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Q61315

- APC_MOUSE

UniProt

Q61315 - APC_MOUSE

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Protein
Adenomatous polyposis coli protein
Gene
Apc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration By similarity. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization By similarity.1 Publication

GO - Molecular functioni

  1. beta-catenin binding Source: UniProtKB
  2. microtubule binding Source: UniProtKB
  3. microtubule plus-end binding Source: UniProtKB
  4. protease binding Source: BHF-UCL
  5. protein binding Source: UniProtKB
  6. protein kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. T cell differentiation in thymus Source: MGI
  2. Wnt signaling pathway Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. axis specification Source: MGI
  5. axonogenesis Source: MGI
  6. canonical Wnt signaling pathway Source: MGI
  7. canonical Wnt signaling pathway involved in negative regulation of apoptotic process Source: MGI
  8. canonical Wnt signaling pathway involved in positive regulation of apoptotic process Source: MGI
  9. cell cycle arrest Source: UniProtKB
  10. cell migration Source: MGI
  11. cellular response to DNA damage stimulus Source: UniProtKB
  12. chromosome organization Source: MGI
  13. cytoplasmic microtubule organization Source: MGI
  14. dorsal/ventral pattern formation Source: MGI
  15. hair follicle development Source: MGI
  16. kidney development Source: MGI
  17. metaphase/anaphase transition of mitotic cell cycle Source: MGI
  18. mitotic cytokinesis Source: MGI
  19. muscle cell cellular homeostasis Source: MGI
  20. negative regulation of MAPK cascade Source: MGI
  21. negative regulation of Wnt signaling pathway Source: MGI
  22. negative regulation of apoptotic process Source: MGI
  23. negative regulation of canonical Wnt signaling pathway Source: MGI
  24. negative regulation of cell proliferation Source: UniProtKB
  25. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
  26. negative regulation of epithelial cell proliferation Source: MGI
  27. negative regulation of epithelial cell proliferation involved in prostate gland development Source: MGI
  28. negative regulation of microtubule depolymerization Source: UniProtKB
  29. negative regulation of odontogenesis Source: MGI
  30. pattern specification process Source: MGI
  31. positive regulation of apoptotic process Source: MGI
  32. positive regulation of cell adhesion Source: MGI
  33. positive regulation of cell differentiation Source: MGI
  34. positive regulation of cell division Source: MGI
  35. positive regulation of cell migration Source: MGI
  36. positive regulation of epithelial cell differentiation Source: MGI
  37. positive regulation of microtubule polymerization Source: MGI
  38. positive regulation of protein catabolic process Source: MGI
  39. protein complex assembly Source: UniProtKB
  40. proximal/distal pattern formation Source: MGI
  41. regulation of attachment of spindle microtubules to kinetochore Source: MGI
  42. regulation of cell cycle Source: MGI
  43. regulation of cell differentiation Source: MGI
  44. regulation of cell migration Source: MGI
  45. regulation of epithelial cell differentiation Source: MGI
  46. regulation of microtubule-based process Source: UniProtKB
  47. regulation of nitrogen compound metabolic process Source: MGI
  48. regulation of osteoblast differentiation Source: MGI
  49. regulation of osteoclast differentiation Source: MGI
  50. retina development in camera-type eye Source: MGI
  51. skin development Source: MGI
  52. somatic stem cell maintenance Source: MGI
  53. stem cell maintenance Source: MGI
  54. thymus development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Adenomatous polyposis coli protein
Short name:
Protein APC
Short name:
mAPC
Gene namesi
Name:Apc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:88039. Apc.

Subcellular locationi

Cell junctionadherens junction By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity. Cell projectionruffle membrane By similarity. Cytoplasm By similarity. Cell membrane By similarity
Note: Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane By similarity.

GO - Cellular componenti

  1. Scrib-APC-beta-catenin complex Source: BHF-UCL
  2. adherens junction Source: UniProtKB-SubCell
  3. axon Source: MGI
  4. axonal growth cone Source: MGI
  5. beta-catenin destruction complex Source: UniProtKB
  6. cell projection Source: MGI
  7. cell projection membrane Source: MGI
  8. centrosome Source: UniProtKB
  9. cytoplasm Source: UniProtKB
  10. growth cone Source: MGI
  11. kinetochore Source: UniProtKB
  12. lamellipodium Source: UniProtKB
  13. microtubule Source: UniProtKB-KW
  14. nucleus Source: UniProtKB
  15. plasma membrane Source: UniProtKB
  16. ruffle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Microtubule

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 28452844Adenomatous polyposis coli protein
PRO_0000064628Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei742 – 7421Phosphoserine By similarity
Modified residuei778 – 7781Phosphoserine By similarity
Modified residuei1040 – 10401Phosphoserine By similarity
Modified residuei1359 – 13591Phosphoserine By similarity
Modified residuei1859 – 18591Phosphoserine By similarity
Modified residuei1861 – 18611Phosphoserine By similarity
Modified residuei1862 – 18621Phosphoserine By similarity
Modified residuei2151 – 21511Phosphothreonine By similarity
Modified residuei2260 – 22601Phosphoserine By similarity
Modified residuei2270 – 22701Phosphoserine By similarity
Modified residuei2283 – 22831Phosphoserine By similarity
Modified residuei2473 – 24731Phosphoserine By similarity
Modified residuei2535 – 25351Phosphoserine By similarity
Modified residuei2671 – 26711Phosphoserine By similarity
Modified residuei2674 – 26741Phosphoserine By similarity
Modified residuei2679 – 26791Phosphothreonine By similarity
Modified residuei2791 – 27911Phosphoserine By similarity

Post-translational modificationi

Phosphorylated by GSK3B By similarity.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61315.
PaxDbiQ61315.
PRIDEiQ61315.

PTM databases

PhosphoSiteiQ61315.

Expressioni

Tissue specificityi

Expressed in liver, spleen, kidney, heart, lung, brain, stomach, intestine, testis and ovary.

Gene expression databases

CleanExiMM_APC.
GenevestigatoriQ61315.

Interactioni

Subunit structurei

Forms homooligomers and heterooligomers with APC2. Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with ARHGEF4 (via N-terminus) By similarity. Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with DIAPH1 and DIAPH2. Interacts with SCRIB; may mediate targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain) By similarity. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B. Interacts at the cell membrane with AMER1 and AMER2 (via ARM repeats) By similarity.2 Publications

Protein-protein interaction databases

IntActiQ61315. 2 interactions.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VJ6NMR-B2834-2845[»]
ProteinModelPortaliQ61315.
SMRiQ61315. Positions 2-55, 128-237, 324-734, 1485-1527.

Miscellaneous databases

EvolutionaryTraceiQ61315.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati451 – 49343ARM 1
Add
BLAST
Repeati503 – 54543ARM 2
Add
BLAST
Repeati546 – 58944ARM 3
Add
BLAST
Repeati590 – 63647ARM 4
Add
BLAST
Repeati637 – 68145ARM 5
Add
BLAST
Repeati682 – 72342ARM 6
Add
BLAST
Repeati724 – 76542ARM 7
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1864 – 189128Highly charged
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2 – 6160 Reviewed prediction
Add
BLAST
Coiled coili125 – 245121 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi2805 – 28084Microtubule tip localization signal
Motifi2843 – 28453PDZ-binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 728728Leu-rich
Add
BLAST
Compositional biasi739 – 28342096Ser-rich
Add
BLAST
Compositional biasi1130 – 115627Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi1556 – 157520Asp/Glu-rich (acidic)
Add
BLAST

Domaini

The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends By similarity.

Sequence similaritiesi

Contains 7 ARM repeats.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG259696.
HOGENOMiHOG000033986.
HOVERGENiHBG004264.
InParanoidiQ61315.
PhylomeDBiQ61315.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]
PANTHERiPTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
PfamiPF05972. APC_15aa. 4 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF00514. Arm. 3 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]
SMARTiSM00185. ARM. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q61315-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ     50
LQGSIEDETM TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS 100
VSSRSGECSP VPMGSFPRRT FVNGSRESTG YLEELEKERS LLLADLDKEE 150
KEKDWYYAQL QNLTKRIDSL PLTENFSLQT DMTRRQLEYE ARQIRAAMEE 200
QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA ERSSQSRHDA 250
ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 300
RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC 350
LPLLIQLLHG NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR 400
EIRVLHLLEQ IRAYCETCWE WQEAHEQGMD QDKNPMPAPV EHQICPAVCV 450
LMKLSFDEEH RHAMNELGGL QAIAELLQVD CEMYGLTNDH YSVTLRRYAG 500
MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ VIASVLRNLS 550
WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 600
KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH 650
RQILRENNCL QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG 700
AVSMLKNLIH SKHKMIAMGS AAALRNLMAN RPAKYKDANI MSPGSSLPSL 750
HVRKQKALEA ELDAQHLSET FDNIDNLSPK ASHRSKQRHK QNLYGDYAFD 800
ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD SSRSEKDRSL 850
ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 900
DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA 950
KVEYKRSSND SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA 1000
DLAHKIHSAN HMDDNDGELD TPINYSLKYS DEQLNSGRQS PSQNERWARP 1050
KHVIEDEIKQ NEQRQARSQN TSYPVYSENT DDKHLKFQPH FGQQECVSPY 1100
RSRGTSGSET NRMGSSHAIN QNVNQSLCQE DDYEDDKPTN YSERYSEEEQ 1150
HEEEEERPTN YSIKYNEEKH HVDQPIDYSL KYATDISSSQ KPSFSFSKNS 1200
SAQSTKPEHL SPSSENTAVP PSNAKRQNQL RPSSAQRNGQ TQKGTTCKVP 1250
SINQETIQTY CVEDTPICFS RCSSLSSLSS ADDEIGCDQT TQEADSANTL 1300
QTAEVKENDV TRSAEDPATE VPAVSQNARA KPSRLQASGL SSESTRHNKA 1350
VEFSSGAKSP SKSGAQTPKS PPEHYVQETP LVFSRCTSVS SLDSFESRSI 1400
ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP PPQTVQAKRE 1450
VPKSKVPAAE KRESGPKQTA VNAAVQRVQV LPDVDTLLHF ATESTPDGFS 1500
CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEESNENQDK 1550
EVEKPDSEKD LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP 1600
PPVARKPSQL PVYKLLPAQN RLQAQKHVSF TPGDDVPRVY CVEGTPINFS 1650
TATSLSDLTI ESPPNELATG DGVRAGIQSG EFEKRDTIPT EGRSTDDAQR 1700
GKISSIVTPD LDDNKAEEGD ILAECINSAM PKGKSHKPFR VKKIMDQVQQ 1750
ASSTSSGANK NQVDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1800
ETFSDNKDSK KPSLQTNAKA FNEKLPNNED RVRGTFALDS PHHYTPIEGT 1850
PYCFSRNDSL SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCRPEPNS 1900
SQQAASKSQA SIKHPANRAQ SKPVLQKQPT FPQSSKDGPD RGAATDEKLQ 1950
NLAIENTPVC FSRNSSLSSL SDIDQENNNN KESEPIKEAE PANSQGEPSK 2000
PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE CISSAMPKKK 2050
RPSRLKSESE KQSPRKVGGI LAEDLTLDLK DLQRPDSEHA FSPGSENFDW 2100
KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GISLGSPFHL 2150
TPDQEEKPFT SNKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT 2200
GKIRSNSEIS SQMKQPLPTN MPSISRGRTM IHIPGLRNSS SSTSPVSKKG 2250
PPLKTPASKS PSEGPGATTS PRGTKPAGKS ELSPITRQTS QISGSNKGSS 2300
RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISPPN KLSQLPRTSS 2350
PSTASTKSSG SGKMSYTSPG RQLSQQNLTK QASLSKNASS IPRSESASKG 2400
LNQMSNGNGS NKKVELSRMS STKSSGSESD SSERPALVRQ STFIKEAPSP 2450
TLRRKLEESA SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ 2500
AGGWRKLPPN LSPTIEYNDG RPTKRHDIAR SHSESPSRLP INRAGTWKRE 2550
HSKHSSSLPR VSTWRRTGSS SSILSASSES SEKAKSEDER HVSSMPAPRQ 2600
MKENQVPTKG TWRKIKESDI SPTGMASQSA SSGAASGAES KPLIYQMAPP 2650
VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDS 2700
KDTHGKQSVG SGSPVQTVGL ETRLNSFVQV EAPEQKGTEA KPGQSNPVSI 2750
AETAETCIAE RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST 2800
SARPSQIPTP VSTNTKKRDS KTDITESSGA QSPKRHSGSY LVTSV 2845
Length:2,845
Mass (Da):311,089
Last modified:November 1, 1996 - v1
Checksum:i145CA73CF570A499
GO
Isoform 2 (identifier: Q61315-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-276: Missing.

Show »
Length:2,811
Mass (Da):307,676
Checksum:i26917A1088E0B295
GO
Isoform 3 (identifier: Q61315-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     310-410: Missing.

Show »
Length:2,744
Mass (Da):299,882
Checksum:i7E887CE032058082
GO
Isoform 4 (identifier: Q61315-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-276: Missing.
     310-410: Missing.

Show »
Length:2,710
Mass (Da):296,469
Checksum:i76584921956DDB03
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201T → A in strain: CAST/Ei.
Natural varianti493 – 4931V → I in strain: CAST/Ei.
Natural varianti797 – 7971Y → F in strain: CAST/Ei.
Natural varianti1330 – 13301A → T in strain: CAST/Ei.
Natural varianti1618 – 16181A → S in strain: CAST/Ei.
Natural varianti2294 – 22941G → A in strain: CAST/Ei.
Natural varianti2496 – 24961H → Q in strain: CAST/Ei.
Natural varianti2523 – 25231T → A in strain: CAST/Ei.
Natural varianti2813 – 28131T → S in strain: CAST/Ei.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei243 – 27634Missing in isoform 2 and isoform 4.
VSP_004116Add
BLAST
Alternative sequencei310 – 410101Missing in isoform 3 and isoform 4.
VSP_004117Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88127 mRNA. Translation: AAB59632.1.
U02937 Unassigned DNA. Translation: AAA03443.1.
PIRiI49505.
UniGeneiMm.384171.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M88127 mRNA. Translation: AAB59632.1 .
U02937 Unassigned DNA. Translation: AAA03443.1 .
PIRi I49505.
UniGenei Mm.384171.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VJ6 NMR - B 2834-2845 [» ]
ProteinModelPortali Q61315.
SMRi Q61315. Positions 2-55, 128-237, 324-734, 1485-1527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61315. 2 interactions.

PTM databases

PhosphoSitei Q61315.

Proteomic databases

MaxQBi Q61315.
PaxDbi Q61315.
PRIDEi Q61315.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:88039. Apc.

Phylogenomic databases

eggNOGi NOG259696.
HOGENOMi HOG000033986.
HOVERGENi HBG004264.
InParanoidi Q61315.
PhylomeDBi Q61315.

Miscellaneous databases

ChiTaRSi APC. mouse.
EvolutionaryTracei Q61315.
PROi Q61315.
SOURCEi Search...

Gene expression databases

CleanExi MM_APC.
Genevestigatori Q61315.

Family and domain databases

Gene3Di 1.25.10.10. 2 hits.
InterProi IPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view ]
PANTHERi PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF11. PTHR12607:SF11. 1 hit.
Pfami PF05972. APC_15aa. 4 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF00514. Arm. 3 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view ]
SMARTi SM00185. ARM. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene."
    Su L.-K., Kinzler K.W., Vogelstein B., Preisinger A.C., Moser A.R., Luongo C., Gould K.A., Dove W.F.
    Science 256:668-670(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS.
    Strain: C57BL/6J and CAST/Ei.
    Tissue: Brain.
  2. "The murine APC gene: alternative splicing of 5' untranslated region segments."
    Dicker F., Lambertz S., Reitmair A., Ballhausen W.G.
    Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45.
    Strain: BALB/c.
    Tissue: Liver.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1795-1810, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. "APC gene messenger RNA: novel isoforms that lack exon 7."
    Oshima M., Sugiyama H., Kitagawa K., Taketo M.
    Cancer Res. 53:5589-5591(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING.
  5. "EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration."
    Wen Y., Eng C.H., Schmoranzer J., Cabrera-Poch N., Morris E.J.S., Chen M., Wallar B.J., Alberts A.S., Gundersen G.G.
    Nat. Cell Biol. 6:820-830(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DIAPH1; DIAPH2 AND MAPRE1.
  6. "Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli."
    Takizawa S., Nagasaka K., Nakagawa S., Yano T., Nakagawa K., Yasugi T., Takeuchi T., Kanda T., Huibregtse J.M., Akiyama T., Taketani Y.
    Genes Cells 11:453-464(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCRIB.
  7. "The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
    Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T.
    EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiAPC_MOUSE
AccessioniPrimary (citable) accession number: Q61315
Secondary accession number(s): Q62044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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