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Q61285

- ABCD2_MOUSE

UniProt

Q61285 - ABCD2_MOUSE

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Protein
ATP-binding cassette sub-family D member 2
Gene
Abcd2, Aldr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable transporter By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi512 – 5198ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB
  2. positive regulation of fatty acid beta-oxidation Source: Ensembl
  3. very long-chain fatty acid catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_197984. ABCA transporters in lipid homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene namesi
Name:Abcd2
Synonyms:Aldr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1349467. Abcd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei107 – 12721Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei251 – 27121Helical; Reviewed prediction
Add
BLAST
Transmembranei351 – 37121Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: MGI
  3. peroxisomal membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 741741ATP-binding cassette sub-family D member 2
PRO_0000093307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ61285.
PRIDEiQ61285.

PTM databases

PhosphoSiteiQ61285.

Expressioni

Gene expression databases

ArrayExpressiQ61285.
BgeeiQ61285.
GenevestigatoriQ61285.

Interactioni

Subunit structurei

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 By similarity.

Protein-protein interaction databases

BioGridi205032. 1 interaction.
IntActiQ61285. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ61285.
SMRiQ61285. Positions 498-667.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 399293ABC transmembrane type-1
Add
BLAST
Domaini479 – 705227ABC transporter
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 218218Interaction with PEX19 By similarity
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4178.
GeneTreeiENSGT00390000003950.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiQ61285.
KOiK05676.
OrthoDBiEOG70ZZMP.
PhylomeDBiQ61285.
TreeFamiTF105205.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61285-1 [UniParc]FASTAAdd to Basket

« Hide

MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPII GKRLKQPGHR    50
KAKAEAYSPA ENREILHCTE IICKKPAPGL NAAFFKQLLE LRKILFPKLV 100
TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW 150
LMIAIPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD 200
GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG 250
ASPIGPTLLA GLVVYATAKV LKACSPKFGS LVAEEAHRKG YLRYVHSRII 300
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY 350
VWSSCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS 400
GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN 450
HSKRGGNLEL PLSDTLAIKG TVIDVDHGII CENVPIITPA GEVVASRLNF 500
KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR 550
PYMSLGSLRD QVIYPDSADD MREKGYTDQD LERILHSVHL YHIVQREGGW 600
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ 650
AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE 700
KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTPEKT S 741
Length:741
Mass (Da):83,483
Last modified:November 1, 1996 - v1
Checksum:i24B9952F7B1B49D9
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti296 – 2961H → R in BAC38542. 1 Publication
Sequence conflicti737 – 7371P → A in BAC34641. 1 Publication
Sequence conflicti737 – 7371P → A in BAC38542. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48670 mRNA. Translation: CAA88589.1.
AK051445 mRNA. Translation: BAC34641.1.
AK082588 mRNA. Translation: BAC38542.1.
BC019187 mRNA. Translation: AAH19187.1.
CCDSiCCDS27760.1.
RefSeqiNP_036124.2. NM_011994.2.
UniGeneiMm.295456.

Genome annotation databases

EnsembliENSMUST00000069511; ENSMUSP00000068940; ENSMUSG00000055782.
GeneIDi26874.
KEGGimmu:26874.
UCSCiuc007xhx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z48670 mRNA. Translation: CAA88589.1 .
AK051445 mRNA. Translation: BAC34641.1 .
AK082588 mRNA. Translation: BAC38542.1 .
BC019187 mRNA. Translation: AAH19187.1 .
CCDSi CCDS27760.1.
RefSeqi NP_036124.2. NM_011994.2.
UniGenei Mm.295456.

3D structure databases

ProteinModelPortali Q61285.
SMRi Q61285. Positions 498-667.
ModBasei Search...

Protein-protein interaction databases

BioGridi 205032. 1 interaction.
IntActi Q61285. 3 interactions.

PTM databases

PhosphoSitei Q61285.

Proteomic databases

PaxDbi Q61285.
PRIDEi Q61285.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000069511 ; ENSMUSP00000068940 ; ENSMUSG00000055782 .
GeneIDi 26874.
KEGGi mmu:26874.
UCSCi uc007xhx.1. mouse.

Organism-specific databases

CTDi 225.
MGIi MGI:1349467. Abcd2.

Phylogenomic databases

eggNOGi COG4178.
GeneTreei ENSGT00390000003950.
HOGENOMi HOG000206081.
HOVERGENi HBG050438.
InParanoidi Q61285.
KOi K05676.
OrthoDBi EOG70ZZMP.
PhylomeDBi Q61285.
TreeFami TF105205.

Enzyme and pathway databases

Reactomei REACT_197984. ABCA transporters in lipid homeostasis.

Miscellaneous databases

ChiTaRSi ABCD2. mouse.
NextBioi 304675.
PROi Q61285.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61285.
Bgeei Q61285.
Genevestigatori Q61285.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR010509. ABC_Peroxi_TM.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEi PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern."
    Lombard-Platet G., Savary S., Sarde C.-O., Mandel J.-L., Chimini G.
    Proc. Natl. Acad. Sci. U.S.A. 93:1265-1269(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Spinal ganglion.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiABCD2_MOUSE
AccessioniPrimary (citable) accession number: Q61285
Secondary accession number(s): Q8BQ63, Q8C4B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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