##gff-version 3 Q61327 UniProtKB Chain 1 619 . . . ID=PRO_0000214753;Note=Sodium-dependent dopamine transporter Q61327 UniProtKB Topological domain 1 68 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 69 89 . . . Note=Helical%3B Name%3D1;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 96 116 . . . Note=Helical%3B Name%3D2;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 140 160 . . . Note=Helical%3B Name%3D3;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Topological domain 161 236 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 237 255 . . . Note=Helical%3B Name%3D4;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 264 281 . . . Note=Helical%3B Name%3D5;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 317 334 . . . Note=Helical%3B Name%3D6;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 346 367 . . . Note=Helical%3B Name%3D7;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 400 419 . . . Note=Helical%3B Name%3D8;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 446 464 . . . Note=Helical%3B Name%3D9;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 480 500 . . . Note=Helical%3B Name%3D10;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 521 540 . . . Note=Helical%3B Name%3D11;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Transmembrane 559 577 . . . Note=Helical%3B Name%3D12;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Topological domain 578 619 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Region 560 589 . . . Note=Interaction with TGFB1I1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q61327 UniProtKB Binding site 75 75 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 77 77 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 78 78 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 82 82 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 320 320 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 352 352 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 417 417 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 420 420 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Binding site 421 421 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Site 105 105 . . . Note=Contributes to high-affinity binding to cocaine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12606774;Dbxref=PMID:12606774 Q61327 UniProtKB Glycosylation 181 181 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Glycosylation 188 188 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Glycosylation 196 196 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Glycosylation 204 204 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q61327 UniProtKB Disulfide bond 180 189 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q7K4Y6 Q61327 UniProtKB Disulfide bond 305 305 . . . Note=Interchain;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q01959 Q61327 UniProtKB Mutagenesis 105 105 . . . Note=Very low dopamine transporter activity. F->A%2CI%2CL%2CN%2CQ%2CS%2CT;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12606774;Dbxref=PMID:12606774 Q61327 UniProtKB Mutagenesis 105 105 . . . Note=Reduced sensitivity to cocaine. F->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12606774;Dbxref=PMID:12606774 Q61327 UniProtKB Mutagenesis 105 105 . . . Note=Functional dopamine transporter with 4-fold decrease in cocaine sensitivity. F->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12606774;Dbxref=PMID:12606774 Q61327 UniProtKB Mutagenesis 105 105 . . . Note=Retention of dopamine transporter activity and high sensitivity to cocaine. F->W%2CY;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12606774;Dbxref=PMID:12606774