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Q61324 (ARNT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aryl hydrocarbon receptor nuclear translocator 2

Short name=ARNT protein 2
Gene names
Name:Arnt2
Synonyms:Kiaa0307
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length712 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Specifically recognizes the xenobiotic response element (XRE).

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3. Ref.4

Subcellular location

Nucleus Potential.

Tissue specificity

Restricted to adult brain and kidney.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Contains 1 PAC (PAS-associated C-terminal) domain.

Contains 2 PAS (PER-ARNT-SIM) domains.

Sequence caution

The sequence BAC41409.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcentral nervous system development

Inferred from mutant phenotype PubMed 11318878. Source: UniProtKB

in utero embryonic development

Inferred from expression pattern PubMed 12502753. Source: UniProtKB

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 14701734. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay Ref.1. Source: UniProtKB

regulation of transcription, DNA-templated

Inferred from sequence alignment PubMed 11782478. Source: MGI

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Traceable author statement PubMed 12502753. Source: UniProtKB

response to toxic substance

Traceable author statement PubMed 12502753. Source: UniProtKB

response to xenobiotic stimulus

Traceable author statement PubMed 12502753. Source: UniProtKB

signal transduction

Non-traceable author statement PubMed 12502753. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

nucleus

Non-traceable author statement PubMed 12215665. Source: UniProtKB

transcription factor complex

Inferred from direct assay PubMed 14701734. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 14701734. Source: MGI

aryl hydrocarbon receptor binding

Inferred from physical interaction Ref.1. Source: UniProtKB

protein heterodimerization activity

Inferred from physical interaction PubMed 8927054. Source: UniProtKB

sequence-specific DNA binding transcription factor activity

Inferred from direct assay Ref.1. Source: UniProtKB

signal transducer activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q61324-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q61324-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-11: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 712712Aryl hydrocarbon receptor nuclear translocator 2
PRO_0000127123

Regions

Domain63 – 11654bHLH
Domain134 – 20976PAS 1
Domain323 – 39371PAS 2
Domain398 – 44144PAC
Compositional bias73 – 764Poly-Arg
Compositional bias440 – 4456Poly-Gln
Compositional bias552 – 5554Poly-Ser

Natural variations

Alternative sequence1 – 1111Missing in isoform 2.
VSP_022689

Experimental info

Sequence conflict2061M → I in BAA09799. Ref.1
Sequence conflict4321I → T in AAH54546. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 6, 2007. Version 2.
Checksum: FACD27033F7F18DE

FASTA71277,902
        10         20         30         40         50         60 
MATPAAVNPP EMASDIPGSV ALPVAPMAAT GQVRMAGAMP ARGGKRRSGM DFDDEDGEGP 

        70         80         90        100        110        120 
SKFSRENHSE IERRRRNKMT QYITELSDMV PTCSALARKP DKLTILRMAV SHMKSMRGTG 

       130        140        150        160        170        180 
NKSTDGAYKP SFLTEQELKH LILEAADGFL FVVAAETGRV IYVSDSVTPV LNQPQSEWFG 

       190        200        210        220        230        240 
STLYEQVHPD DVEKLREQLC TSENSMTGRI LDLKTGTVKK EGQQSSMRMC MGSRRSFICR 

       250        260        270        280        290        300 
MRCGNAPLDH LPLNRITTMR KRFRNGLGPV KEGEAQYAVV HCTGYIKAWP PAGMTIPEED 

       310        320        330        340        350        360 
ADVGQGSKYC LVAIGRLQVT SSPVCMDMSG MSVPTEFLSR HNSDGIITFV DPRCISVIGY 

       370        380        390        400        410        420 
QPQDLLGKDI LEFCHPEDQS HLRESFQQVV KLKGQVLSVM YRFRTKNREW LLIRTSSFTF 

       430        440        450        460        470        480 
QNPYSDEIEY VICTNTNVKQ LQQQQAELEV HQRDGLSSYD LSQVPVPNLP AGVHEAGKSV 

       490        500        510        520        530        540 
EKADAIFSQE RDPRFAEMFA GISASEKKMM SSASASGSQQ IYSQGSPFPA GHSGKAFSSS 

       550        560        570        580        590        600 
VVHVPGVNDI QSSSSTGQNI SQISRQLNQG QVAWTGSRPP FPGQPSKTQS SAFGIGSSHP 

       610        620        630        640        650        660 
YPADPSSYSP LSSPAASSPS GNAYPSLANR TPGFAESGQS GGQFQGRPSE VWSQWQSQHH 

       670        680        690        700        710 
GQQSGEQHSH QQPGQTEVFQ DMLPMPGDPT QGTGNYNIED FADLGMFPPF SE 

« Hide

Isoform 2 [UniParc].

Checksum: 67C24CE8E77A7E59
Show »

FASTA70176,823

References

« Hide 'large scale' references
[1]"cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt)."
Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., Saijo Y., Gotoh O., Sogawa K., Fujii-Kuriyama Y.
Mol. Cell. Biol. 16:1706-1713(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Embryo.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[4]"Isolation and characterization of AINT: a novel ARNT interacting protein expressed during murine embryonic development."
Sadek C.M., Jalaguier S., Feeney E.P., Aitola M., Damdimopoulos A.E., Pelto-Huikko M., Gustafsson J.-A.
Mech. Dev. 97:13-26(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH TACC3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D63644 mRNA. Translation: BAA09799.1.
AB093225 mRNA. Translation: BAC41409.1. Different initiation.
BC054546 mRNA. Translation: AAH54546.1.
CCDSCCDS59733.1. [Q61324-1]
RefSeqNP_031514.3. NM_007488.3. [Q61324-1]
XP_006507303.1. XM_006507240.1. [Q61324-2]
XP_006507304.1. XM_006507241.1. [Q61324-2]
XP_006507305.1. XM_006507242.1. [Q61324-2]
UniGeneMm.38594.

3D structure databases

ProteinModelPortalQ61324.
SMRQ61324. Positions 62-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ61324. 2 interactions.

PTM databases

PhosphoSiteQ61324.

Proteomic databases

PaxDbQ61324.
PRIDEQ61324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085077; ENSMUSP00000082154; ENSMUSG00000015709. [Q61324-1]
GeneID11864.
KEGGmmu:11864.
UCSCuc009ief.1. mouse. [Q61324-1]

Organism-specific databases

CTD9915.
MGIMGI:107188. Arnt2.
RougeSearch...

Phylogenomic databases

eggNOGNOG293303.
GeneTreeENSGT00650000092935.
HOGENOMHOG000234380.
HOVERGENHBG000164.
InParanoidQ61324.
KOK15589.
OMAVCMDMSG.
OrthoDBEOG7V1FQ8.
PhylomeDBQ61324.
TreeFamTF319983.

Gene expression databases

BgeeQ61324.
CleanExMM_ARNT2.
GenevestigatorQ61324.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
IPR001067. Nuc_translocat.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamPF00010. HLH. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSPR00785. NCTRNSLOCATR.
SMARTSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 4 hits.
TIGRFAMsTIGR00229. sensory_box. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279871.
PROQ61324.
SOURCESearch...

Entry information

Entry nameARNT2_MOUSE
AccessionPrimary (citable) accession number: Q61324
Secondary accession number(s): Q7TQG2, Q8CHG9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 6, 2007
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot