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Q61313

- AP2B_MOUSE

UniProt

Q61313 - AP2B_MOUSE

Protein

Transcription factor AP-2-beta

Gene

Tfap2b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia.

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
    3. enhancer sequence-specific DNA binding Source: Ensembl
    4. protein binding Source: MGI
    5. protein dimerization activity Source: UniProtKB
    6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    7. RNA polymerase II core promoter sequence-specific DNA binding Source: UniProtKB
    8. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: UniProtKB
    9. RNA polymerase II transcription coactivator activity Source: UniProtKB
    10. RNA polymerase II transcription corepressor activity Source: UniProtKB
    11. sequence-specific DNA binding Source: UniProtKB
    12. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    13. transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    1. aorta morphogenesis Source: UniProtKB
    2. calcium ion homeostasis Source: UniProtKB
    3. cellular ammonia homeostasis Source: UniProtKB
    4. cellular creatinine homeostasis Source: UniProtKB
    5. cellular urea homeostasis Source: UniProtKB
    6. collecting duct development Source: UniProtKB
    7. distal tubule development Source: UniProtKB
    8. ductus arteriosus closure Source: UniProtKB
    9. fat cell differentiation Source: UniProtKB
    10. forelimb morphogenesis Source: UniProtKB
    11. glucose homeostasis Source: UniProtKB
    12. glucose metabolic process Source: UniProtKB
    13. hindlimb morphogenesis Source: UniProtKB
    14. kidney development Source: MGI
    15. magnesium ion homeostasis Source: UniProtKB
    16. metanephric nephron development Source: UniProtKB
    17. negative regulation of apoptotic process Source: UniProtKB
    18. negative regulation of cell proliferation Source: UniProtKB
    19. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: GOC
    20. negative regulation of neuron apoptotic process Source: MGI
    21. negative regulation of transcription, DNA-templated Source: UniProtKB
    22. phosphate ion homeostasis Source: UniProtKB
    23. positive regulation of cell proliferation Source: UniProtKB
    24. positive regulation of neuron apoptotic process Source: UniProtKB
    25. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    26. positive regulation of urine volume Source: UniProtKB
    27. potassium ion homeostasis Source: UniProtKB
    28. regulation of BMP signaling pathway Source: UniProtKB
    29. regulation of cell differentiation Source: UniProtKB
    30. regulation of insulin secretion Source: UniProtKB
    31. regulation of transcription, DNA-templated Source: UniProtKB
    32. renal water homeostasis Source: UniProtKB
    33. response to drug Source: Ensembl
    34. response to lithium ion Source: Ensembl
    35. retina layer formation Source: Ensembl
    36. sensory organ development Source: UniProtKB
    37. skin development Source: UniProtKB
    38. sodium ion homeostasis Source: UniProtKB
    39. sympathetic nervous system development Source: MGI
    40. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor AP-2-beta
    Short name:
    AP2-beta
    Alternative name(s):
    Activating enhancer-binding protein 2-beta
    Gene namesi
    Name:Tfap2b
    Synonyms:Tcfap2b
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:104672. Tfap2b.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 459459Transcription factor AP-2-betaPRO_0000184802Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki21 – 21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei258 – 2581Phosphoserine; by PKABy similarity

    Post-translational modificationi

    Sumoylated on Lys-21; which inhibits transcriptional activity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ61313.

    PTM databases

    PhosphoSiteiQ61313.

    Expressioni

    Developmental stagei

    Expressed from embryo day 9.5 to birth. In day 13.5 embryo, expressed abundantly in cells coating the neural tube. Expression continues posteriorly in the spinal cord, the dorsal root ganglia, in the prevertebal sympathic ganglia and the ganglion nodosum. High expression found in the dorsal and anteriolateral primordium of the midbrain. Expression also found in skin, kidneys and in many areas of the facial mesenchyme. In adults, expressed in the eye, skin, kidney, prostate, thymus, skeletal muscle and, very weakly in the brain. Highest levels found in kidney.

    Inductioni

    During retinoic acid-mediated differentiation.

    Gene expression databases

    BgeeiQ61313.
    CleanExiMM_TCFAP2B.
    GenevestigatoriQ61313.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity By similarity.By similarity

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni299 – 429131H-S-H (helix-span-helix), dimerizationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 13198Gln/Pro-rich (transactivation domain)Add
    BLAST

    Sequence similaritiesi

    Belongs to the AP-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG300693.
    GeneTreeiENSGT00550000074577.
    HOGENOMiHOG000231737.
    HOVERGENiHBG002455.
    InParanoidiQ61313.
    KOiK09176.
    OMAiIGHPGME.
    OrthoDBiEOG7HHWS1.
    PhylomeDBiQ61313.
    TreeFamiTF313718.

    Family and domain databases

    InterProiIPR004979. TF_AP2.
    IPR008122. TF_AP2_beta.
    IPR013854. TF_AP2_C.
    [Graphical view]
    PANTHERiPTHR10812. PTHR10812. 1 hit.
    PfamiPF03299. TF_AP-2. 1 hit.
    [Graphical view]
    PRINTSiPR01750. AP2BTNSCPFCT.
    PR01748. AP2TNSCPFCT.

    Sequencei

    Sequence statusi: Complete.

    Q61313-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSPPRDQAA IMLWKLVENV KYEDIYEDRH DGVPSHSSRL SQLGSVSQGP    50
    YSSAPPLSHT PSSDFQPPYF PPPYQPLPYH QSQDPYSHVN DPYSLNPLHQ 100
    PQQHPWGQRQ RQEVGSEAGS LLPQPRAALP QLSGLDPRRD YHSVRRPDVL 150
    LHSAHHGLDA GMGDSLSLHG LGHPGMEDVQ SVEDANNSGM NLLDQSVIKK 200
    VPVPPKSVTS LMMNKDGFLG GMSVNTGEVF CSVPGRLSLL SSTSKYKVTV 250
    GEVQRRLSPP ECLNASLLGG VLRRAKSKNG GRSLRERLEK IGLNLPAGRR 300
    KAANVTLLTS LVEGEAVHLA RDFGYICETE FPAKAVSEYL NRQHTDPSDL 350
    HSRKNMLLAT KQLCKEFTDL LAQDRTPIGN SRPSPILEPG IQSCLTHFSL 400
    ITHGFGAPAI CAALTALQNY LTEALKGMDK MFLNNTTNRH TSGEGPGSKT 450
    GDKEEKHRK 459
    Length:459
    Mass (Da):50,373
    Last modified:July 10, 2007 - v2
    Checksum:iB1932B329D3D98EE
    GO

    Sequence cautioni

    The sequence CAA55036.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78197 mRNA. Translation: CAA55036.1. Different initiation.
    AK017373 mRNA. Translation: BAB30714.2.
    CCDSiCCDS14839.1.
    PIRiS45112.
    RefSeqiNP_033360.2. NM_009334.3.
    UniGeneiMm.137021.

    Genome annotation databases

    EnsembliENSMUST00000027059; ENSMUSP00000027059; ENSMUSG00000025927.
    GeneIDi21419.
    KEGGimmu:21419.
    UCSCiuc007akr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78197 mRNA. Translation: CAA55036.1 . Different initiation.
    AK017373 mRNA. Translation: BAB30714.2 .
    CCDSi CCDS14839.1.
    PIRi S45112.
    RefSeqi NP_033360.2. NM_009334.3.
    UniGenei Mm.137021.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q61313.

    Proteomic databases

    PRIDEi Q61313.

    Protocols and materials databases

    DNASUi 21419.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027059 ; ENSMUSP00000027059 ; ENSMUSG00000025927 .
    GeneIDi 21419.
    KEGGi mmu:21419.
    UCSCi uc007akr.1. mouse.

    Organism-specific databases

    CTDi 7021.
    MGIi MGI:104672. Tfap2b.

    Phylogenomic databases

    eggNOGi NOG300693.
    GeneTreei ENSGT00550000074577.
    HOGENOMi HOG000231737.
    HOVERGENi HBG002455.
    InParanoidi Q61313.
    KOi K09176.
    OMAi IGHPGME.
    OrthoDBi EOG7HHWS1.
    PhylomeDBi Q61313.
    TreeFami TF313718.

    Miscellaneous databases

    NextBioi 300728.
    PROi Q61313.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61313.
    CleanExi MM_TCFAP2B.
    Genevestigatori Q61313.

    Family and domain databases

    InterProi IPR004979. TF_AP2.
    IPR008122. TF_AP2_beta.
    IPR013854. TF_AP2_C.
    [Graphical view ]
    PANTHERi PTHR10812. PTHR10812. 1 hit.
    Pfami PF03299. TF_AP-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01750. AP2BTNSCPFCT.
    PR01748. AP2TNSCPFCT.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a second AP-2 transcription factor: AP-2 beta."
      Moser M., Imhof A., Pscherer A., Bauer R., Amselgruber W., Sinowatz F., Schule R., Buettner R.
      Development 121:2779-2788(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head.
    3. "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells."
      Yahata T., Takedatsu H., Dunwoodie S.L., Braganca J., Swingler T., Withington S.L., Hur J., Coser K.R., Isselbacher K.J., Bhattacharya S., Shioda T.
      Genomics 80:601-613(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CITED4.

    Entry informationi

    Entry nameiAP2B_MOUSE
    AccessioniPrimary (citable) accession number: Q61313
    Secondary accession number(s): Q8CEP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3