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Protein

B-cell receptor-associated protein 31

Gene

Bcap31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis.2 Publications

GO - Molecular functioni

  • MHC class I protein binding Source: MGI
  • protein complex binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-111465. Apoptotic cleavage of cellular proteins.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell receptor-associated protein 31
Short name:
BCR-associated protein 31
Short name:
Bap31
Alternative name(s):
p28
Gene namesi
Name:Bcap31
Synonyms:Bap31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1350933. Bcap31.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 6LumenalSequence analysis5
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 43CytoplasmicSequence analysisAdd BLAST16
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 102LumenalSequence analysisAdd BLAST38
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Topological domaini124 – 245CytoplasmicSequence analysisAdd BLAST122

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001428922 – 245B-cell receptor-associated protein 31Add BLAST244

Post-translational modificationi

Cleaved by CASP8 and other caspases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei164 – 165Cleavage; by caspase-8Sequence analysis2

Proteomic databases

EPDiQ61335.
MaxQBiQ61335.
PaxDbiQ61335.
PRIDEiQ61335.
TopDownProteomicsiQ61335.

PTM databases

iPTMnetiQ61335.
PhosphoSitePlusiQ61335.
SwissPalmiQ61335.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSMUSG00000002015.
CleanExiMM_BCAP31.
GenevisibleiQ61335. MM.

Interactioni

Subunit structurei

Homodimer and heterodimer with BCAP29. Binds CASP8 as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with HACD2 (By similarity).By similarity

GO - Molecular functioni

  • MHC class I protein binding Source: MGI
  • protein complex binding Source: MGI

Protein-protein interaction databases

IntActiQ61335. 4 interactors.
MINTiMINT-1797765.
STRINGi10090.ENSMUSP00000002091.

Structurei

3D structure databases

ProteinModelPortaliQ61335.
SMRiQ61335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili165 – 236By similarityAdd BLAST72

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi242 – 245Di-lysine motif4

Sequence similaritiesi

Belongs to the BCAP29/BCAP31 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1962. Eukaryota.
COG5374. LUCA.
GeneTreeiENSGT00390000011863.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
InParanoidiQ61335.
KOiK14009.
OMAiMQHSMRL.
OrthoDBiEOG091G0MHN.
TreeFamiTF315310.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 2 hits.
PfamiPF05529. Bap31. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61335-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQWTTVAT FLYAEVFAVL LLCIPFISPK RWQKVFKSRL VELVVTYGNT
60 70 80 90 100
FFVVLIVILV LLVIDAVREI LKYDDVTEKV NLQNNPGAME HFHMKLFRAQ
110 120 130 140 150
RNLYIAGFSL LLSFLLRRLV TLISQQATLL ASNEAFKKQA ESASEAAKKY
160 170 180 190 200
MEENDQLKKG AAEDGDKLDI GNTEMKLEEN KSLKNDLRKL KDELASTKKK
210 220 230 240
LEKAENEALA MQKQSEGLTK EYDRLLEEHA KLQASVRGPS VKKEE
Length:245
Mass (Da):27,957
Last modified:October 3, 2012 - v4
Checksum:iA8C53B7A04E06C97
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28S → Y in BAB25427 (PubMed:16141072).Curated1
Sequence conflicti108F → L in CAA57414 (PubMed:8612576).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81816 mRNA. Translation: CAA57414.1.
AK008043 mRNA. Translation: BAB25427.1.
AK011500 mRNA. Translation: BAB27660.1.
AL805924 Genomic DNA. Translation: CAM21061.1.
CH466650 Genomic DNA. Translation: EDL29886.1.
BC002106 mRNA. Translation: AAH02106.1.
CCDSiCCDS30209.1.
PIRiS71116.
RefSeqiNP_001300627.1. NM_001313698.1.
NP_036190.2. NM_012060.5.
XP_006528111.1. XM_006528048.2.
XP_011245902.1. XM_011247600.2.
UniGeneiMm.17.

Genome annotation databases

EnsembliENSMUST00000002091; ENSMUSP00000002091; ENSMUSG00000002015.
GeneIDi27061.
KEGGimmu:27061.
UCSCiuc009tmj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81816 mRNA. Translation: CAA57414.1.
AK008043 mRNA. Translation: BAB25427.1.
AK011500 mRNA. Translation: BAB27660.1.
AL805924 Genomic DNA. Translation: CAM21061.1.
CH466650 Genomic DNA. Translation: EDL29886.1.
BC002106 mRNA. Translation: AAH02106.1.
CCDSiCCDS30209.1.
PIRiS71116.
RefSeqiNP_001300627.1. NM_001313698.1.
NP_036190.2. NM_012060.5.
XP_006528111.1. XM_006528048.2.
XP_011245902.1. XM_011247600.2.
UniGeneiMm.17.

3D structure databases

ProteinModelPortaliQ61335.
SMRiQ61335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61335. 4 interactors.
MINTiMINT-1797765.
STRINGi10090.ENSMUSP00000002091.

PTM databases

iPTMnetiQ61335.
PhosphoSitePlusiQ61335.
SwissPalmiQ61335.

Proteomic databases

EPDiQ61335.
MaxQBiQ61335.
PaxDbiQ61335.
PRIDEiQ61335.
TopDownProteomicsiQ61335.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000002091; ENSMUSP00000002091; ENSMUSG00000002015.
GeneIDi27061.
KEGGimmu:27061.
UCSCiuc009tmj.1. mouse.

Organism-specific databases

CTDi10134.
MGIiMGI:1350933. Bcap31.

Phylogenomic databases

eggNOGiKOG1962. Eukaryota.
COG5374. LUCA.
GeneTreeiENSGT00390000011863.
HOGENOMiHOG000204790.
HOVERGENiHBG050661.
InParanoidiQ61335.
KOiK14009.
OMAiMQHSMRL.
OrthoDBiEOG091G0MHN.
TreeFamiTF315310.

Enzyme and pathway databases

ReactomeiR-MMU-111465. Apoptotic cleavage of cellular proteins.
R-MMU-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiBcap31. mouse.
PROiQ61335.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002015.
CleanExiMM_BCAP31.
GenevisibleiQ61335. MM.

Family and domain databases

InterProiIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERiPTHR12701. PTHR12701. 2 hits.
PfamiPF05529. Bap31. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBAP31_MOUSE
AccessioniPrimary (citable) accession number: Q61335
Secondary accession number(s): A2ALM8, Q9D0E9, Q9D8G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 3, 2012
Last modified: November 2, 2016
This is version 137 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.