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UniProtKB - Q61292 (LAMB2_MOUSE)

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Protein

Laminin subunit beta-2

Gene

Lamb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.1 Publication
Laminin-3 (S-laminin) regulates the formation of motor nerve terminals.1 Publication

GO - Molecular functioni

  • integrin binding Source: MGI
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • astrocyte development Source: MGI
  • axon extension involved in regeneration Source: MGI
  • axon guidance Source: MGI
  • cell adhesion Source: UniProtKB-KW
  • cell morphogenesis involved in differentiation Source: MGI
  • metanephric glomerular basement membrane development Source: MGI
  • metanephric glomerular visceral epithelial cell development Source: MGI
  • neuromuscular junction development Source: MGI
  • neuron projection development Source: MGI
  • retina development in camera-type eye Source: MGI
  • Schwann cell development Source: MGI
  • synapse organization Source: MGI
  • visual perception Source: MGI
View the complete GO annotation on QuickGO ...

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-3000157 Laminin interactions
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8874081 MET activates PTK2 signaling
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
Gene namesi
Name:Lamb2
Synonyms:Lams
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:99916 Lamb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000001706936 – 1799Laminin subunit beta-2Add BLAST1764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi251N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi286 ↔ 295PROSITE-ProRule annotation
Disulfide bondi288 ↔ 313PROSITE-ProRule annotation
Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi327 ↔ 347PROSITE-ProRule annotation
Disulfide bondi350 ↔ 359PROSITE-ProRule annotation
Disulfide bondi352 ↔ 377PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi392 ↔ 410PROSITE-ProRule annotation
Disulfide bondi413 ↔ 426PROSITE-ProRule annotation
Disulfide bondi415 ↔ 441PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi455 ↔ 470PROSITE-ProRule annotation
Disulfide bondi473 ↔ 487PROSITE-ProRule annotation
Disulfide bondi475 ↔ 494PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi508 ↔ 522PROSITE-ProRule annotation
Disulfide bondi525 ↔ 537PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi784 ↔ 796PROSITE-ProRule annotation
Disulfide bondi786 ↔ 803PROSITE-ProRule annotation
Disulfide bondi805 ↔ 814PROSITE-ProRule annotation
Disulfide bondi817 ↔ 829PROSITE-ProRule annotation
Disulfide bondi832 ↔ 844PROSITE-ProRule annotation
Disulfide bondi834 ↔ 851PROSITE-ProRule annotation
Disulfide bondi853 ↔ 862PROSITE-ProRule annotation
Disulfide bondi865 ↔ 875PROSITE-ProRule annotation
Disulfide bondi878 ↔ 887PROSITE-ProRule annotation
Disulfide bondi880 ↔ 894PROSITE-ProRule annotation
Disulfide bondi897 ↔ 906PROSITE-ProRule annotation
Disulfide bondi909 ↔ 925PROSITE-ProRule annotation
Disulfide bondi928 ↔ 944PROSITE-ProRule annotation
Disulfide bondi930 ↔ 955PROSITE-ProRule annotation
Disulfide bondi957 ↔ 966PROSITE-ProRule annotation
Disulfide bondi969 ↔ 984PROSITE-ProRule annotation
Disulfide bondi987 ↔ 1001PROSITE-ProRule annotation
Disulfide bondi989 ↔ 1008PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1020PROSITE-ProRule annotation
Disulfide bondi1023 ↔ 1036PROSITE-ProRule annotation
Disulfide bondi1039 ↔ 1059PROSITE-ProRule annotation
Disulfide bondi1041 ↔ 1066PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1080 ↔ 1093PROSITE-ProRule annotation
Glycosylationi1086N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1096 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1098 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1129 ↔ 1141PROSITE-ProRule annotation
Disulfide bondi1144 ↔ 1156PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1163PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1174PROSITE-ProRule annotation
Disulfide bondi1177 ↔ 1188PROSITE-ProRule annotation
Disulfide bondi1191InterchainCurated
Disulfide bondi1194InterchainCurated
Glycosylationi1250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1309N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1500N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1533PhosphoserineBy similarity1
Disulfide bondi1798InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61292
PaxDbiQ61292
PeptideAtlasiQ61292
PRIDEiQ61292

PTM databases

iPTMnetiQ61292
PhosphoSitePlusiQ61292

Expressioni

Tissue specificityi

Neuromuscular synapse and kidney glomerulus.

Gene expression databases

BgeeiENSMUSG00000052911
CleanExiMM_LAMB2
ExpressionAtlasiQ61292 baseline and differential
GenevisibleiQ61292 MM

Interactioni

Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

GO - Molecular functioni

  • integrin binding Source: MGI
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActiQ61292, 2 interactors
MINTiQ61292
STRINGi10090.ENSMUSP00000069087

Structurei

3D structure databases

ProteinModelPortaliQ61292
SMRiQ61292
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 285Laminin N-terminalPROSITE-ProRule annotationAdd BLAST240
Domaini286 – 349Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST64
Domaini350 – 412Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini413 – 472Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST60
Domaini473 – 524Laminin EGF-like 4PROSITE-ProRule annotationAdd BLAST52
Domaini525 – 555Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd BLAST31
Domaini564 – 778Laminin IV type BPROSITE-ProRule annotationAdd BLAST215
Domaini784 – 831Laminin EGF-like 6PROSITE-ProRule annotationAdd BLAST48
Domaini832 – 877Laminin EGF-like 7PROSITE-ProRule annotationAdd BLAST46
Domaini878 – 927Laminin EGF-like 8PROSITE-ProRule annotationAdd BLAST50
Domaini928 – 986Laminin EGF-like 9PROSITE-ProRule annotationAdd BLAST59
Domaini987 – 1038Laminin EGF-like 10PROSITE-ProRule annotationAdd BLAST52
Domaini1039 – 1095Laminin EGF-like 11PROSITE-ProRule annotationAdd BLAST57
Domaini1096 – 1143Laminin EGF-like 12PROSITE-ProRule annotationAdd BLAST48
Domaini1144 – 1190Laminin EGF-like 13PROSITE-ProRule annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1191 – 1410Domain IIAdd BLAST220
Regioni1411 – 1443Domain alphaAdd BLAST33
Regioni1444 – 1799Domain IAdd BLAST356

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1257 – 1304Sequence analysisAdd BLAST48
Coiled coili1473 – 1527Sequence analysisAdd BLAST55
Coiled coili1577 – 1791Sequence analysisAdd BLAST215

Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0994 Eukaryota
ENOG410XPEG LUCA
GeneTreeiENSGT00780000121851
HOGENOMiHOG000007552
HOVERGENiHBG052301
InParanoidiQ61292
KOiK06243
OMAiGACICKH
OrthoDBiEOG091G009B
TreeFamiTF312903

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR013015 Laminin_IV_B
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 13 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 8 hits
SM00180 EGF_Lam, 13 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 10 hits
PS01186 EGF_2, 2 hits
PS01248 EGF_LAM_1, 12 hits
PS50027 EGF_LAM_2, 13 hits
PS51116 LAMININ_IVB, 1 hit
PS51117 LAMININ_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61292-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWASGEPGR GRQGQPLPWE LRLGLLLSVL AATLAQAPSL DVPGCSRGSC 
        60         70         80         90        100
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF 
       110        120        130        140        150
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH 
       160        170        180        190        200
LIMTFKTFRP AAMLVERSAD FGRTWHVYRY FSYDCGADFP GIPLAPPRRW 
       210        220        230        240        250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV 
       260        270        280        290        300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG 
       310        320        330        340        350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC 
       360        370        380        390        400
ECNGHTHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE FCRPFFYRDP 
       410        420        430        440        450
TKDMRDPAVC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT 
       460        470        480        490        500
RCQQCRDGFF GLSASDPRGC QRCQCNSRGT VPGSSPCDSS SGTCFCKRLV 
       510        520        530        540        550
TGHGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCRCRQHM 
       560        570        580        590        600
IGRRCEQVQP GYFRPFLDHL TWEAEAAQGQ GLEVVERLVT NRETPSWTGP 
       610        620        630        640        650
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELMVQRPGP 
       660        670        680        690        700
VSAHSPCGHV LPKDDRIQGM LHPNTRFLVF PRPVCLEPGI SYKLKLKLIG 
       710        720        730        740        750
TGGRAQPETS YSGLLIDSLV LQPHVLVLEM FSGGDAAALE RRTTFERYRC 
       760        770        780        790        800
HEEGLMPSKA PLSETCAPLL ISVSALIYNG ALPCQCDPQG SLSSECSPHG 
       810        820        830        840        850
GQCRCKPGVV GRRCDVCATG YYGFGPAGCQ ACQCSPDGAL SALCEGTSGQ 
       860        870        880        890        900
CPCRPGAFGL RCDHCQRGQW GFPNCRPCVC NGRADECDTH TGACLGCRDY 
       910        920        930        940        950
TGGEHCERCI AGFHGDPRLP YGGQCRPCPC PEGPGSQRHF ATSCHRDGYS 
       960        970        980        990       1000
QQIVCQCREG YTGLRCEACA PGHFGDPSKP GGRCQLCECS GNIDPMDPDA 
      1010       1020       1030       1040       1050
CDPHTGQCLR CLHNTEGPHC GYCKPGFHGQ AARQSCHRCT CNLLGTDPRR 
      1060       1070       1080       1090       1100
CPSTDLCHCD PSTGQCPCLP HVQGLNCDHC APNFWNFTSG RGCQPCACHP 
      1110       1120       1130       1140       1150
SRARGPTCNE FTGQCHCHAG FGGRTCSECQ ELYWGDPGLQ CRACDCDPRG 
      1160       1170       1180       1190       1200
IDKPQCHRST GHCSCRPGVS GVRCDQCARG FSGVFPACHP CHACFGDWDR 
      1210       1220       1230       1240       1250
VVQDLAARTR RLEQWAQELQ QTGVLGAFES SFLNMQGKLG MVQAIMSARN 
      1260       1270       1280       1290       1300
ASAASTAKLV EATEGLRHEI GKTTERLTQL EAELTAVQDE NFNANHALSG 
      1310       1320       1330       1340       1350
LERDGLALNL TLRQLDQHLE ILKHSNFLGA YDSIRHAHSQ STEAERRANA 
      1360       1370       1380       1390       1400
STFAVPSPVS NSADTRRRTE VLMGAQKENF NRQHLANQQA LGRLSAHAHT 
      1410       1420       1430       1440       1450
LSLTGINELV CGAPGDAPCA TSPCGGAGCR DEDGQPRCGG LGCSGAAATA 
      1460       1470       1480       1490       1500
DLALGRARHT QAELQRALVE GGGILSRVSE TRRQAEEAQQ RAQAALDKAN 
      1510       1520       1530       1540       1550
ASRGQVEQAN QELRELIQNV KDFLSQEGAD PDSIEMVATR VLDISIPASP 
      1560       1570       1580       1590       1600
EQIQRLASEI AERVRSLADV DTILAHTMGD VRRAEQLLQD AHRARSRAEG 
      1610       1620       1630       1640       1650
ERQKAETVQA ALEEAQRAQG AAQGAIWGAV VDTQNTEQTL QRVQERMAGA 
      1660       1670       1680       1690       1700
EKSLNSAGER ARQLDALLEA LKLKRAGNSL AASTAEETAG SAQSRAREAE 
      1710       1720       1730       1740       1750
KQLREQVGDQ YQTVRALAER KAEGVLAAQA RAEQLRDEAR DLLQAAQDKL 
      1760       1770       1780       1790 
QRLQELEGTY EENERALEGK AAQLDGLEAR MRSVLQAINL QVQIYNTCQ
Length:1,799
Mass (Da):196,579
Last modified:July 27, 2011 - v2
Checksum:i37CA24B9CDA0791F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545R → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti581G → V in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti677F → V in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti956Q → H in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti959E → A in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti973H → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1306L → F in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1449T → P in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1460T → S in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1487E → A in AAC53535 (PubMed:8662701).Curated1
Sequence conflicti1627W → R in AAC53535 (PubMed:8662701).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43541, U42624 Genomic DNA Translation: AAC53535.1
CH466560 Genomic DNA Translation: EDL21291.1
CH466560 Genomic DNA Translation: EDL21292.1
BC026051 mRNA Translation: AAH26051.1
X75928 mRNA Translation: CAA53532.1
CCDSiCCDS23528.1
PIRiI48749
RefSeqiNP_032509.2, NM_008483.3
XP_006511711.1, XM_006511648.2
UniGeneiMm.27560
Mm.425599

Genome annotation databases

EnsembliENSMUST00000065014; ENSMUSP00000069087; ENSMUSG00000052911
GeneIDi16779
KEGGimmu:16779
UCSCiuc009rpr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLAMB2_MOUSE
AccessioniPrimary (citable) accession number: Q61292
Secondary accession number(s): Q62182, Q8R0Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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