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Q61321

- SIX4_MOUSE

UniProt

Q61321 - SIX4_MOUSE

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Protein

Homeobox protein SIX4

Gene

Six4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer (PubMed:14966291). Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA protein (PubMed:10490620). Acts synergistically with SIX1 to regulate target genes involved in formation of various organs, including muscle, kidney, gonad, ganglia, olfactory epithelium and cranial skeleton. Plays a role in several important steps of muscle development. Controls the genesis of hypaxial myogenic progenitors in the dermomyotome by transactivating PAX3 and the delamination and migration of the hypaxial precursors from the ventral lip to the limb buds through the transactivation of PAX3, MET and LBX1 (PubMed:15788460). Controls myoblast determination by transactivating MYF5, MYOD1 and MYF6 (PubMed:15788460, PubMed:17592144). Controls somitic differentiation in myocyte through MYOG transactivation (PubMed:15788460). Plays a role in synaptogenesis and sarcomere organization by participating in myofiber specialization during embryogenesis by activating fast muscle program in the primary myotome resulting in an up-regulation of fast muscle genes, including ATP2A1, MYL1 and TNNT3 (PubMed:19962975, PubMed:21884692). Simultaneously, is also able to activate inhibitors of slow muscle genes, such as SOX6, HRASLS, and HDAC4, thereby restricting the activation of the slow muscle genes (PubMed:21884692). During muscle regeneration, negatively regulates differentiation of muscle satellite cells through down-regulation of MYOG expression (PubMed:20696153). During kidney development regulates the early stages of metanephros development and ureteric bud formation through regulation of GDNF, SALL1, PAX8 and PAX2 expression (PubMed:17300925). Plays a role in gonad development by regulating both testis determination and size determination. In gonadal sex determination, transactivates ZFPM2 by binding a MEF3 consensus sequence, resulting in SRY up-regulation. In gonadal size determination, transactivates NR5A1 by binding a MEF3 consensus sequence resulting in gonadal precursor cell formation regulation (PubMed:23987514). During olfactory development mediates the specification and patterning of olfactory placode through fibroblast growth factor and BMP4 signaling pathways and also regulates epithelial cell proliferation during placode formation (PubMed:19027001). Promotes survival of sensory neurons during early trigeminal gangliogenesis (PubMed:16938278). In the developing dorsal root ganglia, up-regulates SLC12A2 transcription (PubMed:15955062). Regulates early thymus/parathyroid organogenesis through regulation of GCM2 and FOXN1 expression (PubMed:16530750). Forms gustatory papillae during development of the tongue (PubMed:21978088). Also plays a role during embryonic cranial skeleton morphogenesis (PubMed:20515681).15 Publications1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi216 – 27560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anatomical structure development Source: MGI
  2. embryonic cranial skeleton morphogenesis Source: MGI
  3. embryonic skeletal system morphogenesis Source: MGI
  4. generation of neurons Source: UniProtKB
  5. inner ear morphogenesis Source: MGI
  6. metanephric mesenchyme development Source: UniProtKB
  7. myoblast migration Source: MGI
  8. negative regulation of neuron apoptotic process Source: UniProtKB
  9. positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  10. positive regulation of transcription, DNA-templated Source: UniProtKB
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of ureteric bud formation Source: UniProtKB
  13. regulation of branch elongation involved in ureteric bud branching Source: UniProtKB
  14. regulation of gene expression Source: MGI
  15. regulation of protein localization Source: MGI
  16. regulation of synaptic growth at neuromuscular junction Source: MGI
  17. skeletal muscle tissue development Source: MGI
  18. thymus development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX4
Alternative name(s):
Sine oculis homeobox homolog 4
Skeletal muscle-specific ARE-binding protein AREC3
Gene namesi
Name:Six4
Synonyms:Arec3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:106034. Six4.

Subcellular locationi

Nucleus 2 Publications. Cytoplasm 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable and fertile; no gross morphological or histological abnormalities, or defects in hearing ability are detected in homozygous mice (PubMed:11313460). Double homozygous SIX1 and SIX4 knockout mice die soon after birth and show developmental defects in various organs (PubMed:15955062). Double homozygous SIX1 and SIX4 knockout mice causes severe defects in the trigeminal ganglia (PubMed:16938278). Double homozygous SIX1 and SIX4 knockout mice exhibit more severe kidney phenotypes than the SIX1 knockout mice. Double homozygous SIX1 and SIX4 knockout embryos show distinct morphological changes: fusion of the lateral lingual swellings is delayed, and the tongue is poorly developed. The primordia of fungiform papillae appears earlier, and the papillae rapidly increases in size; thus fusion of each papilla is evident. The circumvallate papillae show severe defects: invagination of the trenches starts asymmetrically, which results in longer and shorter trenches (PubMed:21978088). Double homozygous SIX1 and SIX4 knockout neonatal mice have a male-to-female sex-reversal phenotype in XY mutant gonads (PubMed:23987514). Double homozygous SIX1 and SIX4 knockout neonatal mice are characterized by severe craniofacial and rib defects, and general muscle hypoplasia (PubMed:15788460).6 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 775774Homeobox protein SIX4PRO_0000049304Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei634 – 6341PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61321.
PRIDEiQ61321.

PTM databases

PhosphoSiteiQ61321.

Expressioni

Tissue specificityi

Mainly expressed in the skeletal muscle (isoform 1 and isoform 2 but not isoform 3), and weakly in the heart. Also found in the retina and the distal tube of kidney. Expressed in skeletal muscle, nasal epithelium, cochlea, parathyroid and salivary gland (PubMed:11313460). Expressed in muscle satellite cells of normal and regenerating muscles (PubMed:20696153).2 Publications

Developmental stagei

At E8.5 expressed at the surface ectoderm outside the neural folds, somites, presomitic mesoderm. At E9.5 expressed at the nasal and otic placodes, cranial ganglia, branchial arches, somites (dermamyotomes and sclerotomes). At E10.5-E11.5 expressed at the nasal pits, otic vesicles, cranial ganglia, dorsal root ganglia, branchial arches, somites, myotomes, limb mesenchyme, notochord, mesonephros. At E12.5-E13.5 expressed in skeletal muscles, mesenchyme in limbs and digits, nasal epithelium, inner ear (PubMed:11313460). Weakly expressed in the nephrogenic cord on E9.5 and in the metanephric mesenchyme on E10.5 (PubMed:17300925). At E11.5 expressed in the epithelium of the lateral lingual swellings, and in the tongue epithelium, mesenchyme, and muscles at E12.5. In the fungiform papillae, expressed in the epithelium at E14-E16.5. In the circumvallate and foliate papillae, expression is observed in the trench wall of these papillae at E15.5-P0 (PubMed:21978088). At E11.5 mainly found in limbs, and somites, where is expressed in the dorsal root ganglion, myotomes, and ventral and dorsal dermomyotomal lips (PubMed:15788460). Expressed in a wide domain of the ectoderm in the presumptive olfactory region and in the thickened olfactory placode. Expressed in the peripheral precursors of the pit. At E12.5-E14.5, expression become progressively restricted to the apical and basal progenitors.Also expressed strongly in the preplacodal region at E8.0 and in the presumptive olfactory ectoderm at E9.0 (PubMed:19027001). At E10.5 expressed in the progenitors of the dermomyotome and in the myocytes (PubMed:19962975).6 Publications

Gene expression databases

BgeeiQ61321.
ExpressionAtlasiQ61321. baseline and differential.
GenevestigatoriQ61321.

Interactioni

Subunit structurei

Interacts with EYA3; acts cooperatively with EYA3 to transactivate target genes through interaction and nuclear translocation of EYA3 protein (PubMed:12215533, PubMed:10490620).2 Publications1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Kdm6aO705462EBI-986524,EBI-1573712

Protein-protein interaction databases

IntActiQ61321. 2 interactions.
MINTiMINT-7949316.

Structurei

3D structure databases

ProteinModelPortaliQ61321.
SMRiQ61321. Positions 97-272.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni582 – 775194Transactivation domainAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 54Poly-Ser
Compositional biasi58 – 614Poly-Ala
Compositional biasi70 – 767Poly-Ala
Compositional biasi92 – 954Poly-Ala

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244874.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000261651.
HOVERGENiHBG017802.
InParanoidiQ61321.
KOiK15615.
OMAiIKQENGM.
OrthoDBiEOG7C5M8Z.
PhylomeDBiQ61321.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 1 (identifier: Q61321-1) [UniParc]FASTAAdd to Basket

Also known as: SM

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSSPTGQI ASAADIKQEN GMESASEGQE AHREVAGGAA AGLSPPAPAP
60 70 80 90 100
FPLEPGDAAA ASRVSREEGA AAAGAADQVQ LHSELLGRHQ HAAAAQPPLA
110 120 130 140 150
FSPDHVACVC EALQQGGNLD RLARFLWSLP QSDLLRGNES LLKARALVAF
160 170 180 190 200
HQGIYPELYS ILESHSFESA NHPLLQQLWY KARYTEAERA RGRPLGAVDK
210 220 230 240 250
YRLRRKFPLP RTIWDGEETV YCFKEKSRNA LKELYKQNRY PSPAEKRHLA
260 270 280 290 300
KITGLSLTQV SNWFKNRRQR DRNPSETQSK SESDGNPSTE DESSKGHEDL
310 320 330 340 350
SPHPLSGASD GVTNLSLSSH VEPVYMQQIG NAKISLSSSG VLLNGSLVPA
360 370 380 390 400
STSPVFLNGN SFIQGHNGVI LNGLNVGNTQ TVSLNPPKMS SNIVGNGIAM
410 420 430 440 450
TDILGSTSQD VKEFKVLQSS AVNSAATTSY SPSAPVSFPG LIPCTEVKRE
460 470 480 490 500
GIQTVASQDG GSVVTFTTPV QINQYGIVQI PNSGANGQFL NGSIGFSPLQ
510 520 530 540 550
LPPVSVAASQ GNLSVTPSTS DGSTFTSEPA TVQHGKLFLS PLTPSAVVYT
560 570 580 590 600
VPNSGQTVGA VKQEGLERGL VFSQLMPVNH SAQVNASLSS ENLSGSGLHP
610 620 630 640 650
LTSSLVNVSA AHGFSLTPPT LLNPTELNPD LAESQPVSAP VASKCTVSSV
660 670 680 690 700
SNTNYATLQN CSLIPGQDLL SGPMTQAALG EIVPTAEEQV SHASTAVHQD
710 720 730 740 750
FVREQRLVLQ SVPNIKENFL QNSENKATNN LMMLDSKSKY VLDGMVEAGC
760 770
EDLGTDKKEL AKLQTVQLDE DMQDL
Length:775
Mass (Da):82,263
Last modified:November 1, 1996 - v1
Checksum:iB06EBB64E04E5061
GO
Isoform 2 (identifier: Q61321-2) [UniParc]FASTAAdd to Basket

Also known as: M18

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MSSSSPTGQ → QKAAIRLHYFALAAILM
     37-100: Missing.

Note: Incomplete sequence.

Show »
Length:719
Mass (Da):77,203
Checksum:iC977A113A9400399
GO
Isoform 3 (identifier: Q61321-3) [UniParc]FASTAAdd to Basket

Also known as: M8

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MSSSSPTGQ → QKAAIRLHYFALAAILM
     188-319: ERARGRPLGA...DGVTNLSLSS → AGNSPCPAPS...CNKLEMLRYH
     320-775: Missing.

Note: Incomplete sequence.

Show »
Length:327
Mass (Da):35,213
Checksum:i6DA3154D4C09125A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 99MSSSSPTGQ → QKAAIRLHYFALAAILM in isoform 2 and isoform 3. CuratedVSP_002293
Alternative sequencei37 – 10064Missing in isoform 2. CuratedVSP_002294Add
BLAST
Alternative sequencei188 – 319132ERARG…LSLSS → AGNSPCPAPSGTARRRCIVS RRSRATRSRSSTSRIATPRR LRSGTWPRSPASPSPRSATG SRTGGSVTETPPRPSPKANR MATPVPRMNPARDMRICLLI HFQAHLMASPTSASLATWSQ YICNKLEMLRYH in isoform 3. CuratedVSP_002295Add
BLAST
Alternative sequencei320 – 775456Missing in isoform 3. CuratedVSP_002296Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50416 mRNA. Translation: BAA08915.1.
D50417 mRNA. Translation: BAA08916.1.
D50418 mRNA. Translation: BAA08917.1.
BC137931 mRNA. Translation: AAI37932.1.
BC137934 mRNA. Translation: AAI37935.1.
CCDSiCCDS25974.1. [Q61321-1]
PIRiS63626.
S63628.
S63629.
RefSeqiNP_035512.1. NM_011382.2. [Q61321-1]
UniGeneiMm.249575.

Genome annotation databases

EnsembliENSMUST00000043208; ENSMUSP00000036150; ENSMUSG00000034460. [Q61321-1]
GeneIDi20474.
KEGGimmu:20474.
UCSCiuc007nwb.1. mouse. [Q61321-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50416 mRNA. Translation: BAA08915.1 .
D50417 mRNA. Translation: BAA08916.1 .
D50418 mRNA. Translation: BAA08917.1 .
BC137931 mRNA. Translation: AAI37932.1 .
BC137934 mRNA. Translation: AAI37935.1 .
CCDSi CCDS25974.1. [Q61321-1 ]
PIRi S63626.
S63628.
S63629.
RefSeqi NP_035512.1. NM_011382.2. [Q61321-1 ]
UniGenei Mm.249575.

3D structure databases

ProteinModelPortali Q61321.
SMRi Q61321. Positions 97-272.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61321. 2 interactions.
MINTi MINT-7949316.

PTM databases

PhosphoSitei Q61321.

Proteomic databases

MaxQBi Q61321.
PRIDEi Q61321.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000043208 ; ENSMUSP00000036150 ; ENSMUSG00000034460 . [Q61321-1 ]
GeneIDi 20474.
KEGGi mmu:20474.
UCSCi uc007nwb.1. mouse. [Q61321-1 ]

Organism-specific databases

CTDi 51804.
MGIi MGI:106034. Six4.

Phylogenomic databases

eggNOGi NOG244874.
GeneTreei ENSGT00540000070251.
HOGENOMi HOG000261651.
HOVERGENi HBG017802.
InParanoidi Q61321.
KOi K15615.
OMAi IKQENGM.
OrthoDBi EOG7C5M8Z.
PhylomeDBi Q61321.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298591.
PROi Q61321.
SOURCEi Search...

Gene expression databases

Bgeei Q61321.
ExpressionAtlasi Q61321. baseline and differential.
Genevestigatori Q61321.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development."
    Kawakami K., Ohto H., Ikeda K., Roeder R.G.
    Nucleic Acids Res. 24:303-310(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3), SUBCELLULAR LOCATION.
    Strain: BALB/c.
    Tissue: Myoblast and Skeletal muscle.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Localization of Six4/AREC3 in the developing mouse retina; implications in mammalian retinal development."
    Niiya A., Ohto H., Kawakami K., Araki M.
    Exp. Eye Res. 67:699-707(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  4. "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
    Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
    Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development."
    Ozaki H., Watanabe Y., Takahashi K., Kitamura K., Tanaka A., Urase K., Momoi T., Sudo K., Sakagami J., Asano M., Iwakura Y., Kawakami K.
    Mol. Cell. Biol. 21:3343-3350(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  6. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
    Ikeda K., Watanabe Y., Ohto H., Kawakami K.
    Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA3.
  7. "Quantitative proteomic identification of six4 as the trex-binding factor in the muscle creatine kinase enhancer."
    Himeda C.L., Ranish J.A., Angello J.C., Maire P., Aebersold R., Hauschka S.D.
    Mol. Cell. Biol. 24:2132-2143(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo."
    Grifone R., Demignon J., Houbron C., Souil E., Niro C., Seller M.J., Hamard G., Maire P.
    Development 132:2235-2249(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  9. "Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4."
    Ando Z., Sato S., Ikeda K., Kawakami K.
    FEBS J. 272:3026-3041(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  10. "Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis."
    Konishi Y., Ikeda K., Iwakura Y., Kawakami K.
    Brain Res. 1116:93-102(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  11. "Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1."
    Zou D., Silvius D., Davenport J., Grifone R., Maire P., Xu P.X.
    Dev. Biol. 293:499-512(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects."
    Kobayashi H., Kawakami K., Asashima M., Nishinakamura R.
    Mech. Dev. 124:290-303(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, FUNCTION.
  13. "Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs."
    Giordani J., Bajard L., Demignon J., Daubas P., Buckingham M., Maire P.
    Proc. Natl. Acad. Sci. U.S.A. 104:11310-11315(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4."
    Chen B., Kim E.H., Xu P.X.
    Dev. Biol. 326:75-85(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  15. "Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome."
    Niro C., Demignon J., Vincent S., Liu Y., Giordani J., Sgarioto N., Favier M., Guillet-Deniau I., Blais A., Maire P.
    Dev. Biol. 338:168-182(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE.
  16. "Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base."
    He G., Tavella S., Hanley K.P., Self M., Oliver G., Grifone R., Hanley N., Ward C., Bobola N.
    Dev. Biol. 344:720-730(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Six family genes control the proliferation and differentiation of muscle satellite cells."
    Yajima H., Motohashi N., Ono Y., Sato S., Ikeda K., Masuda S., Yada E., Kanesaki H., Miyagoe-Suzuki Y., Takeda S., Kawakami K.
    Exp. Cell Res. 316:2932-2944(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  18. "Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression."
    Richard A.F., Demignon J., Sakakibara I., Pujol J., Favier M., Strochlic L., Le Grand F., Sgarioto N., Guernec A., Schmitt A., Cagnard N., Huang R., Legay C., Guillet-Deniau I., Maire P.
    Dev. Biol. 359:303-320(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  19. "Development of gustatory papillae in the absence of Six1 and Six4."
    Suzuki Y., Ikeda K., Kawakami K.
    J. Anat. 219:710-721(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.
  20. "Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development."
    Fujimoto Y., Tanaka S.S., Yamaguchi Y.L., Kobayashi H., Kuroki S., Tachibana M., Shinomura M., Kanai Y., Morohashi K., Kawakami K., Nishinakamura R.
    Dev. Cell 26:416-430(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSIX4_MOUSE
AccessioniPrimary (citable) accession number: Q61321
Secondary accession number(s): B2RQH3, Q61322, Q61323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

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