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Protein

Aryl hydrocarbon receptor nuclear translocator 2

Gene

Arnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).By similarity

GO - Molecular functioni

  1. aryl hydrocarbon receptor binding Source: UniProtKB
  2. DNA binding Source: MGI
  3. protein heterodimerization activity Source: UniProtKB
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  6. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. signal transducer activity Source: InterPro

GO - Biological processi

  1. brain development Source: UniProtKB
  2. central nervous system development Source: UniProtKB
  3. in utero embryonic development Source: UniProtKB
  4. negative regulation of apoptotic process Source: Ensembl
  5. positive regulation of cell proliferation Source: Ensembl
  6. positive regulation of transcription, DNA-templated Source: UniProtKB
  7. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  8. regulation of transcription, DNA-templated Source: MGI
  9. response to estradiol Source: Ensembl
  10. response to hypoxia Source: UniProtKB
  11. response to toxic substance Source: UniProtKB
  12. response to xenobiotic stimulus Source: UniProtKB
  13. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator 2
Short name:
ARNT protein 2
Gene namesi
Name:Arnt2
Synonyms:Kiaa0307
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107188. Arnt2.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 712712Aryl hydrocarbon receptor nuclear translocator 2PRO_0000127123Add
BLAST

Proteomic databases

MaxQBiQ61324.
PaxDbiQ61324.
PRIDEiQ61324.

PTM databases

PhosphoSiteiQ61324.

Expressioni

Tissue specificityi

Restricted to adult brain and kidney.

Gene expression databases

BgeeiQ61324.
CleanExiMM_ARNT2.
GenevestigatoriQ61324.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3.1 Publication

Protein-protein interaction databases

IntActiQ61324. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61324.
SMRiQ61324. Positions 62-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini63 – 11654bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini134 – 20976PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini323 – 39371PAS 2PROSITE-ProRule annotationAdd
BLAST
Domaini398 – 44144PACAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi73 – 764Poly-Arg
Compositional biasi440 – 4456Poly-Gln
Compositional biasi552 – 5554Poly-Ser

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG293303.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234380.
HOVERGENiHBG000164.
InParanoidiQ61324.
KOiK15589.
OMAiVCMDMSG.
OrthoDBiEOG7V1FQ8.
PhylomeDBiQ61324.
TreeFamiTF319983.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM
60 70 80 90 100
DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP
110 120 130 140 150
DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL
160 170 180 190 200
FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC
210 220 230 240 250
TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH
260 270 280 290 300
LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED
310 320 330 340 350
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV
360 370 380 390 400
DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM
410 420 430 440 450
YRFRTKNREW LLIRTSSFTF QNPYSDEIEY VICTNTNVKQ LQQQQAELEV
460 470 480 490 500
HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA
510 520 530 540 550
GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS VVHVPGVNDI
560 570 580 590 600
QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP
610 620 630 640 650
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE
660 670 680 690 700
VWSQWQSQHH GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED
710
FADLGMFPPF SE
Length:712
Mass (Da):77,902
Last modified:February 6, 2007 - v2
Checksum:iFACD27033F7F18DE
GO
Isoform 2 (identifier: Q61324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:701
Mass (Da):76,823
Checksum:i67C24CE8E77A7E59
GO

Sequence cautioni

The sequence BAC41409.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti206 – 2061M → I in BAA09799 (PubMed:8657146).Curated
Sequence conflicti432 – 4321I → T in AAH54546 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_022689Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63644 mRNA. Translation: BAA09799.1.
AB093225 mRNA. Translation: BAC41409.1. Different initiation.
BC054546 mRNA. Translation: AAH54546.1.
CCDSiCCDS59733.1. [Q61324-1]
RefSeqiNP_031514.3. NM_007488.3. [Q61324-1]
XP_006507303.1. XM_006507240.1. [Q61324-2]
XP_006507305.1. XM_006507242.1. [Q61324-2]
UniGeneiMm.38594.

Genome annotation databases

EnsembliENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709. [Q61324-1]
GeneIDi11864.
KEGGimmu:11864.
UCSCiuc009ief.1. mouse. [Q61324-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63644 mRNA. Translation: BAA09799.1.
AB093225 mRNA. Translation: BAC41409.1. Different initiation.
BC054546 mRNA. Translation: AAH54546.1.
CCDSiCCDS59733.1. [Q61324-1]
RefSeqiNP_031514.3. NM_007488.3. [Q61324-1]
XP_006507303.1. XM_006507240.1. [Q61324-2]
XP_006507305.1. XM_006507242.1. [Q61324-2]
UniGeneiMm.38594.

3D structure databases

ProteinModelPortaliQ61324.
SMRiQ61324. Positions 62-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61324. 2 interactions.

PTM databases

PhosphoSiteiQ61324.

Proteomic databases

MaxQBiQ61324.
PaxDbiQ61324.
PRIDEiQ61324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709. [Q61324-1]
GeneIDi11864.
KEGGimmu:11864.
UCSCiuc009ief.1. mouse. [Q61324-1]

Organism-specific databases

CTDi9915.
MGIiMGI:107188. Arnt2.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG293303.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234380.
HOVERGENiHBG000164.
InParanoidiQ61324.
KOiK15589.
OMAiVCMDMSG.
OrthoDBiEOG7V1FQ8.
PhylomeDBiQ61324.
TreeFamiTF319983.

Miscellaneous databases

ChiTaRSiArnt2. mouse.
NextBioi279871.
PROiQ61324.
SOURCEiSearch...

Gene expression databases

BgeeiQ61324.
CleanExiMM_ARNT2.
GenevestigatoriQ61324.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00785. NCTRNSLOCATR.
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)."
    Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., Saijo Y., Gotoh O., Sogawa K., Fujii-Kuriyama Y.
    Mol. Cell. Biol. 16:1706-1713(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development."
    Sadek C.M., Jalaguier S., Feeney E.P., Aitola M., Damdimopoulos A.E., Pelto-Huikko M., Gustafsson J.-A.
    Mech. Dev. 97:13-26(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TACC3.

Entry informationi

Entry nameiARNT2_MOUSE
AccessioniPrimary (citable) accession number: Q61324
Secondary accession number(s): Q7TQG2, Q8CHG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: April 1, 2015
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.