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Q61292

- LAMB2_MOUSE

UniProt

Q61292 - LAMB2_MOUSE

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Protein

Laminin subunit beta-2

Gene
Lamb2, Lams
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.1 Publication
Laminin-3 (S-laminin) regulates the formation of motor nerve terminals.1 Publication

GO - Molecular functioni

  1. integrin binding Source: MGI

GO - Biological processi

  1. astrocyte development Source: MGI
  2. axon extension involved in regeneration Source: MGI
  3. axon guidance Source: MGI
  4. cell adhesion Source: UniProtKB-KW
  5. cell morphogenesis involved in differentiation Source: MGI
  6. metanephric glomerular basement membrane development Source: MGI
  7. metanephric glomerular visceral epithelial cell development Source: MGI
  8. neuromuscular junction development Source: MGI
  9. neuron projection development Source: MGI
  10. retina development in camera-type eye Source: MGI
  11. Schwann cell development Source: MGI
  12. synapse organization Source: MGI
  13. visual perception Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_196606. ECM proteoglycans.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_202342. Laminin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin subunit beta-2
Alternative name(s):
Laminin-11 subunit beta
Laminin-14 subunit beta
Laminin-15 subunit beta
Laminin-3 subunit beta
Laminin-4 subunit beta
Laminin-7 subunit beta
Laminin-9 subunit beta
S-laminin subunit beta
Short name:
S-LAM beta
Gene namesi
Name:Lamb2
Synonyms:Lams
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:99916. Lamb2.

Subcellular locationi

GO - Cellular componenti

  1. basal lamina Source: MGI
  2. basement membrane Source: UniProtKB
  3. extracellular region Source: Reactome
  4. laminin-3 complex Source: MGI
  5. laminin complex Source: MGI
  6. synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3535 Reviewed predictionAdd
BLAST
Chaini36 – 17991764Laminin subunit beta-2PRO_0000017069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi251 – 2511N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi286 ↔ 295 By similarity
Disulfide bondi288 ↔ 313 By similarity
Disulfide bondi315 ↔ 324 By similarity
Disulfide bondi327 ↔ 347 By similarity
Disulfide bondi350 ↔ 359 By similarity
Disulfide bondi352 ↔ 377 By similarity
Glycosylationi371 – 3711N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi380 ↔ 389 By similarity
Disulfide bondi392 ↔ 410 By similarity
Disulfide bondi413 ↔ 426 By similarity
Disulfide bondi415 ↔ 441 By similarity
Disulfide bondi443 ↔ 452 By similarity
Disulfide bondi455 ↔ 470 By similarity
Disulfide bondi473 ↔ 487 By similarity
Disulfide bondi475 ↔ 494 By similarity
Disulfide bondi496 ↔ 505 By similarity
Disulfide bondi508 ↔ 522 By similarity
Disulfide bondi525 ↔ 537 By similarity
Disulfide bondi527 ↔ 544 By similarity
Disulfide bondi546 ↔ 555 By similarity
Disulfide bondi784 ↔ 796 By similarity
Disulfide bondi786 ↔ 803 By similarity
Disulfide bondi805 ↔ 814 By similarity
Disulfide bondi817 ↔ 829 By similarity
Disulfide bondi832 ↔ 844 By similarity
Disulfide bondi834 ↔ 851 By similarity
Disulfide bondi853 ↔ 862 By similarity
Disulfide bondi865 ↔ 875 By similarity
Disulfide bondi878 ↔ 887 By similarity
Disulfide bondi880 ↔ 894 By similarity
Disulfide bondi897 ↔ 906 By similarity
Disulfide bondi909 ↔ 925 By similarity
Disulfide bondi928 ↔ 944 By similarity
Disulfide bondi930 ↔ 955 By similarity
Disulfide bondi957 ↔ 966 By similarity
Disulfide bondi969 ↔ 984 By similarity
Disulfide bondi987 ↔ 1001 By similarity
Disulfide bondi989 ↔ 1008 By similarity
Disulfide bondi1011 ↔ 1020 By similarity
Disulfide bondi1023 ↔ 1036 By similarity
Disulfide bondi1039 ↔ 1059 By similarity
Disulfide bondi1041 ↔ 1066 By similarity
Disulfide bondi1068 ↔ 1077 By similarity
Disulfide bondi1080 ↔ 1093 By similarity
Glycosylationi1086 – 10861N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1096 ↔ 1108 By similarity
Disulfide bondi1098 ↔ 1115 By similarity
Disulfide bondi1117 ↔ 1126 By similarity
Disulfide bondi1129 ↔ 1141 By similarity
Disulfide bondi1144 ↔ 1156 By similarity
Disulfide bondi1146 ↔ 1163 By similarity
Disulfide bondi1165 ↔ 1174 By similarity
Disulfide bondi1177 ↔ 1188 By similarity
Disulfide bondi1191 – 1191Interchain Inferred
Disulfide bondi1194 – 1194Interchain Inferred
Glycosylationi1250 – 12501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1309 – 13091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1349 – 13491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1500 – 15001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1798 – 1798Interchain Inferred

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ61292.
PaxDbiQ61292.
PRIDEiQ61292.

PTM databases

PhosphoSiteiQ61292.

Expressioni

Tissue specificityi

Neuromuscular synapse and kidney glomerulus.

Gene expression databases

ArrayExpressiQ61292.
BgeeiQ61292.
CleanExiMM_LAMB2.
GenevestigatoriQ61292.

Interactioni

Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-2 is a subunit of laminin-3 (laminin-121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-7 (laminin-321 or KS-laminin), laminin-9 (laminin-421), laminin-11 (laminin-521), laminin-14 (laminin-423) and laminin-15 (laminin-523).

Protein-protein interaction databases

IntActiQ61292. 2 interactions.
MINTiMINT-4100139.
STRINGi10090.ENSMUSP00000069087.

Structurei

3D structure databases

ProteinModelPortaliQ61292.
SMRiQ61292. Positions 44-507.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 285240Laminin N-terminalAdd
BLAST
Domaini286 – 34964Laminin EGF-like 1Add
BLAST
Domaini350 – 41263Laminin EGF-like 2Add
BLAST
Domaini413 – 47260Laminin EGF-like 3Add
BLAST
Domaini473 – 52452Laminin EGF-like 4Add
BLAST
Domaini525 – 55531Laminin EGF-like 5; truncatedAdd
BLAST
Domaini564 – 778215Laminin IV type BAdd
BLAST
Domaini784 – 83148Laminin EGF-like 6Add
BLAST
Domaini832 – 87746Laminin EGF-like 7Add
BLAST
Domaini878 – 92750Laminin EGF-like 8Add
BLAST
Domaini928 – 98659Laminin EGF-like 9Add
BLAST
Domaini987 – 103852Laminin EGF-like 10Add
BLAST
Domaini1039 – 109557Laminin EGF-like 11Add
BLAST
Domaini1096 – 114348Laminin EGF-like 12Add
BLAST
Domaini1144 – 119047Laminin EGF-like 13Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1191 – 1410220Domain IIAdd
BLAST
Regioni1411 – 144333Domain alphaAdd
BLAST
Regioni1444 – 1799356Domain IAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1257 – 130448 Reviewed predictionAdd
BLAST
Coiled coili1473 – 152755 Reviewed predictionAdd
BLAST
Coiled coili1577 – 1791215 Reviewed predictionAdd
BLAST

Domaini

The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.
Domains VI and IV are globular.

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG241384.
GeneTreeiENSGT00720000108616.
HOGENOMiHOG000007552.
HOVERGENiHBG052301.
InParanoidiQ8R0Y0.
KOiK06243.
OMAiQPYCIVS.
OrthoDBiEOG75XGK0.
TreeFamiTF312903.

Family and domain databases

InterProiIPR002049. EGF_laminin.
IPR013015. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 10 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 12 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61292-1 [UniParc]FASTAAdd to Basket

« Hide

MEWASGEPGR GRQGQPLPWE LRLGLLLSVL AATLAQAPSL DVPGCSRGSC     50
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF 100
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH 150
LIMTFKTFRP AAMLVERSAD FGRTWHVYRY FSYDCGADFP GIPLAPPRRW 200
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV 250
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG 300
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC 350
ECNGHTHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE FCRPFFYRDP 400
TKDMRDPAVC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT 450
RCQQCRDGFF GLSASDPRGC QRCQCNSRGT VPGSSPCDSS SGTCFCKRLV 500
TGHGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCRCRQHM 550
IGRRCEQVQP GYFRPFLDHL TWEAEAAQGQ GLEVVERLVT NRETPSWTGP 600
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELMVQRPGP 650
VSAHSPCGHV LPKDDRIQGM LHPNTRFLVF PRPVCLEPGI SYKLKLKLIG 700
TGGRAQPETS YSGLLIDSLV LQPHVLVLEM FSGGDAAALE RRTTFERYRC 750
HEEGLMPSKA PLSETCAPLL ISVSALIYNG ALPCQCDPQG SLSSECSPHG 800
GQCRCKPGVV GRRCDVCATG YYGFGPAGCQ ACQCSPDGAL SALCEGTSGQ 850
CPCRPGAFGL RCDHCQRGQW GFPNCRPCVC NGRADECDTH TGACLGCRDY 900
TGGEHCERCI AGFHGDPRLP YGGQCRPCPC PEGPGSQRHF ATSCHRDGYS 950
QQIVCQCREG YTGLRCEACA PGHFGDPSKP GGRCQLCECS GNIDPMDPDA 1000
CDPHTGQCLR CLHNTEGPHC GYCKPGFHGQ AARQSCHRCT CNLLGTDPRR 1050
CPSTDLCHCD PSTGQCPCLP HVQGLNCDHC APNFWNFTSG RGCQPCACHP 1100
SRARGPTCNE FTGQCHCHAG FGGRTCSECQ ELYWGDPGLQ CRACDCDPRG 1150
IDKPQCHRST GHCSCRPGVS GVRCDQCARG FSGVFPACHP CHACFGDWDR 1200
VVQDLAARTR RLEQWAQELQ QTGVLGAFES SFLNMQGKLG MVQAIMSARN 1250
ASAASTAKLV EATEGLRHEI GKTTERLTQL EAELTAVQDE NFNANHALSG 1300
LERDGLALNL TLRQLDQHLE ILKHSNFLGA YDSIRHAHSQ STEAERRANA 1350
STFAVPSPVS NSADTRRRTE VLMGAQKENF NRQHLANQQA LGRLSAHAHT 1400
LSLTGINELV CGAPGDAPCA TSPCGGAGCR DEDGQPRCGG LGCSGAAATA 1450
DLALGRARHT QAELQRALVE GGGILSRVSE TRRQAEEAQQ RAQAALDKAN 1500
ASRGQVEQAN QELRELIQNV KDFLSQEGAD PDSIEMVATR VLDISIPASP 1550
EQIQRLASEI AERVRSLADV DTILAHTMGD VRRAEQLLQD AHRARSRAEG 1600
ERQKAETVQA ALEEAQRAQG AAQGAIWGAV VDTQNTEQTL QRVQERMAGA 1650
EKSLNSAGER ARQLDALLEA LKLKRAGNSL AASTAEETAG SAQSRAREAE 1700
KQLREQVGDQ YQTVRALAER KAEGVLAAQA RAEQLRDEAR DLLQAAQDKL 1750
QRLQELEGTY EENERALEGK AAQLDGLEAR MRSVLQAINL QVQIYNTCQ 1799
Length:1,799
Mass (Da):196,579
Last modified:July 27, 2011 - v2
Checksum:i37CA24B9CDA0791F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti545 – 5451R → P in AAC53535. 1 Publication
Sequence conflicti581 – 5811G → V in AAC53535. 1 Publication
Sequence conflicti677 – 6771F → V in AAC53535. 1 Publication
Sequence conflicti956 – 9561Q → H in AAC53535. 1 Publication
Sequence conflicti959 – 9591E → A in AAC53535. 1 Publication
Sequence conflicti973 – 9731H → P in AAC53535. 1 Publication
Sequence conflicti1306 – 13061L → F in AAC53535. 1 Publication
Sequence conflicti1449 – 14491T → P in AAC53535. 1 Publication
Sequence conflicti1460 – 14601T → S in AAC53535. 1 Publication
Sequence conflicti1487 – 14871E → A in AAC53535. 1 Publication
Sequence conflicti1627 – 16271W → R in AAC53535. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43541, U42624 Genomic DNA. Translation: AAC53535.1.
CH466560 Genomic DNA. Translation: EDL21291.1.
CH466560 Genomic DNA. Translation: EDL21292.1.
BC026051 mRNA. Translation: AAH26051.1.
X75928 mRNA. Translation: CAA53532.1.
CCDSiCCDS23528.1.
PIRiI48749.
RefSeqiNP_032509.2. NM_008483.3.
XP_006511711.1. XM_006511648.1.
UniGeneiMm.425599.

Genome annotation databases

EnsembliENSMUST00000065014; ENSMUSP00000069087; ENSMUSG00000052911.
GeneIDi16779.
KEGGimmu:16779.
UCSCiuc009rpr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U43541 , U42624 Genomic DNA. Translation: AAC53535.1 .
CH466560 Genomic DNA. Translation: EDL21291.1 .
CH466560 Genomic DNA. Translation: EDL21292.1 .
BC026051 mRNA. Translation: AAH26051.1 .
X75928 mRNA. Translation: CAA53532.1 .
CCDSi CCDS23528.1.
PIRi I48749.
RefSeqi NP_032509.2. NM_008483.3.
XP_006511711.1. XM_006511648.1.
UniGenei Mm.425599.

3D structure databases

ProteinModelPortali Q61292.
SMRi Q61292. Positions 44-507.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q61292. 2 interactions.
MINTi MINT-4100139.
STRINGi 10090.ENSMUSP00000069087.

PTM databases

PhosphoSitei Q61292.

Proteomic databases

MaxQBi Q61292.
PaxDbi Q61292.
PRIDEi Q61292.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065014 ; ENSMUSP00000069087 ; ENSMUSG00000052911 .
GeneIDi 16779.
KEGGi mmu:16779.
UCSCi uc009rpr.2. mouse.

Organism-specific databases

CTDi 3913.
MGIi MGI:99916. Lamb2.

Phylogenomic databases

eggNOGi NOG241384.
GeneTreei ENSGT00720000108616.
HOGENOMi HOG000007552.
HOVERGENi HBG052301.
InParanoidi Q8R0Y0.
KOi K06243.
OMAi QPYCIVS.
OrthoDBi EOG75XGK0.
TreeFami TF312903.

Enzyme and pathway databases

Reactomei REACT_196606. ECM proteoglycans.
REACT_196607. Non-integrin membrane-ECM interactions.
REACT_202342. Laminin interactions.

Miscellaneous databases

ChiTaRSi LAMB2. mouse.
NextBioi 290628.
PROi Q61292.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61292.
Bgeei Q61292.
CleanExi MM_LAMB2.
Genevestigatori Q61292.

Family and domain databases

InterProi IPR002049. EGF_laminin.
IPR013015. Laminin_IV.
IPR008211. Laminin_N.
[Graphical view ]
Pfami PF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view ]
SMARTi SM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 10 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 12 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural organization of the human and mouse laminin beta2 chain genes, and alternative splicing at the 5' end of the human transcript."
    Durkin M.E., Gautam M., Loechel S., Sanes J.R., Merlie J.P., Albrechtsen R., Wewer U.M.
    J. Biol. Chem. 271:13407-13416(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. "S-laminin gene (Lams) maps to F1 band of mouse chromosome 9."
    Aberdam D., Galliano M.-F., Mattei M.-G., Ortonne J.-P., Meneguzzi G.
    Mamm. Genome 5:393-394(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 348-428.
    Tissue: Lung.
  5. "Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2."
    Noakes P.G., Gautam M., Mudd J., Sanes J.R., Merlie J.P.
    Nature 374:258-262(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: 129/J.

Entry informationi

Entry nameiLAMB2_MOUSE
AccessioniPrimary (citable) accession number: Q61292
Secondary accession number(s): Q62182, Q8R0Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi