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Protein

ATP-binding cassette sub-family D member 2

Gene

Abcd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi512 – 519ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family D member 2
Alternative name(s):
Adrenoleukodystrophy-related protein
Gene namesi
Name:Abcd2
Synonyms:Aldr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1349467. Abcd2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei107 – 127HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei144 – 164HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei251 – 271HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei351 – 371HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933071 – 741ATP-binding cassette sub-family D member 2Add BLAST741

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58PhosphoserineCombined sources1
Glycosylationi190N-linked (GlcNAc...)Sequence analysis1
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ61285.
PaxDbiQ61285.
PRIDEiQ61285.

PTM databases

iPTMnetiQ61285.
PhosphoSitePlusiQ61285.

Expressioni

Gene expression databases

BgeeiENSMUSG00000055782.

Interactioni

Subunit structurei

Can form heterodimers with ABCD1/ALD and ABCD3/PMP70. Dimerization is necessary to form an active transporter. Interacts with PEX19 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi205032. 1 interactor.
IntActiQ61285. 4 interactors.
STRINGi10090.ENSMUSP00000068940.

Structurei

3D structure databases

ProteinModelPortaliQ61285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini107 – 399ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST293
Domaini479 – 705ABC transporterPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 218Interaction with PEX19By similarityAdd BLAST218

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiQ61285.
KOiK05676.
PhylomeDBiQ61285.
TreeFamiTF105205.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031239. ABCD2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF24. PTHR11384:SF24. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61285-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHMLNAAAY RVKWTRSGAA KRAACLVAAA YALKTLYPII GKRLKQPGHR
60 70 80 90 100
KAKAEAYSPA ENREILHCTE IICKKPAPGL NAAFFKQLLE LRKILFPKLV
110 120 130 140 150
TTETGWLCLH SVALISRTFL SIYVAGLDGK IVKSIVEKKP RTFIIKLIKW
160 170 180 190 200
LMIAIPATFV NSAIRYLECK LALAFRTRLV DHAYETYFAN QTYYKVINMD
210 220 230 240 250
GRLANPDQSL TEDIMMFSQS VAHLYSNLTK PILDVILTSY TLIRTATSRG
260 270 280 290 300
ASPIGPTLLA GLVVYATAKV LKACSPKFGS LVAEEAHRKG YLRYVHSRII
310 320 330 340 350
ANVEEIAFYR GHKVEMKQLQ KCYKALAYQM NLILSKRLWY IMIEQFLMKY
360 370 380 390 400
VWSSCGLIMV AIPIITATGF ADGDLEDGPK QAMVSDRTEA FTTARNLLAS
410 420 430 440 450
GADAIERIMS SYKEITELAG YTARVYNMFW VFDEVKRGIY KRTVTQEPEN
460 470 480 490 500
HSKRGGNLEL PLSDTLAIKG TVIDVDHGII CENVPIITPA GEVVASRLNF
510 520 530 540 550
KVEEGMHLLI TGPNGCGKSS LFRILSGLWP VYEGVLYKPP PQHMFYIPQR
560 570 580 590 600
PYMSLGSLRD QVIYPDSADD MREKGYTDQD LERILHSVHL YHIVQREGGW
610 620 630 640 650
DAVMDWKDVL SGGEKQRMGM ARMFYHKPKY ALLDECTSAV SIDVEGKIFQ
660 670 680 690 700
AAIGAGISLL SITHRPSLWK YHTHLLQFDG EGGWRFEQLD TAIRLTLSEE
710 720 730 740
KQKLESQLAG IPKMQQRLNE LCKILGEDSV LKTIQTPEKT S
Length:741
Mass (Da):83,483
Last modified:November 1, 1996 - v1
Checksum:i24B9952F7B1B49D9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296H → R in BAC38542 (PubMed:16141072).Curated1
Sequence conflicti737P → A in BAC34641 (PubMed:16141072).Curated1
Sequence conflicti737P → A in BAC38542 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48670 mRNA. Translation: CAA88589.1.
AK051445 mRNA. Translation: BAC34641.1.
AK082588 mRNA. Translation: BAC38542.1.
BC019187 mRNA. Translation: AAH19187.1.
CCDSiCCDS27760.1.
RefSeqiNP_036124.2. NM_011994.2.
UniGeneiMm.295456.

Genome annotation databases

GeneIDi26874.
KEGGimmu:26874.
UCSCiuc007xhx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48670 mRNA. Translation: CAA88589.1.
AK051445 mRNA. Translation: BAC34641.1.
AK082588 mRNA. Translation: BAC38542.1.
BC019187 mRNA. Translation: AAH19187.1.
CCDSiCCDS27760.1.
RefSeqiNP_036124.2. NM_011994.2.
UniGeneiMm.295456.

3D structure databases

ProteinModelPortaliQ61285.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205032. 1 interactor.
IntActiQ61285. 4 interactors.
STRINGi10090.ENSMUSP00000068940.

PTM databases

iPTMnetiQ61285.
PhosphoSitePlusiQ61285.

Proteomic databases

MaxQBiQ61285.
PaxDbiQ61285.
PRIDEiQ61285.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26874.
KEGGimmu:26874.
UCSCiuc007xhx.1. mouse.

Organism-specific databases

CTDi225.
MGIiMGI:1349467. Abcd2.

Phylogenomic databases

eggNOGiKOG0064. Eukaryota.
COG4178. LUCA.
HOGENOMiHOG000206081.
HOVERGENiHBG050438.
InParanoidiQ61285.
KOiK05676.
PhylomeDBiQ61285.
TreeFamiTF105205.

Miscellaneous databases

ChiTaRSiAbcd2. mouse.
PROiQ61285.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055782.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR031239. ABCD2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11384:SF24. PTHR11384:SF24. 1 hit.
PfamiPF06472. ABC_membrane_2. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCD2_MOUSE
AccessioniPrimary (citable) accession number: Q61285
Secondary accession number(s): Q8BQ63, Q8C4B6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.