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Q61245

- COBA1_MOUSE

UniProt

Q61245 - COBA1_MOUSE

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Protein

Collagen alpha-1(XI) chain

Gene

Col11a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1623 – 16231CalciumBy similarity
Metal bindingi1625 – 16251CalciumBy similarity
Metal bindingi1626 – 16261Calcium; via carbonyl oxygenBy similarity
Metal bindingi1628 – 16281Calcium; via carbonyl oxygenBy similarity
Metal bindingi1631 – 16311CalciumBy similarity

GO - Molecular functioni

  1. extracellular matrix structural constituent Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cartilage condensation Source: MGI
  2. cartilage development Source: MGI
  3. chondrocyte development Source: MGI
  4. collagen fibril organization Source: MGI
  5. detection of mechanical stimulus involved in sensory perception of sound Source: Ensembl
  6. embryonic skeletal system morphogenesis Source: MGI
  7. heart morphogenesis Source: MGI
  8. inner ear morphogenesis Source: MGI
  9. proteoglycan metabolic process Source: MGI
  10. skeletal system morphogenesis Source: MGI
  11. tendon development Source: MGI
  12. ventricular cardiac muscle tissue morphogenesis Source: MGI
  13. visual perception Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XI) chain
Gene namesi
Name:Col11a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88446. Col11a1.

Subcellular locationi

Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

GO - Cellular componenti

  1. collagen trimer Source: MGI
  2. extracellular matrix Source: MGI
  3. proteinaceous extracellular matrix Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Col11a1 are associated with chondrodysplasia, an autosomal recessive disease characterized by skeletal defects caused by abnormalities in the cartilage of limbs, ribs, mandibles and trachea.1 Publication

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Propeptidei35 – 511477N-terminal propeptideSequence AnalysisPRO_0000005777Add
BLAST
Chaini512 – 15611050Collagen alpha-1(XI) chainPRO_0000005778Add
BLAST
Propeptidei1562 – 1804243C-terminal propeptidePRO_0000005779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi60 ↔ 242PROSITE-ProRule annotation
Disulfide bondi181 ↔ 235PROSITE-ProRule annotation
Modified residuei610 – 6101Allysine
Modified residuei1450 – 14501Allysine
Disulfide bondi1605 ↔ 1637PROSITE-ProRule annotation
Disulfide bondi1628 – 1628InterchainPROSITE-ProRule annotation
Glycosylationi1638 – 16381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi1646 ↔ 1801PROSITE-ProRule annotation
Disulfide bondi1712 ↔ 1755PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ61245.
PaxDbiQ61245.
PRIDEiQ61245.

PTM databases

PhosphoSiteiQ61245.

Expressioni

Gene expression databases

BgeeiQ61245.
CleanExiMM_COL11A1.
ExpressionAtlasiQ61245. baseline and differential.
GenevestigatoriQ61245.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha 1(XI), alpha 2(XI), and alpha 3(XI). Alpha 3(XI) is a post-translational modification of alpha 1(II). Alpha 1(V) can also be found instead of alpha 3(XI)=1(II) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ61245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 242173Laminin G-likeAdd
BLAST
Domaini440 – 48849Collagen-like 1Add
BLAST
Domaini527 – 58458Collagen-like 2Add
BLAST
Domaini567 – 62357Collagen-like 3Add
BLAST
Domaini728 – 78154Collagen-like 4Add
BLAST
Domaini1427 – 148256Collagen-like 5Add
BLAST
Domaini1481 – 153959Collagen-like 6Add
BLAST
Domaini1575 – 1803229Fibrillar collagen NC1PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni229 – 417189Nonhelical regionAdd
BLAST
Regioni418 – 50689Triple-helical region (interrupted)Add
BLAST
Regioni507 – 5093Short nonhelical segment
Regioni510 – 52718TelopeptideAdd
BLAST
Regioni528 – 15401013Triple-helical regionAdd
BLAST
Regioni1541 – 156121Nonhelical region (C-terminal)Add
BLAST

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 6 collagen-like domains.Curated
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00770000120467.
HOGENOMiHOG000085654.
HOVERGENiHBG004933.
InParanoidiQ61245.
KOiK06236.
OMAiHPGKEGQ.
OrthoDBiEOG7XPZ4W.
TreeFamiTF323987.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 6 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q61245-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPWSRWKTK RWIWDLTIST LALTFLFQAR EVRGAAPVDI LKALDFHNSP
60 70 80 90 100
VGISKTTGFC TNRKNSKDPD VAYRVTEEAQ ISAPTKQLFP GGIFPQDFSI
110 120 130 140 150
LFTIKPKKGT QAFLLSLYNE HGIQQLGVEV GRSPVFLFED HTGKPTPENY
160 170 180 190 200
PLFSTVNIAD GKWHRVAISV EKKTVTMIVD CKKKITKPLD RSERSIVDTN
210 220 230 240 250
GIMVFGTRIL ETDVFQGDIQ QFLITGDPKA AYDYCDHYSP DCDLTSKAAQ
260 270 280 290 300
AQEPHIDEYA PEDIIEYDYE YGETDYKEAE SVTEMPTFTE ETVAQTEANI
310 320 330 340 350
VDDFQDYNYG TMEPYQTETP RRVSGSNEPN PVEEGFTEEY LTGEDYDVQR
360 370 380 390 400
NTSEDILYGN KGVDGRDSDL LVDGDLGEYD FYEYKEYEER TTTSPNEEFG
410 420 430 440 450
PGVPAETDFT ETSINGHGAY GEKGQKGEPA VVEPGMLVEG PPGPAGPAGL
460 470 480 490 500
MGPPGLQGPS GLPGDPGDRG PPGRPGLPGA DGLPGPPGTM LMLPFRYGGD
510 520 530 540 550
GSKGPTISAQ EAQAQAILQQ ARIALRGPPG PMGLTGRPGP VGGPGSAGAK
560 570 580 590 600
GESGDPGPQG PRGVQGPPGP TGKPGKRGRP GADGGRGMPG ESGSKGDRGF
610 620 630 640 650
DGLPGLPGDK GHRGERGPQG PPGLPGDDGM RGEDGEIGPR GLPGEAGPRG
660 670 680 690 700
LLGPRGTPGP PGQPGIGGID GPQGPKGNMG PQGEPGPPGQ QGNPGPQGLP
710 720 730 740 750
GPQGPIGPPG EKGPQGKPGL AGLPGADGPP GHPGKEGQSG EKGALGPPGP
760 770 780 790 800
QGPIGYPGPR GVKGADGVRG LKGSKGEKGE DGFPGFKGDM GLKGDRGEVG
810 820 830 840 850
QVGPRGEDGP EGPKGRAGPT GDPGPSGQAG EKGKLGVPGL PGYPGRQGPK
860 870 880 890 900
GSTGFPGFPG ANGEKGARGI AGKPGPRGQR GPTGPRGSRG ARGPTGKPGP
910 920 930 940 950
KGTSGGDGPP GPPGERGPQG PQGPVGFPGP KGPPGPAGKD GLPGHPGQRG
960 970 980 990 1000
ETGFQGKTGP PGPGGVVGPQ GPTGETGPIG ERGHPGPPGP PGEQGLPGAA
1010 1020 1030 1040 1050
GKEGAKGDPG PQGISGKDGP AGIRGFPGER GLPGAQGAPG LKGGEGPQGP
1060 1070 1080 1090 1100
QGPVGSPGER GSAGTAGPIG LPGRPGPQGP PGPAGEKGAP GEKGPQGPAG
1110 1120 1130 1140 1150
RDGVQGPVGL PGPAGPAGSP GEDGDKGEIG EPGQKGSKGD KGENGPPGPP
1160 1170 1180 1190 1200
GLQGPVGAPG IAGGDGEPGP RGQQGMFGQK GDEGARGFPG LPGPIGLQGL
1210 1220 1230 1240 1250
PGPPGEKGEN GDVGPMGPPG PPGPRGPQGP NGADGPQGPP GSIGSVGVVG
1260 1270 1280 1290 1300
DKGEPGEAGN PGPPGEAGSG GLKGERGEKG EAGPPGAAGP AGIKGPPGDD
1310 1320 1330 1340 1350
GPKGNPGPVG FPGDPGPPGE PGPAGQDGVG GDKGEDGDPG QPGPPGPSGE
1360 1370 1380 1390 1400
AGPPGPPGKR GPPGASGSEG RQGEKGAKGE AGAEGPPGKT GPVGPQGPSG
1410 1420 1430 1440 1450
KPGPEGLRGI PGPVGEQGLP GAAGQDGPPG PLGPPGLPGL KGDPGSKGEK
1460 1470 1480 1490 1500
GHPGLIGLIG PPGEQGEKGD RGLPGTQGSP GAKGDGGIPG PAGPIGPPGP
1510 1520 1530 1540 1550
PGLPGPAGPK GNKGSSGPTG QKGDSGMPGP PGPPGPPGEV IQPLPILSPK
1560 1570 1580 1590 1600
KTRRHTESIQ GDAGDNILDY SDGMEEIFGS LNSLKQDIEH MKFPMGTQTN
1610 1620 1630 1640 1650
PARTCKDLQL SHPDFPDGEY WIDPNQGCSG DSFKVYCNFT AGGETCIYPD
1660 1670 1680 1690 1700
KKSEGVRISS WPKEKPGSWY SEFKRGKLLS YLDVEGNSIN MVQMTFLKLL
1710 1720 1730 1740 1750
TASARQNFTY NCHQSAAWYD VLSGSYDKAL RFLGSNDEEM SYENNPHIKA
1760 1770 1780 1790 1800
LYDGCASRKG YEKTVIEINT PKIDQVPIID VMINDFGDQN QKFGFEVGPA

CFLG
Length:1,804
Mass (Da):181,032
Last modified:July 27, 2011 - v2
Checksum:i918C3D4B8C964470
GO
Isoform Short (identifier: Q61245-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     329-413: Missing.

Show »
Length:1,719
Mass (Da):171,401
Checksum:i82E461C5F6246038
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti212 – 2121T → A in BAA07367. (PubMed:8530046)Curated
Sequence conflicti370 – 3701L → V in BAA07367. (PubMed:8530046)Curated
Sequence conflicti547 – 5471A → T in BAA07367. (PubMed:8530046)Curated
Sequence conflicti696 – 6961P → S in BAA07367. (PubMed:8530046)Curated
Sequence conflicti1065 – 10651T → A in BAA07367. (PubMed:8530046)Curated
Sequence conflicti1476 – 14761T → S in BAA07367. (PubMed:8530046)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei329 – 41385Missing in isoform Short. CuratedVSP_001147Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38162 mRNA. Translation: BAA07367.1.
BC052161 mRNA. Translation: AAH52161.1.
S74574 mRNA. Translation: AAB33439.1.
CCDSiCCDS17778.1. [Q61245-1]
PIRiA55648.
RefSeqiNP_031755.2. NM_007729.2. [Q61245-1]
UniGeneiMm.209715.

Genome annotation databases

EnsembliENSMUST00000092155; ENSMUSP00000089793; ENSMUSG00000027966. [Q61245-1]
GeneIDi12814.
KEGGimmu:12814.
UCSCiuc008rbk.1. mouse. [Q61245-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38162 mRNA. Translation: BAA07367.1 .
BC052161 mRNA. Translation: AAH52161.1 .
S74574 mRNA. Translation: AAB33439.1 .
CCDSi CCDS17778.1. [Q61245-1 ]
PIRi A55648.
RefSeqi NP_031755.2. NM_007729.2. [Q61245-1 ]
UniGenei Mm.209715.

3D structure databases

ProteinModelPortali Q61245.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q61245.

Proteomic databases

MaxQBi Q61245.
PaxDbi Q61245.
PRIDEi Q61245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092155 ; ENSMUSP00000089793 ; ENSMUSG00000027966 . [Q61245-1 ]
GeneIDi 12814.
KEGGi mmu:12814.
UCSCi uc008rbk.1. mouse. [Q61245-1 ]

Organism-specific databases

CTDi 1301.
MGIi MGI:88446. Col11a1.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00770000120467.
HOGENOMi HOG000085654.
HOVERGENi HBG004933.
InParanoidi Q61245.
KOi K06236.
OMAi HPGKEGQ.
OrthoDBi EOG7XPZ4W.
TreeFami TF323987.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199046. Assembly of collagen fibrils and other multimeric structures.
REACT_199055. Collagen degradation.

Miscellaneous databases

ChiTaRSi Col11a1. mouse.
NextBioi 282270.
PROi Q61245.
SOURCEi Search...

Gene expression databases

Bgeei Q61245.
CleanExi MM_COL11A1.
ExpressionAtlasi Q61245. baseline and differential.
Genevestigatori Q61245.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008160. Collagen.
IPR013320. ConA-like_dom.
IPR000885. Fib_collagen_C.
IPR001791. Laminin_G.
[Graphical view ]
Pfami PF01410. COLFI. 1 hit.
PF01391. Collagen. 6 hits.
PF02210. Laminin_G_2. 1 hit.
[Graphical view ]
ProDomi PD002078. Fib_collagen_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00038. COLFI. 1 hit.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS51461. NC1_FIB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1)."
    Yoshioka H., Inoguchi K., Khaleduzzaman M., Ninomiya Y., Andrikopoulos K., Ramirez F.
    Genomics 28:337-340(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), ALTERNATIVE SPLICING.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 181-198, DISEASE.
    Strain: C57BL/6.

Entry informationi

Entry nameiCOBA1_MOUSE
AccessioniPrimary (citable) accession number: Q61245
Secondary accession number(s): Q64047, Q80WR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3