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Q61312

- AP2C_MOUSE

UniProt

Q61312 - AP2C_MOUSE

Protein

Transcription factor AP-2 gamma

Gene

Tfap2c

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: MGI
    3. RNA polymerase II distal enhancer sequence-specific DNA binding Source: MGI
    4. RNA polymerase II regulatory region sequence-specific DNA binding Source: MGI
    5. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    6. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. cell differentiation Source: MGI
    2. cerebral cortex development Source: MGI
    3. dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: MGI
    4. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
    5. forebrain neuron fate commitment Source: MGI
    6. germ-line stem cell maintenance Source: MGI
    7. hair follicle development Source: MGI
    8. keratinocyte development Source: MGI
    9. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    10. regulation of epidermis development Source: MGI
    11. regulation of transcription, DNA-templated Source: MGI
    12. regulation of transcription from RNA polymerase II promoter Source: MGI
    13. sebaceous gland development Source: MGI
    14. skin development Source: MGI
    15. somatic stem cell maintenance Source: MGI
    16. stem cell maintenance Source: MGI
    17. transcription from RNA polymerase II promoter Source: GOC
    18. trophectodermal cell differentiation Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor AP-2 gamma
    Short name:
    AP2-gamma
    Alternative name(s):
    AP-2.2
    Activating enhancer-binding protein 2 gamma
    Gene namesi
    Name:Tfap2c
    Synonyms:Tcfap2c
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:106032. Tfap2c.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Transcription factor AP-2 gammaPRO_0000184804Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki10 – 10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
    Modified residuei251 – 2511Phosphoserine; by PKABy similarity
    Modified residuei433 – 4331PhosphoserineBy similarity

    Post-translational modificationi

    Sumoylated on Lys-10; which inhibits transcriptional activity.By similarity

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ61312.
    PRIDEiQ61312.

    PTM databases

    PhosphoSiteiQ61312.

    Expressioni

    Tissue specificityi

    Expressed in lung, ovary and testis. Expressed in most squamous epithelia. Also, detected in several exocrine glands including the prostate, the preputial and salivary glands, serous glands of the tongue and ocular harderian glands.

    Inductioni

    During retinoic acid-mediated differentiation.

    Gene expression databases

    BgeeiQ61312.
    CleanExiMM_TCFAP2C.
    GenevestigatoriQ61312.

    Interactioni

    Subunit structurei

    Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with UBE2I By similarity. Interacts with CITED4. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ61312. 1 interaction.
    MINTiMINT-4124067.
    STRINGi10090.ENSMUSP00000096657.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61312.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni292 – 423132H-S-H (helix-span-helix), dimerizationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi59 – 646WW-binding

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi30 – 10980Gln/Pro-rich (transactivation domain)Add
    BLAST

    Domaini

    The WW-binding motif mediates interaction with WWOX.By similarity

    Sequence similaritiesi

    Belongs to the AP-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG300693.
    GeneTreeiENSGT00550000074577.
    HOGENOMiHOG000231737.
    HOVERGENiHBG002455.
    KOiK09177.
    OrthoDBiEOG7HHWS1.
    TreeFamiTF313718.

    Family and domain databases

    InterProiIPR004979. TF_AP2.
    IPR013854. TF_AP2_C.
    IPR008123. TF_AP2_gamma.
    [Graphical view]
    PANTHERiPTHR10812. PTHR10812. 1 hit.
    PfamiPF03299. TF_AP-2. 1 hit.
    [Graphical view]
    PRINTSiPR01751. AP2CTNSCPFCT.
    PR01748. AP2TNSCPFCT.

    Sequencei

    Sequence statusi: Complete.

    Q61312-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLWKITDNVK YEEDCEDRHD SSSNGNPRIP HLSSPGQHLY SPAPPLSHTG    50
    VAEYQPPPYF PPPYQQLAYS QSADHYSHLG EAYAAAMNPL HQPAATGSQQ 100
    QAWPGRQSQE GSSLASHHSR SASLIPHISG LEGGSVSARR EVYRRSDLLL 150
    PHAHALEAGL AENLGLHEMA HPIEEVQNVD DAHLLLHDQT VIRKGPISMT 200
    KNPLGLPCQK DLVGVVMNPS EVFCSVPGRL SLLSSTSKYK VTVAEVQRRL 250
    SPPECLNASL LGGVLRRAKS KNGGRSLREK LDKIGLNLPA GRRKAAHVTL 300
    LTSLVEGEAV HLARDFAYVC EAEFPSKAVA DYLTRPHLGG RNEMATRKSM 350
    LLAAQQVCKE FTDLLHQDRT PNGNNRPAQV LEPNIQNCLS HFSLITHGFG 400
    SQAICAAVSA VQNYIKEALI AIDKSYMNPG DQSPADSSKT MEKMEKHRK 449
    Length:449
    Mass (Da):49,137
    Last modified:July 27, 2011 - v2
    Checksum:i92490E234697B6A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti67 – 682LA → VV in CAA64357. (PubMed:8660922)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94694 mRNA. Translation: CAA64357.1.
    AK145166 mRNA. Translation: BAE26271.1.
    AL833787 Genomic DNA. Translation: CAM18031.1.
    CH466551 Genomic DNA. Translation: EDL06609.1.
    BC003778 mRNA. Translation: AAH03778.1.
    CCDSiCCDS17135.1.
    RefSeqiNP_001153168.1. NM_001159696.1.
    NP_033361.2. NM_009335.2.
    UniGeneiMm.3629.

    Genome annotation databases

    EnsembliENSMUST00000030391; ENSMUSP00000030391; ENSMUSG00000028640.
    GeneIDi21420.
    KEGGimmu:21420.
    UCSCiuc008ocz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94694 mRNA. Translation: CAA64357.1 .
    AK145166 mRNA. Translation: BAE26271.1 .
    AL833787 Genomic DNA. Translation: CAM18031.1 .
    CH466551 Genomic DNA. Translation: EDL06609.1 .
    BC003778 mRNA. Translation: AAH03778.1 .
    CCDSi CCDS17135.1.
    RefSeqi NP_001153168.1. NM_001159696.1.
    NP_033361.2. NM_009335.2.
    UniGenei Mm.3629.

    3D structure databases

    ProteinModelPortali Q61312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61312. 1 interaction.
    MINTi MINT-4124067.
    STRINGi 10090.ENSMUSP00000096657.

    PTM databases

    PhosphoSitei Q61312.

    Proteomic databases

    PaxDbi Q61312.
    PRIDEi Q61312.

    Protocols and materials databases

    DNASUi 21420.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000030391 ; ENSMUSP00000030391 ; ENSMUSG00000028640 .
    GeneIDi 21420.
    KEGGi mmu:21420.
    UCSCi uc008ocz.2. mouse.

    Organism-specific databases

    CTDi 7022.
    MGIi MGI:106032. Tfap2c.

    Phylogenomic databases

    eggNOGi NOG300693.
    GeneTreei ENSGT00550000074577.
    HOGENOMi HOG000231737.
    HOVERGENi HBG002455.
    KOi K09177.
    OrthoDBi EOG7HHWS1.
    TreeFami TF313718.

    Miscellaneous databases

    NextBioi 300734.
    PROi Q61312.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61312.
    CleanExi MM_TCFAP2C.
    Genevestigatori Q61312.

    Family and domain databases

    InterProi IPR004979. TF_AP2.
    IPR013854. TF_AP2_C.
    IPR008123. TF_AP2_gamma.
    [Graphical view ]
    PANTHERi PTHR10812. PTHR10812. 1 hit.
    Pfami PF03299. TF_AP-2. 1 hit.
    [Graphical view ]
    PRINTSi PR01751. AP2CTNSCPFCT.
    PR01748. AP2TNSCPFCT.
    ProtoNeti Search...

    Publicationsi

    1. "AP-2.2: a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells."
      Oulad-Abdelghani M., Bouillet P., Chazaud C., Dolle P., Chambon P.
      Exp. Cell Res. 225:338-347(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryonic carcinoma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    6. "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells."
      Yahata T., Takedatsu H., Dunwoodie S.L., Braganca J., Swingler T., Withington S.L., Hur J., Coser K.R., Isselbacher K.J., Bhattacharya S., Shioda T.
      Genomics 80:601-613(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CITED4.

    Entry informationi

    Entry nameiAP2C_MOUSE
    AccessioniPrimary (citable) accession number: Q61312
    Secondary accession number(s): Q99L72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3