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Q61329

- ZFHX3_MOUSE

UniProt

Q61329 - ZFHX3_MOUSE

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Protein
Zinc finger homeobox protein 3
Gene
Zfhx3, Atbf1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri79 – 10325C2H2-type 1
Add
BLAST
Zinc fingeri282 – 30524C2H2-type 2
Add
BLAST
Zinc fingeri641 – 66424C2H2-type 3
Add
BLAST
Zinc fingeri672 – 69524C2H2-type 4
Add
BLAST
Zinc fingeri727 – 75125C2H2-type 5
Add
BLAST
Zinc fingeri805 – 82925C2H2-type 6; atypical
Add
BLAST
Zinc fingeri946 – 96924C2H2-type 7; degenerate
Add
BLAST
Zinc fingeri985 – 100925C2H2-type 8; atypical
Add
BLAST
Zinc fingeri1041 – 106525C2H2-type 9; atypical
Add
BLAST
Zinc fingeri1089 – 111325C2H2-type 10; atypical
Add
BLAST
Zinc fingeri1233 – 125624C2H2-type 11; atypical
Add
BLAST
Zinc fingeri1262 – 128524C2H2-type 12
Add
BLAST
Zinc fingeri1370 – 139526C2H2-type 13
Add
BLAST
Zinc fingeri1411 – 143323C2H2-type 14
Add
BLAST
Zinc fingeri1439 – 146224C2H2-type 15
Add
BLAST
Zinc fingeri1555 – 157925C2H2-type 16
Add
BLAST
Zinc fingeri1606 – 163025C2H2-type 17
Add
BLAST
Zinc fingeri1990 – 201324C2H2-type 18
Add
BLAST
DNA bindingi2152 – 221160Homeobox 1
Add
BLAST
DNA bindingi2249 – 230860Homeobox 2
Add
BLAST
Zinc fingeri2335 – 235824C2H2-type 19; atypical
Add
BLAST
Zinc fingeri2539 – 256123C2H2-type 20
Add
BLAST
DNA bindingi2650 – 270960Homeobox 3
Add
BLAST
Zinc fingeri2720 – 274324C2H2-type 21
Add
BLAST
DNA bindingi2952 – 301160Homeobox 4
Add
BLAST
Zinc fingeri3032 – 305625C2H2-type 22
Add
BLAST
Zinc fingeri3552 – 357625C2H2-type 23
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. muscle organ development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Myogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name:
ZFH-3
Gene namesi
Name:Zfhx3
Synonyms:Atbf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:99948. Zfhx3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 37263726Zinc finger homeobox protein 3
PRO_0000046931Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei535 – 5351Phosphoserine By similarity
Modified residuei573 – 5731Phosphoserine By similarity
Modified residuei1207 – 12071Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61329.
PRIDEiQ61329.

PTM databases

PhosphoSiteiQ61329.

Expressioni

Tissue specificityi

Expressed in skeletal muscle. Levels of expression are high in myoblasts but low in differentiated muscle.1 Publication

Gene expression databases

CleanExiMM_ZFHX3.
GenevestigatoriQ61329.

Interactioni

Subunit structurei

Interacts with ALKBH4 and PIAS3 By similarity. Interacts with FNBP3.1 Publication

Protein-protein interaction databases

IntActiQ61329. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61329.
SMRiQ61329. Positions 663-749, 799-855, 985-1013, 1233-1281, 1375-1459, 1549-1574, 1596-1628, 2153-2214, 2254-2312, 2645-2707, 2955-3012, 3028-3073.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi461 – 49131Poly-Glu
Add
BLAST
Compositional biasi771 – 78515Poly-Ala
Add
BLAST
Compositional biasi1314 – 13174Poly-Ala
Compositional biasi1734 – 174815Poly-Gln
Add
BLAST
Compositional biasi1794 – 17996Poly-Gln
Compositional biasi1856 – 18638Poly-Gln
Compositional biasi2044 – 205916Poly-Pro
Add
BLAST
Compositional biasi2405 – 24084Poly-Ala
Compositional biasi3216 – 32205Poly-Pro
Compositional biasi3380 – 340930Poly-Gln
Add
BLAST
Compositional biasi3412 – 34209Poly-Gln
Compositional biasi3534 – 355017Poly-Gly
Add
BLAST
Compositional biasi3620 – 36234Poly-Pro
Compositional biasi3659 – 36624Poly-Ser

Sequence similaritiesi

Contains 23 C2H2-type zinc fingers.

Keywords - Domaini

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG301069.
HOGENOMiHOG000155777.
HOVERGENiHBG050606.
InParanoidiQ61329.
PhylomeDBiQ61329.

Family and domain databases

Gene3Di1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamiPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 4 hits.
PROSITEiPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61329-1 [UniParc]FASTAAdd to Basket

« Hide

MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL     50
DSLRAPFNER LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP 100
GTHPPPALRE ESASDTSEEG EEESDVENLA GEIVYQPDGS AYIVESLSQL 150
AQSGAACGSS SGSGAVPSLF LNSLPGVGGK QGDPSCAAPV YPQIINTSHI 200
ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS NKDYLNSDGS 250
AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 300
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP 350
LVSTGNLIGP GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL 400
LNLGGLTSSV LKTPITSVPL GPLASSPTKS SEGKDSGAAE GDKQESGGHQ 450
DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE EEEEEEEEEE EASKGLFPND 500
LEEELEDSPS EESGPPAGGT TKKDLALSNP SISNSPLMPN VLQTLSRGPA 550
STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 600
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGESPSGSG VECPKCDTVL 650
GSSRSLGGHM TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG 700
SCVYCKSGQP HPRLARGESY TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK 750
HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA AAAAANIGSS WGAPSPTKPK 800
TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM TQIQHNRHLG 850
LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 900
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV 950
CNKFTTDNLD MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF 1000
QLHCKTDKHV QKYQLVAHIK EGGKANEWRL KCVAIGNPVH LKCNACDYYT 1050
NSLEKLRLHT VNSRHEASLK LYKHLQQHES GVEGESCYYH CVLCNYSTKA 1100
KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF TIRRCPSTDP 1150
EEPVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 1200
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV 1250
HAMTQHSVQP LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT 1300
APEMVMPSSM FLPAAAADRD GNSTLEEVGK QPEASEDPGK NILPPASMEH 1350
GGDLKPTSAD PSCGREDSGF LCWKKGCNQV FKTSATLQTH FNEVHAKRPQ 1400
LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM CCLCQRSFRT 1450
FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 1500
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD 1550
PSRPYKCTVC KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS 1600
PDNKPFKCNT CNVAYSQSST LEIHMRSVLH QTKARAAKLE AASGNSNGTG 1650
NSGGVSLSSS TPSPVGSSGA NNTFTATNPS SAAMAPSVNA LSQVPPESVV 1700
MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ QQQQQQAQTL 1750
AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 1800
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KVQVQIPQQS 1850
HQQILQQQQQ QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE 1900
GPEGAEGNTG PQESLPDASK AKEKKDLAPG GGSEGTMLPP RIASDARGNA 1950
TKALLENFGF ELVIQYNENK QKAQKKNGKA EQGGESLEKL ECDSCGKLFS 2000
NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR PQTPEPPPPP 2050
PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 2100
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ 2150
QNKRPRTRIT DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF 2200
RNTLFKERQR NKDSPYNFSN PPITSLEELK IDSRPPSPEP QKQEYWGSKR 2250
SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE QLSNLLNLPT RVIVVWFQNA 2300
RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC SLVFQRIFDL 2350
IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 2400
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN 2450
QTQEKQGQPK PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ 2500
CPLPQSSPSP SQLSHLPLKP LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS 2550
FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD MPFMLFDPSN PLLASQLLSG 2600
AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS GTGGEEPQRD 2650
KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 2700
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA 2750
GYNLTLSAML LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT 2800
MELSPRTLLS PSSIKVEGIE DFESPSMSSV NLNFDQTKLD NDDCSSVNTA 2850
ITDTTTGDEG NADNDSATGI ATETKSSAPN EGLTKAAMMA MSEYEDRLSS 2900
GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG SAGKSGDGGD 2950
RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 3000
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH 3050
IFSQQHISKV KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG 3100
LAAQQQGMFD NAPLQALNLP TTYPALQGIP PVLLPGLNRP SLPGFTPANT 3150
ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK PSSASLSSPT PAQATMAMAP 3200
QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD GEKGKEKEKA 3250
HKGKGEPLPV PKKEKGEAPP AGTGTISAPL PAMEYAVDPA QLQALQAALT 3300
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP 3350
ALSRPLMGLS PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQQQQRQL 3400
QQQQQQQQQK VQQQQQQQQQ PKASQTPVPQ GAASPDKDPA KESPKPEEQK 3450
NVPRELSPLL PKPPEEPEAE SKSASADSLC DPFIVPKVQY KLVCRKCQAG 3500
FGDEEAARSH LKSLCCFGQS VVNLQEMVLH VPTGSGGGGG GGGGSGGGGG 3550
SYHCLACESA LCGEEALSQH LESALHKHRT ITRAARNAKE HPSLLPHSAC 3600
FPDPSTASTS QSAAHSNDSP PPPSAAPSSS ASPHASRKSW PPVGSRASAA 3650
KPPSFPPLSS SSTVTSSSCS TSGVQPSMPT DDYSEESDTD LSQKSDGPAS 3700
PVEGPKDPSC PKDSGLTSVG TDTFRL 3726
Length:3,726
Mass (Da):406,570
Last modified:November 1, 1996 - v1
Checksum:i915ACBE588A72C98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26046 mRNA. Translation: BAA05046.1.
UniGeneiMm.416972.
Mm.477670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D26046 mRNA. Translation: BAA05046.1 .
UniGenei Mm.416972.
Mm.477670.

3D structure databases

ProteinModelPortali Q61329.
SMRi Q61329. Positions 663-749, 799-855, 985-1013, 1233-1281, 1375-1459, 1549-1574, 1596-1628, 2153-2214, 2254-2312, 2645-2707, 2955-3012, 3028-3073.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61329. 2 interactions.

PTM databases

PhosphoSitei Q61329.

Proteomic databases

MaxQBi Q61329.
PRIDEi Q61329.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:99948. Zfhx3.

Phylogenomic databases

eggNOGi NOG301069.
HOGENOMi HOG000155777.
HOVERGENi HBG050606.
InParanoidi Q61329.
PhylomeDBi Q61329.

Miscellaneous databases

ChiTaRSi ZFHX3. mouse.
PROi Q61329.
SOURCEi Search...

Gene expression databases

CleanExi MM_ZFHX3.
Genevestigatori Q61329.

Family and domain databases

Gene3Di 1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view ]
Pfami PF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 4 hits.
PROSITEi PS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of the cDNA encoding the mouse ATBF1 transcription factor."
    Ido A., Miura Y., Watanabe M., Sakai M., Inoue Y., Miki T., Hashimoto T., Morinaga T., Nishi S., Tamaoki T.
    Gene 168:227-231(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/MK X ICR.
    Tissue: Brain.
  2. "FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
    Bedford M.T., Chan D.C., Leder P.
    EMBO J. 16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FNBP3.
  3. "Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
    Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
    J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiZFHX3_MOUSE
AccessioniPrimary (citable) accession number: Q61329
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi