Reviewed, UniProtKB/Swiss-Prot Q61288 (ACVL1_MOUSE)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase receptor R3
      Short name=SKR3
    EC=2.7.11.30
Alternative name(s):
    Activin receptor-like kinase 1
      Short name=ALK-1
    TGF-B superfamily receptor type I
      Short name=TSR-I

Gene names

Name:	Acvrl1
Synonyms:	Acvrlk1, Alk-1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	angiogenesis Inferred from mutant phenotype. Source: MGI in utero embryonic development Inferred from mutant phenotype. Source: MGI protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transforming growth factor beta receptor signaling pathway Inferred from direct assay. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 502	480	Serine/threonine-protein kinase receptor R3		PRO_0000024421
Regions
	Topological domain	23 – 119	97	Extracellular Potential
	Transmembrane	120 – 140	21	Potential
	Topological domain	141 – 502	362	Cytoplasmic Potential
	Domain	171 – 200	30	GS
	Domain	201 – 502	302	Protein kinase
	Nucleotide binding	207 – 215	9	ATP By similarity
Sites
	Active site	329	1	Proton acceptor By similarity
	Binding site	228	1	ATP By similarity
Amino acid modifications
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Glycosylation	97	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	17	1	F → L in CAA83484. Ref.2
	Sequence conflict	21	1	R → Q Ref.2
	Sequence conflict	23	1	D → R Ref.2
	Sequence conflict	25 – 26	2	RR → AK Ref.2
	Sequence conflict	305	1	A → P in CAA83484. Ref.2
	Sequence conflict	358 – 359	2	SD → NE in CAA83484. Ref.2
	Sequence conflict	366	1	N → T in CAA83484. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q61288-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 092ABB29778BB004	FASTA	502	56,632
	10 20 30 40 50 60 MTLGSFRRGL LMLSVAFGLT RGDLRRPSKL VNCTCESPHC KRPFCQGSWC TVVLVREQGR 70 80 90 100 110 120 HPQVYRGCGS LNQELCLGRP TEFLNHHCCY RSFCNHNVSL MLEATQTPSE EPEVDAHLPL 130 140 150 160 170 180 ILGPVLALPV LVALGALGLW RVRRRQEKQR DLHSDLGESS LILKASEQAD SMLGDFLDSD 190 200 210 220 230 240 CTTGSGSGLP FLVQRTVARQ VALVECVGKG RYGEVWRGSW HGESVAVKIF SSRDEQSWFR 250 260 270 280 290 300 ETEIYNTVLL RHDNILGFIA SDMTSRNSST QLWLITHYHE HGSLYDFLQR QTLEPQLALR 310 320 330 340 350 360 LAVSAACGLA HLHVEIFGTQ GKPAIAHRDL KSRNVLVKSN LQCCIADLGL AVMHSQSSDY 370 380 390 400 410 420 LDIGNNPRVG TKRYMAPEVL DEHIRTDCFE SYKWTDIWAF GLVLWEIARR TIINGIVEDY 430 440 450 460 470 480 RPPFYDMVPN DPSFEDMKKV VCVDQQTPTI PNRLAADPVL SGLAQMMREC WYPNPSARLT 490 500 ALRIKKTLQK LSHNPEKPKV IH

References

[1]	"Cloning and characterization of the murine activin receptor like kinase-1 (ALK-1) homolog." Wu X., Robinson C.E., Fong H.W., Crabtree J.S., Rodriguez B.R., Roe B.A., Gimble J.M. Biochem. Biophys. Res. Commun. 216:78-83(1995) [PubMed: 7488127] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[2]	"Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis." Dewulf N., Verschueren K., Lonnoy O., Moren A., Grimsby S., Spiegle K., Miyazono K., Huylebroeck D., ten Dijke P. Endocrinology 136:2652-2663(1995) [PubMed: 7750489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L48015 mRNA. Translation: AAB03642.1. Z31664 mRNA. Translation: CAA83484.1.
PIR	I48241. JC4337.
RefSeq	NP_033742.2.
UniGene	Mm.279542
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBase	Search...
PTM databases
PhosphoSite	Q61288.
Genome annotation databases
Ensembl	ENSMUSG00000000530. Mus musculus. [Contig view]
GeneID	11482.
KEGG	mmu:11482.
Organism-specific databases
MGI	MGI:1338946. Acvrl1.
Phylogenomic databases
HOGENOM	Q61288.
HOVERGEN	Q61288.
Gene expression databases
ArrayExpress	Q61288.
CleanEx	MM_ACVRL1.
GermOnline	ENSMUSG00000000530. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278836.
SOURCE	Search...

Entry information

Entry name

ACVL1_MOUSE

Accession

Primary (citable) accession number: Q61288
Secondary accession number(s): Q61289

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	November 25, 2008
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)