Skip Header

Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q61271 (ACV1B_MOUSE)

Last modified February 9, 2010. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Activin receptor type-1B
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type IB
      Short name=ACTR-IB
    Serine/threonine-protein kinase receptor R2
      Short name=SKR2
    Activin receptor-like kinase 4
      Short name=ALK-4
Gene names
Name: Acvr1b
Synonyms: Alk4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TTRAP. Ref.2

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subunit structure

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity. Interacts with TTRAP. Ref.2

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Post-translational modification

Autophosphorylated By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 GS domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 505482Activin receptor type-1B
PRO_0000024418

Regions

Topological domain24 – 126103Extracellular Potential
Transmembrane127 – 14923 Potential
Topological domain150 – 505356Cytoplasmic Potential
Domain177 – 20630GS
Domain207 – 497291Protein kinase
Nucleotide binding213 – 2219ATP By similarity

Sites

Active site3351Proton acceptor By similarity
Binding site2341ATP By similarity

Amino acid modifications

Modified residue3801Phosphotyrosine By similarity
Glycosylation431N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q61271-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 56E9EEF1607A2517

FASTA50556,700
        10         20         30         40         50         60 
MAESAGASSF FPLVVLLLAG SGGSGPRGIQ ALLCACTSCL QTNYTCETDG ACMVSIFNLD 

        70         80         90        100        110        120 
GVEHHVRTCI PKVELVPAGK PFYCLSSEDL RNTHCCYIDF CNKIDLRVPS GHLKEPAHPS 

       130        140        150        160        170        180 
MWGPVELVGI IAGPVFLLFL IIIIVFLVIN YHQRVYHNRQ RLDMEDPSCE MCLSKDKTLQ 

       190        200        210        220        230        240 
DLVYDLSTSG SGSGLPLFVQ RTVARTIVLQ EIIGKGRFGE VWRGRWRGGD VAVKIFSSRE 

       250        260        270        280        290        300 
ERSWFREAEI YQTVMLRHEN ILGFIAADNK DNGTWTQLWL VSDYHEHGSL FDYLNRYTVT 

       310        320        330        340        350        360 
IEGMIKLALS AASGLAHLHM EIVGTQGKPG IAHRDLKSKN ILVKKNGMCA IADLGLAVRH 

       370        380        390        400        410        420 
DAVTDTIDIA PNQRVGTKRY MAPEVLDETI NMKHFDSFKC ADIYALGLVY WEIARRCNSG 

       430        440        450        460        470        480 
GVHEDYQLPY YDLVPSDPSI EEMRKVVCDQ KLRPNVPNWW QSYEALRVMG KMMRECWYAN 

       490        500 
GAARLTALRI KKTLSQLSVQ EDVKI 

« Hide

References

[1]"Expression of type I and type IB receptors for activin in midgestation mouse embryos suggests distinct functions in organogensis."
Verschuern K., Dewulf N., Goumans M.J., Lonnoy O., Freijen A., Grimsby S., Vande Spiegle K., ten Dijke P., Moren A., Vanscheeuwijck P., Heldin C.H., Miyazono K., Mummery C., Van Den Eijnden-Van Raaij J., Huylebroeck D.
Mech. Dev. 52:109-123(1995) [PubMed: 7577669] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Placenta.
[2]"Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination."
Esguerra C.V., Nelles L., Vermeire L., Ibrahimi A., Crawford A.D., Derua R., Janssens E., Waelkens E., Carmeliet P., Collen D., Huylebroeck D.
Development 134:4381-4393(2007) [PubMed: 18039968] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TTRAP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z31663 mRNA. Translation: CAA83483.1.
IPIIPI00119012.
RefSeqNP_031421.1.
UniGeneMm.308467

3D structure databases

SMRQ61271. Positions 31-106, 178-501.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ61271.

Proteomic databases

PRIDEQ61271.

Genome annotation databases

EnsemblENSMUST00000000544; ENSMUSP00000000544; ENSMUSG00000000532; Mus musculus. [Genome view]
GeneID11479.
KEGGmmu:11479.
UCSCuc007xsr.1. mouse.

Organism-specific databases

CTD11479.
MGIMGI:1338944. Acvr1b.

Phylogenomic databases

HOGENOMHBG314718.
HOVERGENQ61271.
InParanoidQ61271.
OMASSWGPVE.
OrthoDBEOG9B5RQK.
PhylomeDBQ61271.

Enzyme and pathway databases

BRENDA2.7.11.30. 244.

Gene expression databases

ArrayExpressQ61271.
BgeeQ61271.
CleanExMM_ACVR1B.
GenevestigatorQ61271.
GermOnlineENSMUSG00000000532. Mus musculus.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR003605. TGF_beta_rcpt_GS.
[Graphical view]
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
PF08515. TGF_beta_GS. 1 hit.
[Graphical view]
SMARTSM00467. GS. 1 hit.
[Graphical view]
PROSITEPS51256. GS. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio278824.
SOURCESearch...

Entry information

Entry nameACV1B_MOUSE
AccessionPrimary (citable) accession number: Q61271
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents