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Q61235

- SNTB2_MOUSE

UniProt

Q61235 - SNTB2_MOUSE

Protein

Beta-2-syntrophin

Gene

Sntb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 May 1997)
      Previous versions | rss
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    Functioni

    Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Keywords - Ligandi

    Actin-binding, Calcium, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-2-syntrophin
    Alternative name(s):
    59 kDa dystrophin-associated protein A1 basic component 2
    Syntrophin-3
    Short name:
    SNT3
    Syntrophin-like
    Short name:
    SNTL
    Gene namesi
    Name:Sntb2
    Synonyms:Snt2b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:101771. Sntb2.

    Subcellular locationi

    Membrane 1 Publication. Cytoplasmic vesiclesecretory vesicle membrane 1 Publication; Peripheral membrane protein 1 Publication. Cell junction By similarity. Cytoplasmcytoskeleton 1 Publication
    Note: Membrane-associated. In insulinoma cell line, it is enriched in secretory granules By similarity. In muscle, it is exclusively localized at the neuromuscular junction.By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-SubCell
    2. microtubule Source: UniProtKB-KW
    3. protein complex Source: MGI
    4. synapse Source: MGI
    5. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 520520Beta-2-syntrophinPRO_0000184012Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei75 – 751Phosphoserine1 Publication
    Modified residuei90 – 901Phosphoserine2 Publications
    Modified residuei202 – 2021PhosphoserineBy similarity
    Modified residuei213 – 2131PhosphoserineBy similarity
    Modified residuei373 – 3731PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated. Partially dephosphorylated upon insulin stimulation By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ61235.
    PaxDbiQ61235.
    PRIDEiQ61235.

    PTM databases

    PhosphoSiteiQ61235.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed at high levels in the testis.1 Publication

    Gene expression databases

    ArrayExpressiQ61235.
    BgeeiQ61235.
    CleanExiMM_SNTB2.
    GenevestigatoriQ61235.

    Interactioni

    Subunit structurei

    Monomer and homodimer Probable. Interacts with the dystrophin protein DMD and related protein DTNA; and with the other members of the syntrophin family: SNTA1 and SNTB1. Interacts with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN By similarity. Interacts with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin related protein UTRN.By similarity3 PublicationsCurated

    Protein-protein interaction databases

    BioGridi203384. 1 interaction.
    IntActiQ61235. 4 interactions.
    MINTiMINT-99343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ61235.
    SMRiQ61235. Positions 6-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini95 – 17884PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini143 – 280138PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini305 – 417113PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini464 – 52057SUAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni498 – 52023Calmodulin-bindingBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi57 – 604Poly-Gly

    Domaini

    The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
    The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane By similarity.By similarity
    The SU domain binds calmodulin in a calcium-dependent manner.By similarity

    Sequence similaritiesi

    Belongs to the syntrophin family.Curated
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG318350.
    GeneTreeiENSGT00550000074581.
    HOGENOMiHOG000231596.
    HOVERGENiHBG054204.
    InParanoidiQ61235.
    OMAiLYQGRQC.
    OrthoDBiEOG7R56VZ.
    PhylomeDBiQ61235.
    TreeFamiTF317932.

    Family and domain databases

    Gene3Di2.30.42.10. 1 hit.
    InterProiIPR001478. PDZ.
    IPR001849. PH_domain.
    IPR028550. SNTB2.
    IPR015482. Syntrophin.
    [Graphical view]
    PANTHERiPTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF8. PTHR10554:SF8. 1 hit.
    PfamiPF00595. PDZ. 1 hit.
    [Graphical view]
    SMARTiSM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    PROSITEiPS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q61235-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVWTRATKA GLVELLLRER WVRVVAELSG ESLSLTGDAA AVEPEPPAAA    50
    FNGLPNGGGG ESLPGSPNRG LGPPSPPAPP RGPAGEASAS PPVRRVRVVK 100
    QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD 150
    LRQATHDQAV QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGASP 200
    QSPSFSGSED SGSPKHQNTT KDRKVIPLKM CFAARNLSMP DLENRLIELH 250
    SPDSRNTLIL RCKDTATAHS WFVAIHTNIM ALLPQVLAEL NAMLGATSTA 300
    GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY DCMPWTRDAW 350
    ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE 400
    THRDLSTWTR ILVQGCHAAA ELIKEVSLGC TLSGQEVRFT VHYEHGFTIT 450
    RDNGGASSIL YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP 500
    IVFVLHTFLS AKVTRMGLLV 520
    Length:520
    Mass (Da):56,382
    Last modified:May 1, 1997 - v2
    Checksum:i9F6886837C1CDB20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00678 mRNA. Translation: AAC53060.1.
    CCDSiCCDS22642.1.
    RefSeqiNP_033255.1. NM_009229.4.
    UniGeneiMm.30228.

    Genome annotation databases

    EnsembliENSMUST00000047425; ENSMUSP00000037324; ENSMUSG00000041308.
    GeneIDi20650.
    KEGGimmu:20650.
    UCSCiuc009ngt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U00678 mRNA. Translation: AAC53060.1 .
    CCDSi CCDS22642.1.
    RefSeqi NP_033255.1. NM_009229.4.
    UniGenei Mm.30228.

    3D structure databases

    ProteinModelPortali Q61235.
    SMRi Q61235. Positions 6-279.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203384. 1 interaction.
    IntActi Q61235. 4 interactions.
    MINTi MINT-99343.

    PTM databases

    PhosphoSitei Q61235.

    Proteomic databases

    MaxQBi Q61235.
    PaxDbi Q61235.
    PRIDEi Q61235.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000047425 ; ENSMUSP00000037324 ; ENSMUSG00000041308 .
    GeneIDi 20650.
    KEGGi mmu:20650.
    UCSCi uc009ngt.1. mouse.

    Organism-specific databases

    CTDi 6645.
    MGIi MGI:101771. Sntb2.

    Phylogenomic databases

    eggNOGi NOG318350.
    GeneTreei ENSGT00550000074581.
    HOGENOMi HOG000231596.
    HOVERGENi HBG054204.
    InParanoidi Q61235.
    OMAi LYQGRQC.
    OrthoDBi EOG7R56VZ.
    PhylomeDBi Q61235.
    TreeFami TF317932.

    Miscellaneous databases

    ChiTaRSi SNTB2. mouse.
    NextBioi 299071.
    PROi Q61235.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q61235.
    Bgeei Q61235.
    CleanExi MM_SNTB2.
    Genevestigatori Q61235.

    Family and domain databases

    Gene3Di 2.30.42.10. 1 hit.
    InterProi IPR001478. PDZ.
    IPR001849. PH_domain.
    IPR028550. SNTB2.
    IPR015482. Syntrophin.
    [Graphical view ]
    PANTHERi PTHR10554. PTHR10554. 1 hit.
    PTHR10554:SF8. PTHR10554:SF8. 1 hit.
    Pfami PF00595. PDZ. 1 hit.
    [Graphical view ]
    SMARTi SM00228. PDZ. 1 hit.
    SM00233. PH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    PROSITEi PS50106. PDZ. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse alpha 1- and beta 2-syntrophin gene structure, chromosome localization, and homology with a discs large domain."
      Adams M.E., Dwyer T.M., Dowler L.L., White R.A., Froehner S.C.
      J. Biol. Chem. 270:25859-25865(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Diaphragm.
    2. "Two forms of mouse syntrophin, a 58 kDa dystrophin-associated protein, differ in primary structure and tissue distribution."
      Adams M.E., Butler M.H., Dwyer T.M., Peters M.F., Murnane A.A., Froehner S.C.
      Neuron 11:531-540(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 91-520.
      Tissue: Diaphragm.
    3. "Differential association of syntrophin pairs with the dystrophin complex."
      Peters M.F., Adams M.E., Froehner S.C.
      J. Cell Biol. 138:81-93(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH UTRN.
    4. "Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins."
      Gee S.H., Madhavan R., Levinson S.R., Caldwell J.H., Sealock R., Froehner S.C.
      J. Neurosci. 18:128-137(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCN4A AND SCN5A.
    5. "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases."
      Lumeng C., Phelps S., Crawford G.E., Walden P.D., Barald K., Chamberlain J.S.
      Nat. Neurosci. 2:611-617(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SAST; MAST205; MICROTUBULES AND MICROTUBULE-ASSOCIATED PROTEINS.
    6. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
      Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
      Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain cortex.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    8. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75 AND SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSNTB2_MOUSE
    AccessioniPrimary (citable) accession number: Q61235
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: May 1, 1997
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3