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Q61324

- ARNT2_MOUSE

UniProt

Q61324 - ARNT2_MOUSE

Protein

Aryl hydrocarbon receptor nuclear translocator 2

Gene

Arnt2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    Specifically recognizes the xenobiotic response element (XRE).

    GO - Molecular functioni

    1. aryl hydrocarbon receptor binding Source: UniProtKB
    2. DNA binding Source: MGI
    3. protein heterodimerization activity Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. signal transducer activity Source: InterPro

    GO - Biological processi

    1. central nervous system development Source: UniProtKB
    2. in utero embryonic development Source: UniProtKB
    3. negative regulation of apoptotic process Source: Ensembl
    4. positive regulation of cell proliferation Source: Ensembl
    5. positive regulation of transcription, DNA-templated Source: UniProtKB
    6. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    7. regulation of transcription, DNA-templated Source: MGI
    8. response to estradiol Source: Ensembl
    9. response to hypoxia Source: UniProtKB
    10. response to toxic substance Source: UniProtKB
    11. response to xenobiotic stimulus Source: UniProtKB
    12. signal transduction Source: UniProtKB
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aryl hydrocarbon receptor nuclear translocator 2
    Short name:
    ARNT protein 2
    Gene namesi
    Name:Arnt2
    Synonyms:Kiaa0307
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107188. Arnt2.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 712712Aryl hydrocarbon receptor nuclear translocator 2PRO_0000127123Add
    BLAST

    Proteomic databases

    PaxDbiQ61324.
    PRIDEiQ61324.

    PTM databases

    PhosphoSiteiQ61324.

    Expressioni

    Tissue specificityi

    Restricted to adult brain and kidney.

    Gene expression databases

    BgeeiQ61324.
    CleanExiMM_ARNT2.
    GenevestigatoriQ61324.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3.1 Publication

    Protein-protein interaction databases

    IntActiQ61324. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61324.
    SMRiQ61324. Positions 62-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini63 – 11654bHLHPROSITE-ProRule annotationAdd
    BLAST
    Domaini134 – 20976PAS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini323 – 39371PAS 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini398 – 44144PACAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi73 – 764Poly-Arg
    Compositional biasi440 – 4456Poly-Gln
    Compositional biasi552 – 5554Poly-Ser

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
    Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG293303.
    GeneTreeiENSGT00650000092935.
    HOGENOMiHOG000234380.
    HOVERGENiHBG000164.
    InParanoidiQ61324.
    KOiK15589.
    OMAiVCMDMSG.
    OrthoDBiEOG7V1FQ8.
    PhylomeDBiQ61324.
    TreeFamiTF319983.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00785. NCTRNSLOCATR.
    SMARTiSM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 4 hits.
    TIGRFAMsiTIGR00229. sensory_box. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q61324-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM    50
    DFDDEDGEGP SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP 100
    DKLTILRMAV SHMKSMRGTG NKSTDGAYKP SFLTEQELKH LILEAADGFL 150
    FVVAAETGRV IYVSDSVTPV LNQPQSEWFG STLYEQVHPD DVEKLREQLC 200
    TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR MRCGNAPLDH 250
    LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED 300
    ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV 350
    DPRCISVIGY QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM 400
    YRFRTKNREW LLIRTSSFTF QNPYSDEIEY VICTNTNVKQ LQQQQAELEV 450
    HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV EKADAIFSQE RDPRFAEMFA 500
    GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS VVHVPGVNDI 550
    QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP 600
    YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE 650
    VWSQWQSQHH GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED 700
    FADLGMFPPF SE 712
    Length:712
    Mass (Da):77,902
    Last modified:February 6, 2007 - v2
    Checksum:iFACD27033F7F18DE
    GO
    Isoform 2 (identifier: Q61324-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-11: Missing.

    Show »
    Length:701
    Mass (Da):76,823
    Checksum:i67C24CE8E77A7E59
    GO

    Sequence cautioni

    The sequence BAC41409.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti206 – 2061M → I in BAA09799. (PubMed:8657146)Curated
    Sequence conflicti432 – 4321I → T in AAH54546. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1111Missing in isoform 2. 1 PublicationVSP_022689Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63644 mRNA. Translation: BAA09799.1.
    AB093225 mRNA. Translation: BAC41409.1. Different initiation.
    BC054546 mRNA. Translation: AAH54546.1.
    CCDSiCCDS59733.1. [Q61324-1]
    RefSeqiNP_031514.3. NM_007488.3. [Q61324-1]
    XP_006507303.1. XM_006507240.1. [Q61324-2]
    XP_006507304.1. XM_006507241.1. [Q61324-2]
    XP_006507305.1. XM_006507242.1. [Q61324-2]
    UniGeneiMm.38594.

    Genome annotation databases

    EnsembliENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709. [Q61324-1]
    GeneIDi11864.
    KEGGimmu:11864.
    UCSCiuc009ief.1. mouse. [Q61324-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D63644 mRNA. Translation: BAA09799.1 .
    AB093225 mRNA. Translation: BAC41409.1 . Different initiation.
    BC054546 mRNA. Translation: AAH54546.1 .
    CCDSi CCDS59733.1. [Q61324-1 ]
    RefSeqi NP_031514.3. NM_007488.3. [Q61324-1 ]
    XP_006507303.1. XM_006507240.1. [Q61324-2 ]
    XP_006507304.1. XM_006507241.1. [Q61324-2 ]
    XP_006507305.1. XM_006507242.1. [Q61324-2 ]
    UniGenei Mm.38594.

    3D structure databases

    ProteinModelPortali Q61324.
    SMRi Q61324. Positions 62-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61324. 2 interactions.

    PTM databases

    PhosphoSitei Q61324.

    Proteomic databases

    PaxDbi Q61324.
    PRIDEi Q61324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085077 ; ENSMUSP00000082154 ; ENSMUSG00000015709 . [Q61324-1 ]
    GeneIDi 11864.
    KEGGi mmu:11864.
    UCSCi uc009ief.1. mouse. [Q61324-1 ]

    Organism-specific databases

    CTDi 9915.
    MGIi MGI:107188. Arnt2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG293303.
    GeneTreei ENSGT00650000092935.
    HOGENOMi HOG000234380.
    HOVERGENi HBG000164.
    InParanoidi Q61324.
    KOi K15589.
    OMAi VCMDMSG.
    OrthoDBi EOG7V1FQ8.
    PhylomeDBi Q61324.
    TreeFami TF319983.

    Miscellaneous databases

    NextBioi 279871.
    PROi Q61324.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61324.
    CleanExi MM_ARNT2.
    Genevestigatori Q61324.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    IPR001067. Nuc_translocat.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00785. NCTRNSLOCATR.
    SMARTi SM00353. HLH. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    SSF55785. SSF55785. 4 hits.
    TIGRFAMsi TIGR00229. sensory_box. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    PS50112. PAS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)."
      Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., Saijo Y., Gotoh O., Sogawa K., Fujii-Kuriyama Y.
      Mol. Cell. Biol. 16:1706-1713(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
      DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development."
      Sadek C.M., Jalaguier S., Feeney E.P., Aitola M., Damdimopoulos A.E., Pelto-Huikko M., Gustafsson J.-A.
      Mech. Dev. 97:13-26(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TACC3.

    Entry informationi

    Entry nameiARNT2_MOUSE
    AccessioniPrimary (citable) accession number: Q61324
    Secondary accession number(s): Q7TQG2, Q8CHG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3