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Q61285

- ABCD2_MOUSE

UniProt

Q61285 - ABCD2_MOUSE

Protein

ATP-binding cassette sub-family D member 2

Gene

Abcd2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probable transporter.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi512 – 5198ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. fatty acid beta-oxidation Source: UniProtKB
    2. positive regulation of fatty acid beta-oxidation Source: Ensembl
    3. very long-chain fatty acid catabolic process Source: Ensembl

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family D member 2
    Alternative name(s):
    Adrenoleukodystrophy-related protein
    Gene namesi
    Name:Abcd2
    Synonyms:Aldr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1349467. Abcd2.

    Subcellular locationi

    Peroxisome membrane By similarity; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrion Source: MGI
    3. peroxisomal membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 741741ATP-binding cassette sub-family D member 2PRO_0000093307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi190 – 1901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ61285.
    PRIDEiQ61285.

    PTM databases

    PhosphoSiteiQ61285.

    Expressioni

    Gene expression databases

    ArrayExpressiQ61285.
    BgeeiQ61285.
    GenevestigatoriQ61285.

    Interactioni

    Subunit structurei

    Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi205032. 1 interaction.
    IntActiQ61285. 3 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61285.
    SMRiQ61285. Positions 498-667.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei107 – 12721HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei144 – 16421HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei251 – 27121HelicalPROSITE-ProRule annotationAdd
    BLAST
    Transmembranei351 – 37121HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini107 – 399293ABC transmembrane type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini479 – 705227ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 218218Interaction with PEX19By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4178.
    GeneTreeiENSGT00390000003950.
    HOGENOMiHOG000206081.
    HOVERGENiHBG050438.
    InParanoidiQ61285.
    KOiK05676.
    OrthoDBiEOG70ZZMP.
    PhylomeDBiQ61285.
    TreeFamiTF105205.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61285-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPII GKRLKQPGHR    50
    KAKAEAYSPA ENREILHCTE IICKKPAPGL NAAFFKQLLE LRKILFPKLV 100
    TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW 150
    LMIAIPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD 200
    GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG 250
    ASPIGPTLLA GLVVYATAKV LKACSPKFGS LVAEEAHRKG YLRYVHSRII 300
    ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY 350
    VWSSCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS 400
    GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN 450
    HSKRGGNLEL PLSDTLAIKG TVIDVDHGII CENVPIITPA GEVVASRLNF 500
    KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR 550
    PYMSLGSLRD QVIYPDSADD MREKGYTDQD LERILHSVHL YHIVQREGGW 600
    DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ 650
    AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE 700
    KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTPEKT S 741
    Length:741
    Mass (Da):83,483
    Last modified:November 1, 1996 - v1
    Checksum:i24B9952F7B1B49D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti296 – 2961H → R in BAC38542. (PubMed:16141072)Curated
    Sequence conflicti737 – 7371P → A in BAC34641. (PubMed:16141072)Curated
    Sequence conflicti737 – 7371P → A in BAC38542. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48670 mRNA. Translation: CAA88589.1.
    AK051445 mRNA. Translation: BAC34641.1.
    AK082588 mRNA. Translation: BAC38542.1.
    BC019187 mRNA. Translation: AAH19187.1.
    CCDSiCCDS27760.1.
    RefSeqiNP_036124.2. NM_011994.2.
    UniGeneiMm.295456.

    Genome annotation databases

    EnsembliENSMUST00000069511; ENSMUSP00000068940; ENSMUSG00000055782.
    GeneIDi26874.
    KEGGimmu:26874.
    UCSCiuc007xhx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z48670 mRNA. Translation: CAA88589.1 .
    AK051445 mRNA. Translation: BAC34641.1 .
    AK082588 mRNA. Translation: BAC38542.1 .
    BC019187 mRNA. Translation: AAH19187.1 .
    CCDSi CCDS27760.1.
    RefSeqi NP_036124.2. NM_011994.2.
    UniGenei Mm.295456.

    3D structure databases

    ProteinModelPortali Q61285.
    SMRi Q61285. Positions 498-667.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205032. 1 interaction.
    IntActi Q61285. 3 interactions.

    PTM databases

    PhosphoSitei Q61285.

    Proteomic databases

    PaxDbi Q61285.
    PRIDEi Q61285.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000069511 ; ENSMUSP00000068940 ; ENSMUSG00000055782 .
    GeneIDi 26874.
    KEGGi mmu:26874.
    UCSCi uc007xhx.1. mouse.

    Organism-specific databases

    CTDi 225.
    MGIi MGI:1349467. Abcd2.

    Phylogenomic databases

    eggNOGi COG4178.
    GeneTreei ENSGT00390000003950.
    HOGENOMi HOG000206081.
    HOVERGENi HBG050438.
    InParanoidi Q61285.
    KOi K05676.
    OrthoDBi EOG70ZZMP.
    PhylomeDBi Q61285.
    TreeFami TF105205.

    Enzyme and pathway databases

    Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

    Miscellaneous databases

    ChiTaRSi ABCD2. mouse.
    NextBioi 304675.
    PROi Q61285.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61285.
    Bgeei Q61285.
    Genevestigatori Q61285.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR010509. ABC_Peroxi_TM.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF06472. ABC_membrane_2. 1 hit.
    PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF90123. SSF90123. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 1 hit.
    PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern."
      Lombard-Platet G., Savary S., Sarde C.-O., Mandel J.-L., Chimini G.
      Proc. Natl. Acad. Sci. U.S.A. 93:1265-1269(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: DBA/2.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Spinal ganglion.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiABCD2_MOUSE
    AccessioniPrimary (citable) accession number: Q61285
    Secondary accession number(s): Q8BQ63, Q8C4B6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3