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Q61361 (PGCB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Brevican core protein
Gene names
Name:Bcan
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length883 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Subunit structure

Interacts with TNR By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Brain.

Post-translational modification

Contains mostly chondroitin sulfate By similarity.

Sequence similarities

Belongs to the aggrecan/versican proteoglycan family.

Contains 1 C-type lectin domain.

Contains 1 EGF-like domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Contains 2 Link domains.

Contains 1 Sushi (CCP/SCR) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 883861Brevican core protein
PRO_0000017512

Regions

Domain35 – 154120Ig-like V-type
Domain156 – 25196Link 1
Domain256 – 35398Link 2
Domain622 – 65837EGF-like
Domain658 – 786129C-type lectin
Domain789 – 84961Sushi

Amino acid modifications

Glycosylation1291N-linked (GlcNAc...) Potential
Glycosylation3361N-linked (GlcNAc...) Potential
Disulfide bond56 ↔ 136 By similarity
Disulfide bond178 ↔ 249 By similarity
Disulfide bond202 ↔ 223 By similarity
Disulfide bond276 ↔ 351 By similarity
Disulfide bond300 ↔ 321 By similarity
Disulfide bond626 ↔ 637 By similarity
Disulfide bond631 ↔ 646 By similarity
Disulfide bond648 ↔ 657 By similarity
Disulfide bond664 ↔ 675 By similarity
Disulfide bond692 ↔ 784 By similarity
Disulfide bond760 ↔ 776 By similarity
Disulfide bond791 ↔ 834 By similarity
Disulfide bond820 ↔ 847 By similarity

Experimental info

Sequence conflict421T → A in CAA60575. Ref.1
Sequence conflict651H → R in CAA60575. Ref.1
Sequence conflict5041G → D in CAA60575. Ref.1
Sequence conflict5141V → F in CAA60575. Ref.1
Sequence conflict528 – 5303GSP → WSA in CAA60575. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61361 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 64DDE4D951D2042A

FASTA88395,815
        10         20         30         40         50         60 
MIPLLLSLLA ALVLTQAPAA LADDLKEDSS EDRAFRVRIG ATQLRGVLGG ALAIPCHVHH 

        70         80         90        100        110        120 
LRPPHSRRAA PGFPRVKWTF LSGDREVEVL VARGLRVKVN EAYRFRVALP AYPASLTDVS 

       130        140        150        160        170        180 
LVLSELRPND SGVYRCEVQH GIDDSSDAVE VKVKGVVFLY REGSARYAFS FAGAQEACAR 

       190        200        210        220        230        240 
IGARIATPEQ LYAAYLGGYE QCDAGWLSDQ TVRYPIQNPR EACSGDMDGY PGVRNYGVVG 

       250        260        270        280        290        300 
PDDLYDVYCY AEDLNGELFL GAPPSKLTWE EARDYCLERG AQIASTGQLY AAWNGGLDRC 

       310        320        330        340        350        360 
SPGWLADGSV RYPIITPSQR CGGGLPGVKT LFLFPNQTGF PSKQNRFNVY CFRDSAHPSA 

       370        380        390        400        410        420 
SSEASSPASD GLEAIVTVTE KLEELQLPQE AMESESRGAI YSIPISEDGG GGSSTPEDPA 

       430        440        450        460        470        480 
EAPRTPLESE TQSIAPPTES SEEEGVALEE EERFKDLEAL EEEKEQEDLW VWPRELSSPL 

       490        500        510        520        530        540 
PTGSETEHSL SQVSPPAQAV LQLGASPSPG PPRVRGPPAE TLLPPREGSP TSTPGGAREV 

       550        560        570        580        590        600 
GGETGSPELS GVPRESEEAG SSSLEDGPSL LPATWAPVGP RELETPSEEK SGRTVLAGTS 

       610        620        630        640        650        660 
VQAQPVLPTD SASHGGVAVA PSSGDCIPSP CHNGGTCLEE KEGFRCLCLP GYGGDLCDVG 

       670        680        690        700        710        720 
LHFCSPGWEA FQGACYKHFS TRRSWEEAES QCRALGAHLT SICTPEEQDF VNDRYREYQW 

       730        740        750        760        770        780 
IGLNDRTIEG DFLWSDGAPL LYENWNPGQP DSYFLSGENC VVMVWHDQGQ WSDVPCNYHL 

       790        800        810        820        830        840 
SYTCKMGLVS CGPPPQLPLA QIFGRPRLRY AVDTVLRYRC RDGLAQRNLP LIRCQENGLW 

       850        860        870        880 
EAPQISCVPR RPGRALRSMD APEGPRGQLS RHRKAPLTPP SSL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and chromosomal localization of the mouse brevican gene."
Rauch U., Meyer H., Brakebusch C., Seidenbecher C., Gundelfinger E.D., Beier D.R., Fassler R.
Genomics 44:15-21(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[4]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87096 mRNA. Translation: CAA60575.1.
CH466547 Genomic DNA. Translation: EDL15323.1.
BC052032 mRNA. Translation: AAH52032.1.
CCDSCCDS17462.1.
PIRS57653.
RefSeqNP_001103228.1. NM_001109758.1.
NP_031555.2. NM_007529.2.
XP_006500999.1. XM_006500936.1.
XP_006501000.1. XM_006500937.1.
UniGeneMm.4598.

3D structure databases

ProteinModelPortalQ61361.
SMRQ61361. Positions 42-142, 160-250, 266-356, 626-787.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61361. 2 interactions.
MINTMINT-4107305.
STRING10090.ENSMUSP00000088491.

PTM databases

PhosphoSiteQ61361.

Proteomic databases

MaxQBQ61361.
PaxDbQ61361.
PRIDEQ61361.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000090971; ENSMUSP00000088491; ENSMUSG00000004892.
GeneID12032.
KEGGmmu:12032.
UCSCuc008pto.2. mouse.

Organism-specific databases

CTD63827.
MGIMGI:1096385. Bcan.

Phylogenomic databases

eggNOGNOG136696.
GeneTreeENSGT00750000117316.
HOGENOMHOG000115520.
HOVERGENHBG008175.
InParanoidQ80WT7.
KOK06795.
OMAYAFSFAG.
OrthoDBEOG7PS1F3.
TreeFamTF332134.

Gene expression databases

BgeeQ61361.
CleanExMM_BCAN.
GenevestigatorQ61361.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.100.10. 3 hits.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
IPR000538. Link.
IPR000436. Sushi_SCR_CCP.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF00059. Lectin_C. 1 hit.
PF00084. Sushi. 1 hit.
PF07686. V-set. 1 hit.
PF00193. Xlink. 2 hits.
[Graphical view]
PRINTSPR01265. LINKMODULE.
SMARTSM00032. CCP. 1 hit.
SM00034. CLECT. 1 hit.
SM00181. EGF. 1 hit.
SM00406. IGv. 1 hit.
SM00445. LINK. 2 hits.
[Graphical view]
SUPFAMSSF56436. SSF56436. 3 hits.
SSF57535. SSF57535. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
PS01241. LINK_1. 2 hits.
PS50963. LINK_2. 2 hits.
PS50923. SUSHI. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCAN. mouse.
NextBio280271.
PROQ61361.
SOURCESearch...

Entry information

Entry namePGCB_MOUSE
AccessionPrimary (citable) accession number: Q61361
Secondary accession number(s): Q80WT7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot