Reviewed, UniProtKB/Swiss-Prot Q61239 (FNTA_MOUSE)

Names and origin

Protein names

Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    EC=2.5.1.58
    EC=2.5.1.59
Alternative name(s):
    CAAX farnesyltransferase subunit alpha
    Ras proteins prenyltransferase subunit alpha
    FTase-alpha
    Type I protein geranyl-geranyltransferase subunit alpha
      Short name=GGTase-I-alpha

Gene names

Name:

Fnta

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Subunit structure	Heterodimer of an alpha and a beta subunit.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats.

Ontologies

Keywords
Domain	Repeat
Molecular function	Prenyltransferase Transferase
PTM	Acetylation
Gene Ontology (GO)
Biological process	neurotransmitter receptor metabolic process Inferred from mutant phenotype. Source: MGI protein amino acid prenylation Inferred from electronic annotation. Source: InterPro
Molecular function	CAAX-protein geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC acetylcholine receptor regulator activity Inferred from mutant phenotype. Source: MGI protein farnesyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 377	376	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha		PRO_0000119747
Regions
	Repeat	112 – 146	35	PFTA 1
	Repeat	147 – 181	35	PFTA 2
	Repeat	182 – 214	33	PFTA 3
	Repeat	215 – 249	35	PFTA 4
	Repeat	255 – 289	35	PFTA 5
	Compositional bias	22 – 30	9	Poly-Pro
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
Experimental info
	Sequence conflict	191	1	D → N in AAH12711. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q61239-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: F3D60B9899F36D66	FASTA	377	44,013
	10 20 30 40 50 60 MAATEGVGES AAGGEPGQPE QPPPPPPPPP AQQPQEEEMA AEAGEAAASP MDDGFLSLDS 70 80 90 100 110 120 PTYVLYRDRA EWADIDPVPQ NDGPNPVVQI IYSEKFRDVY DYFRAVLQRD ERSERAFKLT 130 140 150 160 170 180 RDAIELNAAN YTVWHFRRVL LRSLQKDLQE EMNYITAIIE EQPKNYQVWH HRRVLVEWLK 190 200 210 220 230 240 DPSQELEFIA DILSQDAKNY HAWQHRQWVI QEFRLWDNEL QYVDQLLKED VRNNSVWNQR 250 260 270 280 290 300 HFVISNTTGY SDRAVLEREV QYTLEMIKLV PHNESAWNYL KGILQDRGLS RYPNLLNQLL 310 320 330 340 350 360 DLQPSHSSPY LIAFLVDVYE DMLENQCDNK EDILNKALEL CEILAKEKDT IRKEYWRYIG 370 RSLQSKHCRE SDIPASV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing of the murine farnesyltransferase alpha-encoding cDNA from a cell line which expresses the human papillomavirus type-16 E6 gene." Shirasawa H., Kinoshita T., Shino Y., Mori K., Shimizu K., Simizu B. Gene 164:373-374(1995) [PubMed: 7590362] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49744 mRNA. Translation: BAA08578.1. BC012711 mRNA. Translation: AAH12711.1.
IPI	IPI00118904.
PIR	JC4368.
RefSeq	NP_032059.1.
UniGene	Mm.3496
3D structure databases
SMR	Q61239. Positions 55-377.
ModBase	Search...
Protein-protein interaction databases
STRING	Q61239.
PTM databases
PhosphoSite	Q61239.
Proteomic databases
PRIDE	Q61239.
Genome annotation databases
Ensembl	ENSMUST00000016138; ENSMUSP00000016138; ENSMUSG00000015994; Mus musculus. [Genome view]
GeneID	14272.
KEGG	mmu:14272.
UCSC	uc009lhi.1. mouse.
Organism-specific databases
CTD	14272.
MGI	MGI:104683. Fnta.
Phylogenomic databases
HOGENOM	HBG623262.
HOVERGEN	Q61239.
InParanoid	Q61239.
OMA	VEWLRDP.
OrthoDB	EOG9909VB.
PhylomeDB	Q61239.
Enzyme and pathway databases
BRENDA	2.5.1.58. 244. 2.5.1.59. 244.
Gene expression databases
ArrayExpress	Q61239.
Bgee	Q61239.
CleanEx	MM_FNTA.
Genevestigator	Q61239.
GermOnline	ENSMUSG00000015994. Mus musculus.
Family and domain databases
InterPro	IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
Pfam	PF01239. PPTA. 5 hits. [Graphical view]
PROSITE	PS51147. PFTA. 5 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	285645.
SOURCE	Search...

Entry information

Entry name

FNTA_MOUSE

Accession

Primary (citable) accession number: Q61239
Secondary accession number(s): Q921F7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)