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Protein

Beta-2-syntrophin

Gene

Sntb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 2
Syntrophin-3
Short name:
SNT3
Syntrophin-like
Short name:
SNTL
Gene namesi
Name:Sntb2
Synonyms:Snt2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:101771. Sntb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840121 – 520Beta-2-syntrophinAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei109PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Partially dephosphorylated upon insulin stimulation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61235.
MaxQBiQ61235.
PaxDbiQ61235.
PRIDEiQ61235.

PTM databases

iPTMnetiQ61235.
PhosphoSitePlusiQ61235.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000041308.
CleanExiMM_SNTB2.
ExpressionAtlasiQ61235. baseline and differential.
GenevisibleiQ61235. MM.

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the dystrophin protein DMD and related protein DTNA; and with the other members of the syntrophin family: SNTA1 and SNTB1. Interacts with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN (By similarity). Interacts with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin related protein UTRN.By similarityCurated3 Publications

Protein-protein interaction databases

BioGridi203384. 1 interactor.
IntActiQ61235. 4 interactors.
MINTiMINT-99343.
STRINGi10090.ENSMUSP00000037324.

Structurei

3D structure databases

ProteinModelPortaliQ61235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 178PDZPROSITE-ProRule annotationAdd BLAST84
Domaini143 – 280PH 1PROSITE-ProRule annotationAdd BLAST138
Domaini305 – 417PH 2PROSITE-ProRule annotationAdd BLAST113
Domaini464 – 520SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 520Calmodulin-bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 60Poly-Gly4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated
Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRK. Eukaryota.
ENOG4111J6R. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ61235.
OMAiGFTITRE.
OrthoDBiEOG091G0O31.
PhylomeDBiQ61235.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF8. PTHR10554:SF8. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWTRATKA GLVELLLRER WVRVVAELSG ESLSLTGDAA AVEPEPPAAA
60 70 80 90 100
FNGLPNGGGG ESLPGSPNRG LGPPSPPAPP RGPAGEASAS PPVRRVRVVK
110 120 130 140 150
QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD
160 170 180 190 200
LRQATHDQAV QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGASP
210 220 230 240 250
QSPSFSGSED SGSPKHQNTT KDRKVIPLKM CFAARNLSMP DLENRLIELH
260 270 280 290 300
SPDSRNTLIL RCKDTATAHS WFVAIHTNIM ALLPQVLAEL NAMLGATSTA
310 320 330 340 350
GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY DCMPWTRDAW
360 370 380 390 400
ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE
410 420 430 440 450
THRDLSTWTR ILVQGCHAAA ELIKEVSLGC TLSGQEVRFT VHYEHGFTIT
460 470 480 490 500
RDNGGASSIL YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP
510 520
IVFVLHTFLS AKVTRMGLLV
Length:520
Mass (Da):56,382
Last modified:May 1, 1997 - v2
Checksum:i9F6886837C1CDB20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00678 mRNA. Translation: AAC53060.1.
CCDSiCCDS22642.1.
RefSeqiNP_033255.1. NM_009229.4.
UniGeneiMm.30228.

Genome annotation databases

EnsembliENSMUST00000212524; ENSMUSP00000148684; ENSMUSG00000041308.
GeneIDi20650.
KEGGimmu:20650.
UCSCiuc009ngt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00678 mRNA. Translation: AAC53060.1.
CCDSiCCDS22642.1.
RefSeqiNP_033255.1. NM_009229.4.
UniGeneiMm.30228.

3D structure databases

ProteinModelPortaliQ61235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203384. 1 interactor.
IntActiQ61235. 4 interactors.
MINTiMINT-99343.
STRINGi10090.ENSMUSP00000037324.

PTM databases

iPTMnetiQ61235.
PhosphoSitePlusiQ61235.

Proteomic databases

EPDiQ61235.
MaxQBiQ61235.
PaxDbiQ61235.
PRIDEiQ61235.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000212524; ENSMUSP00000148684; ENSMUSG00000041308.
GeneIDi20650.
KEGGimmu:20650.
UCSCiuc009ngt.1. mouse.

Organism-specific databases

CTDi6645.
MGIiMGI:101771. Sntb2.

Phylogenomic databases

eggNOGiENOG410IMRK. Eukaryota.
ENOG4111J6R. LUCA.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ61235.
OMAiGFTITRE.
OrthoDBiEOG091G0O31.
PhylomeDBiQ61235.
TreeFamiTF317932.

Miscellaneous databases

ChiTaRSiSntb2. mouse.
PROiQ61235.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041308.
CleanExiMM_SNTB2.
ExpressionAtlasiQ61235. baseline and differential.
GenevisibleiQ61235. MM.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF8. PTHR10554:SF8. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNTB2_MOUSE
AccessioniPrimary (citable) accession number: Q61235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1997
Last modified: November 30, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.