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Q61335

- BAP31_MOUSE

UniProt

Q61335 - BAP31_MOUSE

Protein

B-cell receptor-associated protein 31

Gene

Bcap31

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 4 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei164 – 1652Cleavage; by caspase-8Sequence Analysis

    GO - Molecular functioni

    1. MHC class I protein binding Source: MGI
    2. protein binding Source: MGI
    3. protein complex binding Source: MGI

    GO - Biological processi

    1. calcium-mediated signaling using intracellular calcium source Source: Ensembl
    2. ER to Golgi vesicle-mediated transport Source: MGI
    3. intracellular protein transport Source: InterPro
    4. negative regulation of endoplasmic reticulum calcium ion concentration Source: Ensembl
    5. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    6. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    7. positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
    8. positive regulation of mitochondrial calcium ion concentration Source: Ensembl
    9. protein localization to endoplasmic reticulum exit site Source: MGI
    10. spermatogenesis Source: BHF-UCL

    Keywords - Biological processi

    Apoptosis, ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_224460. Apoptotic cleavage of cellular proteins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    B-cell receptor-associated protein 31
    Short name:
    BCR-associated protein 31
    Short name:
    Bap31
    Alternative name(s):
    p28
    Gene namesi
    Name:Bcap31
    Synonyms:Bap31
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1350933. Bcap31.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Multi-pass membrane protein By similarity
    Note: May shuttle between the ER and the intermediate compartment/cis-Golgi complex.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. Golgi membrane Source: MGI
    4. integral component of plasma membrane Source: Ensembl
    5. lipid particle Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 245244B-cell receptor-associated protein 31PRO_0000142892Add
    BLAST

    Post-translational modificationi

    Cleaved by CASP8 and other caspases.By similarity

    Proteomic databases

    MaxQBiQ61335.
    PaxDbiQ61335.
    PRIDEiQ61335.

    PTM databases

    PhosphoSiteiQ61335.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    CleanExiMM_BCAP31.
    GenevestigatoriQ61335.

    Interactioni

    Subunit structurei

    Homodimer and heterodimer with BCAP29. Binds CASP8 as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61335. 4 interactions.
    MINTiMINT-1797765.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61335.
    SMRiQ61335. Positions 178-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 65LumenalSequence Analysis
    Topological domaini28 – 4316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini65 – 10238LumenalSequence AnalysisAdd
    BLAST
    Topological domaini124 – 245122CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei44 – 6421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei103 – 12321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili165 – 23672By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi242 – 2454Di-lysine motif

    Sequence similaritiesi

    Belongs to the BCAP29/BCAP31 family.Curated

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG244998.
    GeneTreeiENSGT00390000011863.
    HOGENOMiHOG000204790.
    HOVERGENiHBG050661.
    InParanoidiQ61335.
    KOiK14009.
    OMAiHSMRLFR.
    OrthoDBiEOG7B5WXD.
    TreeFamiTF315310.

    Family and domain databases

    InterProiIPR008417. BAP29/BAP31.
    [Graphical view]
    PANTHERiPTHR12701. PTHR12701. 1 hit.
    PfamiPF05529. Bap31. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61335-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLQWTTVAT FLYAEVFAVL LLCIPFISPK RWQKVFKSRL VELVVTYGNT    50
    FFVVLIVILV LLVIDAVREI LKYDDVTEKV NLQNNPGAME HFHMKLFRAQ 100
    RNLYIAGFSL LLSFLLRRLV TLISQQATLL ASNEAFKKQA ESASEAAKKY 150
    MEENDQLKKG AAEDGDKLDI GNTEMKLEEN KSLKNDLRKL KDELASTKKK 200
    LEKAENEALA MQKQSEGLTK EYDRLLEEHA KLQASVRGPS VKKEE 245
    Length:245
    Mass (Da):27,957
    Last modified:October 3, 2012 - v4
    Checksum:iA8C53B7A04E06C97
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281S → Y in BAB25427. (PubMed:16141072)Curated
    Sequence conflicti108 – 1081F → L in CAA57414. (PubMed:8612576)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81816 mRNA. Translation: CAA57414.1.
    AK008043 mRNA. Translation: BAB25427.1.
    AK011500 mRNA. Translation: BAB27660.1.
    AL805924 Genomic DNA. Translation: CAM21061.1.
    CH466650 Genomic DNA. Translation: EDL29886.1.
    BC002106 mRNA. Translation: AAH02106.1.
    CCDSiCCDS30209.1.
    PIRiS71116.
    RefSeqiNP_036190.2. NM_012060.4.
    XP_006528111.1. XM_006528048.1.
    UniGeneiMm.17.

    Genome annotation databases

    EnsembliENSMUST00000002091; ENSMUSP00000002091; ENSMUSG00000002015.
    GeneIDi27061.
    KEGGimmu:27061.
    UCSCiuc009tmj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81816 mRNA. Translation: CAA57414.1 .
    AK008043 mRNA. Translation: BAB25427.1 .
    AK011500 mRNA. Translation: BAB27660.1 .
    AL805924 Genomic DNA. Translation: CAM21061.1 .
    CH466650 Genomic DNA. Translation: EDL29886.1 .
    BC002106 mRNA. Translation: AAH02106.1 .
    CCDSi CCDS30209.1.
    PIRi S71116.
    RefSeqi NP_036190.2. NM_012060.4.
    XP_006528111.1. XM_006528048.1.
    UniGenei Mm.17.

    3D structure databases

    ProteinModelPortali Q61335.
    SMRi Q61335. Positions 178-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61335. 4 interactions.
    MINTi MINT-1797765.

    PTM databases

    PhosphoSitei Q61335.

    Proteomic databases

    MaxQBi Q61335.
    PaxDbi Q61335.
    PRIDEi Q61335.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000002091 ; ENSMUSP00000002091 ; ENSMUSG00000002015 .
    GeneIDi 27061.
    KEGGi mmu:27061.
    UCSCi uc009tmj.1. mouse.

    Organism-specific databases

    CTDi 10134.
    MGIi MGI:1350933. Bcap31.

    Phylogenomic databases

    eggNOGi NOG244998.
    GeneTreei ENSGT00390000011863.
    HOGENOMi HOG000204790.
    HOVERGENi HBG050661.
    InParanoidi Q61335.
    KOi K14009.
    OMAi HSMRLFR.
    OrthoDBi EOG7B5WXD.
    TreeFami TF315310.

    Enzyme and pathway databases

    Reactomei REACT_224460. Apoptotic cleavage of cellular proteins.

    Miscellaneous databases

    ChiTaRSi BCAP31. mouse.
    NextBioi 305025.
    PROi Q61335.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_BCAP31.
    Genevestigatori Q61335.

    Family and domain databases

    InterProi IPR008417. BAP29/BAP31.
    [Graphical view ]
    PANTHERi PTHR12701. PTHR12701. 1 hit.
    Pfami PF05529. Bap31. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence."
      Adachi T., Schamel W.W.A., Kim K.-M., Watanabe T., Becker B., Nielsen P.J., Reth M.
      EMBO J. 15:1534-1541(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-11, INTERACTION WITH BCAP29 AND IGD, TISSUE SPECIFICITY.
      Tissue: Plasmacytoma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Small intestine.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary tumor.
    6. "Two new proteins preferentially associated with membrane immunoglobulin D."
      Kim K.-M., Adachi T., Nielsen P.J., Terashima M., Lamers M.C., Koehler G., Reth M.
      EMBO J. 13:3793-3800(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 150-157; 168-180; 205-213; 214-220; 221-231 AND 232-242, INTERACTION WITH BCAP29 AND IGD.
    7. "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31."
      Annaert W.G., Becker B., Kistner U., Reth M., Jahn R.
      J. Cell Biol. 139:1397-1410(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH VAMP3.
    8. "Bap29/31 influences the intracellular traffic of MHC class I molecules."
      Paquet M.E., Cohen-Doyle M., Shore G.C., Williams D.B.
      J. Immunol. 172:7548-7555(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiBAP31_MOUSE
    AccessioniPrimary (citable) accession number: Q61335
    Secondary accession number(s): A2ALM8, Q9D0E9, Q9D8G7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 116 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3