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Protein

Tumor necrosis factor alpha-induced protein 2

Gene

Tnfaip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as a mediator of inflammation and angiogenesis.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor alpha-induced protein 2
Short name:
TNF alpha-induced protein 2
Alternative name(s):
Primary response gene B94 protein
Gene namesi
Name:Tnfaip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:104960. Tnfaip2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 691691Tumor necrosis factor alpha-induced protein 2PRO_0000118933Add
BLAST

Proteomic databases

MaxQBiQ61333.
PaxDbiQ61333.
PRIDEiQ61333.

PTM databases

PhosphoSiteiQ61333.

Expressioni

Developmental stagei

In 10-day embryos B94 is expressed prominently in the myocardium and in the aortic arch. By the 15th day of gestation, expression is restricted largely to the liver, the bone forming regions of the jaw, the aortic endothelium, and the nasopharynx: a pattern that is maintained until just prior to birth. Postnatally, expression shifts to the red pulp of the spleen and the thymic medulla.

Gene expression databases

BgeeiQ61333.
CleanExiMM_TNFAIP2.
ExpressionAtlasiQ61333. baseline and differential.
GenevisibleiQ61333. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099806.

Structurei

3D structure databases

ProteinModelPortaliQ61333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC6 family.Curated

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000060133.
HOVERGENiHBG079271.
InParanoidiQ61333.
KOiK19989.
OrthoDBiEOG7RFTGW.
PhylomeDBiQ61333.
TreeFamiTF314979.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKMVTFFQG FPGQQSVPGT LNFAVSPQKP RSTSEAESET SMSEASSEDL
60 70 80 90 100
MPSPEAPDGE EESAKKKEKK SKGLANMFSV FTKGKKKKKD QPRLSDLEVQ
110 120 130 140 150
PKPRPELDGP LPTVEELKEA LEHGRLEVAW QVLALERQLE AAAAAGGMSN
160 170 180 190 200
EELVWRQSKV EALYVLLCDQ VLGVLRRPLE AAPERLSQAL AVVSQEELED
210 220 230 240 250
RRASGGPLAA ALEATRPRRW LQRWRGVVAE VAAERLDAQP ATAPEGRSEA
260 270 280 290 300
ESRFLHMGRT MKEDLEVVVE RLKPLFPDEF NVVRTYAESY HYHFASHLCA
310 320 330 340 350
LAQFELCERD TYLLLLWVQN LYPNDILNSP KLAQELQGVG LGSLLPPKQI
360 370 380 390 400
RLLEAMFLSN EVTSVKQLMA RALELESQRW TQDVAPQSLD GHCHSELAID
410 420 430 440 450
ILQIISQGQT KAENITSDVG MQIKQLLLVE LAALLRSYQR AFDEFLEKSK
460 470 480 490 500
LLRNYRVNIM ANINNCLFFW TSVEQKWQIS HDSLNRLLEP LKDLKAHGFD
510 520 530 540 550
TLLQSLFLDL KPLFKKFTQT RWANPVETLE EIITTVSSSL PEFSELQDCF
560 570 580 590 600
REELMETVHL HLVKEYIIRL CKRRLVLKTA EQQQQLARHI LANADAIQGF
610 620 630 640 650
CTENGSTATW LHRALPMIAE IIRLQDSSAI KIEVATYATW YPDFSKGHLN
660 670 680 690
AILAIKGNLP SSEVRSIRNI LDINTGVQEP PRPLFSLIKV T
Length:691
Mass (Da):78,102
Last modified:May 31, 2011 - v2
Checksum:iEFA579705B72F5D2
GO

Sequence cautioni

The sequence AAA72044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti569 – 5691R → G in BAE41977 (PubMed:16141072).Curated
Sequence conflicti687 – 6871L → P in BAE41977 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154405 mRNA. Translation: BAE32563.1.
AK170719 mRNA. Translation: BAE41977.1.
AK172653 mRNA. Translation: BAE43114.1.
L24118 mRNA. Translation: AAA72044.1. Different initiation.
BC008165 mRNA. Translation: AAH08165.1.
CCDSiCCDS26178.2.
PIRiI49523.
RefSeqiNP_033422.2. NM_009396.2.
UniGeneiMm.255332.

Genome annotation databases

EnsembliENSMUST00000102745; ENSMUSP00000099806; ENSMUSG00000021281.
GeneIDi21928.
KEGGimmu:21928.
UCSCiuc007pcz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154405 mRNA. Translation: BAE32563.1.
AK170719 mRNA. Translation: BAE41977.1.
AK172653 mRNA. Translation: BAE43114.1.
L24118 mRNA. Translation: AAA72044.1. Different initiation.
BC008165 mRNA. Translation: AAH08165.1.
CCDSiCCDS26178.2.
PIRiI49523.
RefSeqiNP_033422.2. NM_009396.2.
UniGeneiMm.255332.

3D structure databases

ProteinModelPortaliQ61333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099806.

PTM databases

PhosphoSiteiQ61333.

Proteomic databases

MaxQBiQ61333.
PaxDbiQ61333.
PRIDEiQ61333.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102745; ENSMUSP00000099806; ENSMUSG00000021281.
GeneIDi21928.
KEGGimmu:21928.
UCSCiuc007pcz.2. mouse.

Organism-specific databases

CTDi7127.
MGIiMGI:104960. Tnfaip2.

Phylogenomic databases

eggNOGiKOG2286. Eukaryota.
COG5173. LUCA.
GeneTreeiENSGT00530000062934.
HOGENOMiHOG000060133.
HOVERGENiHBG079271.
InParanoidiQ61333.
KOiK19989.
OrthoDBiEOG7RFTGW.
PhylomeDBiQ61333.
TreeFamiTF314979.

Miscellaneous databases

ChiTaRSiTnfaip2. mouse.
PROiQ61333.
SOURCEiSearch...

Gene expression databases

BgeeiQ61333.
CleanExiMM_TNFAIP2.
ExpressionAtlasiQ61333. baseline and differential.
GenevisibleiQ61333. MM.

Family and domain databases

InterProiIPR010326. Sec6.
[Graphical view]
PANTHERiPTHR21292. PTHR21292. 1 hit.
PfamiPF06046. Sec6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. "B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome."
    Wolf F.W., Sarma V., Seldin M., Drake S., Suchard S.J., Shao H., O'Shea K.S., Dixit V.M.
    J. Biol. Chem. 269:3633-3640(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-691.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 489-691.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen.

Entry informationi

Entry nameiTNAP2_MOUSE
AccessioniPrimary (citable) accession number: Q61333
Secondary accession number(s): Q3T9B0, Q3TCH9, Q922G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: May 31, 2011
Last modified: June 8, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.