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Protein

Aryl hydrocarbon receptor nuclear translocator 2

Gene

Arnt2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE).By similarity

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: UniProtKB
  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • brain development Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • negative regulation of apoptotic process Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • regulation of transcription, DNA-templated Source: MGI
  • response to estradiol Source: Ensembl
  • response to hypoxia Source: MGI
  • response to toxic substance Source: UniProtKB
  • response to xenobiotic stimulus Source: UniProtKB
  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-211945 Phase I - Functionalization of compounds
R-MMU-211976 Endogenous sterols
R-MMU-211981 Xenobiotics
R-MMU-8937144 Aryl hydrocarbon receptor signalling

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl hydrocarbon receptor nuclear translocator 2
Short name:
ARNT protein 2
Gene namesi
Name:Arnt2
Synonyms:Kiaa0307
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107188 Arnt2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271231 – 712Aryl hydrocarbon receptor nuclear translocator 2Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Omega-N-methylarginineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ61324
PeptideAtlasiQ61324
PRIDEiQ61324

PTM databases

iPTMnetiQ61324
PhosphoSitePlusiQ61324

Expressioni

Tissue specificityi

Restricted to adult brain and kidney.

Gene expression databases

BgeeiENSMUSG00000015709
CleanExiMM_ARNT2
ExpressionAtlasiQ61324 baseline and differential
GenevisibleiQ61324 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein (By similarity). Heterodimer with NPAS4 (By similarity). Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein (By similarity). Interacts with TACC3 (PubMed:11025203).By similarity1 Publication

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: UniProtKB
  • protein heterodimerization activity Source: UniProtKB

Protein-protein interaction databases

IntActiQ61324, 2 interactors
STRINGi10090.ENSMUSP00000082154

Structurei

3D structure databases

ProteinModelPortaliQ61324
SMRiQ61324
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini63 – 116bHLHPROSITE-ProRule annotationAdd BLAST54
Domaini134 – 209PAS 1PROSITE-ProRule annotationAdd BLAST76
Domaini323 – 393PAS 2PROSITE-ProRule annotationAdd BLAST71
Domaini398 – 441PACAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 76Poly-Arg4
Compositional biasi440 – 445Poly-Gln6
Compositional biasi552 – 555Poly-Ser4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410KD32 Eukaryota
ENOG410XS5S LUCA
GeneTreeiENSGT00760000118788
HOGENOMiHOG000234380
HOVERGENiHBG000164
InParanoidiQ61324
KOiK15589
OMAiIVEPQHY
OrthoDBiEOG091G03AI
PhylomeDBiQ61324
TreeFamiTF319983

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 4 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61324-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM
60 70 80 90 100
DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP
110 120 130 140 150
DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL
160 170 180 190 200
FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC
210 220 230 240 250
TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH
260 270 280 290 300
LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED
310 320 330 340 350
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV
360 370 380 390 400
DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM
410 420 430 440 450
YRFRTKNREW LLIRTSSFTF QNPYSDEIEY VICTNTNVKQ LQQQQAELEV
460 470 480 490 500
HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA
510 520 530 540 550
GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS VVHVPGVNDI
560 570 580 590 600
QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP
610 620 630 640 650
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE
660 670 680 690 700
VWSQWQSQHH GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED
710
FADLGMFPPF SE
Length:712
Mass (Da):77,902
Last modified:February 6, 2007 - v2
Checksum:iFACD27033F7F18DE
GO
Isoform 2 (identifier: Q61324-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Show »
Length:701
Mass (Da):76,823
Checksum:i67C24CE8E77A7E59
GO

Sequence cautioni

The sequence BAC41409 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti206M → I in BAA09799 (PubMed:8657146).Curated1
Sequence conflicti432I → T in AAH54546 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226891 – 11Missing in isoform 2. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63644 mRNA Translation: BAA09799.1
AB093225 mRNA Translation: BAC41409.1 Different initiation.
BC054546 mRNA Translation: AAH54546.1
CCDSiCCDS59733.1 [Q61324-1]
RefSeqiNP_031514.3, NM_007488.3 [Q61324-1]
XP_006507303.1, XM_006507240.2 [Q61324-2]
XP_006507305.1, XM_006507242.2 [Q61324-2]
XP_011239957.1, XM_011241655.2 [Q61324-2]
UniGeneiMm.38594

Genome annotation databases

EnsembliENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709 [Q61324-1]
ENSMUST00000208232; ENSMUSP00000146413; ENSMUSG00000015709 [Q61324-2]
ENSMUST00000209133; ENSMUSP00000147129; ENSMUSG00000015709 [Q61324-2]
GeneIDi11864
KEGGimmu:11864
UCSCiuc009ief.2 mouse [Q61324-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARNT2_MOUSE
AccessioniPrimary (citable) accession number: Q61324
Secondary accession number(s): Q7TQG2, Q8CHG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: March 28, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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