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Q61313

- AP2B_MOUSE

UniProt

Q61313 - AP2B_MOUSE

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Protein
Transcription factor AP-2-beta
Gene
Tfap2b, Tcfap2b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
  3. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. RNA polymerase II transcription coactivator activity Source: UniProtKB
  5. RNA polymerase II transcription corepressor activity Source: UniProtKB
  6. chromatin binding Source: Ensembl
  7. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
  8. enhancer sequence-specific DNA binding Source: Ensembl
  9. protein binding Source: MGI
  10. protein dimerization activity Source: UniProtKB
  11. sequence-specific DNA binding Source: UniProtKB
  12. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  13. transcription coactivator activity Source: UniProtKB

GO - Biological processi

  1. aorta morphogenesis Source: UniProtKB
  2. calcium ion homeostasis Source: UniProtKB
  3. cellular ammonia homeostasis Source: UniProtKB
  4. cellular creatinine homeostasis Source: UniProtKB
  5. cellular urea homeostasis Source: UniProtKB
  6. collecting duct development Source: UniProtKB
  7. distal tubule development Source: UniProtKB
  8. ductus arteriosus closure Source: UniProtKB
  9. fat cell differentiation Source: UniProtKB
  10. forelimb morphogenesis Source: UniProtKB
  11. glucose homeostasis Source: UniProtKB
  12. glucose metabolic process Source: UniProtKB
  13. hindlimb morphogenesis Source: UniProtKB
  14. kidney development Source: MGI
  15. magnesium ion homeostasis Source: UniProtKB
  16. metanephric nephron development Source: UniProtKB
  17. negative regulation of apoptotic process Source: UniProtKB
  18. negative regulation of cell proliferation Source: UniProtKB
  19. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
  20. negative regulation of neuron apoptotic process Source: MGI
  21. negative regulation of transcription, DNA-templated Source: UniProtKB
  22. phosphate ion homeostasis Source: UniProtKB
  23. positive regulation of cell proliferation Source: UniProtKB
  24. positive regulation of neuron apoptotic process Source: UniProtKB
  25. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  26. positive regulation of urine volume Source: UniProtKB
  27. potassium ion homeostasis Source: UniProtKB
  28. regulation of BMP signaling pathway Source: UniProtKB
  29. regulation of cell differentiation Source: UniProtKB
  30. regulation of insulin secretion Source: UniProtKB
  31. regulation of transcription, DNA-templated Source: UniProtKB
  32. renal water homeostasis Source: UniProtKB
  33. response to drug Source: Ensembl
  34. response to lithium ion Source: Ensembl
  35. retina layer formation Source: Ensembl
  36. sensory organ development Source: UniProtKB
  37. skin development Source: UniProtKB
  38. sodium ion homeostasis Source: UniProtKB
  39. sympathetic nervous system development Source: MGI
  40. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2-beta
Short name:
AP2-beta
Alternative name(s):
Activating enhancer-binding protein 2-beta
Gene namesi
Name:Tfap2b
Synonyms:Tcfap2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:104672. Tfap2b.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Transcription factor AP-2-beta
PRO_0000184802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) By similarity
Modified residuei258 – 2581Phosphoserine; by PKA By similarity

Post-translational modificationi

Sumoylated on Lys-21; which inhibits transcriptional activity By similarity.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ61313.

PTM databases

PhosphoSiteiQ61313.

Expressioni

Developmental stagei

Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney.

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiQ61313.
CleanExiMM_TCFAP2B.
GenevestigatoriQ61313.

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity By similarity.1 Publication

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni299 – 429131H-S-H (helix-span-helix), dimerization
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 13198Gln/Pro-rich (transactivation domain)
Add
BLAST

Sequence similaritiesi

Belongs to the AP-2 family.

Phylogenomic databases

eggNOGiNOG300693.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ61313.
KOiK09176.
OMAiIGHPGME.
OrthoDBiEOG7HHWS1.
PhylomeDBiQ61313.
TreeFamiTF313718.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR008122. TF_AP2_beta.
IPR013854. TF_AP2_C.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01750. AP2BTNSCPFCT.
PR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

Q61313-1 [UniParc]FASTAAdd to Basket

« Hide

MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP    50
YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ 100
PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL 150
LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK 200
VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV 250
GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR 300
KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL 350
HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL 400
ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTNRH TSGEGPGSKT 450
GDKEEKHRK 459
Length:459
Mass (Da):50,373
Last modified:July 10, 2007 - v2
Checksum:iB1932B329D3D98EE
GO

Sequence cautioni

The sequence CAA55036.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78197 mRNA. Translation: CAA55036.1. Different initiation.
AK017373 mRNA. Translation: BAB30714.2.
CCDSiCCDS14839.1.
PIRiS45112.
RefSeqiNP_033360.2. NM_009334.3.
UniGeneiMm.137021.

Genome annotation databases

EnsembliENSMUST00000027059; ENSMUSP00000027059; ENSMUSG00000025927.
GeneIDi21419.
KEGGimmu:21419.
UCSCiuc007akr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78197 mRNA. Translation: CAA55036.1 . Different initiation.
AK017373 mRNA. Translation: BAB30714.2 .
CCDSi CCDS14839.1.
PIRi S45112.
RefSeqi NP_033360.2. NM_009334.3.
UniGenei Mm.137021.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61313.

Proteomic databases

PRIDEi Q61313.

Protocols and materials databases

DNASUi 21419.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027059 ; ENSMUSP00000027059 ; ENSMUSG00000025927 .
GeneIDi 21419.
KEGGi mmu:21419.
UCSCi uc007akr.1. mouse.

Organism-specific databases

CTDi 7021.
MGIi MGI:104672. Tfap2b.

Phylogenomic databases

eggNOGi NOG300693.
GeneTreei ENSGT00550000074577.
HOGENOMi HOG000231737.
HOVERGENi HBG002455.
InParanoidi Q61313.
KOi K09176.
OMAi IGHPGME.
OrthoDBi EOG7HHWS1.
PhylomeDBi Q61313.
TreeFami TF313718.

Miscellaneous databases

NextBioi 300728.
PROi Q61313.
SOURCEi Search...

Gene expression databases

Bgeei Q61313.
CleanExi MM_TCFAP2B.
Genevestigatori Q61313.

Family and domain databases

InterProi IPR004979. TF_AP2.
IPR008122. TF_AP2_beta.
IPR013854. TF_AP2_C.
[Graphical view ]
PANTHERi PTHR10812. PTHR10812. 1 hit.
Pfami PF03299. TF_AP-2. 1 hit.
[Graphical view ]
PRINTSi PR01750. AP2BTNSCPFCT.
PR01748. AP2TNSCPFCT.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a second AP-2 transcription factor: AP-2 beta."
    Moser M., Imhof A., Pscherer A., Bauer R., Amselgruber W., Sinowatz F., Schule R., Buettner R.
    Development 121:2779-2788(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells."
    Yahata T., Takedatsu H., Dunwoodie S.L., Braganca J., Swingler T., Withington S.L., Hur J., Coser K.R., Isselbacher K.J., Bhattacharya S., Shioda T.
    Genomics 80:601-613(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CITED4.

Entry informationi

Entry nameiAP2B_MOUSE
AccessioniPrimary (citable) accession number: Q61313
Secondary accession number(s): Q8CEP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi