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Q61245

- COBA1_MOUSE

UniProt

Q61245 - COBA1_MOUSE

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Protein
Collagen alpha-1(XI) chain
Gene
Col11a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1623 – 16231Calcium By similarity
Metal bindingi1625 – 16251Calcium By similarity
Metal bindingi1626 – 16261Calcium; via carbonyl oxygen By similarity
Metal bindingi1628 – 16281Calcium; via carbonyl oxygen By similarity
Metal bindingi1631 – 16311Calcium By similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cartilage condensation Source: MGI
  2. cartilage development Source: MGI
  3. chondrocyte development Source: MGI
  4. collagen fibril organization Source: MGI
  5. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  6. embryonic skeletal system morphogenesis Source: MGI
  7. heart morphogenesis Source: MGI
  8. inner ear morphogenesis Source: MGI
  9. proteoglycan metabolic process Source: MGI
  10. skeletal system morphogenesis Source: MGI
  11. tendon development Source: MGI
  12. ventricular cardiac muscle tissue morphogenesis Source: MGI
  13. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XI) chain
Gene namesi
Name:Col11a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88446. Col11a1.

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: MGI
  2. extracellular matrix Source: MGI
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Propeptidei35 – 511477N-terminal propeptide Reviewed prediction
PRO_0000005777Add
BLAST
Chaini512 – 15611050Collagen alpha-1(XI) chain
PRO_0000005778Add
BLAST
Propeptidei1562 – 1804243C-terminal propeptide
PRO_0000005779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 242 By similarity
Disulfide bondi181 ↔ 235 By similarity
Modified residuei610 – 6101Allysine
Modified residuei1450 – 14501Allysine
Disulfide bondi1605 ↔ 1637 By similarity
Disulfide bondi1628 – 1628Interchain By similarity
Glycosylationi1638 – 16381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1646 ↔ 1801 By similarity
Disulfide bondi1712 ↔ 1755 By similarity

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ61245.
PaxDbiQ61245.
PRIDEiQ61245.

PTM databases

PhosphoSiteiQ61245.

Expressioni

Gene expression databases

ArrayExpressiQ61245.
BgeeiQ61245.
CleanExiMM_COL11A1.
GenevestigatoriQ61245.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ61245.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 242173Laminin G-like
Add
BLAST
Domaini440 – 48849Collagen-like 1
Add
BLAST
Domaini527 – 58458Collagen-like 2
Add
BLAST
Domaini567 – 62357Collagen-like 3
Add
BLAST
Domaini728 – 78154Collagen-like 4
Add
BLAST
Domaini1427 – 148256Collagen-like 5
Add
BLAST
Domaini1481 – 153959Collagen-like 6
Add
BLAST
Domaini1575 – 1803229Fibrillar collagen NC1
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 417189Nonhelical region
Add
BLAST
Regioni418 – 50689Triple-helical region (interrupted)
Add
BLAST
Regioni507 – 5093Short nonhelical segment
Regioni510 – 52718Telopeptide
Add
BLAST
Regioni528 – 15401013Triple-helical region
Add
BLAST
Regioni1541 – 156121Nonhelical region (C-terminal)
Add
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00710000106385.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
KOiK06236.
OMAiHPGKEGQ.
OrthoDBiEOG7XPZ4W.
TreeFamiTF323987.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 6 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q61245-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPWSRWKTK RWIWDLTIST LALTFLFQAR EVRGAAPVDI LKALDFHNSP     50
VGISKTTGFC TNRKNSKDPD VAYRVTEEAQ ISAPTKQLFP GGIFPQDFSI 100
LFTIKPKKGT QAFLLSLYNE HGIQQLGVEV GRSPVFLFED HTGKPTPENY 150
PLFSTVNIAD GKWHRVAISV EKKTVTMIVD CKKKITKPLD RSERSIVDTN 200
GIMVFGTRIL ETDVFQGDIQ QFLITGDPKA AYDYCDHYSP DCDLTSKAAQ 250
AQEPHIDEYA PEDIIEYDYE YGETDYKEAE SVTEMPTFTE ETVAQTEANI 300
VDDFQDYNYG TMEPYQTETP RRVSGSNEPN PVEEGFTEEY LTGEDYDVQR 350
NTSEDILYGN KGVDGRDSDL LVDGDLGEYD FYEYKEYEER TTTSPNEEFG 400
PGVPAETDFT ETSINGHGAY GEKGQKGEPA VVEPGMLVEG PPGPAGPAGL 450
MGPPGLQGPS GLPGDPGDRG PPGRPGLPGA DGLPGPPGTM LMLPFRYGGD 500
GSKGPTISAQ EAQAQAILQQ ARIALRGPPG PMGLTGRPGP VGGPGSAGAK 550
GESGDPGPQG PRGVQGPPGP TGKPGKRGRP GADGGRGMPG ESGSKGDRGF 600
DGLPGLPGDK GHRGERGPQG PPGLPGDDGM RGEDGEIGPR GLPGEAGPRG 650
LLGPRGTPGP PGQPGIGGID GPQGPKGNMG PQGEPGPPGQ QGNPGPQGLP 700
GPQGPIGPPG EKGPQGKPGL AGLPGADGPP GHPGKEGQSG EKGALGPPGP 750
QGPIGYPGPR GVKGADGVRG LKGSKGEKGE DGFPGFKGDM GLKGDRGEVG 800
QVGPRGEDGP EGPKGRAGPT GDPGPSGQAG EKGKLGVPGL PGYPGRQGPK 850
GSTGFPGFPG ANGEKGARGI AGKPGPRGQR GPTGPRGSRG ARGPTGKPGP 900
KGTSGGDGPP GPPGERGPQG PQGPVGFPGP KGPPGPAGKD GLPGHPGQRG 950
ETGFQGKTGP PGPGGVVGPQ GPTGETGPIG ERGHPGPPGP PGEQGLPGAA 1000
GKEGAKGDPG PQGISGKDGP AGIRGFPGER GLPGAQGAPG LKGGEGPQGP 1050
QGPVGSPGER GSAGTAGPIG LPGRPGPQGP PGPAGEKGAP GEKGPQGPAG 1100
RDGVQGPVGL PGPAGPAGSP GEDGDKGEIG EPGQKGSKGD KGENGPPGPP 1150
GLQGPVGAPG IAGGDGEPGP RGQQGMFGQK GDEGARGFPG LPGPIGLQGL 1200
PGPPGEKGEN GDVGPMGPPG PPGPRGPQGP NGADGPQGPP GSIGSVGVVG 1250
DKGEPGEAGN PGPPGEAGSG GLKGERGEKG EAGPPGAAGP AGIKGPPGDD 1300
GPKGNPGPVG FPGDPGPPGE PGPAGQDGVG GDKGEDGDPG QPGPPGPSGE 1350
AGPPGPPGKR GPPGASGSEG RQGEKGAKGE AGAEGPPGKT GPVGPQGPSG 1400
KPGPEGLRGI PGPVGEQGLP GAAGQDGPPG PLGPPGLPGL KGDPGSKGEK 1450
GHPGLIGLIG PPGEQGEKGD RGLPGTQGSP GAKGDGGIPG PAGPIGPPGP 1500
PGLPGPAGPK GNKGSSGPTG QKGDSGMPGP PGPPGPPGEV IQPLPILSPK 1550
KTRRHTESIQ GDAGDNILDY SDGMEEIFGS LNSLKQDIEH MKFPMGTQTN 1600
PARTCKDLQL SHPDFPDGEY WIDPNQGCSG DSFKVYCNFT AGGETCIYPD 1650
KKSEGVRISS WPKEKPGSWY SEFKRGKLLS YLDVEGNSIN MVQMTFLKLL 1700
TASARQNFTY NCHQSAAWYD VLSGSYDKAL RFLGSNDEEM SYENNPHIKA 1750
LYDGCASRKG YEKTVIEINT PKIDQVPIID VMINDFGDQN QKFGFEVGPA 1800
CFLG 1804
Length:1,804
Mass (Da):181,032
Last modified:July 27, 2011 - v2
Checksum:i918C3D4B8C964470
GO
Isoform Short (identifier: Q61245-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-413: Missing.

Show »
Length:1,719
Mass (Da):171,401
Checksum:i82E461C5F6246038
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 41385Missing in isoform Short.
VSP_001147Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121T → A in BAA07367. 1 Publication
Sequence conflicti370 – 3701L → V in BAA07367. 1 Publication
Sequence conflicti547 – 5471A → T in BAA07367. 1 Publication
Sequence conflicti696 – 6961P → S in BAA07367. 1 Publication
Sequence conflicti1065 – 10651T → A in BAA07367. 1 Publication
Sequence conflicti1476 – 14761T → S in BAA07367. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38162 mRNA. Translation: BAA07367.1.
BC052161 mRNA. Translation: AAH52161.1.
S74574 mRNA. Translation: AAB33439.1.
CCDSiCCDS17778.1. [Q61245-1]
PIRiA55648.
RefSeqiNP_031755.2. NM_007729.2. [Q61245-1]
UniGeneiMm.209715.

Genome annotation databases

EnsembliENSMUST00000092155; ENSMUSP00000089793; ENSMUSG00000027966. [Q61245-1]
GeneIDi12814.
KEGGimmu:12814.
UCSCiuc008rbk.1. mouse. [Q61245-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38162 mRNA. Translation: BAA07367.1 .
BC052161 mRNA. Translation: AAH52161.1 .
S74574 mRNA. Translation: AAB33439.1 .
CCDSi CCDS17778.1. [Q61245-1 ]
PIRi A55648.
RefSeqi NP_031755.2. NM_007729.2. [Q61245-1 ]
UniGenei Mm.209715.

3D structure databases

ProteinModelPortali Q61245.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61245.

Proteomic databases

MaxQBi Q61245.
PaxDbi Q61245.
PRIDEi Q61245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092155 ; ENSMUSP00000089793 ; ENSMUSG00000027966 . [Q61245-1 ]
GeneIDi 12814.
KEGGi mmu:12814.
UCSCi uc008rbk.1. mouse. [Q61245-1 ]

Organism-specific databases

CTDi 1301.
MGIi MGI:88446. Col11a1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00710000106385.
HOGENOMi HOG000085654.
HOVERGENi HBG004933.
KOi K06236.
OMAi HPGKEGQ.
OrthoDBi EOG7XPZ4W.
TreeFami TF323987.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.

Miscellaneous databases

NextBioi 282270.
PROi Q61245.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61245.
Bgeei Q61245.
CleanExi MM_COL11A1.
Genevestigatori Q61245.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008160. Collagen.
IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 6 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51461. NC1_FIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1)."
    Yoshioka H., Inoguchi K., Khaleduzzaman M., Ninomiya Y., Andrikopoulos K., Ramirez F.
    Genomics 28:337-340(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), ALTERNATIVE SPLICING.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-198, DISEASE.
    Strain: C57BL/6.

Entry informationi

Entry nameiCOBA1_MOUSE
AccessioniPrimary (citable) accession number: Q61245
Secondary accession number(s): Q64047, Q80WR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi