Q61315 (APC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenomatous polyposis coli protein
Short name=Protein APC
Short name=mAPC

Gene names

Name:

Apc

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	2845 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration By similarity. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization By similarity. Ref.11
Subunit structure	Forms homooligomers and heterooligomers with APC2. Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with ARHGEF4 (via N-terminus) By similarity. Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with DIAPH1 and DIAPH2. Interacts with SCRIB; may mediate targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain) By similarity. Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B. Interacts at the cell membrane with AMER1 and AMER2 (via ARM repeats) By similarity. Ref.6 Ref.7
Subcellular location	Cell junction › adherens junction By similarity. Cytoplasm › cytoskeleton By similarity. Cell projection › lamellipodium By similarity. Cell projection › ruffle membrane By similarity. Cytoplasm By similarity. Cell membrane By similarity. Note: Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane By similarity.
Tissue specificity	Expressed in liver, spleen, kidney, heart, lung, brain, stomach, intestine, testis and ovary.
Domain	The microtubule tip localization signal (MtLS) motif; mediates interaction with MAPRE1 and targeting to the growing microtubule plus ends By similarity.
Post-translational modification	Phosphorylated by GSK3B By similarity. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID By similarity.
Sequence similarities	Belongs to the adenomatous polyposis coli (APC) family. Contains 7 ARM repeats.

Ontologies

Keywords
Biological process	Wnt signaling pathway
Cellular component	Cell junction Cell membrane Cell projection Cytoplasm Cytoskeleton Membrane Microtubule
Coding sequence diversity	Alternative splicing
Disease	Tumor suppressor
Domain	Coiled coil Repeat
PTM	Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	T cell differentiation in thymus Inferred from mutant phenotype PubMed 16025118. Source: MGI anterior/posterior pattern specification Inferred from mutant phenotype PubMed 12645927. Source: MGI axis specification Inferred from mutant phenotype PubMed 12645927. Source: MGI axonogenesis Inferred from mutant phenotype PubMed 15207235PubMed 18716223. Source: MGI canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 16887818. Source: MGI cell cycle arrest Inferred from sequence or structural similarity. Source: UniProtKB cell migration Inferred from mutant phenotype PubMed 15198980. Source: MGI chromosome organization Inferred from mutant phenotype PubMed 17200209. Source: MGI cytokinesis after mitosis Inferred from mutant phenotype PubMed 17570218PubMed 17893240. Source: MGI cytoplasmic microtubule organization Inferred from genetic interaction PubMed 18716223. Source: MGI dorsal/ventral pattern formation Inferred from mutant phenotype PubMed 12645927. Source: MGI hair follicle development Inferred from mutant phenotype PubMed 17002498. Source: MGI kidney development Inferred from mutant phenotype PubMed 15550389. Source: MGI mitotic metaphase/anaphase transition Inferred from mutant phenotype PubMed 15767571PubMed 16025118. Source: MGI muscle cell homeostasis Inferred from genetic interaction PubMed 18056981. Source: MGI negative regulation of MAPK cascade Inferred from mutant phenotype PubMed 16478791. Source: MGI negative regulation of apoptotic process Inferred from mutant phenotype PubMed 11756652PubMed 16950562. Source: MGI negative regulation of canonical Wnt receptor signaling pathway Inferred from mutant phenotype PubMed 11756652PubMed 15198980PubMed 15563600. Source: MGI negative regulation of cyclin-dependent protein serine/threonine kinase activity Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of epithelial cell proliferation involved in prostate gland development Inferred from mutant phenotype PubMed 17363566. Source: MGI negative regulation of microtubule depolymerization Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of odontogenesis Inferred from mutant phenotype PubMed 17002498. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 17227893. Source: MGI positive regulation of cell adhesion Inferred from mutant phenotype PubMed 16368433. Source: MGI positive regulation of cell division Inferred from mutant phenotype PubMed 16950562. Source: MGI positive regulation of cell migration Inferred from mutant phenotype PubMed 17192415. Source: MGI positive regulation of epithelial cell differentiation Inferred from genetic interaction PubMed 15314168. Source: MGI positive regulation of microtubule polymerization Inferred from mutant phenotype PubMed 16525027. Source: MGI positive regulation of protein catabolic process Inferred from mutant phenotype PubMed 16478791. Source: MGI protein complex assembly Inferred from sequence or structural similarity. Source: UniProtKB proximal/distal pattern formation Inferred from mutant phenotype PubMed 16887818. Source: MGI regulation of attachment of spindle microtubules to kinetochore Inferred from mutant phenotype PubMed 17227893. Source: MGI regulation of nitrogen compound metabolic process Inferred from mutant phenotype PubMed 16740478. Source: MGI regulation of osteoblast differentiation Inferred from mutant phenotype PubMed 15802266. Source: MGI regulation of osteoclast differentiation Inferred from mutant phenotype PubMed 15802266. Source: MGI response to DNA damage stimulus Inferred from sequence or structural similarity. Source: UniProtKB retina development in camera-type eye Inferred from mutant phenotype PubMed 10982921. Source: MGI skin development Inferred from mutant phenotype PubMed 9453487. Source: MGI somatic stem cell maintenance Inferred from mutant phenotype PubMed 1541640. Source: MGI thymus development Inferred from mutant phenotype PubMed 16025118PubMed 17002498. Source: MGI
Cellular_component	Scrib-APC-beta-catenin complex Inferred from direct assay Ref.7. Source: BHF-UCL adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell axonal growth cone Inferred from direct assay PubMed 18716223. Source: MGI beta-catenin destruction complex Inferred from sequence or structural similarity. Source: UniProtKB centrosome Inferred from sequence or structural similarity. Source: UniProtKB cytoplasmic microtubule Inferred from direct assay PubMed 16525027PubMed 16621792. Source: MGI kinetochore Inferred from sequence or structural similarity. Source: UniProtKB lamellipodium Inferred from sequence or structural similarity. Source: UniProtKB microtubule plus end Inferred from direct assay PubMed 18716223. Source: MGI nucleus Inferred from sequence or structural similarity. Source: UniProtKB ruffle membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	beta-catenin binding Inferred from sequence or structural similarity. Source: UniProtKB microtubule plus-end binding Inferred from sequence or structural similarity. Source: UniProtKB protein kinase regulator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q61315-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q61315-2)

The sequence of this isoform differs from the canonical sequence as follows:
     243-276: Missing.

Isoform 3 (identifier: Q61315-3)

The sequence of this isoform differs from the canonical sequence as follows:
     310-410: Missing.

Isoform 4 (identifier: Q61315-4)

The sequence of this isoform differs from the canonical sequence as follows:
     243-276: Missing.
     310-410: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2845	2845	Adenomatous polyposis coli protein		PRO_0000064628
Regions
	Repeat	451 – 493	43	ARM 1
	Repeat	503 – 545	43	ARM 2
	Repeat	546 – 589	44	ARM 3
	Repeat	590 – 636	47	ARM 4
	Repeat	637 – 681	45	ARM 5
	Repeat	682 – 723	42	ARM 6
	Repeat	724 – 765	42	ARM 7
	Region	1864 – 1891	28	Highly charged
	Coiled coil	1 – 61	61	Potential
	Coiled coil	125 – 245	121	Potential
	Motif	2805 – 2808	4	Microtubule tip localization signal
	Motif	2843 – 2845	3	PDZ-binding By similarity
	Compositional bias	1 – 728	728	Leu-rich
	Compositional bias	739 – 2834	2096	Ser-rich
	Compositional bias	1130 – 1156	27	Asp/Glu-rich (acidic)
	Compositional bias	1556 – 1575	20	Asp/Glu-rich (acidic)
Amino acid modifications
	Modified residue	742	1	Phosphoserine By similarity
	Modified residue	778	1	Phosphoserine By similarity
	Modified residue	1036	1	Phosphoserine Ref.9
	Modified residue	1040	1	Phosphoserine By similarity
	Modified residue	1179	1	Phosphoserine By similarity
	Modified residue	1359	1	Phosphoserine By similarity
	Modified residue	1370	1	Phosphoserine Ref.8
	Modified residue	1557	1	Phosphoserine Ref.10
	Modified residue	1695	1	Phosphothreonine By similarity
	Modified residue	1859	1	Phosphoserine By similarity
	Modified residue	1861	1	Phosphoserine By similarity
	Modified residue	1862	1	Phosphoserine By similarity
	Modified residue	2151	1	Phosphothreonine By similarity
	Modified residue	2260	1	Phosphoserine By similarity
	Modified residue	2270	1	Phosphoserine By similarity
	Modified residue	2283	1	Phosphoserine By similarity
	Modified residue	2473	1	Phosphoserine By similarity
	Modified residue	2535	1	Phosphoserine By similarity
	Modified residue	2671	1	Phosphoserine By similarity
	Modified residue	2674	1	Phosphoserine Ref.8
	Modified residue	2679	1	Phosphothreonine By similarity
	Modified residue	2713	1	Phosphoserine Ref.8
	Modified residue	2791	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	243 – 276	34	Missing in isoform 2 and isoform 4.		VSP_004116
	Alternative sequence	310 – 410	101	Missing in isoform 3 and isoform 4.		VSP_004117
	Natural variant	120	1	T → A in strain: CAST/Ei.
	Natural variant	493	1	V → I in strain: CAST/Ei.
	Natural variant	797	1	Y → F in strain: CAST/Ei.
	Natural variant	1330	1	A → T in strain: CAST/Ei.
	Natural variant	1618	1	A → S in strain: CAST/Ei.
	Natural variant	2294	1	G → A in strain: CAST/Ei.
	Natural variant	2496	1	H → Q in strain: CAST/Ei.
	Natural variant	2523	1	T → A in strain: CAST/Ei.
	Natural variant	2813	1	T → S in strain: CAST/Ei.

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 145CA73CF570A499	FASTA	2,845	311,089
	10 20 30 40 50 60 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 70 80 90 100 110 120 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 130 140 150 160 170 180 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 190 200 210 220 230 240 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 250 260 270 280 290 300 ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 310 320 330 340 350 360 RLTSHLGTKV EMVYSLLSML GTHDKDDMSR TLLAMSSSQD SCISMRQSGC LPLLIQLLHG 370 380 390 400 410 420 NDKDSVLLGN SRGSKEARAR ASAALHNIIH SQPDDKRGRR EIRVLHLLEQ IRAYCETCWE 430 440 450 460 470 480 WQEAHEQGMD QDKNPMPAPV EHQICPAVCV LMKLSFDEEH RHAMNELGGL QAIAELLQVD 490 500 510 520 530 540 CEMYGLTNDH YSVTLRRYAG MALTNLTFGD VANKATLCSM KGCMRALVAQ LKSESEDLQQ 550 560 570 580 590 600 VIASVLRNLS WRADVNSKKT LREVGSVKAL MECALEVKKE STLKSVLSAL WNLSAHCTEN 610 620 630 640 650 660 KADICAVDGA LAFLVGTLTY RSQTNTLAII ESGGGILRNV SSLIATNEDH RQILRENNCL 670 680 690 700 710 720 QTLLQHLKSH SLTIVSNACG TLWNLSARNP KDQEALWDMG AVSMLKNLIH SKHKMIAMGS 730 740 750 760 770 780 AAALRNLMAN RPAKYKDANI MSPGSSLPSL HVRKQKALEA ELDAQHLSET FDNIDNLSPK 790 800 810 820 830 840 ASHRSKQRHK QNLYGDYAFD ANRHDDSRSD NFNTGNMTVL SPYLNTTVLP SSSSSRGSLD 850 860 870 880 890 900 SSRSEKDRSL ERERGIGLSA YHPTTENAGT SSKRGLQITT TAAQIAKVME EVSAIHTSQD 910 920 930 940 950 960 DRSSASTTEF HCVADDRSAA RRSSASHTHS NTYNFTKSEN SNRTCSMPYA KVEYKRSSND 970 980 990 1000 1010 1020 SLNSVTSSDG YGKRGQMKPS VESYSEDDES KFCSYGQYPA DLAHKIHSAN HMDDNDGELD 1030 1040 1050 1060 1070 1080 TPINYSLKYS DEQLNSGRQS PSQNERWARP KHVIEDEIKQ NEQRQARSQN TSYPVYSENT 1090 1100 1110 1120 1130 1140 DDKHLKFQPH FGQQECVSPY RSRGTSGSET NRMGSSHAIN QNVNQSLCQE DDYEDDKPTN 1150 1160 1170 1180 1190 1200 YSERYSEEEQ HEEEEERPTN YSIKYNEEKH HVDQPIDYSL KYATDISSSQ KPSFSFSKNS 1210 1220 1230 1240 1250 1260 SAQSTKPEHL SPSSENTAVP PSNAKRQNQL RPSSAQRNGQ TQKGTTCKVP SINQETIQTY 1270 1280 1290 1300 1310 1320 CVEDTPICFS RCSSLSSLSS ADDEIGCDQT TQEADSANTL QTAEVKENDV TRSAEDPATE 1330 1340 1350 1360 1370 1380 VPAVSQNARA KPSRLQASGL SSESTRHNKA VEFSSGAKSP SKSGAQTPKS PPEHYVQETP 1390 1400 1410 1420 1430 1440 LVFSRCTSVS SLDSFESRSI ASSVQSEPCS GMVSGIISPS DLPDSPGQTM PPSRSKTPPP 1450 1460 1470 1480 1490 1500 PPQTVQAKRE VPKSKVPAAE KRESGPKQTA VNAAVQRVQV LPDVDTLLHF ATESTPDGFS 1510 1520 1530 1540 1550 1560 CSSSLSALSL DEPFIQKDVE LRIMPPVQEN DNGNETESEQ PEESNENQDK EVEKPDSEKD 1570 1580 1590 1600 1610 1620 LLDDSDDDDI EILEECIISA MPTKSSRKAK KLAQTASKLP PPVARKPSQL PVYKLLPAQN 1630 1640 1650 1660 1670 1680 RLQAQKHVSF TPGDDVPRVY CVEGTPINFS TATSLSDLTI ESPPNELATG DGVRAGIQSG 1690 1700 1710 1720 1730 1740 EFEKRDTIPT EGRSTDDAQR GKISSIVTPD LDDNKAEEGD ILAECINSAM PKGKSHKPFR 1750 1760 1770 1780 1790 1800 VKKIMDQVQQ ASSTSSGANK NQVDTKKKKP TSPVKPMPQN TEYRTRVRKN TDSKVNVNTE 1810 1820 1830 1840 1850 1860 ETFSDNKDSK KPSLQTNAKA FNEKLPNNED RVRGTFALDS PHHYTPIEGT PYCFSRNDSL 1870 1880 1890 1900 1910 1920 SSLDFDDDDV DLSREKAELR KGKESKDSEA KVTCRPEPNS SQQAASKSQA SIKHPANRAQ 1930 1940 1950 1960 1970 1980 SKPVLQKQPT FPQSSKDGPD RGAATDEKLQ NLAIENTPVC FSRNSSLSSL SDIDQENNNN 1990 2000 2010 2020 2030 2040 KESEPIKEAE PANSQGEPSK PQASGYAPKS FHVEDTPVCF SRNSSLSSLS IDSEDDLLQE 2050 2060 2070 2080 2090 2100 CISSAMPKKK RPSRLKSESE KQSPRKVGGI LAEDLTLDLK DLQRPDSEHA FSPGSENFDW 2110 2120 2130 2140 2150 2160 KAIQEGANSI VSSLHQAAAA AACLSRQASS DSDSILSLKS GISLGSPFHL TPDQEEKPFT 2170 2180 2190 2200 2210 2220 SNKGPRILKP GEKSTLEAKK IESENKGIKG GKKVYKSLIT GKIRSNSEIS SQMKQPLPTN 2230 2240 2250 2260 2270 2280 MPSISRGRTM IHIPGLRNSS SSTSPVSKKG PPLKTPASKS PSEGPGATTS PRGTKPAGKS 2290 2300 2310 2320 2330 2340 ELSPITRQTS QISGSNKGSS RSGSRDSTPS RPTQQPLSRP MQSPGRNSIS PGRNGISPPN 2350 2360 2370 2380 2390 2400 KLSQLPRTSS PSTASTKSSG SGKMSYTSPG RQLSQQNLTK QASLSKNASS IPRSESASKG 2410 2420 2430 2440 2450 2460 LNQMSNGNGS NKKVELSRMS STKSSGSESD SSERPALVRQ STFIKEAPSP TLRRKLEESA 2470 2480 2490 2500 2510 2520 SFESLSPSSR PDSPTRSQAQ TPVLSPSLPD MSLSTHPSVQ AGGWRKLPPN LSPTIEYNDG 2530 2540 2550 2560 2570 2580 RPTKRHDIAR SHSESPSRLP INRAGTWKRE HSKHSSSLPR VSTWRRTGSS SSILSASSES 2590 2600 2610 2620 2630 2640 SEKAKSEDER HVSSMPAPRQ MKENQVPTKG TWRKIKESDI SPTGMASQSA SSGAASGAES 2650 2660 2670 2680 2690 2700 KPLIYQMAPP VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDS 2710 2720 2730 2740 2750 2760 KDTHGKQSVG SGSPVQTVGL ETRLNSFVQV EAPEQKGTEA KPGQSNPVSI AETAETCIAE 2770 2780 2790 2800 2810 2820 RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST SARPSQIPTP VSTNTKKRDS 2830 2840 KTDITESSGA QSPKRHSGSY LVTSV
	Isoform 2 [UniParc]. Checksum: 26917A1088E0B295	FASTA	2,811	307,676
	10 20 30 40 50 60 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 70 80 90 100 110 120 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 130 140 150 160 170 180 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 190 200 210 220 230 240 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 250 260 270 280 290 300 ERSPATRVDH ETASVLSSSG THSAPRRLTS HLGTKVEMVY SLLSMLGTHD KDDMSRTLLA 310 320 330 340 350 360 MSSSQDSCIS MRQSGCLPLL IQLLHGNDKD SVLLGNSRGS KEARARASAA LHNIIHSQPD 370 380 390 400 410 420 DKRGRREIRV LHLLEQIRAY CETCWEWQEA HEQGMDQDKN PMPAPVEHQI CPAVCVLMKL 430 440 450 460 470 480 SFDEEHRHAM NELGGLQAIA ELLQVDCEMY GLTNDHYSVT LRRYAGMALT NLTFGDVANK 490 500 510 520 530 540 ATLCSMKGCM RALVAQLKSE SEDLQQVIAS VLRNLSWRAD VNSKKTLREV GSVKALMECA 550 560 570 580 590 600 LEVKKESTLK SVLSALWNLS AHCTENKADI CAVDGALAFL VGTLTYRSQT NTLAIIESGG 610 620 630 640 650 660 GILRNVSSLI ATNEDHRQIL RENNCLQTLL QHLKSHSLTI VSNACGTLWN LSARNPKDQE 670 680 690 700 710 720 ALWDMGAVSM LKNLIHSKHK MIAMGSAAAL RNLMANRPAK YKDANIMSPG SSLPSLHVRK 730 740 750 760 770 780 QKALEAELDA QHLSETFDNI DNLSPKASHR SKQRHKQNLY GDYAFDANRH DDSRSDNFNT 790 800 810 820 830 840 GNMTVLSPYL NTTVLPSSSS SRGSLDSSRS EKDRSLERER GIGLSAYHPT TENAGTSSKR 850 860 870 880 890 900 GLQITTTAAQ IAKVMEEVSA IHTSQDDRSS ASTTEFHCVA DDRSAARRSS ASHTHSNTYN 910 920 930 940 950 960 FTKSENSNRT CSMPYAKVEY KRSSNDSLNS VTSSDGYGKR GQMKPSVESY SEDDESKFCS 970 980 990 1000 1010 1020 YGQYPADLAH KIHSANHMDD NDGELDTPIN YSLKYSDEQL NSGRQSPSQN ERWARPKHVI 1030 1040 1050 1060 1070 1080 EDEIKQNEQR QARSQNTSYP VYSENTDDKH LKFQPHFGQQ ECVSPYRSRG TSGSETNRMG 1090 1100 1110 1120 1130 1140 SSHAINQNVN QSLCQEDDYE DDKPTNYSER YSEEEQHEEE EERPTNYSIK YNEEKHHVDQ 1150 1160 1170 1180 1190 1200 PIDYSLKYAT DISSSQKPSF SFSKNSSAQS TKPEHLSPSS ENTAVPPSNA KRQNQLRPSS 1210 1220 1230 1240 1250 1260 AQRNGQTQKG TTCKVPSINQ ETIQTYCVED TPICFSRCSS LSSLSSADDE IGCDQTTQEA 1270 1280 1290 1300 1310 1320 DSANTLQTAE VKENDVTRSA EDPATEVPAV SQNARAKPSR LQASGLSSES TRHNKAVEFS 1330 1340 1350 1360 1370 1380 SGAKSPSKSG AQTPKSPPEH YVQETPLVFS RCTSVSSLDS FESRSIASSV QSEPCSGMVS 1390 1400 1410 1420 1430 1440 GIISPSDLPD SPGQTMPPSR SKTPPPPPQT VQAKREVPKS KVPAAEKRES GPKQTAVNAA 1450 1460 1470 1480 1490 1500 VQRVQVLPDV DTLLHFATES TPDGFSCSSS LSALSLDEPF IQKDVELRIM PPVQENDNGN 1510 1520 1530 1540 1550 1560 ETESEQPEES NENQDKEVEK PDSEKDLLDD SDDDDIEILE ECIISAMPTK SSRKAKKLAQ 1570 1580 1590 1600 1610 1620 TASKLPPPVA RKPSQLPVYK LLPAQNRLQA QKHVSFTPGD DVPRVYCVEG TPINFSTATS 1630 1640 1650 1660 1670 1680 LSDLTIESPP NELATGDGVR AGIQSGEFEK RDTIPTEGRS TDDAQRGKIS SIVTPDLDDN 1690 1700 1710 1720 1730 1740 KAEEGDILAE CINSAMPKGK SHKPFRVKKI MDQVQQASST SSGANKNQVD TKKKKPTSPV 1750 1760 1770 1780 1790 1800 KPMPQNTEYR TRVRKNTDSK VNVNTEETFS DNKDSKKPSL QTNAKAFNEK LPNNEDRVRG 1810 1820 1830 1840 1850 1860 TFALDSPHHY TPIEGTPYCF SRNDSLSSLD FDDDDVDLSR EKAELRKGKE SKDSEAKVTC 1870 1880 1890 1900 1910 1920 RPEPNSSQQA ASKSQASIKH PANRAQSKPV LQKQPTFPQS SKDGPDRGAA TDEKLQNLAI 1930 1940 1950 1960 1970 1980 ENTPVCFSRN SSLSSLSDID QENNNNKESE PIKEAEPANS QGEPSKPQAS GYAPKSFHVE 1990 2000 2010 2020 2030 2040 DTPVCFSRNS SLSSLSIDSE DDLLQECISS AMPKKKRPSR LKSESEKQSP RKVGGILAED 2050 2060 2070 2080 2090 2100 LTLDLKDLQR PDSEHAFSPG SENFDWKAIQ EGANSIVSSL HQAAAAAACL SRQASSDSDS 2110 2120 2130 2140 2150 2160 ILSLKSGISL GSPFHLTPDQ EEKPFTSNKG PRILKPGEKS TLEAKKIESE NKGIKGGKKV 2170 2180 2190 2200 2210 2220 YKSLITGKIR SNSEISSQMK QPLPTNMPSI SRGRTMIHIP GLRNSSSSTS PVSKKGPPLK 2230 2240 2250 2260 2270 2280 TPASKSPSEG PGATTSPRGT KPAGKSELSP ITRQTSQISG SNKGSSRSGS RDSTPSRPTQ 2290 2300 2310 2320 2330 2340 QPLSRPMQSP GRNSISPGRN GISPPNKLSQ LPRTSSPSTA STKSSGSGKM SYTSPGRQLS 2350 2360 2370 2380 2390 2400 QQNLTKQASL SKNASSIPRS ESASKGLNQM SNGNGSNKKV ELSRMSSTKS SGSESDSSER 2410 2420 2430 2440 2450 2460 PALVRQSTFI KEAPSPTLRR KLEESASFES LSPSSRPDSP TRSQAQTPVL SPSLPDMSLS 2470 2480 2490 2500 2510 2520 THPSVQAGGW RKLPPNLSPT IEYNDGRPTK RHDIARSHSE SPSRLPINRA GTWKREHSKH 2530 2540 2550 2560 2570 2580 SSSLPRVSTW RRTGSSSSIL SASSESSEKA KSEDERHVSS MPAPRQMKEN QVPTKGTWRK 2590 2600 2610 2620 2630 2640 IKESDISPTG MASQSASSGA ASGAESKPLI YQMAPPVSKT EDVWVRIEDC PINNPRSGRS 2650 2660 2670 2680 2690 2700 PTGNTPPVID SVSEKGSSSI KDSKDSKDTH GKQSVGSGSP VQTVGLETRL NSFVQVEAPE 2710 2720 2730 2740 2750 2760 QKGTEAKPGQ SNPVSIAETA ETCIAERTPF SSSSSSKHSS PSGTVAARVT PFNYNPSPRK 2770 2780 2790 2800 2810 SSADSTSARP SQIPTPVSTN TKKRDSKTDI TESSGAQSPK RHSGSYLVTS V
	Isoform 3 [UniParc]. Checksum: 7E887CE032058082	FASTA	2,744	299,882
	10 20 30 40 50 60 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 70 80 90 100 110 120 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 130 140 150 160 170 180 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 190 200 210 220 230 240 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 250 260 270 280 290 300 ERSSQSRHDA ASHEAGRQHE GHGVAESNTA ASSSGQSPAT RVDHETASVL SSSGTHSAPR 310 320 330 340 350 360 RLTSHLGTKI RAYCETCWEW QEAHEQGMDQ DKNPMPAPVE HQICPAVCVL MKLSFDEEHR 370 380 390 400 410 420 HAMNELGGLQ AIAELLQVDC EMYGLTNDHY SVTLRRYAGM ALTNLTFGDV ANKATLCSMK 430 440 450 460 470 480 GCMRALVAQL KSESEDLQQV IASVLRNLSW RADVNSKKTL REVGSVKALM ECALEVKKES 490 500 510 520 530 540 TLKSVLSALW NLSAHCTENK ADICAVDGAL AFLVGTLTYR SQTNTLAIIE SGGGILRNVS 550 560 570 580 590 600 SLIATNEDHR QILRENNCLQ TLLQHLKSHS LTIVSNACGT LWNLSARNPK DQEALWDMGA 610 620 630 640 650 660 VSMLKNLIHS KHKMIAMGSA AALRNLMANR PAKYKDANIM SPGSSLPSLH VRKQKALEAE 670 680 690 700 710 720 LDAQHLSETF DNIDNLSPKA SHRSKQRHKQ NLYGDYAFDA NRHDDSRSDN FNTGNMTVLS 730 740 750 760 770 780 PYLNTTVLPS SSSSRGSLDS SRSEKDRSLE RERGIGLSAY HPTTENAGTS SKRGLQITTT 790 800 810 820 830 840 AAQIAKVMEE VSAIHTSQDD RSSASTTEFH CVADDRSAAR RSSASHTHSN TYNFTKSENS 850 860 870 880 890 900 NRTCSMPYAK VEYKRSSNDS LNSVTSSDGY GKRGQMKPSV ESYSEDDESK FCSYGQYPAD 910 920 930 940 950 960 LAHKIHSANH MDDNDGELDT PINYSLKYSD EQLNSGRQSP SQNERWARPK HVIEDEIKQN 970 980 990 1000 1010 1020 EQRQARSQNT SYPVYSENTD DKHLKFQPHF GQQECVSPYR SRGTSGSETN RMGSSHAINQ 1030 1040 1050 1060 1070 1080 NVNQSLCQED DYEDDKPTNY SERYSEEEQH EEEEERPTNY SIKYNEEKHH VDQPIDYSLK 1090 1100 1110 1120 1130 1140 YATDISSSQK PSFSFSKNSS AQSTKPEHLS PSSENTAVPP SNAKRQNQLR PSSAQRNGQT 1150 1160 1170 1180 1190 1200 QKGTTCKVPS INQETIQTYC VEDTPICFSR CSSLSSLSSA DDEIGCDQTT QEADSANTLQ 1210 1220 1230 1240 1250 1260 TAEVKENDVT RSAEDPATEV PAVSQNARAK PSRLQASGLS SESTRHNKAV EFSSGAKSPS 1270 1280 1290 1300 1310 1320 KSGAQTPKSP PEHYVQETPL VFSRCTSVSS LDSFESRSIA SSVQSEPCSG MVSGIISPSD 1330 1340 1350 1360 1370 1380 LPDSPGQTMP PSRSKTPPPP PQTVQAKREV PKSKVPAAEK RESGPKQTAV NAAVQRVQVL 1390 1400 1410 1420 1430 1440 PDVDTLLHFA TESTPDGFSC SSSLSALSLD EPFIQKDVEL RIMPPVQEND NGNETESEQP 1450 1460 1470 1480 1490 1500 EESNENQDKE VEKPDSEKDL LDDSDDDDIE ILEECIISAM PTKSSRKAKK LAQTASKLPP 1510 1520 1530 1540 1550 1560 PVARKPSQLP VYKLLPAQNR LQAQKHVSFT PGDDVPRVYC VEGTPINFST ATSLSDLTIE 1570 1580 1590 1600 1610 1620 SPPNELATGD GVRAGIQSGE FEKRDTIPTE GRSTDDAQRG KISSIVTPDL DDNKAEEGDI 1630 1640 1650 1660 1670 1680 LAECINSAMP KGKSHKPFRV KKIMDQVQQA SSTSSGANKN QVDTKKKKPT SPVKPMPQNT 1690 1700 1710 1720 1730 1740 EYRTRVRKNT DSKVNVNTEE TFSDNKDSKK PSLQTNAKAF NEKLPNNEDR VRGTFALDSP 1750 1760 1770 1780 1790 1800 HHYTPIEGTP YCFSRNDSLS SLDFDDDDVD LSREKAELRK GKESKDSEAK VTCRPEPNSS 1810 1820 1830 1840 1850 1860 QQAASKSQAS IKHPANRAQS KPVLQKQPTF PQSSKDGPDR GAATDEKLQN LAIENTPVCF 1870 1880 1890 1900 1910 1920 SRNSSLSSLS DIDQENNNNK ESEPIKEAEP ANSQGEPSKP QASGYAPKSF HVEDTPVCFS 1930 1940 1950 1960 1970 1980 RNSSLSSLSI DSEDDLLQEC ISSAMPKKKR PSRLKSESEK QSPRKVGGIL AEDLTLDLKD 1990 2000 2010 2020 2030 2040 LQRPDSEHAF SPGSENFDWK AIQEGANSIV SSLHQAAAAA ACLSRQASSD SDSILSLKSG 2050 2060 2070 2080 2090 2100 ISLGSPFHLT PDQEEKPFTS NKGPRILKPG EKSTLEAKKI ESENKGIKGG KKVYKSLITG 2110 2120 2130 2140 2150 2160 KIRSNSEISS QMKQPLPTNM PSISRGRTMI HIPGLRNSSS STSPVSKKGP PLKTPASKSP 2170 2180 2190 2200 2210 2220 SEGPGATTSP RGTKPAGKSE LSPITRQTSQ ISGSNKGSSR SGSRDSTPSR PTQQPLSRPM 2230 2240 2250 2260 2270 2280 QSPGRNSISP GRNGISPPNK LSQLPRTSSP STASTKSSGS GKMSYTSPGR QLSQQNLTKQ 2290 2300 2310 2320 2330 2340 ASLSKNASSI PRSESASKGL NQMSNGNGSN KKVELSRMSS TKSSGSESDS SERPALVRQS 2350 2360 2370 2380 2390 2400 TFIKEAPSPT LRRKLEESAS FESLSPSSRP DSPTRSQAQT PVLSPSLPDM SLSTHPSVQA 2410 2420 2430 2440 2450 2460 GGWRKLPPNL SPTIEYNDGR PTKRHDIARS HSESPSRLPI NRAGTWKREH SKHSSSLPRV 2470 2480 2490 2500 2510 2520 STWRRTGSSS SILSASSESS EKAKSEDERH VSSMPAPRQM KENQVPTKGT WRKIKESDIS 2530 2540 2550 2560 2570 2580 PTGMASQSAS SGAASGAESK PLIYQMAPPV SKTEDVWVRI EDCPINNPRS GRSPTGNTPP 2590 2600 2610 2620 2630 2640 VIDSVSEKGS SSIKDSKDSK DTHGKQSVGS GSPVQTVGLE TRLNSFVQVE APEQKGTEAK 2650 2660 2670 2680 2690 2700 PGQSNPVSIA ETAETCIAER TPFSSSSSSK HSSPSGTVAA RVTPFNYNPS PRKSSADSTS 2710 2720 2730 2740 ARPSQIPTPV STNTKKRDSK TDITESSGAQ SPKRHSGSYL VTSV
	Isoform 4 [UniParc]. Checksum: 76584921956DDB03	FASTA	2,710	296,469
	10 20 30 40 50 60 MAAASYDQLL KQVEALKMEN SNLRQELEDN SNHLTKLETE ASNMKEVLKQ LQGSIEDETM 70 80 90 100 110 120 TSGQIDLLER LKEFNLDSNF PGVKLRSKMS LRSYGSREGS VSSRSGECSP VPMGSFPRRT 130 140 150 160 170 180 FVNGSRESTG YLEELEKERS LLLADLDKEE KEKDWYYAQL QNLTKRIDSL PLTENFSLQT 190 200 210 220 230 240 DMTRRQLEYE ARQIRAAMEE QLGTCQDMEK RAQRRIARIQ QIEKDILRVR QLLQSQAAEA 250 260 270 280 290 300 ERSPATRVDH ETASVLSSSG THSAPRRLTS HLGTKIRAYC ETCWEWQEAH EQGMDQDKNP 310 320 330 340 350 360 MPAPVEHQIC PAVCVLMKLS FDEEHRHAMN ELGGLQAIAE LLQVDCEMYG LTNDHYSVTL 370 380 390 400 410 420 RRYAGMALTN LTFGDVANKA TLCSMKGCMR ALVAQLKSES EDLQQVIASV LRNLSWRADV 430 440 450 460 470 480 NSKKTLREVG SVKALMECAL EVKKESTLKS VLSALWNLSA HCTENKADIC AVDGALAFLV 490 500 510 520 530 540 GTLTYRSQTN TLAIIESGGG ILRNVSSLIA TNEDHRQILR ENNCLQTLLQ HLKSHSLTIV 550 560 570 580 590 600 SNACGTLWNL SARNPKDQEA LWDMGAVSML KNLIHSKHKM IAMGSAAALR NLMANRPAKY 610 620 630 640 650 660 KDANIMSPGS SLPSLHVRKQ KALEAELDAQ HLSETFDNID NLSPKASHRS KQRHKQNLYG 670 680 690 700 710 720 DYAFDANRHD DSRSDNFNTG NMTVLSPYLN TTVLPSSSSS RGSLDSSRSE KDRSLERERG 730 740 750 760 770 780 IGLSAYHPTT ENAGTSSKRG LQITTTAAQI AKVMEEVSAI HTSQDDRSSA STTEFHCVAD 790 800 810 820 830 840 DRSAARRSSA SHTHSNTYNF TKSENSNRTC SMPYAKVEYK RSSNDSLNSV TSSDGYGKRG 850 860 870 880 890 900 QMKPSVESYS EDDESKFCSY GQYPADLAHK IHSANHMDDN DGELDTPINY SLKYSDEQLN 910 920 930 940 950 960 SGRQSPSQNE RWARPKHVIE DEIKQNEQRQ ARSQNTSYPV YSENTDDKHL KFQPHFGQQE 970 980 990 1000 1010 1020 CVSPYRSRGT SGSETNRMGS SHAINQNVNQ SLCQEDDYED DKPTNYSERY SEEEQHEEEE 1030 1040 1050 1060 1070 1080 ERPTNYSIKY NEEKHHVDQP IDYSLKYATD ISSSQKPSFS FSKNSSAQST KPEHLSPSSE 1090 1100 1110 1120 1130 1140 NTAVPPSNAK RQNQLRPSSA QRNGQTQKGT TCKVPSINQE TIQTYCVEDT PICFSRCSSL 1150 1160 1170 1180 1190 1200 SSLSSADDEI GCDQTTQEAD SANTLQTAEV KENDVTRSAE DPATEVPAVS QNARAKPSRL 1210 1220 1230 1240 1250 1260 QASGLSSEST RHNKAVEFSS GAKSPSKSGA QTPKSPPEHY VQETPLVFSR CTSVSSLDSF 1270 1280 1290 1300 1310 1320 ESRSIASSVQ SEPCSGMVSG IISPSDLPDS PGQTMPPSRS KTPPPPPQTV QAKREVPKSK 1330 1340 1350 1360 1370 1380 VPAAEKRESG PKQTAVNAAV QRVQVLPDVD TLLHFATEST PDGFSCSSSL SALSLDEPFI 1390 1400 1410 1420 1430 1440 QKDVELRIMP PVQENDNGNE TESEQPEESN ENQDKEVEKP DSEKDLLDDS DDDDIEILEE 1450 1460 1470 1480 1490 1500 CIISAMPTKS SRKAKKLAQT ASKLPPPVAR KPSQLPVYKL LPAQNRLQAQ KHVSFTPGDD 1510 1520 1530 1540 1550 1560 VPRVYCVEGT PINFSTATSL SDLTIESPPN ELATGDGVRA GIQSGEFEKR DTIPTEGRST 1570 1580 1590 1600 1610 1620 DDAQRGKISS IVTPDLDDNK AEEGDILAEC INSAMPKGKS HKPFRVKKIM DQVQQASSTS 1630 1640 1650 1660 1670 1680 SGANKNQVDT KKKKPTSPVK PMPQNTEYRT RVRKNTDSKV NVNTEETFSD NKDSKKPSLQ 1690 1700 1710 1720 1730 1740 TNAKAFNEKL PNNEDRVRGT FALDSPHHYT PIEGTPYCFS RNDSLSSLDF DDDDVDLSRE 1750 1760 1770 1780 1790 1800 KAELRKGKES KDSEAKVTCR PEPNSSQQAA SKSQASIKHP ANRAQSKPVL QKQPTFPQSS 1810 1820 1830 1840 1850 1860 KDGPDRGAAT DEKLQNLAIE NTPVCFSRNS SLSSLSDIDQ ENNNNKESEP IKEAEPANSQ 1870 1880 1890 1900 1910 1920 GEPSKPQASG YAPKSFHVED TPVCFSRNSS LSSLSIDSED DLLQECISSA MPKKKRPSRL 1930 1940 1950 1960 1970 1980 KSESEKQSPR KVGGILAEDL TLDLKDLQRP DSEHAFSPGS ENFDWKAIQE GANSIVSSLH 1990 2000 2010 2020 2030 2040 QAAAAAACLS RQASSDSDSI LSLKSGISLG SPFHLTPDQE EKPFTSNKGP RILKPGEKST 2050 2060 2070 2080 2090 2100 LEAKKIESEN KGIKGGKKVY KSLITGKIRS NSEISSQMKQ PLPTNMPSIS RGRTMIHIPG 2110 2120 2130 2140 2150 2160 LRNSSSSTSP VSKKGPPLKT PASKSPSEGP GATTSPRGTK PAGKSELSPI TRQTSQISGS 2170 2180 2190 2200 2210 2220 NKGSSRSGSR DSTPSRPTQQ PLSRPMQSPG RNSISPGRNG ISPPNKLSQL PRTSSPSTAS 2230 2240 2250 2260 2270 2280 TKSSGSGKMS YTSPGRQLSQ QNLTKQASLS KNASSIPRSE SASKGLNQMS NGNGSNKKVE 2290 2300 2310 2320 2330 2340 LSRMSSTKSS GSESDSSERP ALVRQSTFIK EAPSPTLRRK LEESASFESL SPSSRPDSPT 2350 2360 2370 2380 2390 2400 RSQAQTPVLS PSLPDMSLST HPSVQAGGWR KLPPNLSPTI EYNDGRPTKR HDIARSHSES 2410 2420 2430 2440 2450 2460 PSRLPINRAG TWKREHSKHS SSLPRVSTWR RTGSSSSILS ASSESSEKAK SEDERHVSSM 2470 2480 2490 2500 2510 2520 PAPRQMKENQ VPTKGTWRKI KESDISPTGM ASQSASSGAA SGAESKPLIY QMAPPVSKTE 2530 2540 2550 2560 2570 2580 DVWVRIEDCP INNPRSGRSP TGNTPPVIDS VSEKGSSSIK DSKDSKDTHG KQSVGSGSPV 2590 2600 2610 2620 2630 2640 QTVGLETRLN SFVQVEAPEQ KGTEAKPGQS NPVSIAETAE TCIAERTPFS SSSSSKHSSP 2650 2660 2670 2680 2690 2700 SGTVAARVTP FNYNPSPRKS SADSTSARPS QIPTPVSTNT KKRDSKTDIT ESSGAQSPKR 2710 HSGSYLVTSV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene." Su L.-K., Kinzler K.W., Vogelstein B., Preisinger A.C., Moser A.R., Luongo C., Gould K.A., Dove W.F. Science 256:668-670(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS. Strain: C57BL/6J and CAST/Ei. Tissue: Brain.
[2]	Erratum Su L.-K., Kinzler K.W., Vogelstein B., Preisinger A.C., Moser A.R., Luongo C., Gould K.A., Dove W.F. Science 256:1114-1114(1992)
[3]	"The murine APC gene: alternative splicing of 5' untranslated region segments." Dicker F., Lambertz S., Reitmair A., Ballhausen W.G. Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45. Strain: BALB/c. Tissue: Liver.
[4]	Lubec G., Sunyer B., Chen W.-Q. Submitted (JAN-2009) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1795-1810, MASS SPECTROMETRY. Strain: OF1. Tissue: Hippocampus.
[5]	"APC gene messenger RNA: novel isoforms that lack exon 7." Oshima M., Sugiyama H., Kitagawa K., Taketo M. Cancer Res. 53:5589-5591(1993) [PubMed] [Europe PMC] [Abstract] Cited for: ALTERNATIVE SPLICING.
[6]	"EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration." Wen Y., Eng C.H., Schmoranzer J., Cabrera-Poch N., Morris E.J.S., Chen M., Wallar B.J., Alberts A.S., Gundersen G.G. Nat. Cell Biol. 6:820-830(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH DIAPH1; DIAPH2 AND MAPRE1.
[7]	"Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli." Takizawa S., Nagasaka K., Nakagawa S., Yano T., Nakagawa K., Yasugi T., Takeuchi T., Kanda T., Huibregtse J.M., Akiyama T., Taketani Y. Genes Cells 11:453-464(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SCRIB.
[8]	"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations." Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M. Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1370; SER-2674 AND SER-2713, MASS SPECTROMETRY. Tissue: Brain cortex.
[9]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1036, MASS SPECTROMETRY. Tissue: Liver.
[10]	"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1557, MASS SPECTROMETRY. Tissue: Melanoma.
[11]	"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice." Kawasaki Y., Tsuji S., Muroya K., Furukawa S., Shibata Y., Okuno M., Ohwada S., Akiyama T. EMBO Rep. 10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M88127 mRNA. Translation: AAB59632.1.
U02937 Unassigned DNA. Translation: AAA03443.1.

IPI

IPI00119913.
IPI00229891.
IPI00229894.
IPI00468234.

PIR

I49505.

UniGene

Mm.384171.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VJ6	NMR	-	B	2834-2845	[»]

ProteinModelPortal

Q61315.

SMR

Q61315. Positions 2-55, 128-237, 324-734, 1485-1527.

ModBase

Search...

PTM databases

PhosphoSite

Q61315.

Proteomic databases

PaxDb

Q61315.

PRIDE

Q61315.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

MGI

MGI:88039. Apc.

Phylogenomic databases

eggNOG

NOG259696.

HOGENOM

HOG000033986.

HOVERGEN

HBG004264.

InParanoid

Q61315.

OrthoDB

EOG4D26NZ.

Gene expression databases

CleanEx

MM_APC.

Genevestigator

Q61315.

GermOnline

ENSMUSG00000005871. Mus musculus.

Family and domain databases

Gene3D

1.25.10.10. 2 hits.

InterPro

IPR026836. APC.
IPR009240. APC_15aa_rpt.
IPR009234. APC_basic_dom.
IPR009223. APC_Cys-rich_rpt.
IPR026831. APC_dom.
IPR026818. Apc_fam.
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR009232. EB1-bd.
IPR009224. SAMP.
[Graphical view]

PANTHER

PTHR12607. PTHR12607. 1 hit.
PTHR12607:SF2. PTHR12607:SF2. 1 hit.

Pfam

PF05972. APC_15aa. 4 hits.
PF05956. APC_basic. 1 hit.
PF05923. APC_crr. 7 hits.
PF00514. Arm. 3 hits.
PF05937. EB1_binding. 1 hit.
PF05924. SAMP. 3 hits.
PF11414. Suppressor_APC. 1 hit.
[Graphical view]

SMART

SM00185. ARM. 6 hits.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

PROSITE

PS50176. ARM_REPEAT. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

APC. mouse.

EvolutionaryTrace

Q61315.

SOURCE

Search...

Entry information

Entry name

APC_MOUSE

Accession

Primary (citable) accession number: Q61315
Secondary accession number(s): Q62044

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 119 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program