Alpha-2-antiplasmin precursor - Mus musculus (Mouse)

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Q61247 (A2AP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 106. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Alpha-2-antiplasmin
Short name=Alpha-2-AP

Alternative name(s):
Alpha-2-plasmin inhibitor
Short name=Alpha-2-PI
Serpin F2

Gene names

Name:	Serpinf2
Synonyms:	Pli

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin By similarity.
Subunit structure	Forms protease inhibiting heterodimer with TMPRSS7 By similarity.
Subcellular location	Secreted.
Tissue specificity	Expressed by the liver and secreted in plasma.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Disulfide bond Glycoprotein Sulfation
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW blood vessel morphogenesis Inferred from mutant phenotype PubMed 18436805. Source: BHF-UCL collagen fibril organization Inferred from mutant phenotype PubMed 17958745. Source: BHF-UCL negative regulation of fibrinolysis Inferred from electronic annotation. Source: Compara negative regulation of plasminogen activation Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from electronic annotation. Source: Compara positive regulation of JNK cascade Inferred from electronic annotation. Source: Compara positive regulation of cell differentiation Inferred from mutant phenotype PubMed 20008146. Source: BHF-UCL positive regulation of collagen biosynthetic process Inferred from mutant phenotype PubMed 18436805. Source: BHF-UCL positive regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 18436805. Source: BHF-UCL positive regulation of stress fiber assembly Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 17958745. Source: BHF-UCL positive regulation of transforming growth factor beta production Inferred from mutant phenotype PubMed 17958745. Source: BHF-UCL regulation of blood vessel size by renin-angiotensin Inferred from mutant phenotype PubMed 18436805. Source: BHF-UCL regulation of proteolysis Inferred from Biological aspect of Ancestor. Source: RefGenome response to organic substance Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from Biological aspect of Ancestor. Source: RefGenome fibrinogen complex Inferred from electronic annotation. Source: Compara
Molecular_function	eukaryotic cell surface binding Inferred from electronic annotation. Source: Compara serine-type endopeptidase inhibitor activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 27

Ref.3

Chain

28 – 491

464

Alpha-2-antiplasmin

PRO_0000032513

Sites

Site

403 – 404

Reactive bond for plasmin

Site

404 – 405

Reactive bond for chymotrypsin By similarity

Amino acid modifications

Modified residue

484

Sulfotyrosine By similarity

Glycosylation

126

N-linked (GlcNAc...) Potential

Glycosylation

295

N-linked (GlcNAc...) Potential

Glycosylation

309

N-linked (GlcNAc...) Potential

Glycosylation

316

N-linked (GlcNAc...) Potential

Disulfide bond

70 ↔ 143

By similarity

Secondary structure

491

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q61247 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B828DECADF0BB5B4
Show »

FASTA

491

54,972

        10         20         30         40         50         60 
MALLRGLLVL SLSCLQGPCF TFSPVSAVDL PGQQPVSEQA QQKLPLPALF KLDNQDFGDH 

        70         80         90        100        110        120 
ATLKRSPGHC KSVPTAEETR RLAQAMMAFT TDLFSLVAQT STSSNLVLSP LSVALALSHL 

       130        140        150        160        170        180 
ALGAQNQTLH SLHRVLHMNT GSCLPHLLSH FYQNLGPGTI RLAARIYLQK GFPIKDDFLE 

       190        200        210        220        230        240 
QSERLFGAKP VKLTGKQEED LANINQWVKE ATEGKIEDFL SELPDSTVLL LLNAIHFHGF 

       250        260        270        280        290        300 
WRTKFDPSLT QKDFFHLDER FTVSVDMMHA VSYPLRWFLL EQPEIQVAHF PFKNNMSFVV 

       310        320        330        340        350        360 
VMPTYFEWNV SEVLANLTWD TLYHPSLQER PTKVWLPKLH LQQQLDLVAT LSQLGLQELF 

       370        380        390        400        410        420 
QGPDLRGISE QNLVVSSVQH QSTMELSEAG VEAAAATSVA MNRMSLSSFT VNRPFLFFIM 

       430        440        450        460        470        480 
EDTIGVPLFV GSVRNPNPSA LPQLQEQRDS PDNRLIGQND KADFHGGKTF GPDLKLAPRM 

       490 
EEDYPQFSSP K

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The kidney is a major site of alpha(2)-antiplasmin production." Menoud P.-A., Sappino N., Boudal-Khoshbeen M., Vassalli J.-D., Sappino A.P. J. Clin. Invest. 97:2478-2484(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: C57BL/6 X CBA. Tissue: Liver.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Liver.
[3]	"Characterization of the murine plasma fibrinolytic system." Lijnen H.R., van Hoef B., Beelen V., Collen D. Eur. J. Biochem. 224:863-871(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 28-33.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z36774 mRNA. Translation: CAA85350.1.
BC026756 mRNA. Translation: AAH26756.1.

IPI

IPI00118924.

PIR

S47217.

RefSeq

NP_032904.1. NM_008878.2.

UniGene

Mm.279733.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2R9Y	X-ray	2.65	A	71-491	[»]

ProteinModelPortal

Q61247.

SMR

Q61247. Positions 73-446.

ModBase

Search...

Protein family/group databases

MEROPS

I04.023.

PTM databases

PhosphoSite

Q61247.

Proteomic databases

PaxDb

Q61247.

PRIDE

Q61247.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000043696; ENSMUSP00000048704; ENSMUSG00000038224.
ENSMUST00000108437; ENSMUSP00000104076; ENSMUSG00000038224.

GeneID

18816.

KEGG

mmu:18816.

Organism-specific databases

CTD

5345.

MGI

MGI:107173. Serpinf2.

Phylogenomic databases

eggNOG

COG4826.

GeneTree

ENSGT00560000076649.

HOGENOM

HOG000231761.

HOVERGEN

HBG000043.

InParanoid

Q61247.

K03983.

OMA

RDSFHLD.

OrthoDB

EOG4DV5MT.

Gene expression databases

ArrayExpress

Q61247.

Bgee

Q61247.

Genevestigator

Q61247.

GermOnline

ENSMUSG00000038224. Mus musculus.

Family and domain databases

InterPro

IPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]

PANTHER

PTHR11461. PTHR11461. 1 hit.

Pfam

PF00079. Serpin. 1 hit.
[Graphical view]

SMART

SM00093. SERPIN. 1 hit.
[Graphical view]

SUPFAM

SSF56574. Prot_inh_serpin. 1 hit.

PROSITE

PS00284. SERPIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q61247.

NextBio

295170.

SOURCE

Search...

Entry information

Entry name

A2AP_MOUSE

Accession

Primary (citable) accession number: Q61247

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Amino acid modifications

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents