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Protein

Beta-2-syntrophin

Gene

Sntb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Calmodulin-binding
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-syntrophin
Alternative name(s):
59 kDa dystrophin-associated protein A1 basic component 2
Syntrophin-3
Short name:
SNT3
Syntrophin-like
Short name:
SNTL
Gene namesi
Name:Sntb2
Synonyms:Snt2b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:101771 Sntb2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840121 – 520Beta-2-syntrophinAdd BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75PhosphoserineCombined sources1
Modified residuei90PhosphoserineCombined sources1
Modified residuei109PhosphoserineBy similarity1
Modified residuei191PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei213PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated. Partially dephosphorylated upon insulin stimulation (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ61235
MaxQBiQ61235
PaxDbiQ61235
PRIDEiQ61235

PTM databases

iPTMnetiQ61235
PhosphoSitePlusiQ61235

Expressioni

Tissue specificityi

Ubiquitous. Expressed at high levels in the testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000041308
CleanExiMM_SNTB2
ExpressionAtlasiQ61235 baseline and differential
GenevisibleiQ61235 MM

Interactioni

Subunit structurei

Monomer and homodimer (Probable). Interacts with the dystrophin protein DMD and related protein DTNA; and with the other members of the syntrophin family: SNTA1 and SNTB1. Interacts with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN (By similarity). Interacts with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins. Interacts with the dystrophin related protein UTRN.By similarityCurated3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2033841 interactor.
CORUMiQ61235
IntActiQ61235 4 interactors.
MINTiQ61235
STRINGi10090.ENSMUSP00000037324

Structurei

3D structure databases

ProteinModelPortaliQ61235
SMRiQ61235
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini95 – 178PDZPROSITE-ProRule annotationAdd BLAST84
Domaini143 – 280PH 1PROSITE-ProRule annotationAdd BLAST138
Domaini305 – 417PH 2PROSITE-ProRule annotationAdd BLAST113
Domaini464 – 520SUAdd BLAST57

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 520Calmodulin-bindingBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 60Poly-Gly4

Domaini

The PH 1 domain mediates the oligomerization in a calcium dependent manner.By similarity
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).By similarity
The SU domain binds calmodulin in a calcium-dependent manner.By similarity

Sequence similaritiesi

Belongs to the syntrophin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IMRK Eukaryota
ENOG4111J6R LUCA
GeneTreeiENSGT00550000074581
HOGENOMiHOG000231596
HOVERGENiHBG054204
InParanoidiQ61235
OMAiFRVETHW
OrthoDBiEOG091G0O31
PhylomeDBiQ61235
TreeFamiTF317932

Family and domain databases

Gene3Di2.30.29.301 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR028550 SNTB2
IPR015482 Syntrophin
PANTHERiPTHR10554 PTHR10554, 1 hit
PTHR10554:SF8 PTHR10554:SF8, 1 hit
PfamiView protein in Pfam
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00233 PH, 2 hits
SUPFAMiSSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q61235-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVWTRATKA GLVELLLRER WVRVVAELSG ESLSLTGDAA AVEPEPPAAA
60 70 80 90 100
FNGLPNGGGG ESLPGSPNRG LGPPSPPAPP RGPAGEASAS PPVRRVRVVK
110 120 130 140 150
QEAGGLGISI KGGRENRMPI LISKIFPGLA ADQSRALRLG DAILSVNGTD
160 170 180 190 200
LRQATHDQAV QALKRAGKEV LLEVKFIREV TPYIKKPSLV SDLPWEGASP
210 220 230 240 250
QSPSFSGSED SGSPKHQNTT KDRKVIPLKM CFAARNLSMP DLENRLIELH
260 270 280 290 300
SPDSRNTLIL RCKDTATAHS WFVAIHTNIM ALLPQVLAEL NAMLGATSTA
310 320 330 340 350
GGSKEVKHIA WLAEQAKLDG GRQQWRPVLM AVTEKDLLLY DCMPWTRDAW
360 370 380 390 400
ASPCHSYPLV ATRLVHSGSG CRSPSLGSDL TFATRTGSRQ GIEMHLFRVE
410 420 430 440 450
THRDLSTWTR ILVQGCHAAA ELIKEVSLGC TLSGQEVRFT VHYEHGFTIT
460 470 480 490 500
RDNGGASSIL YRYPFERLKM SADDGIRNLY LDFGGPEGEL TMDLHSCPKP
510 520
IVFVLHTFLS AKVTRMGLLV
Length:520
Mass (Da):56,382
Last modified:May 1, 1997 - v2
Checksum:i9F6886837C1CDB20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00678 mRNA Translation: AAC53060.1
CCDSiCCDS22642.1
RefSeqiNP_033255.1, NM_009229.4
UniGeneiMm.30228

Genome annotation databases

EnsembliENSMUST00000212524; ENSMUSP00000148684; ENSMUSG00000041308
GeneIDi20650
KEGGimmu:20650
UCSCiuc009ngt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSNTB2_MOUSE
AccessioniPrimary (citable) accession number: Q61235
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 1, 1997
Last modified: April 25, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome