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Protein

Catenin alpha-2

Gene

Ctnna2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation.3 Publications

GO - Molecular functioni

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • brain morphogenesis Source: UniProtKB
  • dendrite morphogenesis Source: UniProtKB
  • prepulse inhibition Source: UniProtKB
  • radial glia guided migration of Purkinje cell Source: UniProtKB
  • regulation of synapse structural plasticity Source: UniProtKB
  • single organismal cell-cell adhesion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Catenin alpha-2
Alternative name(s):
Alpha N-catenin
Gene namesi
Name:Ctnna2
Synonyms:Catna2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:88275. Ctnna2.

Subcellular locationi

  • Cell membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication
  • Cell junctionadherens junction 2 Publications
  • Cell projectionaxon 2 Publications
  • Nucleus By similarity

GO - Cellular componenti

  • actin cytoskeleton Source: InterPro
  • adherens junction Source: UniProtKB
  • axon Source: UniProtKB
  • basolateral plasma membrane Source: MGI
  • cell-cell adherens junction Source: MGI
  • cytoplasm Source: UniProtKB
  • lamellipodium Source: MGI
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice generally die within 24 hours after birth. They display altered Purkinje cells migration, unstable synaptic junctions, defective ventricular architecture, impaired axon migration, reduced number of neurons in specific nuclei, and disordered laminar formation.4 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 953953Catenin alpha-2PRO_0000064264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei632 – 6321PhosphothreonineCombined sources
Modified residuei640 – 6401PhosphoserineCombined sources
Modified residuei651 – 6511PhosphoserineCombined sources
Modified residuei901 – 9011PhosphoserineCombined sources
Modified residuei939 – 9391PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61301.
PaxDbiQ61301.
PeptideAtlasiQ61301.
PRIDEiQ61301.

PTM databases

iPTMnetiQ61301.
PhosphoSiteiQ61301.

Expressioni

Tissue specificityi

Expressed almost exclusively in the nervous system.1 Publication

Developmental stagei

The ratio of the two isoforms changes during development; isoform 1 is more abundant than isoform 2 in earlier embryonic stages, whereas isoform 2 is predominant in the adult stage. Expressed in the ventricular zone and in neurons of the developing cortical plate (at protein level). Expressed in migrating neurons of the external granule cell layer at E13.5 while expression appears in the Purkinje cell layer at E17.5 (at protein level). Expressed postnatally in Purkinje cells and hippocampus (at protein level).4 Publications

Gene expression databases

BgeeiENSMUSG00000063063.
CleanExiMM_CTNNA2.
ExpressionAtlasiQ61301. baseline and differential.

Interactioni

Subunit structurei

Interacts with CDH1 and CDH2 (By similarity). Interacts with ZNF639; recruits CTNNA2 to the nucleus (By similarity).By similarity

Protein-protein interaction databases

BioGridi198511. 1 interaction.
DIPiDIP-31971N.
IntActiQ61301. 4 interactions.
MINTiMINT-4092530.
STRINGi10090.ENSMUSP00000124376.

Structurei

Secondary structure

1
953
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3918Combined sources
Helixi55 – 8127Combined sources
Beta strandi83 – 853Combined sources
Helixi86 – 11227Combined sources
Helixi117 – 16549Combined sources
Helixi169 – 19628Combined sources
Helixi200 – 22930Combined sources
Helixi234 – 25825Combined sources
Helixi668 – 6736Combined sources
Helixi677 – 70226Combined sources
Helixi710 – 72920Combined sources
Helixi738 – 76326Combined sources
Helixi769 – 79123Combined sources
Beta strandi798 – 8025Combined sources
Beta strandi805 – 8095Combined sources
Helixi859 – 89436Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K1OX-ray2.60A651-953[»]
4ONSX-ray2.80A/C18-264[»]
4P9TX-ray2.50A/B/C/D13-261[»]
ProteinModelPortaliQ61301.
SMRiQ61301. Positions 18-924.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vinculin/alpha-catenin family.Curated

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
InParanoidiQ61301.
KOiK05691.
PhylomeDBiQ61301.
TreeFamiTF313686.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030046. CTNNA2.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 2 hits.
PTHR18914:SF23. PTHR18914:SF23. 2 hits.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 5 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q61301-1) [UniParc]FASTAAdd to basket
Also known as: alpha N-catenin II

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK
60 70 80 90 100
KGRSKKAHVL AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG
110 120 130 140 150
ETMRIASSEF ADDPCSSVKR GTMVRAARAL LSAVTRLLIL ADMADVMRLL
160 170 180 190 200
SHLKIVEEAL EAVKNATNEQ DLANRFKEFG KEMVKLNYVA ARRQQELKDP
210 220 230 240 250
HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR DYVFKQVQEA
260 270 280 290 300
IAGISSAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR
310 320 330 340 350
PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM
360 370 380 390 400
NNTGRKEKGD PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL
410 420 430 440 450
VLIEAAKSGN EKEVKEYAQV FREHANKLVE VANLACSISN NEEGVKLVRM
460 470 480 490 500
AATQIDSLCP QVINAALTLA ARPQSKVAQD NMDVFKDQWE KQVRVLTEAV
510 520 530 540 550
DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA GAIRGRAARV
560 570 580 590 600
IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV
610 620 630 640 650
PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR
660 670 680 690 700
SRTSVQTEDD QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE
710 720 730 740 750
VAKWDDSGND IIVLAKQMCM IMMEMTDFTR GKGPLKNTSD VINAAKKIAE
760 770 780 790 800
AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ RIALYCHQLN ICSKVKAEVQ
810 820 830 840 850
NLGGELIVSG TGVQSTFTTF YEVDCDVIDG GRASQLSTHL PTCAEGAPIG
860 870 880 890 900
SGSSDSSMLD SATSLIQAAK NLMNAVVLTV KASYVASTKY QKVYGTAAVN
910 920 930 940 950
SPVVSWKMKA PEKKPLVKRE KPEEFQTRVR RGSQKKHISP VQALSEFKAM

DSF
Length:953
Mass (Da):105,286
Last modified:January 23, 2007 - v3
Checksum:i52DC5230A4A4A159
GO
Isoform 2 (identifier: Q61301-2) [UniParc]FASTAAdd to basket
Also known as: alpha N-catenin I

The sequence of this isoform differs from the canonical sequence as follows:
     811-858: Missing.

Show »
Length:905
Mass (Da):100,420
Checksum:i2BD70D8D07920ACB
GO
Isoform 3 (identifier: Q61301-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MTDIHSSYTYTGSM
     811-858: Missing.

Show »
Length:918
Mass (Da):101,864
Checksum:iE896D234CC63FF38
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031M → K in BAA04970 (PubMed:8174789).Curated
Sequence conflicti103 – 1031M → K in BAA04969 (PubMed:8174789).Curated
Sequence conflicti331 – 3311I → M in BAA04970 (PubMed:8174789).Curated
Sequence conflicti331 – 3311I → M in BAA04969 (PubMed:8174789).Curated
Sequence conflicti349 – 3491Y → D in BAA04970 (PubMed:8174789).Curated
Sequence conflicti349 – 3491Y → D in BAA04969 (PubMed:8174789).Curated
Sequence conflicti558 – 5581M → I in AAH79648 (PubMed:15489334).Curated
Sequence conflicti618 – 6181D → Y in BAA04970 (PubMed:8174789).Curated
Sequence conflicti618 – 6181D → Y in BAA04969 (PubMed:8174789).Curated
Sequence conflicti648 – 6481Missing in AAH79648 (PubMed:15489334).Curated
Sequence conflicti660 – 6601D → R in BAA04970 (PubMed:8174789).Curated
Sequence conflicti660 – 6601D → R in BAA04969 (PubMed:8174789).Curated
Sequence conflicti817 – 8171F → S in BAA04970 (PubMed:8174789).Curated
Sequence conflicti862 – 8621A → S in BAA04970 (PubMed:8174789).Curated
Sequence conflicti862 – 8621A → S in BAA04969 (PubMed:8174789).Curated
Sequence conflicti911 – 9111P → S in BAE34726 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MTDIHSSYTYTGSM in isoform 3. 1 PublicationVSP_038010
Alternative sequencei811 – 85848Missing in isoform 2 and isoform 3. 3 PublicationsVSP_006734Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25282 mRNA. Translation: BAA04970.1.
D25281 mRNA. Translation: BAA04969.1.
AK158916 mRNA. Translation: BAE34726.1.
BC079648 mRNA. Translation: AAH79648.1.
CCDSiCCDS20250.1. [Q61301-1]
CCDS39521.1. [Q61301-2]
PIRiI49499.
I49500.
RefSeqiNP_001103234.1. NM_001109764.1. [Q61301-1]
NP_033949.2. NM_009819.2. [Q61301-1]
NP_663785.2. NM_145732.2. [Q61301-2]
XP_011239496.1. XM_011241194.1. [Q61301-3]
UniGeneiMm.34637.

Genome annotation databases

EnsembliENSMUST00000075340; ENSMUSP00000074809; ENSMUSG00000063063. [Q61301-2]
ENSMUST00000159626; ENSMUSP00000124376; ENSMUSG00000063063. [Q61301-1]
ENSMUST00000161846; ENSMUSP00000123714; ENSMUSG00000063063. [Q61301-3]
GeneIDi12386.
KEGGimmu:12386.
UCSCiuc009cjq.2. mouse. [Q61301-1]
uc012enl.1. mouse. [Q61301-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25282 mRNA. Translation: BAA04970.1.
D25281 mRNA. Translation: BAA04969.1.
AK158916 mRNA. Translation: BAE34726.1.
BC079648 mRNA. Translation: AAH79648.1.
CCDSiCCDS20250.1. [Q61301-1]
CCDS39521.1. [Q61301-2]
PIRiI49499.
I49500.
RefSeqiNP_001103234.1. NM_001109764.1. [Q61301-1]
NP_033949.2. NM_009819.2. [Q61301-1]
NP_663785.2. NM_145732.2. [Q61301-2]
XP_011239496.1. XM_011241194.1. [Q61301-3]
UniGeneiMm.34637.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4K1OX-ray2.60A651-953[»]
4ONSX-ray2.80A/C18-264[»]
4P9TX-ray2.50A/B/C/D13-261[»]
ProteinModelPortaliQ61301.
SMRiQ61301. Positions 18-924.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198511. 1 interaction.
DIPiDIP-31971N.
IntActiQ61301. 4 interactions.
MINTiMINT-4092530.
STRINGi10090.ENSMUSP00000124376.

PTM databases

iPTMnetiQ61301.
PhosphoSiteiQ61301.

Proteomic databases

MaxQBiQ61301.
PaxDbiQ61301.
PeptideAtlasiQ61301.
PRIDEiQ61301.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075340; ENSMUSP00000074809; ENSMUSG00000063063. [Q61301-2]
ENSMUST00000159626; ENSMUSP00000124376; ENSMUSG00000063063. [Q61301-1]
ENSMUST00000161846; ENSMUSP00000123714; ENSMUSG00000063063. [Q61301-3]
GeneIDi12386.
KEGGimmu:12386.
UCSCiuc009cjq.2. mouse. [Q61301-1]
uc012enl.1. mouse. [Q61301-2]

Organism-specific databases

CTDi1496.
MGIiMGI:88275. Ctnna2.

Phylogenomic databases

eggNOGiKOG3681. Eukaryota.
ENOG410XSRU. LUCA.
GeneTreeiENSGT00550000074411.
HOGENOMiHOG000280724.
HOVERGENiHBG000069.
InParanoidiQ61301.
KOiK05691.
PhylomeDBiQ61301.
TreeFamiTF313686.

Enzyme and pathway databases

ReactomeiR-MMU-375170. CDO in myogenesis.

Miscellaneous databases

ChiTaRSiCtnna2. mouse.
PROiQ61301.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000063063.
CleanExiMM_CTNNA2.
ExpressionAtlasiQ61301. baseline and differential.

Family and domain databases

InterProiIPR001033. Alpha_catenin.
IPR030046. CTNNA2.
IPR006077. Vinculin/catenin.
IPR000633. Vinculin_CS.
[Graphical view]
PANTHERiPTHR18914. PTHR18914. 2 hits.
PTHR18914:SF23. PTHR18914:SF23. 2 hits.
PfamiPF01044. Vinculin. 2 hits.
[Graphical view]
PRINTSiPR00805. ALPHACATENIN.
SUPFAMiSSF47220. SSF47220. 5 hits.
PROSITEiPS00663. VINCULIN_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTNA2_MOUSE
AccessioniPrimary (citable) accession number: Q61301
Secondary accession number(s): Q3TY37, Q61300, Q6AXD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The cdf (cerebellar deficient folia) mice are viable but are ataxic and have cerebellar hypoplasia associated with abnormal lobulation of the cerebellum. They also display defects in Purkinje cells positioning and in packing density and lamination. Fear conditioning and prepulse inhibition of the startle response are altered in cdf mice. Those phenotypes are associated with alteration of the Ctnna2 gene which results in the C-terminal truncation of the protein and are rescued by expression of a Ctnna2 transgene (isoform 2).

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.