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Protein

Contactin-2

Gene

Cntn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region.By similarity

GO - Molecular functioni

  • carbohydrate binding Source: MGI
  • glycoprotein binding Source: MGI
  • protein self-association Source: MGI

GO - Biological processi

  • adult walking behavior Source: MGI
  • axonal fasciculation Source: MGI
  • axon guidance Source: MGI
  • cell-matrix adhesion Source: Ensembl
  • central nervous system myelination Source: MGI
  • cerebral cortex GABAergic interneuron migration Source: MGI
  • clustering of voltage-gated potassium channels Source: BHF-UCL
  • establishment of protein localization to juxtaparanode region of axon Source: BHF-UCL
  • learning Source: MGI
  • microtubule cytoskeleton organization Source: MGI
  • negative regulation of neuron differentiation Source: MGI
  • neuron migration Source: MGI
  • neuron projection development Source: MGI
  • positive regulation of adenosine receptor signaling pathway Source: MGI
  • positive regulation of protein processing Source: MGI
  • presynaptic membrane organization Source: UniProtKB
  • protein localization to juxtaparanode region of axon Source: BHF-UCL
  • receptor internalization Source: MGI
  • regulation of astrocyte differentiation Source: MGI
  • regulation of axon diameter Source: MGI
  • regulation of cell morphogenesis involved in differentiation Source: MGI
  • regulation of neuronal synaptic plasticity Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-2
Alternative name(s):
Axonal glycoprotein TAG-1
Axonin-1
Transient axonal glycoprotein 1
Short name:
TAX-1
Gene namesi
Name:Cntn2
Synonyms:Tax
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104518. Cntn2.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • axon Source: MGI
  • cell surface Source: MGI
  • juxtaparanode region of axon Source: BHF-UCL
  • myelin sheath Source: BHF-UCL
  • neuronal cell body Source: MGI
  • neuron projection Source: MGI
  • node of Ranvier Source: BHF-UCL
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030By similarityAdd
BLAST
Chaini31 – 1014984Contactin-2PRO_0000014697Add
BLAST
Propeptidei1015 – 104026Removed in mature formSequence analysisPRO_0000014698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi63 ↔ 113PROSITE-ProRule annotation
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi157 ↔ 209PROSITE-ProRule annotation
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi263 ↔ 308PROSITE-ProRule annotation
Disulfide bondi350 ↔ 397PROSITE-ProRule annotation
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence analysis
Glycosylationi479 – 4791N-linked (GlcNAc...)Sequence analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence analysis
Glycosylationi527 – 5271N-linked (GlcNAc...)Sequence analysis
Glycosylationi777 – 7771N-linked (GlcNAc...)Sequence analysis
Glycosylationi832 – 8321N-linked (GlcNAc...)Sequence analysis
Glycosylationi920 – 9201N-linked (GlcNAc...)Sequence analysis
Glycosylationi942 – 9421N-linked (GlcNAc...)Sequence analysis
Lipidationi1014 – 10141GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiQ61330.
PaxDbiQ61330.
PeptideAtlasiQ61330.
PRIDEiQ61330.

PTM databases

iPTMnetiQ61330.
PhosphoSiteiQ61330.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053024.
CleanExiMM_CNTN2.
ExpressionAtlasiQ61330. baseline and differential.
GenevisibleiQ61330. MM.

Interactioni

GO - Molecular functioni

  • glycoprotein binding Source: MGI
  • protein self-association Source: MGI

Protein-protein interaction databases

IntActiQ61330. 2 interactions.
STRINGi10090.ENSMUSP00000083707.

Structurei

3D structure databases

ProteinModelPortaliQ61330.
SMRiQ61330. Positions 36-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 13092Ig-like C2-type 1Add
BLAST
Domaini135 – 22490Ig-like C2-type 2Add
BLAST
Domaini241 – 32484Ig-like C2-type 3Add
BLAST
Domaini329 – 41385Ig-like C2-type 4Add
BLAST
Domaini419 – 50688Ig-like C2-type 5Add
BLAST
Domaini511 – 60595Ig-like C2-type 6Add
BLAST
Domaini612 – 71099Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini715 – 81298Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini817 – 91397Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini917 – 100892Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi796 – 7983Cell attachment siteSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi608 – 6147Gly/Pro-rich

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ61330.
KOiK06760.
OMAiECFAFGN.
OrthoDBiEOG091G00X7.
PhylomeDBiQ61330.
TreeFamiTF351103.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAPARKRAS LLLLLLATMA LVSSPGWSFS QGTPATFGPV FEEQPVGLLF
60 70 80 90 100
PEESAEDQVT LACRARASPP ATYRWKMNGT EMNLEPGSRH QLMGGNLVIM
110 120 130 140 150
SPTKAQDAGV YQCLASNPVG TVVSKEAVLR FGFLQEFSKE ERDPVKTHEG
160 170 180 190 200
WGVMLPCNPP AHYPGLSYRW LLNEFPNFIP TDGRHFVSQT TGNLYIARTN
210 220 230 240 250
ASDLGNYSCL ATSHLDFSTK SVFSKFAQLN LAAEDPRLFA PSIKARFPPE
260 270 280 290 300
TYALVGQQVT LECFAFGNPV PRIKWRKVDG SLSPQWGTAE PTLQIPSVSF
310 320 330 340 350
EDEGTYECEA ENSKGRDTVQ GRIIVQAQPE WLKVISDTEA DIGSNLRWGC
360 370 380 390 400
AAAGKPRPMV RWLRNGEPLA SQNRVEVLAG DLRFSKLNLE DSGMYQCVAE
410 420 430 440 450
NKHGTIYASA ELAVQALAPD FRQNPVRRLI PAARGGEISI PCQPRAAPKA
460 470 480 490 500
TILWSKGTEI LGNSTRVTVT LDGTLIIRNI SRSDEGKYTC FAENFMGKAN
510 520 530 540 550
STGILSVRDA TKITLAPSSA DINVGDNLTL QCHASHDPTM DLTFTWTLDD
560 570 580 590 600
FPVDFDKPGG HYRRASVKET IGDLTILNAQ LRHGGTYTCM AQTVVDGASK
610 620 630 640 650
EATVLVRGPP GPPGGVVVRD IGDTTVQLSW SRGFDNHSPI AKYTLQARTP
660 670 680 690 700
PSGKWKQVRT NPVNIEGNAE TAQVLGLMPW MDYEFRVSAS NILGTGEPSG
710 720 730 740 750
PSSRIRTKEA VPSVAPSGLS GGGGAPGELT INWTPMSREY QNGDGFGYLL
760 770 780 790 800
SFRRQGSSSW QTARVPGADT QYFVYSNDSI HPYTPFEVKI RSYNRRGDGP
810 820 830 840 850
ESLTAIVYSA EEEPKVAPAK VWAKGSSSSE MNVSWEPVLQ DMNGILLGYE
860 870 880 890 900
IRYWKAGDKE AAADRVRTAG LDSSARVTGL YPNTKYHVTV RAYNRAGTGP
910 920 930 940 950
ASPSADAMTM KPPPRRPPGN ISWTFSSSSL SLKWDPVVPL RNESTVTGYK
960 970 980 990 1000
MLYQNDLQPT PMLHLTSKNW IEIPVPEDIG HALVQIRTTG PGGDGIPAEV
1010 1020 1030 1040
HIVRNGGTSM MVESSAVRPA HPGPVFSCMV ILMLAGCQRL
Length:1,040
Mass (Da):113,217
Last modified:August 31, 2004 - v2
Checksum:i012C05DDF7F97462
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti665 – 6651I → M in CAA57130 (Ref. 2) Curated
Sequence conflicti861 – 8611A → R in CAA57130 (Ref. 2) Curated
Sequence conflicti881 – 8811Y → N in CAA57130 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066106 mRNA. Translation: AAH66106.1.
BC053033 mRNA. Translation: AAH53033.1.
X81365 mRNA. Translation: CAA57130.1.
CCDSiCCDS15288.1.
RefSeqiNP_796103.2. NM_177129.5.
XP_006529424.1. XM_006529361.2.
XP_006529425.1. XM_006529362.2.
UniGeneiMm.260861.

Genome annotation databases

EnsembliENSMUST00000086521; ENSMUSP00000083707; ENSMUSG00000053024.
GeneIDi21367.
KEGGimmu:21367.
UCSCiuc007cpa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066106 mRNA. Translation: AAH66106.1.
BC053033 mRNA. Translation: AAH53033.1.
X81365 mRNA. Translation: CAA57130.1.
CCDSiCCDS15288.1.
RefSeqiNP_796103.2. NM_177129.5.
XP_006529424.1. XM_006529361.2.
XP_006529425.1. XM_006529362.2.
UniGeneiMm.260861.

3D structure databases

ProteinModelPortaliQ61330.
SMRiQ61330. Positions 36-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61330. 2 interactions.
STRINGi10090.ENSMUSP00000083707.

PTM databases

iPTMnetiQ61330.
PhosphoSiteiQ61330.

Proteomic databases

MaxQBiQ61330.
PaxDbiQ61330.
PeptideAtlasiQ61330.
PRIDEiQ61330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000086521; ENSMUSP00000083707; ENSMUSG00000053024.
GeneIDi21367.
KEGGimmu:21367.
UCSCiuc007cpa.1. mouse.

Organism-specific databases

CTDi6900.
MGIiMGI:104518. Cntn2.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ61330.
KOiK06760.
OMAiECFAFGN.
OrthoDBiEOG091G00X7.
PhylomeDBiQ61330.
TreeFamiTF351103.

Miscellaneous databases

PROiQ61330.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053024.
CleanExiMM_CNTN2.
ExpressionAtlasiQ61330. baseline and differential.
GenevisibleiQ61330. MM.

Family and domain databases

Gene3Di2.60.40.10. 9 hits.
InterProiIPR032993. Contactin-2.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF50. PTHR10489:SF50. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN2_MOUSE
AccessioniPrimary (citable) accession number: Q61330
Secondary accession number(s): Q6NZJ4, Q7TSJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 31, 2004
Last modified: September 7, 2016
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.