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Q61329 (ZFHX3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger homeobox protein 3
Alternative name(s):
AT motif-binding factor 1
AT-binding transcription factor 1
Alpha-fetoprotein enhancer-binding protein
Zinc finger homeodomain protein 3
Short name=ZFH-3
Gene names
Name:Zfhx3
Synonyms:Atbf1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length3726 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression By similarity.

Subunit structure

Interacts with ALKBH4 and PIAS3 By similarity. Interacts with FNBP3. Ref.2

Subcellular location

Nucleus.

Tissue specificity

Expressed in skeletal muscle. Levels of expression are high in myoblasts but low in differentiated muscle. Ref.3

Sequence similarities

Contains 23 C2H2-type zinc fingers.

Contains 4 homeobox DNA-binding domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 37263726Zinc finger homeobox protein 3
PRO_0000046931

Regions

Zinc finger79 – 10325C2H2-type 1
Zinc finger282 – 30524C2H2-type 2
Zinc finger641 – 66424C2H2-type 3
Zinc finger672 – 69524C2H2-type 4
Zinc finger727 – 75125C2H2-type 5
Zinc finger805 – 82925C2H2-type 6; atypical
Zinc finger946 – 96924C2H2-type 7; degenerate
Zinc finger985 – 100925C2H2-type 8; atypical
Zinc finger1041 – 106525C2H2-type 9; atypical
Zinc finger1089 – 111325C2H2-type 10; atypical
Zinc finger1233 – 125624C2H2-type 11; atypical
Zinc finger1262 – 128524C2H2-type 12
Zinc finger1370 – 139526C2H2-type 13
Zinc finger1411 – 143323C2H2-type 14
Zinc finger1439 – 146224C2H2-type 15
Zinc finger1555 – 157925C2H2-type 16
Zinc finger1606 – 163025C2H2-type 17
Zinc finger1990 – 201324C2H2-type 18
DNA binding2152 – 221160Homeobox 1
DNA binding2249 – 230860Homeobox 2
Zinc finger2335 – 235824C2H2-type 19; atypical
Zinc finger2539 – 256123C2H2-type 20
DNA binding2650 – 270960Homeobox 3
Zinc finger2720 – 274324C2H2-type 21
DNA binding2952 – 301160Homeobox 4
Zinc finger3032 – 305625C2H2-type 22
Zinc finger3552 – 357625C2H2-type 23
Compositional bias461 – 49131Poly-Glu
Compositional bias771 – 78515Poly-Ala
Compositional bias1314 – 13174Poly-Ala
Compositional bias1734 – 174815Poly-Gln
Compositional bias1794 – 17996Poly-Gln
Compositional bias1856 – 18638Poly-Gln
Compositional bias2044 – 205916Poly-Pro
Compositional bias2405 – 24084Poly-Ala
Compositional bias3216 – 32205Poly-Pro
Compositional bias3380 – 340930Poly-Gln
Compositional bias3412 – 34209Poly-Gln
Compositional bias3534 – 355017Poly-Gly
Compositional bias3620 – 36234Poly-Pro
Compositional bias3659 – 36624Poly-Ser

Amino acid modifications

Modified residue5351Phosphoserine By similarity
Modified residue5731Phosphoserine By similarity
Modified residue12071Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q61329 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 915ACBE588A72C98

FASTA3,726406,570
        10         20         30         40         50         60 
MEGCDSPVVS GKDNGCGIPQ HRQWTELNSA HLPDKPSSME QPTGESHGPL DSLRAPFNER 

        70         80         90        100        110        120 
LADSSTSAGP PAEPASKEVS CNECSASFSS LQTYMEHHCP GTHPPPALRE ESASDTSEEG 

       130        140        150        160        170        180 
EEESDVENLA GEIVYQPDGS AYIVESLSQL AQSGAACGSS SGSGAVPSLF LNSLPGVGGK 

       190        200        210        220        230        240 
QGDPSCAAPV YPQIINTSHI ASSFGKWFEG SDPAFPNTSA LAGLSPVLHS FRVFDVRHKS 

       250        260        270        280        290        300 
NKDYLNSDGS AKSSCVSKDV PNNVDLSKFD GFVLYGKRKP ILMCFLCKLS FGYVRSFVTH 

       310        320        330        340        350        360 
AVHDHRMTLS EEERKLLSNK NISAIIQGIG KDKEPLVSFL EPKNKNFQHP LVSTGNLIGP 

       370        380        390        400        410        420 
GHSFYGKFSG IRMEGEEALP AVAAAGPEQP QAGLLTPSTL LNLGGLTSSV LKTPITSVPL 

       430        440        450        460        470        480 
GPLASSPTKS SEGKDSGAAE GDKQESGGHQ DCFSEKVEPA EEEEAEEEEE EEEEAEEEEE 

       490        500        510        520        530        540 
EEEEEEEEEE EASKGLFPND LEEELEDSPS EESGPPAGGT TKKDLALSNP SISNSPLMPN 

       550        560        570        580        590        600 
VLQTLSRGPA STTSNSASNF VVFDGANRRS RLSFNSEGVR ANVAEGRRLD FADESANKDS 

       610        620        630        640        650        660 
ATAPEPNEST EGDDGGFVPH HQHAGSLCEL GVGESPSGSG VECPKCDTVL GSSRSLGGHM 

       670        680        690        700        710        720 
TMMHSRNSCK TLKCPKCNWH YKYQQTLEAH MKEKHPEPGG SCVYCKSGQP HPRLARGESY 

       730        740        750        760        770        780 
TCGYKPFRCE VCNYSTTTKG NLSIHMQSDK HLNNMQNLQN GGGEQVFSHS AGAAAAAAAA 

       790        800        810        820        830        840 
AAAAANIGSS WGAPSPTKPK TKPTWRCEVC DYETNVARNL RIHMTSEKHM HNMMLLQQNM 

       850        860        870        880        890        900 
TQIQHNRHLG LGSLPSPAEA ELYQYYLAQN MNLPNLKMDS TASDAQFMMS GFQLDPTGPM 

       910        920        930        940        950        960 
AAMTPALVGG EIPLDMRLGG GQLVSEELMN LGESFIQTND PSLKLFQCAV CNKFTTDNLD 

       970        980        990       1000       1010       1020 
MLGLHMNVER SLSEDEWKAV MGDSYQCKLC RYNTQLKANF QLHCKTDKHV QKYQLVAHIK 

      1030       1040       1050       1060       1070       1080 
EGGKANEWRL KCVAIGNPVH LKCNACDYYT NSLEKLRLHT VNSRHEASLK LYKHLQQHES 

      1090       1100       1110       1120       1130       1140 
GVEGESCYYH CVLCNYSTKA KLNLIQHVRS MKHQRSESLR KLQRLQKGLP EEDEDLGQIF 

      1150       1160       1170       1180       1190       1200 
TIRRCPSTDP EEPVEDAEGP SEASADPEEL AKDQGSGSEE GQSKRAASSS QAEKELTDSP 

      1210       1220       1230       1240       1250       1260 
ATTKRTSFPG SSETPLSSKR PKASEEIKPE QMYQCPYCKY SNADVNRLRV HAMTQHSVQP 

      1270       1280       1290       1300       1310       1320 
LLRCPLCQDM LNNKIHLQLH LTHLHSVAPD CVEKLIMTVT APEMVMPSSM FLPAAAADRD 

      1330       1340       1350       1360       1370       1380 
GNSTLEEVGK QPEASEDPGK NILPPASMEH GGDLKPTSAD PSCGREDSGF LCWKKGCNQV 

      1390       1400       1410       1420       1430       1440 
FKTSATLQTH FNEVHAKRPQ LPVSDRHVYK YRCNQCSLAF KTIEKLQLHS QYHVIRAATM 

      1450       1460       1470       1480       1490       1500 
CCLCQRSFRT FQALKKHLET SHLELSEADI QQLYGGLLAN GDLLAMGDPT LAEDHTIIVE 

      1510       1520       1530       1540       1550       1560 
EDKEEESDLE DKQSPTGSDS GSVQEDSGSE PKRALPFRKG PNFTMEKFLD PSRPYKCTVC 

      1570       1580       1590       1600       1610       1620 
KESFTQKNIL LVHYNSVSHL HKLKRALQES ATGQPEPTSS PDNKPFKCNT CNVAYSQSST 

      1630       1640       1650       1660       1670       1680 
LEIHMRSVLH QTKARAAKLE AASGNSNGTG NSGGVSLSSS TPSPVGSSGA NNTFTATNPS 

      1690       1700       1710       1720       1730       1740 
SAAMAPSVNA LSQVPPESVV MPPLGNPISA NIASPSEPKE ANRKKLADMI ASRQQQQQQQ 

      1750       1760       1770       1780       1790       1800 
QQQQQQAQTL AQAQAQVQAH LQQELQQQAA LIQSQLFNPT LLPHFPMTTE TLLQLQQQQH 

      1810       1820       1830       1840       1850       1860 
LLFPFYIPSA EFQLNPEVSL PVTSGALTLT GSGPGLLEDL KVQVQIPQQS HQQILQQQQQ 

      1870       1880       1890       1900       1910       1920 
QSQLSLSQSH SALLQPSQHP EKKNKVVIKE KDKESQRERE GPEGAEGNTG PQESLPDASK 

      1930       1940       1950       1960       1970       1980 
AKEKKDLAPG GGSEGTMLPP RIASDARGNA TKALLENFGF ELVIQYNENK QKAQKKNGKA 

      1990       2000       2010       2020       2030       2040 
EQGGESLEKL ECDSCGKLFS NILILKSHQE HVHQNYFPFK QLERFAKQYR EHYDKLYPLR 

      2050       2060       2070       2080       2090       2100 
PQTPEPPPPP PPPPPPPLPT APPQPASAPA IPASAPPITS PTIAPAQPSV PLTQLSMPME 

      2110       2120       2130       2140       2150       2160 
LPIFSPLMMQ TMPLQTLPAQ LPPQLGPVEP LPADLAQLYQ HQLNPTLLQQ QNKRPRTRIT 

      2170       2180       2190       2200       2210       2220 
DDQLRVLRQY FDINNSPSEE QIKEMADKSG LPQKVIKHWF RNTLFKERQR NKDSPYNFSN 

      2230       2240       2250       2260       2270       2280 
PPITSLEELK IDSRPPSPEP QKQEYWGSKR SSRTRFTDYQ LRVLQDFFDA NAYPKDDEFE 

      2290       2300       2310       2320       2330       2340 
QLSNLLNLPT RVIVVWFQNA RQKARKNYEN QGEGKDGERR ELTNDRYIRT SNLNYQCKKC 

      2350       2360       2370       2380       2390       2400 
SLVFQRIFDL IKHQKKLCYK DEDEEGQDDS QNEDSMDAME ILTPTSSSCS TPMPSQAYST 

      2410       2420       2430       2440       2450       2460 
PAPSAAAANT APSAFLQLTA ETDELATFNS KAEASDEKPK QADPPSAQPN QTQEKQGQPK 

      2470       2480       2490       2500       2510       2520 
PEMQQQLEQL EQKTNAPQPK LPQPAAPSLP QPPPQAPPPQ CPLPQSSPSP SQLSHLPLKP 

      2530       2540       2550       2560       2570       2580 
LHTSTPQQLA NLPPQLIPYQ CDQCKLAFPS FEHWQEHQQL HFLSAQNQFI HPQFLDRSLD 

      2590       2600       2610       2620       2630       2640 
MPFMLFDPSN PLLASQLLSG AIPQIPASSA TSPSTPTSTM NTLKRKLEEK ASASPGENDS 

      2650       2660       2670       2680       2690       2700 
GTGGEEPQRD KRLRTTITPE QLEILYQKYL LDSNPTRKML DHIAHEVGLK KRVVQVWFQN 

      2710       2720       2730       2740       2750       2760 
TRARERKGQF RAVGPAQAHR RCPFCRALFK AKTALEAHIR SRHWHEAKRA GYNLTLSAML 

      2770       2780       2790       2800       2810       2820 
LDCDGGLQMK GDIFDGTSFS HLPPSSSDGQ GVPLSPVSKT MELSPRTLLS PSSIKVEGIE 

      2830       2840       2850       2860       2870       2880 
DFESPSMSSV NLNFDQTKLD NDDCSSVNTA ITDTTTGDEG NADNDSATGI ATETKSSAPN 

      2890       2900       2910       2920       2930       2940 
EGLTKAAMMA MSEYEDRLSS GLVSPAPSFY SKEYDNEGTV DYSETSSLAD PCSPSPGASG 

      2950       2960       2970       2980       2990       3000 
SAGKSGDGGD RPGQKRFRTQ MTNLQLKVLK SCFNDYRTPT MLECEVLGND IGLPKRVVQV 

      3010       3020       3030       3040       3050       3060 
WFQNARAKEK KSKLSMAKHF GINQTSYEGP KTECTLCGIK YSARLSVRDH IFSQQHISKV 

      3070       3080       3090       3100       3110       3120 
KDTIGSQLDK EKEYFDPATV RQLMAQQELD RIKKANEVLG LAAQQQGMFD NAPLQALNLP 

      3130       3140       3150       3160       3170       3180 
TTYPALQGIP PVLLPGLNRP SLPGFTPANT ALTSPKPNLM GLPSTTVPSP GLPTSGLPNK 

      3190       3200       3210       3220       3230       3240 
PSSASLSSPT PAQATMAMAP QPPPQPQQPQ PPVQQPPPPP AAQQIPAPQL TPQQQRKDKD 

      3250       3260       3270       3280       3290       3300 
GEKGKEKEKA HKGKGEPLPV PKKEKGEAPP AGTGTISAPL PAMEYAVDPA QLQALQAALT 

      3310       3320       3330       3340       3350       3360 
SDPTALLTSQ FLPYFVPGFS PYYAPQIPGA LQSGYLQPMY GMEGLFPYSP ALSRPLMGLS 

      3370       3380       3390       3400       3410       3420 
PGSLLQQYQQ YQQSLQEAIQ QQQQQQQQQQ QQQQQQQRQL QQQQQQQQQK VQQQQQQQQQ 

      3430       3440       3450       3460       3470       3480 
PKASQTPVPQ GAASPDKDPA KESPKPEEQK NVPRELSPLL PKPPEEPEAE SKSASADSLC 

      3490       3500       3510       3520       3530       3540 
DPFIVPKVQY KLVCRKCQAG FGDEEAARSH LKSLCCFGQS VVNLQEMVLH VPTGSGGGGG 

      3550       3560       3570       3580       3590       3600 
GGGGSGGGGG SYHCLACESA LCGEEALSQH LESALHKHRT ITRAARNAKE HPSLLPHSAC 

      3610       3620       3630       3640       3650       3660 
FPDPSTASTS QSAAHSNDSP PPPSAAPSSS ASPHASRKSW PPVGSRASAA KPPSFPPLSS 

      3670       3680       3690       3700       3710       3720 
SSTVTSSSCS TSGVQPSMPT DDYSEESDTD LSQKSDGPAS PVEGPKDPSC PKDSGLTSVG 


TDTFRL 

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References

[1]"Cloning of the cDNA encoding the mouse ATBF1 transcription factor."
Ido A., Miura Y., Watanabe M., Sakai M., Inoue Y., Miki T., Hashimoto T., Morinaga T., Nishi S., Tamaoki T.
Gene 168:227-231(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/MK X ICR.
Tissue: Brain.
[2]"FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands."
Bedford M.T., Chan D.C., Leder P.
EMBO J. 16:2376-2383(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FNBP3.
[3]"Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1."
Berry F.B., Miura Y., Mihara K., Kaspar P., Sakata N., Hashimoto-Tamaoki T., Tamaoki T.
J. Biol. Chem. 276:25057-25065(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D26046 mRNA. Translation: BAA05046.1.
UniGeneMm.416972.
Mm.477670.

3D structure databases

ProteinModelPortalQ61329.
SMRQ61329. Positions 663-749, 799-855, 985-1013, 1233-1281, 1375-1459, 1549-1574, 1596-1628, 2153-2214, 2254-2312, 2645-2707, 2955-3012, 3028-3073.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61329. 2 interactions.

PTM databases

PhosphoSiteQ61329.

Proteomic databases

MaxQBQ61329.
PRIDEQ61329.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:99948. Zfhx3.

Phylogenomic databases

eggNOGNOG301069.
HOGENOMHOG000155777.
HOVERGENHBG050606.
InParanoidQ61329.
PhylomeDBQ61329.

Gene expression databases

CleanExMM_ZFHX3.
GenevestigatorQ61329.

Family and domain databases

Gene3D1.10.10.60. 4 hits.
3.30.160.60. 2 hits.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR003604. Znf_U1.
[Graphical view]
PfamPF00046. Homeobox. 4 hits.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTSM00389. HOX. 4 hits.
SM00355. ZnF_C2H2. 23 hits.
SM00451. ZnF_U1. 7 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 4 hits.
PROSITEPS00027. HOMEOBOX_1. 2 hits.
PS50071. HOMEOBOX_2. 4 hits.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 9 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSZFHX3. mouse.
PROQ61329.
SOURCESearch...

Entry information

Entry nameZFHX3_MOUSE
AccessionPrimary (citable) accession number: Q61329
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot