Reviewed, UniProtKB/Swiss-Prot Q61271 (ACV1B_MOUSE)

Names and origin

Protein names

Recommended name:
    Activin receptor type-1B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IB
      Short name=ACTR-IB
    Serine/threonine-protein kinase receptor R2
      Short name=SKR2
    Activin receptor-like kinase 4
      Short name=ALK-4

Gene names

Name:	Acvr1b
Synonyms:	Alk4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP. Ref.2
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity. Interacts with TTRAP. Ref.2
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Post-translational modification	Autophosphorylated By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	cell surface receptor linked signal transduction Traceable author statement. Source: MGI hair follicle development Inferred from mutant phenotype. Source: MGI in utero embryonic development Inferred from mutant phenotype. Source: MGI peptidyl-threonine phosphorylation Ref.2 Inferred from direct assay. Source: UniProtKB
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin binding Ref.1 Inferred from physical interaction. Source: MGI magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 505	482	Activin receptor type-1B		PRO_0000024418
Regions
	Topological domain	24 – 126	103	Extracellular Potential
	Transmembrane	127 – 149	23	Potential
	Topological domain	150 – 505	356	Cytoplasmic Potential
	Domain	177 – 206	30	GS
	Domain	207 – 497	291	Protein kinase
	Nucleotide binding	213 – 221	9	ATP By similarity
Sites
	Active site	335	1	Proton acceptor By similarity
	Binding site	234	1	ATP By similarity
Amino acid modifications
	Modified residue	380	1	Phosphotyrosine By similarity
	Glycosylation	43	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q61271-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 56E9EEF1607A2517	FASTA	505	56,700
	10 20 30 40 50 60 MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD 70 80 90 100 110 120 GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS 130 140 150 160 170 180 MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 190 200 210 220 230 240 DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 250 260 270 280 290 300 ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 310 320 330 340 350 360 IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 370 380 390 400 410 420 DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 430 440 450 460 470 480 GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN 490 500 GAARLTALRI KKTLSQLSVQ EDVKI

References

[1]	"Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogensis." Verschuern K., Dewulf N., Goumans M.J., Lonnoy O., Freijen A., Grimsby S., Vande Spiegle K., ten Dijke P., Moren A., Vanscheeuwijck P., Heldin C.H., Miyazono K., Mummery C., Van Den Eijnden-Van Raaij J., Huylebroeck D. Mech. Dev. 52:109-123(1995) [PubMed: 7577669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: NIH Swiss. Tissue: Placenta.
[2]	"Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination." Esguerra C.V., Nelles L., Vermeire L., Ibrahimi A., Crawford A.D., Derua R., Janssens E., Waelkens E., Carmeliet P., Collen D., Huylebroeck D. Development 134:4381-4393(2007) [PubMed: 18039968] [Abstract] Cited for: FUNCTION, INTERACTION WITH TTRAP.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z31663 mRNA. Translation: CAA83483.1.
IPI	IPI00119012.
RefSeq	NP_031421.1.
UniGene	Mm.308467
3D structure databases
SMR	Q61271. Positions 31-106, 178-501.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61271.
Proteomic databases
PRIDE	Q61271.
Genome annotation databases
Ensembl	ENSMUST00000000544; ENSMUSP00000000544; ENSMUSG00000000532; Mus musculus. [Genome view]
GeneID	11479.
KEGG	mmu:11479.
UCSC	uc007xsr.1. mouse.
Organism-specific databases
CTD	11479.
MGI	MGI:1338944. Acvr1b.
Phylogenomic databases
HOGENOM	HBG314718.
HOVERGEN	Q61271.
InParanoid	Q61271.
OMA	SSWGPVE.
OrthoDB	EOG9B5RQK.
PhylomeDB	Q61271.
Enzyme and pathway databases
BRENDA	2.7.11.30. 244.
Gene expression databases
ArrayExpress	Q61271.
Bgee	Q61271.
CleanEx	MM_ACVR1B.
Genevestigator	Q61271.
GermOnline	ENSMUSG00000000532. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278824.
SOURCE	Search...

Entry information

Entry name

ACV1B_MOUSE

Accession

Primary (citable) accession number: Q61271

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	November 1, 1996
Last modified:	February 9, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)