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Q61335 (BAP31_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 114. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
B-cell receptor-associated protein 31

Short name=BCR-associated protein 31
Short name=Bap31
Alternative name(s):
p28
Gene names
Name:Bcap31
Synonyms:Bap31
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. Ref.7 Ref.8

Subunit structure

Homodimer and heterodimer with BCAP29. Binds CASP8 as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1. Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II. Interacts with PTPLB By similarity. Ref.1 Ref.6 Ref.7

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein By similarity. Note: May shuttle between the ER and the intermediate compartment/cis-Golgi complex By similarity.

Tissue specificity

Ubiquitous. Ref.1

Post-translational modification

Cleaved by CASP8 and other caspases By similarity.

Sequence similarities

Belongs to the BCAP29/BCAP31 family.

Ontologies

Keywords
   Biological processApoptosis
ER-Golgi transport
Protein transport
Transport
   Cellular componentEndoplasmic reticulum
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processER to Golgi vesicle-mediated transport

Inferred from mutant phenotype Ref.8. Source: MGI

calcium-mediated signaling using intracellular calcium source

Inferred from electronic annotation. Source: Ensembl

intracellular protein transport

Inferred from electronic annotation. Source: InterPro

negative regulation of endoplasmic reticulum calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of intrinsic apoptotic signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of mitochondrial calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

protein localization to endoplasmic reticulum exit site

Inferred from genetic interaction Ref.8. Source: MGI

spermatogenesis

Inferred from expression pattern PubMed 14581517. Source: BHF-UCL

   Cellular_componentGolgi membrane

Inferred from direct assay PubMed 11042173. Source: MGI

endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

endoplasmic reticulum-Golgi intermediate compartment membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of plasma membrane

Inferred from electronic annotation. Source: Ensembl

lipid particle

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionMHC class I protein binding

Inferred from physical interaction Ref.8. Source: MGI

protein binding

Inferred from physical interaction Ref.8. Source: MGI

protein complex binding

Inferred from direct assay Ref.8. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 245244B-cell receptor-associated protein 31
PRO_0000142892

Regions

Topological domain2 – 65Lumenal Potential
Transmembrane7 – 2721Helical; Potential
Topological domain28 – 4316Cytoplasmic Potential
Transmembrane44 – 6421Helical; Potential
Topological domain65 – 10238Lumenal Potential
Transmembrane103 – 12321Helical; Potential
Topological domain124 – 245122Cytoplasmic Potential
Motif242 – 2454Di-lysine motif

Sites

Site164 – 1652Cleavage; by caspase-8 Potential

Experimental info

Sequence conflict281S → Y in BAB25427. Ref.2
Sequence conflict1081F → L in CAA57414. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q61335 [UniParc].

Last modified October 3, 2012. Version 4.
Checksum: A8C53B7A04E06C97

FASTA24527,957
        10         20         30         40         50         60 
MSLQWTTVAT FLYAEVFAVL LLCIPFISPK RWQKVFKSRL VELVVTYGNT FFVVLIVILV 

        70         80         90        100        110        120 
LLVIDAVREI LKYDDVTEKV NLQNNPGAME HFHMKLFRAQ RNLYIAGFSL LLSFLLRRLV 

       130        140        150        160        170        180 
TLISQQATLL ASNEAFKKQA ESASEAAKKY MEENDQLKKG AAEDGDKLDI GNTEMKLEEN 

       190        200        210        220        230        240 
KSLKNDLRKL KDELASTKKK LEKAENEALA MQKQSEGLTK EYDRLLEEHA KLQASVRGPS 


VKKEE 

« Hide

References

« Hide 'large scale' references
[1]"The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence."
Adachi T., Schamel W.W.A., Kim K.-M., Watanabe T., Becker B., Nielsen P.J., Reth M.
EMBO J. 15:1534-1541(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-11, INTERACTION WITH BCAP29 AND IGD, TISSUE SPECIFICITY.
Tissue: Plasmacytoma.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Small intestine.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary tumor.
[6]"Two new proteins preferentially associated with membrane immunoglobulin D."
Kim K.-M., Adachi T., Nielsen P.J., Terashima M., Lamers M.C., Koehler G., Reth M.
EMBO J. 13:3793-3800(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 150-157; 168-180; 205-213; 214-220; 221-231 AND 232-242, INTERACTION WITH BCAP29 AND IGD.
[7]"Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31."
Annaert W.G., Becker B., Kistner U., Reth M., Jahn R.
J. Cell Biol. 139:1397-1410(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH VAMP3.
[8]"Bap29/31 influences the intracellular traffic of MHC class I molecules."
Paquet M.E., Cohen-Doyle M., Shore G.C., Williams D.B.
J. Immunol. 172:7548-7555(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81816 mRNA. Translation: CAA57414.1.
AK008043 mRNA. Translation: BAB25427.1.
AK011500 mRNA. Translation: BAB27660.1.
AL805924 Genomic DNA. Translation: CAM21061.1.
CH466650 Genomic DNA. Translation: EDL29886.1.
BC002106 mRNA. Translation: AAH02106.1.
CCDSCCDS30209.1.
PIRS71116.
RefSeqNP_036190.2. NM_012060.4.
XP_006528111.1. XM_006528048.1.
UniGeneMm.17.

3D structure databases

ProteinModelPortalQ61335.
SMRQ61335. Positions 178-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61335. 4 interactions.
MINTMINT-1797765.

PTM databases

PhosphoSiteQ61335.

Proteomic databases

MaxQBQ61335.
PaxDbQ61335.
PRIDEQ61335.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000002091; ENSMUSP00000002091; ENSMUSG00000002015.
GeneID27061.
KEGGmmu:27061.
UCSCuc009tmj.1. mouse.

Organism-specific databases

CTD10134.
MGIMGI:1350933. Bcap31.

Phylogenomic databases

eggNOGNOG244998.
GeneTreeENSGT00390000011863.
HOGENOMHOG000204790.
HOVERGENHBG050661.
InParanoidQ61335.
KOK14009.
OMAHSMRLFR.
OrthoDBEOG7B5WXD.
TreeFamTF315310.

Gene expression databases

CleanExMM_BCAP31.
GenevestigatorQ61335.

Family and domain databases

InterProIPR008417. BAP29/BAP31.
[Graphical view]
PANTHERPTHR12701. PTHR12701. 1 hit.
PfamPF05529. Bap31. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSBCAP31. mouse.
NextBio305025.
PROQ61335.
SOURCESearch...

Entry information

Entry nameBAP31_MOUSE
AccessionPrimary (citable) accession number: Q61335
Secondary accession number(s): A2ALM8, Q9D0E9, Q9D8G7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot