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Protein

Transcription factor AP-2-beta

Gene

Tfap2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.By similarity

GO - Molecular functioni

GO - Biological processi

  • aorta morphogenesis Source: UniProtKB
  • calcium ion homeostasis Source: UniProtKB
  • cellular ammonia homeostasis Source: UniProtKB
  • cellular creatinine homeostasis Source: UniProtKB
  • cellular urea homeostasis Source: UniProtKB
  • collecting duct development Source: UniProtKB
  • distal tubule development Source: UniProtKB
  • ductus arteriosus closure Source: UniProtKB
  • fat cell differentiation Source: UniProtKB
  • forelimb morphogenesis Source: UniProtKB
  • glucose homeostasis Source: UniProtKB
  • glucose metabolic process Source: UniProtKB
  • hindlimb morphogenesis Source: UniProtKB
  • kidney development Source: MGI
  • magnesium ion homeostasis Source: UniProtKB
  • metanephric nephron development Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of neuron apoptotic process Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • phosphate ion homeostasis Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of neuron apoptotic process Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of urine volume Source: UniProtKB
  • potassium ion homeostasis Source: UniProtKB
  • regulation of BMP signaling pathway Source: UniProtKB
  • regulation of cell differentiation Source: UniProtKB
  • regulation of insulin secretion Source: UniProtKB
  • regulation of transcription, DNA-templated Source: UniProtKB
  • renal water homeostasis Source: UniProtKB
  • response to drug Source: Ensembl
  • response to lithium ion Source: Ensembl
  • retina layer formation Source: Ensembl
  • sensory organ development Source: UniProtKB
  • skin development Source: UniProtKB
  • sodium ion homeostasis Source: UniProtKB
  • sympathetic nervous system development Source: MGI
  • transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-MMU-8866907 Activation of the TFAP2 (AP-2) family of transcription factors

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2-beta
Short name:
AP2-beta
Alternative name(s):
Activating enhancer-binding protein 2-beta
Gene namesi
Name:Tfap2b
Synonyms:Tcfap2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:104672 Tfap2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001848021 – 459Transcription factor AP-2-betaAdd BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei258Phosphoserine; by PKABy similarity1

Post-translational modificationi

Sumoylated on Lys-21; which inhibits transcriptional activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ61313
PaxDbiQ61313
PRIDEiQ61313

PTM databases

iPTMnetiQ61313
PhosphoSitePlusiQ61313

Expressioni

Developmental stagei

Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney.

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiENSMUSG00000025927
CleanExiMM_TCFAP2B
ExpressionAtlasiQ61313 baseline and differential
GenevisibleiQ61313 MM

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027059

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni299 – 429H-S-H (helix-span-helix), dimerizationAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 131Gln/Pro-rich (transactivation domain)Add BLAST98

Sequence similaritiesi

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ61313
KOiK09176
OMAiIGHPGME
OrthoDBiEOG091G0PR6
PhylomeDBiQ61313
TreeFamiTF313718

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR008122 TF_AP2_beta
IPR013854 TF_AP2_C
PANTHERiPTHR10812 PTHR10812, 1 hit
PTHR10812:SF14 PTHR10812:SF14, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01750 AP2BTNSCPFCT
PR01748 AP2TNSCPFCT

Sequencei

Sequence statusi: Complete.

Q61313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP
60 70 80 90 100
YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ
110 120 130 140 150
PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL
160 170 180 190 200
LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK
210 220 230 240 250
VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV
260 270 280 290 300
GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR
310 320 330 340 350
KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL
360 370 380 390 400
HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL
410 420 430 440 450
ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTNRH TSGEGPGSKT

GDKEEKHRK
Length:459
Mass (Da):50,373
Last modified:July 10, 2007 - v2
Checksum:iB1932B329D3D98EE
GO

Sequence cautioni

The sequence CAA55036 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78197 mRNA Translation: CAA55036.1 Different initiation.
AK017373 mRNA Translation: BAB30714.2
CCDSiCCDS14839.1
PIRiS45112
RefSeqiNP_033360.2, NM_009334.3
UniGeneiMm.137021

Genome annotation databases

EnsembliENSMUST00000027059; ENSMUSP00000027059; ENSMUSG00000025927
GeneIDi21419
KEGGimmu:21419
UCSCiuc007akr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAP2B_MOUSE
AccessioniPrimary (citable) accession number: Q61313
Secondary accession number(s): Q8CEP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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