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Protein

Apolipoprotein C-IV

Gene

Apoc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in lipoprotein metabolism.

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
  2. positive regulation of sequestering of triglyceride Source: MGI
  3. triglyceride homeostasis Source: MGI
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-IV
Short name:
Apo-CIV
Short name:
ApoC-IV
Alternative name(s):
Apolipoprotein C2-linked
Short name:
ACL
Apolipoprotein C4
Gene namesi
Name:Apoc4
Synonyms:Acl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:87878. Apoc4.

Subcellular locationi

GO - Cellular componenti

  1. high-density lipoprotein particle Source: MGI
  2. very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 12497Apolipoprotein C-IVPRO_0000002037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ61268.
PaxDbiQ61268.
PRIDEiQ61268.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiQ61268.
GenevestigatoriQ61268.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003071.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C4 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG39292.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiQ61268.
OMAiWLRSSKD.
OrthoDBiEOG76MKBG.
PhylomeDBiQ61268.
TreeFamiTF336879.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q61268-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRCRPRD LPSVSLSVLF LVSFVASMST ESLSPTPGPE SSRWSLVRAR
60 70 80 90 100
VLEMVEPLVT RTRDRWQWFW GPGAVQGFMQ TYYEDHLKDL GPRTQAWLQS
110 120
SRDHLLNKTH SLCPRLLCKD RTQG
Length:124
Mass (Da):14,288
Last modified:October 31, 1997 - v1
Checksum:i97C3CDEE72C9A452
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24722 Genomic DNA. Translation: CAA80850.1.
BC024657 mRNA. Translation: AAH24657.1.
CCDSiCCDS20910.1.
PIRiA54773.
RefSeqiNP_031411.1. NM_007385.3.
UniGeneiMm.477720.

Genome annotation databases

EnsembliENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
GeneIDi11425.
KEGGimmu:11425.
UCSCiuc009fmu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z24722 Genomic DNA. Translation: CAA80850.1.
BC024657 mRNA. Translation: AAH24657.1.
CCDSiCCDS20910.1.
PIRiA54773.
RefSeqiNP_031411.1. NM_007385.3.
UniGeneiMm.477720.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000003071.

Proteomic databases

MaxQBiQ61268.
PaxDbiQ61268.
PRIDEiQ61268.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003071; ENSMUSP00000003071; ENSMUSG00000074336.
GeneIDi11425.
KEGGimmu:11425.
UCSCiuc009fmu.1. mouse.

Organism-specific databases

CTDi346.
MGIiMGI:87878. Apoc4.

Phylogenomic databases

eggNOGiNOG39292.
GeneTreeiENSGT00390000015914.
HOGENOMiHOG000034003.
HOVERGENiHBG050550.
InParanoidiQ61268.
OMAiWLRSSKD.
OrthoDBiEOG76MKBG.
PhylomeDBiQ61268.
TreeFamiTF336879.

Miscellaneous databases

NextBioi278678.
PROiQ61268.
SOURCEiSearch...

Gene expression databases

BgeeiQ61268.
GenevestigatoriQ61268.

Family and domain databases

InterProiIPR028120. APOC4.
[Graphical view]
PANTHERiPTHR32288. PTHR32288. 1 hit.
PfamiPF15119. APOC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The apolipoprotein C2-linked (Acl) gene: a new gene within the mouse apolipoprotein e-c1-c2 gene cluster."
    van Eck M.M., Hoffer M.J., Havekes L.M., Frants R.R., Hofker M.H.
    Genomics 21:110-115(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C57BL/6.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiAPOC4_MOUSE
AccessioniPrimary (citable) accession number: Q61268
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: October 31, 1997
Last modified: February 3, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.