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Protein

Apolipoprotein C-IV

Gene

Apoc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May participate in lipoprotein metabolism.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C2-linked
Short name:
ACL
Apolipoprotein C4
Gene namesi
Name:Apoc4
Synonyms:Acl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:87878. Apoc4.

Subcellular locationi

GO - Cellular componenti

  • high-density lipoprotein particle Source: MGI
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 12497Apolipoprotein C-IVPRO_0000002037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ61268.
PaxDbiQ61268.
PRIDEiQ61268.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiQ61268.
GenevisibleiQ61268. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003071.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiQ61268.
OMAiKTHSLCP.
OrthoDBiEOG76MKBG.
PhylomeDBiQ61268.
TreeFamiTF336879.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PfamiPF15119. APOC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRCRPRD LPSVSLSVLF LVSFVASMST ESLSPTPGPE SSRWSLVRAR
60 70 80 90 100
VLEMVEPLVT RTRDRWQWFW GPGAVQGFMQ TYYEDHLKDL GPRTQAWLQS
110 120
SRDHLLNKTH SLCPRLLCKD RTQG
Length:124
Mass (Da):14,288
Last modified:November 1, 1997 - v1
Checksum:i97C3CDEE72C9A452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24722 Genomic DNA. Translation: CAA80850.1.
BC024657 mRNA. Translation: AAH24657.1.
CCDSiCCDS20910.1.
PIRiA54773.
RefSeqiNP_031411.1. NM_007385.3.
UniGeneiMm.477720.

Genome annotation databases

EnsembliENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
GeneIDi11425.
KEGGimmu:11425.
UCSCiuc009fmu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24722 Genomic DNA. Translation: CAA80850.1.
BC024657 mRNA. Translation: AAH24657.1.
CCDSiCCDS20910.1.
PIRiA54773.
RefSeqiNP_031411.1. NM_007385.3.
UniGeneiMm.477720.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003071.

Proteomic databases

MaxQBiQ61268.
PaxDbiQ61268.
PRIDEiQ61268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
GeneIDi11425.
KEGGimmu:11425.
UCSCiuc009fmu.2. mouse.

Organism-specific databases

CTDi346.
MGIiMGI:87878. Apoc4.

Phylogenomic databases

eggNOGiENOG410JGNY. Eukaryota.
ENOG41118WT. LUCA.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiQ61268.
OMAiKTHSLCP.
OrthoDBiEOG76MKBG.
PhylomeDBiQ61268.
TreeFamiTF336879.

Miscellaneous databases

NextBioi278678.
PROiQ61268.
SOURCEiSearch...

Gene expression databases

BgeeiQ61268.
GenevisibleiQ61268. MM.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PfamiPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster."
    van Eck M.M., Hoffer M.J., Havekes L.M., Frants R.R., Hofker M.H.
    Genomics 21:110-115(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6J.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Liver and Lung.

Entry informationi

Entry nameiAPOC4_MOUSE
AccessioniPrimary (citable) accession number: Q61268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 11, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.