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Q61247

- A2AP_MOUSE

UniProt

Q61247 - A2AP_MOUSE

Protein

Alpha-2-antiplasmin

Gene

Serpinf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei403 – 4042Reactive bond for plasmin
    Sitei404 – 4052Reactive bond for chymotrypsinBy similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. blood vessel morphogenesis Source: BHF-UCL
    3. collagen fibril organization Source: BHF-UCL
    4. negative regulation of endopeptidase activity Source: RefGenome
    5. negative regulation of fibrinolysis Source: Ensembl
    6. negative regulation of plasminogen activation Source: Ensembl
    7. positive regulation of cell differentiation Source: BHF-UCL
    8. positive regulation of collagen biosynthetic process Source: BHF-UCL
    9. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    10. positive regulation of JNK cascade Source: Ensembl
    11. positive regulation of smooth muscle cell proliferation Source: BHF-UCL
    12. positive regulation of stress fiber assembly Source: Ensembl
    13. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    14. positive regulation of transforming growth factor beta production Source: BHF-UCL
    15. regulation of blood vessel size by renin-angiotensin Source: BHF-UCL
    16. regulation of proteolysis Source: RefGenome
    17. response to organic substance Source: Ensembl

    Keywords - Molecular functioni

    Protease inhibitor, Serine protease inhibitor

    Keywords - Biological processi

    Acute phase

    Protein family/group databases

    MEROPSiI04.023.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-2-antiplasmin
    Short name:
    Alpha-2-AP
    Alternative name(s):
    Alpha-2-plasmin inhibitor
    Short name:
    Alpha-2-PI
    Serpin F2
    Gene namesi
    Name:Serpinf2
    Synonyms:Pli
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:107173. Serpinf2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. extracellular space Source: RefGenome
    3. fibrinogen complex Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 27271 PublicationAdd
    BLAST
    Chaini28 – 491464Alpha-2-antiplasminPRO_0000032513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi70 ↔ 143By similarity
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi316 – 3161N-linked (GlcNAc...)Sequence Analysis
    Modified residuei484 – 4841SulfotyrosineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    Proteomic databases

    MaxQBiQ61247.
    PaxDbiQ61247.
    PRIDEiQ61247.

    PTM databases

    PhosphoSiteiQ61247.

    Expressioni

    Tissue specificityi

    Expressed by the liver and secreted in plasma.

    Gene expression databases

    ArrayExpressiQ61247.
    BgeeiQ61247.
    GenevestigatoriQ61247.

    Interactioni

    Subunit structurei

    Forms protease inhibiting heterodimer with TMPRSS7.By similarity

    Protein-protein interaction databases

    IntActiQ61247. 1 interaction.
    MINTiMINT-4086385.

    Structurei

    Secondary structure

    1
    491
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 10025
    Beta strandi103 – 1086
    Helixi110 – 12314
    Helixi126 – 13510
    Helixi144 – 15310
    Beta strandi157 – 16812
    Helixi176 – 18611
    Helixi197 – 21115
    Turni212 – 2143
    Beta strandi228 – 23811
    Beta strandi241 – 2433
    Helixi247 – 2493
    Beta strandi251 – 28030
    Turni281 – 2844
    Beta strandi285 – 30622
    Helixi310 – 3145
    Helixi319 – 3224
    Beta strandi330 – 3378
    Beta strandi339 – 3468
    Helixi348 – 3547
    Helixi357 – 3604
    Turni366 – 3683
    Beta strandi375 – 38612
    Beta strandi390 – 3923
    Beta strandi407 – 4104
    Beta strandi415 – 4217
    Turni422 – 4243
    Beta strandi427 – 4348

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2R9YX-ray2.65A71-491[»]
    ProteinModelPortaliQ61247.
    SMRiQ61247. Positions 73-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ61247.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4826.
    GeneTreeiENSGT00750000117478.
    HOGENOMiHOG000231761.
    HOVERGENiHBG000043.
    InParanoidiQ61247.
    KOiK03983.
    OMAiRWFLLEQ.
    OrthoDBiEOG7WT41R.
    PhylomeDBiQ61247.
    TreeFamiTF317350.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 2 hits.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q61247-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALLRGLLVL SLSCLQGPCF TFSPVSAVDL PGQQPVSEQA QQKLPLPALF    50
    KLDNQDFGDH ATLKRSPGHC KSVPTAEETR RLAQAMMAFT TDLFSLVAQT 100
    STSSNLVLSP LSVALALSHL ALGAQNQTLH SLHRVLHMNT GSCLPHLLSH 150
    FYQNLGPGTI RLAARIYLQK GFPIKDDFLE QSERLFGAKP VKLTGKQEED 200
    LANINQWVKE ATEGKIEDFL SELPDSTVLL LLNAIHFHGF WRTKFDPSLT 250
    QKDFFHLDER FTVSVDMMHA VSYPLRWFLL EQPEIQVAHF PFKNNMSFVV 300
    VMPTYFEWNV SEVLANLTWD TLYHPSLQER PTKVWLPKLH LQQQLDLVAT 350
    LSQLGLQELF QGPDLRGISE QNLVVSSVQH QSTMELSEAG VEAAAATSVA 400
    MNRMSLSSFT VNRPFLFFIM EDTIGVPLFV GSVRNPNPSA LPQLQEQRDS 450
    PDNRLIGQND KADFHGGKTF GPDLKLAPRM EEDYPQFSSP K 491
    Length:491
    Mass (Da):54,972
    Last modified:November 1, 1996 - v1
    Checksum:iB828DECADF0BB5B4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36774 mRNA. Translation: CAA85350.1.
    BC026756 mRNA. Translation: AAH26756.1.
    CCDSiCCDS25046.1.
    PIRiS47217.
    RefSeqiNP_032904.1. NM_008878.2.
    UniGeneiMm.279733.

    Genome annotation databases

    EnsembliENSMUST00000043696; ENSMUSP00000048704; ENSMUSG00000038224.
    ENSMUST00000108437; ENSMUSP00000104076; ENSMUSG00000038224.
    GeneIDi18816.
    KEGGimmu:18816.
    UCSCiuc007kdr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z36774 mRNA. Translation: CAA85350.1 .
    BC026756 mRNA. Translation: AAH26756.1 .
    CCDSi CCDS25046.1.
    PIRi S47217.
    RefSeqi NP_032904.1. NM_008878.2.
    UniGenei Mm.279733.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2R9Y X-ray 2.65 A 71-491 [» ]
    ProteinModelPortali Q61247.
    SMRi Q61247. Positions 73-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q61247. 1 interaction.
    MINTi MINT-4086385.

    Protein family/group databases

    MEROPSi I04.023.

    PTM databases

    PhosphoSitei Q61247.

    Proteomic databases

    MaxQBi Q61247.
    PaxDbi Q61247.
    PRIDEi Q61247.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000043696 ; ENSMUSP00000048704 ; ENSMUSG00000038224 .
    ENSMUST00000108437 ; ENSMUSP00000104076 ; ENSMUSG00000038224 .
    GeneIDi 18816.
    KEGGi mmu:18816.
    UCSCi uc007kdr.2. mouse.

    Organism-specific databases

    CTDi 5345.
    MGIi MGI:107173. Serpinf2.

    Phylogenomic databases

    eggNOGi COG4826.
    GeneTreei ENSGT00750000117478.
    HOGENOMi HOG000231761.
    HOVERGENi HBG000043.
    InParanoidi Q61247.
    KOi K03983.
    OMAi RWFLLEQ.
    OrthoDBi EOG7WT41R.
    PhylomeDBi Q61247.
    TreeFami TF317350.

    Miscellaneous databases

    EvolutionaryTracei Q61247.
    NextBioi 295170.
    PROi Q61247.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61247.
    Bgeei Q61247.
    Genevestigatori Q61247.

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 2 hits.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6 X CBA.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    3. "Characterization of the murine plasma fibrinolytic system."
      Lijnen H.R., van Hoef B., Beelen V., Collen D.
      Eur. J. Biochem. 224:863-871(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 28-33.

    Entry informationi

    Entry nameiA2AP_MOUSE
    AccessioniPrimary (citable) accession number: Q61247
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3