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Q61316

- HSP74_MOUSE

UniProt

Q61316 - HSP74_MOUSE

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Protein
Heat shock 70 kDa protein 4
Gene
Hspa4, Apg2, Hsp110
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. response to stress Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 4
Alternative name(s):
Heat shock 70-related protein APG-2
Gene namesi
Name:Hspa4
Synonyms:Apg2, Hsp110
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1342292. Hspa4.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 841841Heat shock 70 kDa protein 4
PRO_0000078263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531N6-acetyllysine1 Publication
Modified residuei76 – 761Phosphoserine By similarity
Modified residuei89 – 891Phosphotyrosine By similarity
Modified residuei336 – 3361Phosphotyrosine2 Publications
Modified residuei430 – 4301N6-acetyllysine By similarity
Modified residuei540 – 5401Phosphothreonine By similarity
Modified residuei548 – 5481Phosphoserine By similarity
Modified residuei661 – 6611Phosphotyrosine1 Publication
Modified residuei680 – 6801N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ61316.
PaxDbiQ61316.
PRIDEiQ61316.

2D gel databases

REPRODUCTION-2DPAGEQ61316.

PTM databases

PhosphoSiteiQ61316.

Expressioni

Gene expression databases

CleanExiMM_HSPA4.
GenevestigatoriQ61316.

Interactioni

Subunit structurei

Interacts with TJP1/ZO-1 By similarity.

Protein-protein interaction databases

DIPiDIP-46965N.
IntActiQ61316. 3 interactions.
MINTiMINT-1869188.
STRINGi10090.ENSMUSP00000020630.

Structurei

3D structure databases

ProteinModelPortaliQ61316.
SMRiQ61316. Positions 5-698.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0443.
HOVERGENiHBG047955.
InParanoidiQ61316.

Family and domain databases

Gene3Di1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 2 hits.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEiPS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61316-1 [UniParc]FASTAAdd to Basket

« Hide

MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACVS FGPKNRSIGA    50
AAKSQVISNA KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG 100
IKVTYMEEER NFTTEQVTAM LLSKLKETAE SVLKKPVVDC VVSVPSFYTD 150
AERRSVMDAT QIAGLNCLRL MNETTAVALA YGIYKQDLPA LEEKPRNVVF 200
VDMGHSAYQV SVCAFNKGKL KVLATAFDTT LGGRKFDEVL VNHFCEEFGK 250
KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDIDVSGT 300
MNRGKFLEMC DDLLARVEPP LRSVLEQSKL KKEDIYAVEI VGGATRIPAV 350
KEKISKFFGK ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY 400
PISLRWNSPA EEGLSDCEVF PKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ 450
DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV KVRVNVHGIF SVSSAALVEV 500
HKSEESEEPM ETDQNAKEEE KMQVDQEEPH TEEQQQQPQT PAENKAESEE 550
METSQAGSKD KKTDQPPQAK KAKVKTSTVD LPIEHTLWQL DREMLALYTE 600
NEGKMIMQDK LEKERNDAKN AVEEYVYEMR DKLSGEYEKF VSEDDRNTFT 650
LKLEDTENWL YEDGEDQPKQ VYVDKLAELK SLGQPIKTRF QESEERPKLF 700
EELGKQIQQY MKVISSFKNK EDQYEHLDAA DVTKVEKSTN EAMEWMNSKL 750
NLQNKQSLTV DPVVKTKEIE AKIKELTSIC SPIISKPKPK VEPPKEEPKH 800
AEQNGPVDGQ GDNPGSQAAE HGADTAVPSD GDKKLPEMDI D 841
Length:841
Mass (Da):94,133
Last modified:November 1, 1996 - v1
Checksum:iE7FF19F555C115ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85904 mRNA. Translation: BAA12914.1.
UniGeneiMm.239865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D85904 mRNA. Translation: BAA12914.1 .
UniGenei Mm.239865.

3D structure databases

ProteinModelPortali Q61316.
SMRi Q61316. Positions 5-698.
ModBasei Search...

Protein-protein interaction databases

DIPi DIP-46965N.
IntActi Q61316. 3 interactions.
MINTi MINT-1869188.
STRINGi 10090.ENSMUSP00000020630.

PTM databases

PhosphoSitei Q61316.

2D gel databases

REPRODUCTION-2DPAGE Q61316.

Proteomic databases

MaxQBi Q61316.
PaxDbi Q61316.
PRIDEi Q61316.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1342292. Hspa4.

Phylogenomic databases

eggNOGi COG0443.
HOVERGENi HBG047955.
InParanoidi Q61316.

Miscellaneous databases

ChiTaRSi HSPA4. mouse.
PROi Q61316.
SOURCEi Search...

Gene expression databases

CleanExi MM_HSPA4.
Genevestigatori Q61316.

Family and domain databases

Gene3Di 1.20.1270.10. 2 hits.
2.60.34.10. 2 hits.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 2 hits.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 2 hits.
PROSITEi PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of apg-2 encoding a novel member of heat shock protein 110 family."
    Kaneko Y., Kimura T., Kishishita M., Noda Y., Fujita J.
    Gene 189:19-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DDY/STD.
    Tissue: Testis.
  2. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 74-124; 155-169; 186-196; 220-234; 330-346; 361-374; 391-405; 699-705 AND 719-734, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  3. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
    Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
    J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-336 AND TYR-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Mast cell.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-336, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiHSP74_MOUSE
AccessioniPrimary (citable) accession number: Q61316
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi