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Protein

Transcription factor AP-2 gamma

Gene

Tfap2c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.

GO - Molecular functioni

  1. core promoter binding Source: MGI
  2. DNA binding Source: MGI
  3. protein dimerization activity Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: MGI
  5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  6. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
  7. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
  8. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  9. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. cell differentiation Source: MGI
  2. cerebral cortex development Source: MGI
  3. dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: MGI
  4. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
  5. forebrain neuron fate commitment Source: MGI
  6. germ-line stem cell maintenance Source: MGI
  7. hair follicle development Source: MGI
  8. keratinocyte development Source: MGI
  9. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  10. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  11. regulation of cell proliferation Source: GO_Central
  12. regulation of epidermis development Source: MGI
  13. regulation of gene expression, epigenetic Source: MGI
  14. regulation of transcription, DNA-templated Source: MGI
  15. regulation of transcription from RNA polymerase II promoter Source: MGI
  16. sebaceous gland development Source: MGI
  17. skin development Source: MGI
  18. somatic stem cell maintenance Source: MGI
  19. stem cell maintenance Source: MGI
  20. transcription from RNA polymerase II promoter Source: GOC
  21. trophectodermal cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2 gamma
Short name:
AP2-gamma
Alternative name(s):
AP-2.2
Activating enhancer-binding protein 2 gamma
Gene namesi
Name:Tfap2c
Synonyms:Tcfap2c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:106032. Tfap2c.

Subcellular locationi

  1. Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Transcription factor AP-2 gammaPRO_0000184804Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki10 – 10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Modified residuei251 – 2511Phosphoserine; by PKABy similarity
Modified residuei433 – 4331PhosphoserineBy similarity

Post-translational modificationi

Sumoylated on Lys-10; which inhibits transcriptional activity.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ61312.
PRIDEiQ61312.

PTM databases

PhosphoSiteiQ61312.

Expressioni

Tissue specificityi

Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiQ61312.
CleanExiMM_TCFAP2C.
ExpressionAtlasiQ61312. baseline and differential.
GenevestigatoriQ61312.

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with UBE2I (By similarity). Interacts with CITED4. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ61312. 1 interaction.
MINTiMINT-4124067.
STRINGi10090.ENSMUSP00000096657.

Structurei

3D structure databases

ProteinModelPortaliQ61312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni292 – 423132H-S-H (helix-span-helix), dimerizationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi59 – 646WW-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi30 – 10980Gln/Pro-rich (transactivation domain)Add
BLAST

Domaini

The WW-binding motif mediates interaction with WWOX.By similarity

Sequence similaritiesi

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGiNOG300693.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ61312.
KOiK09177.
OrthoDBiEOG7HHWS1.
TreeFamiTF313718.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
IPR008123. TF_AP2_gamma.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01751. AP2CTNSCPFCT.
PR01748. AP2TNSCPFCT.

Sequencei

Sequence statusi: Complete.

Q61312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD SSSNGNPRIP HLSSPGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAMNPL HQPAATGSQQ
110 120 130 140 150
QAWPGRQSQE GSSLASHHSR SASLIPHISG LEGGSVSARR EVYRRSDLLL
160 170 180 190 200
PHAHALEAGL AENLGLHEMA HPIEEVQNVD DAHLLLHDQT VIRKGPISMT
210 220 230 240 250
KNPLGLPCQK DLVGVVMNPS EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL
260 270 280 290 300
SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAAHVTL
310 320 330 340 350
LTSLVEGEAV HLARDFAYVC EAEFPSKAVA DYLTRPHLGG RNEMATRKSM
360 370 380 390 400
LLAAQQVCKE FTDLLHQDRT PNGNNRPAQV LEPNIQNCLS HFSLITHGFG
410 420 430 440
SQAICAAVSA VQNYIKEALI AIDKSYMNPG DQSPADSSKT MEKMEKHRK
Length:449
Mass (Da):49,137
Last modified:July 27, 2011 - v2
Checksum:i92490E234697B6A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti67 – 682LA → VV in CAA64357 (PubMed:8660922).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94694 mRNA. Translation: CAA64357.1.
AK145166 mRNA. Translation: BAE26271.1.
AL833787 Genomic DNA. Translation: CAM18031.1.
CH466551 Genomic DNA. Translation: EDL06609.1.
BC003778 mRNA. Translation: AAH03778.1.
CCDSiCCDS17135.1.
RefSeqiNP_001153168.1. NM_001159696.1.
NP_033361.2. NM_009335.2.
UniGeneiMm.3629.

Genome annotation databases

EnsembliENSMUST00000030391; ENSMUSP00000030391; ENSMUSG00000028640.
GeneIDi21420.
KEGGimmu:21420.
UCSCiuc008ocz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94694 mRNA. Translation: CAA64357.1.
AK145166 mRNA. Translation: BAE26271.1.
AL833787 Genomic DNA. Translation: CAM18031.1.
CH466551 Genomic DNA. Translation: EDL06609.1.
BC003778 mRNA. Translation: AAH03778.1.
CCDSiCCDS17135.1.
RefSeqiNP_001153168.1. NM_001159696.1.
NP_033361.2. NM_009335.2.
UniGeneiMm.3629.

3D structure databases

ProteinModelPortaliQ61312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ61312. 1 interaction.
MINTiMINT-4124067.
STRINGi10090.ENSMUSP00000096657.

PTM databases

PhosphoSiteiQ61312.

Proteomic databases

PaxDbiQ61312.
PRIDEiQ61312.

Protocols and materials databases

DNASUi21420.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030391; ENSMUSP00000030391; ENSMUSG00000028640.
GeneIDi21420.
KEGGimmu:21420.
UCSCiuc008ocz.2. mouse.

Organism-specific databases

CTDi7022.
MGIiMGI:106032. Tfap2c.

Phylogenomic databases

eggNOGiNOG300693.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ61312.
KOiK09177.
OrthoDBiEOG7HHWS1.
TreeFamiTF313718.

Miscellaneous databases

NextBioi300734.
PROiQ61312.
SOURCEiSearch...

Gene expression databases

BgeeiQ61312.
CleanExiMM_TCFAP2C.
ExpressionAtlasiQ61312. baseline and differential.
GenevestigatoriQ61312.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
IPR008123. TF_AP2_gamma.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01751. AP2CTNSCPFCT.
PR01748. AP2TNSCPFCT.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "AP-2.2: a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells."
    Oulad-Abdelghani M., Bouillet P., Chazaud C., Dolle P., Chambon P.
    Exp. Cell Res. 225:338-347(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic carcinoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells."
    Yahata T., Takedatsu H., Dunwoodie S.L., Braganca J., Swingler T., Withington S.L., Hur J., Coser K.R., Isselbacher K.J., Bhattacharya S., Shioda T.
    Genomics 80:601-613(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CITED4.

Entry informationi

Entry nameiAP2C_MOUSE
AccessioniPrimary (citable) accession number: Q61312
Secondary accession number(s): Q99L72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 27, 2011
Last modified: March 4, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.