Q61245 (COBA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Collagen alpha-1(XI) chain

Gene names

Name:

Col11a1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1804 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
Subunit structure	Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) By similarity.
Subcellular location	Secreted › extracellular space › extracellular matrix By similarity.
Domain	The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.
Post-translational modification	Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. N-glycosylated By similarity.
Involvement in disease	Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea. Ref.3
Sequence similarities	Belongs to the fibrillar collagen family. Contains 6 collagen-like domains. Contains 1 fibrillar collagen NC1 domain. Contains 1 laminin G-like domain.

Ontologies

Keywords
Cellular component	Extracellular matrix Secreted
Coding sequence diversity	Alternative splicing
Disease	Disease mutation
Domain	Collagen Repeat Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond Glycoprotein Hydroxylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cartilage condensation Inferred from mutant phenotype PubMed 3070812. Source: MGI chondrocyte development Inferred from mutant phenotype PubMed 4100752. Source: MGI collagen fibril organization Inferred from mutant phenotype PubMed 17029294PubMed 17683922PubMed 21467034PubMed 3070812PubMed 4100752PubMed 4110409Ref.3. Source: MGI detection of mechanical stimulus involved in sensory perception of sound Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from mutant phenotype PubMed 4100752. Source: MGI inner ear morphogenesis Inferred from mutant phenotype PubMed 1952599. Source: MGI proteoglycan metabolic process Inferred from mutant phenotype PubMed 3070812. Source: MGI tendon development Inferred from mutant phenotype PubMed 21467034. Source: MGI ventricular cardiac muscle tissue morphogenesis Inferred from mutant phenotype PubMed 17029294. Source: MGI visual perception Inferred from electronic annotation. Source: Compara
Cellular_component	collagen Inferred from direct assay PubMed 17683922. Source: MGI
Molecular_function	extracellular matrix structural constituent Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Long (identifier: Q61245-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Short (identifier: Q61245-2)

The sequence of this isoform differs from the canonical sequence as follows:
     329-413: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Propeptide	35 – 511	477	N-terminal propeptide Potential		PRO_0000005777
	Chain	512 – 1561	1050	Collagen alpha-1(XI) chain		PRO_0000005778
	Propeptide	1562 – 1804	243	C-terminal propeptide		PRO_0000005779
Regions
	Domain	70 – 242	173	Laminin G-like
	Domain	440 – 488	49	Collagen-like 1
	Domain	527 – 584	58	Collagen-like 2
	Domain	567 – 623	57	Collagen-like 3
	Domain	728 – 781	54	Collagen-like 4
	Domain	1427 – 1482	56	Collagen-like 5
	Domain	1481 – 1539	59	Collagen-like 6
	Domain	1575 – 1803	229	Fibrillar collagen NC1
	Region	229 – 417	189	Nonhelical region
	Region	418 – 506	89	Triple-helical region (interrupted)
	Region	507 – 509	3	Short nonhelical segment
	Region	510 – 527	18	Telopeptide
	Region	528 – 1540	1013	Triple-helical region
	Region	1541 – 1561	21	Nonhelical region (C-terminal)
Sites
	Metal binding	1623	1	Calcium By similarity
	Metal binding	1625	1	Calcium By similarity
	Metal binding	1626	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1628	1	Calcium; via carbonyl oxygen By similarity
	Metal binding	1631	1	Calcium By similarity
Amino acid modifications
	Modified residue	610	1	Allysine
	Modified residue	1450	1	Allysine
	Glycosylation	1638	1	N-linked (GlcNAc...) Potential
	Disulfide bond	60 ↔ 242		By similarity
	Disulfide bond	181 ↔ 235		By similarity
	Disulfide bond	1605 ↔ 1637		By similarity
	Disulfide bond	1628		Interchain By similarity
	Disulfide bond	1646 ↔ 1801		By similarity
	Disulfide bond	1712 ↔ 1755		By similarity
Natural variations
	Alternative sequence	329 – 413	85	Missing in isoform Short.		VSP_001147
Experimental info
	Sequence conflict	212	1	T → A in BAA07367. Ref.1
	Sequence conflict	370	1	L → V in BAA07367. Ref.1
	Sequence conflict	547	1	A → T in BAA07367. Ref.1
	Sequence conflict	696	1	P → S in BAA07367. Ref.1
	Sequence conflict	1065	1	T → A in BAA07367. Ref.1
	Sequence conflict	1476	1	T → S in BAA07367. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform Long [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 918C3D4B8C964470	FASTA	1,804	181,032
	10 20 30 40 50 60 MEPWSRWKTK RWIWDLTIST LALTFLFQAR EVRGAAPVDI LKALDFHNSP VGISKTTGFC 70 80 90 100 110 120 TNRKNSKDPD VAYRVTEEAQ ISAPTKQLFP GGIFPQDFSI LFTIKPKKGT QAFLLSLYNE 130 140 150 160 170 180 HGIQQLGVEV GRSPVFLFED HTGKPTPENY PLFSTVNIAD GKWHRVAISV EKKTVTMIVD 190 200 210 220 230 240 CKKKITKPLD RSERSIVDTN GIMVFGTRIL ETDVFQGDIQ QFLITGDPKA AYDYCDHYSP 250 260 270 280 290 300 DCDLTSKAAQ AQEPHIDEYA PEDIIEYDYE YGETDYKEAE SVTEMPTFTE ETVAQTEANI 310 320 330 340 350 360 VDDFQDYNYG TMEPYQTETP RRVSGSNEPN PVEEGFTEEY LTGEDYDVQR NTSEDILYGN 370 380 390 400 410 420 KGVDGRDSDL LVDGDLGEYD FYEYKEYEER TTTSPNEEFG PGVPAETDFT ETSINGHGAY 430 440 450 460 470 480 GEKGQKGEPA VVEPGMLVEG PPGPAGPAGL MGPPGLQGPS GLPGDPGDRG PPGRPGLPGA 490 500 510 520 530 540 DGLPGPPGTM LMLPFRYGGD GSKGPTISAQ EAQAQAILQQ ARIALRGPPG PMGLTGRPGP 550 560 570 580 590 600 VGGPGSAGAK GESGDPGPQG PRGVQGPPGP TGKPGKRGRP GADGGRGMPG ESGSKGDRGF 610 620 630 640 650 660 DGLPGLPGDK GHRGERGPQG PPGLPGDDGM RGEDGEIGPR GLPGEAGPRG LLGPRGTPGP 670 680 690 700 710 720 PGQPGIGGID GPQGPKGNMG PQGEPGPPGQ QGNPGPQGLP GPQGPIGPPG EKGPQGKPGL 730 740 750 760 770 780 AGLPGADGPP GHPGKEGQSG EKGALGPPGP QGPIGYPGPR GVKGADGVRG LKGSKGEKGE 790 800 810 820 830 840 DGFPGFKGDM GLKGDRGEVG QVGPRGEDGP EGPKGRAGPT GDPGPSGQAG EKGKLGVPGL 850 860 870 880 890 900 PGYPGRQGPK GSTGFPGFPG ANGEKGARGI AGKPGPRGQR GPTGPRGSRG ARGPTGKPGP 910 920 930 940 950 960 KGTSGGDGPP GPPGERGPQG PQGPVGFPGP KGPPGPAGKD GLPGHPGQRG ETGFQGKTGP 970 980 990 1000 1010 1020 PGPGGVVGPQ GPTGETGPIG ERGHPGPPGP PGEQGLPGAA GKEGAKGDPG PQGISGKDGP 1030 1040 1050 1060 1070 1080 AGIRGFPGER GLPGAQGAPG LKGGEGPQGP QGPVGSPGER GSAGTAGPIG LPGRPGPQGP 1090 1100 1110 1120 1130 1140 PGPAGEKGAP GEKGPQGPAG RDGVQGPVGL PGPAGPAGSP GEDGDKGEIG EPGQKGSKGD 1150 1160 1170 1180 1190 1200 KGENGPPGPP GLQGPVGAPG IAGGDGEPGP RGQQGMFGQK GDEGARGFPG LPGPIGLQGL 1210 1220 1230 1240 1250 1260 PGPPGEKGEN GDVGPMGPPG PPGPRGPQGP NGADGPQGPP GSIGSVGVVG DKGEPGEAGN 1270 1280 1290 1300 1310 1320 PGPPGEAGSG GLKGERGEKG EAGPPGAAGP AGIKGPPGDD GPKGNPGPVG FPGDPGPPGE 1330 1340 1350 1360 1370 1380 PGPAGQDGVG GDKGEDGDPG QPGPPGPSGE AGPPGPPGKR GPPGASGSEG RQGEKGAKGE 1390 1400 1410 1420 1430 1440 AGAEGPPGKT GPVGPQGPSG KPGPEGLRGI PGPVGEQGLP GAAGQDGPPG PLGPPGLPGL 1450 1460 1470 1480 1490 1500 KGDPGSKGEK GHPGLIGLIG PPGEQGEKGD RGLPGTQGSP GAKGDGGIPG PAGPIGPPGP 1510 1520 1530 1540 1550 1560 PGLPGPAGPK GNKGSSGPTG QKGDSGMPGP PGPPGPPGEV IQPLPILSPK KTRRHTESIQ 1570 1580 1590 1600 1610 1620 GDAGDNILDY SDGMEEIFGS LNSLKQDIEH MKFPMGTQTN PARTCKDLQL SHPDFPDGEY 1630 1640 1650 1660 1670 1680 WIDPNQGCSG DSFKVYCNFT AGGETCIYPD KKSEGVRISS WPKEKPGSWY SEFKRGKLLS 1690 1700 1710 1720 1730 1740 YLDVEGNSIN MVQMTFLKLL TASARQNFTY NCHQSAAWYD VLSGSYDKAL RFLGSNDEEM 1750 1760 1770 1780 1790 1800 SYENNPHIKA LYDGCASRKG YEKTVIEINT PKIDQVPIID VMINDFGDQN QKFGFEVGPA CFLG
	Isoform Short [UniParc]. Checksum: 82E461C5F6246038	FASTA	1,719	171,401
	10 20 30 40 50 60 MEPWSRWKTK RWIWDLTIST LALTFLFQAR EVRGAAPVDI LKALDFHNSP VGISKTTGFC 70 80 90 100 110 120 TNRKNSKDPD VAYRVTEEAQ ISAPTKQLFP GGIFPQDFSI LFTIKPKKGT QAFLLSLYNE 130 140 150 160 170 180 HGIQQLGVEV GRSPVFLFED HTGKPTPENY PLFSTVNIAD GKWHRVAISV EKKTVTMIVD 190 200 210 220 230 240 CKKKITKPLD RSERSIVDTN GIMVFGTRIL ETDVFQGDIQ QFLITGDPKA AYDYCDHYSP 250 260 270 280 290 300 DCDLTSKAAQ AQEPHIDEYA PEDIIEYDYE YGETDYKEAE SVTEMPTFTE ETVAQTEANI 310 320 330 340 350 360 VDDFQDYNYG TMEPYQTETP RRVSGSNEIN GHGAYGEKGQ KGEPAVVEPG MLVEGPPGPA 370 380 390 400 410 420 GPAGLMGPPG LQGPSGLPGD PGDRGPPGRP GLPGADGLPG PPGTMLMLPF RYGGDGSKGP 430 440 450 460 470 480 TISAQEAQAQ AILQQARIAL RGPPGPMGLT GRPGPVGGPG SAGAKGESGD PGPQGPRGVQ 490 500 510 520 530 540 GPPGPTGKPG KRGRPGADGG RGMPGESGSK GDRGFDGLPG LPGDKGHRGE RGPQGPPGLP 550 560 570 580 590 600 GDDGMRGEDG EIGPRGLPGE AGPRGLLGPR GTPGPPGQPG IGGIDGPQGP KGNMGPQGEP 610 620 630 640 650 660 GPPGQQGNPG PQGLPGPQGP IGPPGEKGPQ GKPGLAGLPG ADGPPGHPGK EGQSGEKGAL 670 680 690 700 710 720 GPPGPQGPIG YPGPRGVKGA DGVRGLKGSK GEKGEDGFPG FKGDMGLKGD RGEVGQVGPR 730 740 750 760 770 780 GEDGPEGPKG RAGPTGDPGP SGQAGEKGKL GVPGLPGYPG RQGPKGSTGF PGFPGANGEK 790 800 810 820 830 840 GARGIAGKPG PRGQRGPTGP RGSRGARGPT GKPGPKGTSG GDGPPGPPGE RGPQGPQGPV 850 860 870 880 890 900 GFPGPKGPPG PAGKDGLPGH PGQRGETGFQ GKTGPPGPGG VVGPQGPTGE TGPIGERGHP 910 920 930 940 950 960 GPPGPPGEQG LPGAAGKEGA KGDPGPQGIS GKDGPAGIRG FPGERGLPGA QGAPGLKGGE 970 980 990 1000 1010 1020 GPQGPQGPVG SPGERGSAGT AGPIGLPGRP GPQGPPGPAG EKGAPGEKGP QGPAGRDGVQ 1030 1040 1050 1060 1070 1080 GPVGLPGPAG PAGSPGEDGD KGEIGEPGQK GSKGDKGENG PPGPPGLQGP VGAPGIAGGD 1090 1100 1110 1120 1130 1140 GEPGPRGQQG MFGQKGDEGA RGFPGLPGPI GLQGLPGPPG EKGENGDVGP MGPPGPPGPR 1150 1160 1170 1180 1190 1200 GPQGPNGADG PQGPPGSIGS VGVVGDKGEP GEAGNPGPPG EAGSGGLKGE RGEKGEAGPP 1210 1220 1230 1240 1250 1260 GAAGPAGIKG PPGDDGPKGN PGPVGFPGDP GPPGEPGPAG QDGVGGDKGE DGDPGQPGPP 1270 1280 1290 1300 1310 1320 GPSGEAGPPG PPGKRGPPGA SGSEGRQGEK GAKGEAGAEG PPGKTGPVGP QGPSGKPGPE 1330 1340 1350 1360 1370 1380 GLRGIPGPVG EQGLPGAAGQ DGPPGPLGPP GLPGLKGDPG SKGEKGHPGL IGLIGPPGEQ 1390 1400 1410 1420 1430 1440 GEKGDRGLPG TQGSPGAKGD GGIPGPAGPI GPPGPPGLPG PAGPKGNKGS SGPTGQKGDS 1450 1460 1470 1480 1490 1500 GMPGPPGPPG PPGEVIQPLP ILSPKKTRRH TESIQGDAGD NILDYSDGME EIFGSLNSLK 1510 1520 1530 1540 1550 1560 QDIEHMKFPM GTQTNPARTC KDLQLSHPDF PDGEYWIDPN QGCSGDSFKV YCNFTAGGET 1570 1580 1590 1600 1610 1620 CIYPDKKSEG VRISSWPKEK PGSWYSEFKR GKLLSYLDVE GNSINMVQMT FLKLLTASAR 1630 1640 1650 1660 1670 1680 QNFTYNCHQS AAWYDVLSGS YDKALRFLGS NDEEMSYENN PHIKALYDGC ASRKGYEKTV 1690 1700 1710 IEINTPKIDQ VPIIDVMIND FGDQNQKFGF EVGPACFLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1)." Yoshioka H., Inoguchi K., Khaleduzzaman M., Ninomiya Y., Andrikopoulos K., Ramirez F. Genomics 28:337-340(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), ALTERNATIVE SPLICING. Tissue: Embryo.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG). Tissue: Embryo.
[3]	"A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis." Li Y., Lacerda D.A., Warman M.L., Beier D.R., Yoshioka H., Ninomiya Y., Oxford J.T., Morris N.P., Andrikopoulos K., Ramirez F., Wardell B.B., Lifferth G.D., Teuscher C., Woodward S.R., Taylor B.A., Seegmiller R.E., Olsen B.R. Cell 80:423-430(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-198, DISEASE. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38162 mRNA. Translation: BAA07367.1. BC052161 mRNA. Translation: AAH52161.1. S74574 mRNA. Translation: AAB33439.1.
IPI	IPI00230065. IPI00400048.
PIR	A55648.
RefSeq	NP_031755.2. NM_007729.2.
UniGene	Mm.209715.
3D structure databases
ProteinModelPortal	Q61245.
ModBase	Search...
PTM databases
PhosphoSite	Q61245.
Proteomic databases
PaxDb	Q61245.
PRIDE	Q61245.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000092155; ENSMUSP00000089793; ENSMUSG00000027966.
GeneID	12814.
KEGG	mmu:12814.
Organism-specific databases
CTD	1301.
MGI	MGI:88446. Col11a1.
Phylogenomic databases
eggNOG	NOG12793.
GeneTree	ENSGT00700000104155.
HOGENOM	HOG000085654.
HOVERGEN	HBG004933.
KO	K06236.
OMA	HPGKEGQ.
OrthoDB	EOG49GKHM.
Gene expression databases
ArrayExpress	Q61245.
Bgee	Q61245.
CleanEx	MM_COL11A1.
Genevestigator	Q61245.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008160. Collagen. IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR000885. Fib_collagen_C. IPR001791. Laminin_G. [Graphical view]
Pfam	PF01410. COLFI. 1 hit. PF01391. Collagen. 6 hits. PF02210. Laminin_G_2. 1 hit. [Graphical view]
ProDom	PD002078. Fib_collagen_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00038. COLFI. 1 hit. SM00282. LamG. 1 hit. SM00210. TSPN. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50025. LAM_G_DOMAIN. False negative. PS51461. NC1_FIB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282270.
SOURCE	Search...

Entry information

Entry name

COBA1_MOUSE

Accession

Primary (citable) accession number: Q61245
Secondary accession number(s): Q64047, Q80WR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program