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Q61268

- APOC4_MOUSE

UniProt

Q61268 - APOC4_MOUSE

Protein

Apolipoprotein C-IV

Gene

Apoc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May participate in lipoprotein metabolism.

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-IV
    Short name:
    Apo-CIV
    Short name:
    ApoC-IV
    Alternative name(s):
    Apolipoprotein C2-linked
    Short name:
    ACL
    Apolipoprotein C4
    Gene namesi
    Name:Apoc4
    Synonyms:Acl
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:87878. Apoc4.

    Subcellular locationi

    GO - Cellular componenti

    1. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 12497Apolipoprotein C-IVPRO_0000002037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ61268.
    PRIDEiQ61268.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    BgeeiQ61268.
    GenevestigatoriQ61268.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000003071.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein C4 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG39292.
    GeneTreeiENSGT00390000015914.
    HOGENOMiHOG000034003.
    HOVERGENiHBG050550.
    InParanoidiQ61268.
    OMAiKTHSLCP.
    OrthoDBiEOG76MKBG.
    PhylomeDBiQ61268.
    TreeFamiTF336879.

    Family and domain databases

    InterProiIPR028120. APOC4.
    [Graphical view]
    PANTHERiPTHR32288. PTHR32288. 1 hit.
    PfamiPF15119. APOC4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61268-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLLRCRPRD LPSVSLSVLF LVSFVASMST ESLSPTPGPE SSRWSLVRAR    50
    VLEMVEPLVT RTRDRWQWFW GPGAVQGFMQ TYYEDHLKDL GPRTQAWLQS 100
    SRDHLLNKTH SLCPRLLCKD RTQG 124
    Length:124
    Mass (Da):14,288
    Last modified:November 1, 1997 - v1
    Checksum:i97C3CDEE72C9A452
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z24722 Genomic DNA. Translation: CAA80850.1.
    BC024657 mRNA. Translation: AAH24657.1.
    CCDSiCCDS20910.1.
    PIRiA54773.
    RefSeqiNP_031411.1. NM_007385.3.
    UniGeneiMm.477720.

    Genome annotation databases

    EnsembliENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
    GeneIDi11425.
    KEGGimmu:11425.
    UCSCiuc009fmu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z24722 Genomic DNA. Translation: CAA80850.1 .
    BC024657 mRNA. Translation: AAH24657.1 .
    CCDSi CCDS20910.1.
    PIRi A54773.
    RefSeqi NP_031411.1. NM_007385.3.
    UniGenei Mm.477720.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000003071.

    Proteomic databases

    PaxDbi Q61268.
    PRIDEi Q61268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000003071 ; ENSMUSP00000003071 ; ENSMUSG00000074336 .
    GeneIDi 11425.
    KEGGi mmu:11425.
    UCSCi uc009fmu.1. mouse.

    Organism-specific databases

    CTDi 346.
    MGIi MGI:87878. Apoc4.

    Phylogenomic databases

    eggNOGi NOG39292.
    GeneTreei ENSGT00390000015914.
    HOGENOMi HOG000034003.
    HOVERGENi HBG050550.
    InParanoidi Q61268.
    OMAi KTHSLCP.
    OrthoDBi EOG76MKBG.
    PhylomeDBi Q61268.
    TreeFami TF336879.

    Miscellaneous databases

    NextBioi 278678.
    PROi Q61268.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q61268.
    Genevestigatori Q61268.

    Family and domain databases

    InterProi IPR028120. APOC4.
    [Graphical view ]
    PANTHERi PTHR32288. PTHR32288. 1 hit.
    Pfami PF15119. APOC4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster."
      van Eck M.M., Hoffer M.J., Havekes L.M., Frants R.R., Hofker M.H.
      Genomics 21:110-115(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C57BL/6.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiAPOC4_MOUSE
    AccessioniPrimary (citable) accession number: Q61268
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3