
GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS
610 620 630 640 650
VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP
660 670 680 690 700
GYGGDLCDVG LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT
710 720 730 740 750
SICTPEEQDF VNDRYREYQW IGLNDRTIEG DFLWSDGAPL LYENWNPGQP
760 770 780 790 800
DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL SYTCKMGLVS CGPPPQLPLA
810 820 830 840 850
QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW EAPQISCVPR
860 870 880
RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL
Length:883
Mass (Da):95,815
Last modified:July 27, 2011 - v2
Checksum:i64DDE4D951D2042A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421T → A in CAA60575 (PubMed:9286696).Curated
Sequence conflicti65 – 651H → R in CAA60575 (PubMed:9286696).Curated
Sequence conflicti504 – 5041G → D in CAA60575 (PubMed:9286696).Curated
Sequence conflicti514 – 5141V → F in CAA60575 (PubMed:9286696).Curated
Sequence conflicti528 – 5303GSP → WSA in CAA60575 (PubMed:9286696).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87096 mRNA. Translation: CAA60575.1.
CH466547 Genomic DNA. Translation: EDL15323.1.
BC052032 mRNA. Translation: AAH52032.1.
CCDSiCCDS17462.1.
PIRiS57653.
RefSeqiNP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGeneiMm.4598.

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
GeneIDi12032.
KEGGimmu:12032.
UCSCiuc008pto.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Brevican

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87096 mRNA. Translation: CAA60575.1.
CH466547 Genomic DNA. Translation: EDL15323.1.
BC052032 mRNA. Translation: AAH52032.1.
CCDSiCCDS17462.1.
PIRiS57653.
RefSeqiNP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGeneiMm.4598.

3D structure databases

ProteinModelPortaliQ61361.
SMRiQ61361. Positions 40-144, 160-250, 266-356, 664-787.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61361. 2 interactions.
MINTiMINT-4107305.
STRINGi10090.ENSMUSP00000088491.

PTM databases

PhosphoSiteiQ61361.

Proteomic databases

MaxQBiQ61361.
PaxDbiQ61361.
PRIDEiQ61361.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
GeneIDi12032.
KEGGimmu:12032.
UCSCiuc008pto.2. mouse.

Organism-specific databases

CTDi63827.
MGIiMGI:1096385. Bcan.

Phylogenomic databases

eggNOGiNOG136696.
GeneTreeiENSGT00760000119025.
HOGENOMiHOG000115520.
HOVERGENiHBG008175.
InParanoidiQ61361.
KOiK06795.
OMAiDVGLRFC.
OrthoDBiEOG7PS1F3.
TreeFamiTF332134.

Enzyme and pathway databases

ReactomeiREACT_196489. A tetrasaccharide linker sequence is required for GAG synthesis.
REACT_196514. Chondroitin sulfate biosynthesis.
REACT_196540. Dermatan sulfate biosynthesis.
REACT_196606. ECM proteoglycans.
REACT_198981. CS/DS degradation.
REACT_199052. Degradation of the extracellular matrix.
REACT_268952. Defective B3GAT3 causes JDSSDHD.
REACT_268957. Defective CHSY1 causes TPBS.
REACT_269050. Defective CHST3 causes SEDCJD.
REACT_269282. Defective B4GALT7 causes EDS, progeroid type.
REACT_271176. Defective CHST14 causes EDS, musculocontractural type.

Miscellaneous databases

ChiTaRSiBcan. mouse.
NextBioi280271.
PROiQ61361.
SOURCEiSearch...

Gene expression databases

BgeeiQ61361.
CleanExiMM_BCAN.
ExpressionAtlasiQ61361. baseline and differential.
GenevestigatoriQ61361.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and chromosomal localization of the mouse brevican gene."
    Rauch U., Meyer H., Brakebusch C., Seidenbecher C., Gundelfinger E.D., Beier D.R., Fassler R.
    Genomics 44:15-21(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.

Entry informationi

Entry nameiPGCB_MOUSE
AccessioniPrimary (citable) accession number: Q61361
Secondary accession number(s): Q80WT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.