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Q61235

- SNTB2_MOUSE

UniProt

Q61235 - SNTB2_MOUSE

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Protein
Beta-2-syntrophin
Gene
Sntb2, Snt2b2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calcium, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 2
Syntrophin-3
Short name:
SNT3
Syntrophin-like
Short name:
SNTL
Gene namesi
Name:Sntb2
Synonyms:Snt2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:101771. Sntb2.

Subcellular locationi

Membrane. Cytoplasmic vesiclesecretory vesicle membrane; Peripheral membrane protein. Cell junction By similarity. Cytoplasmcytoskeleton
Note: Membrane-associated. In insulinoma cell line, it is enriched in secretory granules By similarity. In muscle, it is exclusively localized at the neuromuscular junction.1 Publication

GO - Cellular componenti

  1. cell junction Source: UniProtKB-SubCell
  2. microtubule Source: UniProtKB-KW
  3. protein complex Source: MGI
  4. synapse Source: MGI
  5. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 520520Beta-2-syntrophin
PRO_0000184012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei75 – 751Phosphoserine1 Publication
Modified residuei90 – 901Phosphoserine2 Publications
Modified residuei202 – 2021Phosphoserine By similarity
Modified residuei213 – 2131Phosphoserine By similarity
Modified residuei373 – 3731Phosphoserine By similarity

Post-translational modificationi

Phosphorylated. Partially dephosphorylated upon insulin stimulation By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ61235.
PaxDbiQ61235.
PRIDEiQ61235.

PTM databases

PhosphoSiteiQ61235.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the testis.1 Publication

Gene expression databases

ArrayExpressiQ61235.
BgeeiQ61235.
CleanExiMM_SNTB2.
GenevestigatoriQ61235.

Interactioni

Subunit structurei

Monomer and homodimer Inferred. Interacts with the dystrophin protein DMD and related protein DTNA; and with the other members of the syntrophin family: SNTA1 and SNTB1. Interacts with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN By similarity. Interacts with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin related protein UTRN.3 Publications

Protein-protein interaction databases

BioGridi203384. 1 interaction.
IntActiQ61235. 4 interactions.
MINTiMINT-99343.

Structurei

3D structure databases

ProteinModelPortaliQ61235.
SMRiQ61235. Positions 6-279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini95 – 17884PDZ
Add
BLAST
Domaini143 – 280138PH 1
Add
BLAST
Domaini305 – 417113PH 2
Add
BLAST
Domaini464 – 52057SU
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni498 – 52023Calmodulin-binding By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi57 – 604Poly-Gly

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner By similarity.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.
The SU domain binds calmodulin in a calcium-dependent manner By similarity.

Sequence similaritiesi

Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 2 PH domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG318350.
GeneTreeiENSGT00550000074581.
HOGENOMiHOG000231596.
HOVERGENiHBG054204.
InParanoidiQ61235.
OMAiLYQGRQC.
OrthoDBiEOG7R56VZ.
PhylomeDBiQ61235.
TreeFamiTF317932.

Family and domain databases

Gene3Di2.30.42.10. 1 hit.
InterProiIPR001478. PDZ.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view]
PANTHERiPTHR10554. PTHR10554. 1 hit.
PTHR10554:SF8. PTHR10554:SF8. 1 hit.
PfamiPF00595. PDZ. 1 hit.
[Graphical view]
SMARTiSM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
PROSITEiPS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q61235-1 [UniParc]FASTAAdd to Basket

« Hide

MAVWTRATKA GLVELLLRER WVRVVAELSG ESLSLTGDAA AVEPEPPAAA    50
FNGLPNGGGG ESLPGSPNRG LGPPSPPAPP RGPAGEASAS PPVRRVRVVK 100
QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD 150
LRQATHDQAV QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGASP 200
QSPSFSGSED SGSPKHQNTT KDRKVIPLKM CFAARNLSMP DLENRLIELH 250
SPDSRNTLIL RCKDTATAHS WFVAIHTNIM ALLPQVLAEL NAMLGATSTA 300
GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY DCMPWTRDAW 350
ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE 400
THRDLSTWTR ILVQGCHAAA ELIKEVSLGC TLSGQEVRFT VHYEHGFTIT 450
RDNGGASSIL YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP 500
IVFVLHTFLS AKVTRMGLLV 520
Length:520
Mass (Da):56,382
Last modified:May 1, 1997 - v2
Checksum:i9F6886837C1CDB20
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00678 mRNA. Translation: AAC53060.1.
CCDSiCCDS22642.1.
RefSeqiNP_033255.1. NM_009229.4.
UniGeneiMm.30228.

Genome annotation databases

EnsembliENSMUST00000047425; ENSMUSP00000037324; ENSMUSG00000041308.
GeneIDi20650.
KEGGimmu:20650.
UCSCiuc009ngt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00678 mRNA. Translation: AAC53060.1 .
CCDSi CCDS22642.1.
RefSeqi NP_033255.1. NM_009229.4.
UniGenei Mm.30228.

3D structure databases

ProteinModelPortali Q61235.
SMRi Q61235. Positions 6-279.
ModBasei Search...

Protein-protein interaction databases

BioGridi 203384. 1 interaction.
IntActi Q61235. 4 interactions.
MINTi MINT-99343.

PTM databases

PhosphoSitei Q61235.

Proteomic databases

MaxQBi Q61235.
PaxDbi Q61235.
PRIDEi Q61235.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000047425 ; ENSMUSP00000037324 ; ENSMUSG00000041308 .
GeneIDi 20650.
KEGGi mmu:20650.
UCSCi uc009ngt.1. mouse.

Organism-specific databases

CTDi 6645.
MGIi MGI:101771. Sntb2.

Phylogenomic databases

eggNOGi NOG318350.
GeneTreei ENSGT00550000074581.
HOGENOMi HOG000231596.
HOVERGENi HBG054204.
InParanoidi Q61235.
OMAi LYQGRQC.
OrthoDBi EOG7R56VZ.
PhylomeDBi Q61235.
TreeFami TF317932.

Miscellaneous databases

ChiTaRSi SNTB2. mouse.
NextBioi 299071.
PROi Q61235.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q61235.
Bgeei Q61235.
CleanExi MM_SNTB2.
Genevestigatori Q61235.

Family and domain databases

Gene3Di 2.30.42.10. 1 hit.
InterProi IPR001478. PDZ.
IPR001849. PH_domain.
IPR028550. SNTB2.
IPR015482. Syntrophin.
[Graphical view ]
PANTHERi PTHR10554. PTHR10554. 1 hit.
PTHR10554:SF8. PTHR10554:SF8. 1 hit.
Pfami PF00595. PDZ. 1 hit.
[Graphical view ]
SMARTi SM00228. PDZ. 1 hit.
SM00233. PH. 2 hits.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
PROSITEi PS50106. PDZ. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain."
    Adams M.E., Dwyer T.M., Dowler L.L., White R.A., Froehner S.C.
    J. Biol. Chem. 270:25859-25865(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Diaphragm.
  2. "Two forms of mouse syntrophin, a 58 kDa dystrophin-associated protein, differ in primary structure and tissue distribution."
    Adams M.E., Butler M.H., Dwyer T.M., Peters M.F., Murnane A.A., Froehner S.C.
    Neuron 11:531-540(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-520.
    Tissue: Diaphragm.
  3. "Differential association of syntrophin pairs with the dystrophin complex."
    Peters M.F., Adams M.E., Froehner S.C.
    J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH UTRN.
  4. "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins."
    Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C.
    J. Neurosci. 18:128-137(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCN4A AND SCN5A.
  5. "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases."
    Lumeng C., Phelps S., Crawford G.E., Walden P.D., Barald K., Chamberlain J.S.
    Nat. Neurosci. 2:611-617(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SAST; MAST205; MICROTUBULES AND MICROTUBULE-ASSOCIATED PROTEINS.
  6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  8. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSNTB2_MOUSE
AccessioniPrimary (citable) accession number: Q61235
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1997
Last modified: September 3, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi