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Protein

Forkhead box protein D1

Gene

Foxd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (PubMed:15509772, PubMed:15634693, PubMed:9811586). Involved in transcriptional activation of PGF and C3 genes (By similarity).By similarity3 Publications

Caution

Was originally assigned to be BF-2 (FOXG1).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi130 – 224Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding, bending Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • axon guidance Source: MGI
  • branching involved in ureteric bud morphogenesis Source: MGI
  • dichotomous subdivision of terminal units involved in ureteric bud branching Source: UniProtKB
  • kidney development Source: MGI
  • luteinizing hormone secretion Source: CACAO
  • metanephric capsule development Source: UniProtKB
  • metanephric capsule specification Source: UniProtKB
  • metanephric nephron development Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • nephrogenic mesenchyme development Source: UniProtKB
  • pattern specification involved in metanephros development Source: UniProtKB
  • positive regulation of BMP signaling pathway Source: UniProtKB
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of kidney development Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D1
Alternative name(s):
Brain factor 2
Short name:
BF-2
Forkhead-related protein FKHL8
Forkhead-related transcription factor 4
Short name:
FREAC-4
HFH-BF-2
Gene namesi
Name:Foxd1
Synonyms:Fkhl8, Freac4, Hfhbf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1347463 Foxd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice show disrupted cell identity in the ventrotemporal area of the retina and aberrant morphogenesis of the optic chiasm. Their kidneys remain fused, have a disorganised ureteric tree and fail to ascend to a lumbar position.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918121 – 456Forkhead box protein D1Add BLAST456

Proteomic databases

PaxDbiQ61345
PRIDEiQ61345

PTM databases

PhosphoSitePlusiQ61345

Expressioni

Tissue specificityi

Predominantly expressed in the CNS and temporal half of the retina. Also expressed in the condensed head mesenchyme, metanephric blastema of the developing kidney, cortex of the adrenal gland, condensed mesenchyme at the base of the follicles of vibrassae and cartilage perichondrium of the developing vertebrate.

Developmental stagei

At E9.5 embryos, expressed in a limited region of the neuroepithelium and also in the temporal half of the primary optic cup and the optic stalk. At E10.5, seen in the hypothalamus, temporal half of the optic stalk, and temporal hemiretina. At E12.5 and E13.5 a high expression is seen in regions of condensed mesenchyme of the head, and as neuroepithelial cells begin to differentiate and migrate outward from the ventricular zone, expression declines markedly. By E16.5 levels are diminished and restricted to unfused pockets along the exhausted ventricular zone.

Gene expression databases

BgeeiENSMUSG00000078302
CleanExiMM_FOXD1
GenevisibleiQ61345 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100725

Structurei

3D structure databases

ProteinModelPortaliQ61345
SMRiQ61345
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 32Poly-Glu4
Compositional biasi33 – 36Poly-Asp4
Compositional biasi38 – 46Poly-Gly9
Compositional biasi55 – 58Poly-Arg4
Compositional biasi73 – 76Poly-Asp4
Compositional biasi261 – 267Poly-Pro7
Compositional biasi293 – 302Poly-Ala10
Compositional biasi308 – 319Poly-ProAdd BLAST12
Compositional biasi395 – 400Poly-Gly6
Compositional biasi420 – 425Poly-Ala6

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ61345
KOiK09397
OMAiGYGPYGC
OrthoDBiEOG091G0HW9
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q61345-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLSTEMSDA SGLAEETDID VVGEGEDDEE EEDDDDEGGG GRGGGGSRLP
60 70 80 90 100
SSAQRRRRSY AGEDDLEDLE EEDDDDLLLA SRPAASPAPP GPAPAPGTGS
110 120 130 140 150
GGCSGAGAGG GAGGGTGAGT GGGAKNPLVK PPYSYIALIT MAILQSPKKR
160 170 180 190 200
LTLSEICEFI SSRFPYYREK FPAWQNSIRH NLSLNDCFVK IPREPGNPGK
210 220 230 240 250
GNYWTLDPES ADMFDNGSFL RRRKRFKRQP LLAPHAAAEA LLLRGAGPAA
260 270 280 290 300
GAGDPGAALF PPPPPPPACG YGAYGCAYGL QLPPCAPPSA LFAAAAAAAA
310 320 330 340 350
AAFHPHSPPP PPPPPPPPPG AAAELARTAF GYRSHALAAA LPGPLQAAAV
360 370 380 390 400
KAGGPGAAAL ARSPFSIESL IGRTRGPAAA GAHVSSGAAS GTAPGPGGGG
410 420 430 440 450
CAVQAAAGPA VALTRSLVVA AAAAASSVSS SAALGTLHQG TALSSVENFT

ARISNC
Length:456
Mass (Da):45,371
Last modified:July 27, 2011 - v2
Checksum:i3153172991DC99A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti355P → R in AAC42042 (PubMed:7815060).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38607 mRNA Translation: AAC42042.1
AK132390 mRNA Translation: BAE21140.1
AK142034 mRNA Translation: BAE24920.1
CCDSiCCDS36759.1
RefSeqiNP_032268.2, NM_008242.2
UniGeneiMm.347441

Genome annotation databases

EnsembliENSMUST00000105098; ENSMUSP00000100725; ENSMUSG00000078302
GeneIDi15229
KEGGimmu:15229
UCSCiuc009van.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFOXD1_MOUSE
AccessioniPrimary (citable) accession number: Q61345
Secondary accession number(s): Q3UQW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health